FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9810, 247 aa 1>>>pF1KB9810 247 - 247 aa - 247 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5711+/-0.000806; mu= 12.8301+/- 0.048 mean_var=65.1817+/-12.811, 0's: 0 Z-trim(107.5): 14 B-trim: 0 in 0/48 Lambda= 0.158859 statistics sampled from 9591 (9603) to 9591 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.295), width: 16 Scan time: 2.320 The best scores are: opt bits E(32554) CCDS7866.1 BDNF gene_id:627|Hs108|chr11 ( 247) 1652 387.1 5.8e-108 CCDS7865.1 BDNF gene_id:627|Hs108|chr11 ( 255) 1652 387.1 5.9e-108 CCDS41628.1 BDNF gene_id:627|Hs108|chr11 ( 262) 1652 387.1 6.1e-108 CCDS44558.1 BDNF gene_id:627|Hs108|chr11 ( 329) 1652 387.2 7.4e-108 CCDS8538.1 NTF3 gene_id:4908|Hs108|chr12 ( 257) 574 140.1 1.4e-33 CCDS44806.1 NTF3 gene_id:4908|Hs108|chr12 ( 270) 574 140.1 1.5e-33 CCDS882.1 NGF gene_id:4803|Hs108|chr1 ( 241) 496 122.2 3.2e-28 CCDS12754.1 NTF4 gene_id:4909|Hs108|chr19 ( 210) 475 117.4 8e-27 >>CCDS7866.1 BDNF gene_id:627|Hs108|chr11 (247 aa) initn: 1652 init1: 1652 opt: 1652 Z-score: 2051.8 bits: 387.1 E(32554): 5.8e-108 Smith-Waterman score: 1652; 100.0% identity (100.0% similar) in 247 aa overlap (1-247:1-247) 10 20 30 40 50 60 pF1KB9 MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 DTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 NMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 NMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 FYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 FYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCT 190 200 210 220 230 240 pF1KB9 LTIKRGR ::::::: CCDS78 LTIKRGR >>CCDS7865.1 BDNF gene_id:627|Hs108|chr11 (255 aa) initn: 1652 init1: 1652 opt: 1652 Z-score: 2051.6 bits: 387.1 E(32554): 5.9e-108 Smith-Waterman score: 1652; 100.0% identity (100.0% similar) in 247 aa overlap (1-247:9-255) 10 20 30 40 50 pF1KB9 MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAG :::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 MFHQVRRVMTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 SRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 SRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 YKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 YKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 SKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 SKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIR 190 200 210 220 230 240 240 pF1KB9 IDTSCVCTLTIKRGR ::::::::::::::: CCDS78 IDTSCVCTLTIKRGR 250 >>CCDS41628.1 BDNF gene_id:627|Hs108|chr11 (262 aa) initn: 1652 init1: 1652 opt: 1652 Z-score: 2051.4 bits: 387.1 E(32554): 6.1e-108 Smith-Waterman score: 1652; 100.0% identity (100.0% similar) in 247 aa overlap (1-247:16-262) 10 20 30 40 pF1KB9 MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLES ::::::::::::::::::::::::::::::::::::::::::::: CCDS41 MQSREEEWFHQVRRVMTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLES 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB9 VNGPKAGSRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 VNGPKAGSRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPP 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB9 LLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 LLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVT 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB9 VLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 VLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKR 190 200 210 220 230 240 230 240 pF1KB9 IGWRFIRIDTSCVCTLTIKRGR :::::::::::::::::::::: CCDS41 IGWRFIRIDTSCVCTLTIKRGR 250 260 >>CCDS44558.1 BDNF gene_id:627|Hs108|chr11 (329 aa) initn: 1652 init1: 1652 opt: 1652 Z-score: 2049.8 bits: 387.2 E(32554): 7.4e-108 Smith-Waterman score: 1652; 100.0% identity (100.0% similar) in 247 aa overlap (1-247:83-329) 10 20 30 pF1KB9 MTILFLTMVISYFGCMKAAPMKEANIRGQG :::::::::::::::::::::::::::::: CCDS44 GCAVYLHVSVEFNKLIPENGFIKFHQVRRVMTILFLTMVISYFGCMKAAPMKEANIRGQG 60 70 80 90 100 110 40 50 60 70 80 90 pF1KB9 GLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 GLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLY 120 130 140 150 160 170 100 110 120 130 140 150 pF1KB9 TSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 TSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTA 180 190 200 210 220 230 160 170 180 190 200 210 pF1KB9 ADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 ADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRT 240 250 260 270 280 290 220 230 240 pF1KB9 TQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR ::::::::::::::::::::::::::::::::::::: CCDS44 TQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR 300 310 320 >>CCDS8538.1 NTF3 gene_id:4908|Hs108|chr12 (257 aa) initn: 512 init1: 414 