FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9812, 257 aa 1>>>pF1KB9812 257 - 257 aa - 257 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8808+/-0.000781; mu= 12.8843+/- 0.047 mean_var=82.3239+/-16.008, 0's: 0 Z-trim(110.0): 10 B-trim: 0 in 0/50 Lambda= 0.141355 statistics sampled from 11267 (11275) to 11267 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.725), E-opt: 0.2 (0.346), width: 16 Scan time: 2.090 The best scores are: opt bits E(32554) CCDS8538.1 NTF3 gene_id:4908|Hs108|chr12 ( 257) 1721 360.1 8.8e-100 CCDS44806.1 NTF3 gene_id:4908|Hs108|chr12 ( 270) 1721 360.1 9.2e-100 CCDS882.1 NGF gene_id:4803|Hs108|chr1 ( 241) 601 131.6 4.8e-31 CCDS7866.1 BDNF gene_id:627|Hs108|chr11 ( 247) 574 126.1 2.2e-29 CCDS7865.1 BDNF gene_id:627|Hs108|chr11 ( 255) 574 126.1 2.3e-29 CCDS41628.1 BDNF gene_id:627|Hs108|chr11 ( 262) 574 126.2 2.3e-29 CCDS44558.1 BDNF gene_id:627|Hs108|chr11 ( 329) 574 126.2 2.8e-29 CCDS12754.1 NTF4 gene_id:4909|Hs108|chr19 ( 210) 502 111.4 5.1e-25 >>CCDS8538.1 NTF3 gene_id:4908|Hs108|chr12 (257 aa) initn: 1721 init1: 1721 opt: 1721 Z-score: 1904.9 bits: 360.1 E(32554): 8.8e-100 Smith-Waterman score: 1721; 100.0% identity (100.0% similar) in 257 aa overlap (1-257:1-257) 10 20 30 40 50 60 pF1KB9 MSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 MSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 STLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRYNSPRVLLSDSTPLEPPPLYLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 STLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRYNSPRVLLSDSTPLEPPPLYLM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EDYVGSPVVANRTSRRKRYAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 EDYVGSPVVANRTSRRKRYAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 TGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 TGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWI 190 200 210 220 230 240 250 pF1KB9 RIDTSCVCALSRKIGRT ::::::::::::::::: CCDS85 RIDTSCVCALSRKIGRT 250 >>CCDS44806.1 NTF3 gene_id:4908|Hs108|chr12 (270 aa) initn: 1721 init1: 1721 opt: 1721 Z-score: 1904.6 bits: 360.1 E(32554): 9.2e-100 Smith-Waterman score: 1721; 100.0% identity (100.0% similar) in 257 aa overlap (1-257:14-270) 10 20 30 40 pF1KB9 MSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADILKNK ::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MVTFATILQVNKVMSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADILKNK 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB9 LSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRYNSPRVLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRYNSPRVLLS 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB9 DSTPLEPPPLYLMEDYVGSPVVANRTSRRKRYAEHKSHRGEYSVCDSESLWVTDKSSAID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 DSTPLEPPPLYLMEDYVGSPVVANRTSRRKRYAEHKSHRGEYSVCDSESLWVTDKSSAID 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB9 IRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 IRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRAL 190 200 210 220 230 240 230 240 250 pF1KB9 TSENNKLVGWRWIRIDTSCVCALSRKIGRT :::::::::::::::::::::::::::::: CCDS44 TSENNKLVGWRWIRIDTSCVCALSRKIGRT 250 260 270 >>CCDS882.1 NGF gene_id:4803|Hs108|chr1 (241 aa) initn: 464 init1: 402 opt: 601 Z-score: 670.9 bits: 131.6 E(32554): 4.8e-31 Smith-Waterman score: 634; 42.6% identity (67.4% similar) in 258 aa overlap (1-256:1-239) 10 20 30 40 50 60 pF1KB9 MSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQ ::.:::... :.: :::.. .. ..: . :: : .... . CCDS88 MSMLFYTLITAFLIGIQAEPHSESNVPAGHT------IPQAHWTK---------LQHSLD 10 20 30 40 70 80 90 100 110 pF1KB9 STLPKAEAPREPERGGPAKSAFQPV-IAMDTELLRQQRRYNSPRVLLSDSTPLEPPPLYL ..: .:.. : . :. : : :..: .:... :: :::::.: . : : CCDS88 TALRRARS--APAAAIAARVAGQTRNITVDPRLFKK-RRLRSPRVLFSTQPPREAADTQD 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB9 MEDYVGSPVVANRTSRRKRYAEHKS-HRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGE .. ::. . ::: : :: . : ::::.::::: :.:: ::..: ::.:..: :::: CCDS88 LDFEVGGAAPFNRTHRSKRSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB9 IKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWR .. .:: ::::.::.:.. :: .::::::.::::: : :..:.:.::: .. : ..:: CCDS88 VNINNSVFKQYFFETKCRDPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDG-KQAAWR 170 180 190 200 210 220 240 250 pF1KB9 WIRIDTSCVCALSRKIGRT .:::::.:::.:::: : CCDS88 FIRIDTACVCVLSRKAVRRA 230 240 >>CCDS7866.1 BDNF gene_id:627|Hs108|chr11 (247 aa) initn: 512 init1: 414 opt: 574 Z-score: 641.0 bits: 126.1 E(32554): 2.2e-29 Smith-Waterman score: 582; 45.5% identity (74.2% similar) in 209 aa overlap (60-256:40-247) 30 40 50 60 70 80 pF1KB9 SLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPA-KSAFQPVIA- ..:: ....:. :: . ..:. :: CCDS78 ISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIEE 10 20 30 40 50 60 90 100 110 120 130 pF1KB9 -MDTEL-LRQQRRYN------SPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRY .: . .: ... : . ::.::...::::: :.:.:.: . .:: . : .:. CCDS78 LLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRH 70 80 90 100 110 120 140 150 160 170 180 190 pF1KB9 AEHKSHRGEYSVCDSESLWVT--DKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKE .. ..::: ::::: : ::: ::..:.:. : :::: .. .... .:::::::.:. CCDS78 SD-PARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNP 130 140 150 160 170 180 200 210 220 230 240 250 pF1KB9 ARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT .:.:::::: .::::::.:.:.:::::: ...: .:::.:::::::::.:. : :: CCDS78 MGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR 190 200 210 220 230 240 >>CCDS7865.1 BDNF gene_id:627|Hs108|chr11 (255 aa) initn: 512 init1: 414 opt: 574 Z-score: 640.8 bits: 126.1 E(32554): 2.3e-29 Smith-Waterman score: 582; 45.5% identity (74.2% similar) in 209 aa overlap (60-256:48-255) 30 40 50 60 70 80 pF1KB9 SLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPA-KSAFQPVIA- ..:: ....:. :: . ..:. :: CCDS78 ISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIEE 20 30 40 50 60 70 90 100 110 120 130 pF1KB9 -MDTEL-LRQQRRYN------SPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRY .: . .: ... : . ::.::...::::: :.:.:.: . .:: . : .:. CCDS78 LLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRH 80 90 100 110 120 130 140 150 160 170 180 190 pF1KB9 AEHKSHRGEYSVCDSESLWVT--DKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKE .. ..::: ::::: : ::: ::..:.:. : :::: .. .... .:::::::.:. CCDS78 SD-PARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNP 140 150 160 170 180 190 200 210 220 230 240 250 pF1KB9 ARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT .:.:::::: .::::::.:.:.:::::: ...: .:::.:::::::::.:. : :: CCDS78 MGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR 200 210 220 230 240 250 >>CCDS41628.1 BDNF gene_id:627|Hs108|chr11 (262 aa) initn: 512 init1: 414 opt: 574 Z-score: 640.6 bits: 126.2 E(32554): 2.3e-29 Smith-Waterman score: 582; 45.5% identity (74.2% similar) in 209 aa overlap (60-256:55-262) 30 40 50 60 70 80 pF1KB9 SLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPA-KSAFQPVIA- ..:: ....:. :: . ..:. :: CCDS41 ISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIEE 30 40 50 60 70 80 90 100 110 120 130 pF1KB9 -MDTEL-LRQQRRYN------SPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRY .: . .: ... : . ::.::...::::: :.:.:.: . .:: . : .:. CCDS41 LLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRH 90 100 110 120 130 140 140 150 160 170 180 190 pF1KB9 AEHKSHRGEYSVCDSESLWVT--DKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKE .. ..::: ::::: : ::: ::..:.:. : :::: .. .... .:::::::.:. CCDS41 SD-PARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNP 150 160 170 180 190 200 200 210 220 230 240 250 pF1KB9 ARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT .:.:::::: .::::::.:.:.:::::: ...: .:::.:::::::::.:. : :: CCDS41 MGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR 210 220 230 240 250 260 >>CCDS44558.1 BDNF gene_id:627|Hs108|chr11 (329 aa) initn: 512 init1: 414 opt: 574 Z-score: 639.1 bits