opt: 574 Z-score: 716.3 bits: 140.1 E(32554): 1.4e-33 Smith-Waterman score: 582; 45.5% identity (74.2% similar) in 209 aa overlap (40-247:60-256) 10 20 30 40 50 60 pF1KB9 ISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIEE ..:: ....:. :: . ..:. :: CCDS85 SLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPA-KSAFQPVIA- 30 40 50 60 70 80 70 80 90 100 110 120 pF1KB9 LLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRH .: . .: ... : . ::.::...::::: :.:.:.: . .:: . : .:. CCDS85 -MDTEL-LRQQRRYN------SPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRY 90 100 110 120 130 130 140 150 160 170 180 pF1KB9 SD-PARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNP .. ..::: ::::: : ::: ::..:.:. : :::: .. .... .:::::::.:. CCDS85 AEHKSHRGEYSVCDSESLWVT--DKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKE 140 150 160 170 180 190 190 200 210 220 230 240 pF1KB9 MGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR .:.:::::: .::::::.:.:.:::::: ...: .:::.:::::::::.:. : :: CCDS85 ARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT 200 210 220 230 240 250 >>CCDS44806.1 NTF3 gene_id:4908|Hs108|chr12 (270 aa) initn: 512 init1: 414 opt: 574 Z-score: 716.0 bits: 140.1 E(32554): 1.5e-33 Smith-Waterman score: 582; 45.5% identity (74.2% similar) in 209 aa overlap (40-247:73-269) 10 20 30 40 50 60 pF1KB9 ISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIEE ..:: ....:. :: . ..:. :: CCDS44 SLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPA-KSAFQPVIA- 50 60 70 80 90 100 70 80 90 100 110 120 pF1KB9 LLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRH .: . .: ... : . ::.::...::::: :.:.:.: . .:: . : .:. CCDS44 -MDTEL-LRQQRRYN------SPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRY 110 120 130 140 150 130 140 150 160 170 180 pF1KB9 SD-PARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNP .. ..::: ::::: : ::: ::..:.:. : :::: .. .... .:::::::.:. CCDS44 AEHKSHRGEYSVCDSESLWVT--DKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKE 160 170 180 190 200 210 190 200 210 220 230 240 pF1KB9 MGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR .:.:::::: .::::::.:.:.:::::: ...: .:::.:::::::::.:. : :: CCDS44 ARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT 220 230 240 250 260 270 >>CCDS882.1 NGF gene_id:4803|Hs108|chr1 (241 aa) initn: 435 init1: 272 opt: 496 Z-score: 620.1 bits: 122.2 E(32554): 3.2e-28 Smith-Waterman score: 496; 36.9% identity (64.3% similar) in 249 aa overlap (1-247:1-239) 10 20 30 40 50 60 pF1KB9 MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLA :..:: :.. ... ..: : .:.:. .: . : ..: : . . : :. .. : CCDS88 MSMLFYTLITAFLIGIQAEPHSESNV--PAGHTIP--QAHWTKLQHSLDTALRRARSAPA 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 DTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAA . . .. . ... . . : : . ::..:.: : : :. . CCDS88 AA---IAARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPF 60 70 80 90 100 110 130 140 150 160 170 pF1KB9 NMSMRVRRHSD-PA-RRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLK : . : .: :. : .:::.:::::.: :: .:: ::.:..: : :: .: .... .: CCDS88 NRTHRSKRSSSHPIFHRGEFSVCDSVSVWV--GDKTTATDIKGKEVMVLGEVNINNSVFK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 QYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCV :::.:::: . . ::::::..:::: : ::...:.:::::.:. .::::::::.:: CCDS88 QYFFETKCRDPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQ-AAWRFIRIDTACV 180 190 200 210 220 230 240 pF1KB9 CTLTIKRGR :.:. : : CCDS88 CVLSRKAVRRA 240 >>CCDS12754.1 NTF4 gene_id:4909|Hs108|chr19 (210 aa) initn: 480 init1: 284 opt: 475 Z-score: 595.1 bits: 117.4 E(32554): 8e-27 Smith-Waterman score: 547; 52.0% identity (71.1% similar) in 173 aa overlap (88-247:40-209) 60 70 80 90 100 110 pF1KB9 SLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEE--YKN :: . ::.:: .: :::::::: ... CCDS12 PILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSPRVVLSRGAPAGPPLLFLLEAGAFRE 10 20 30 40 50 60 120 130 140 150 160 170 pF1KB9 YLDA-ANMSMRVRRHSDPA-RRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVS : :: : : .. :: :::::.:::..: ::: :..::::. : : :: .::.. CCDS12 SAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVT--DRRTAVDLRGREVEVLGEVPAA 70 80 90 100 110 120 180 190 200 210 220 pF1KB9 KGQ-LKQYFYETKCN--------PMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKK :. :.:::.::.:. : : ::::.:.::: :.:.. :::::::: :.. CCDS12 GGSPLRQYFFETRCKADNAEEGGP-GAGGGGCRGVDRRHWVSECKAKQSYVRALTADAQG 130 140 150 160 170 180 230 240 pF1KB9 RIGWRFIRIDTSCVCTLTIKRGR :.:::.:::::.::::: . :: CCDS12 RVGWRWIRIDTACVCTLLSRTGRA 190 200 210 247 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 19:09:16 2016 done: Fri Nov 4 19:09:17 2016 Total Scan time: 2.320 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]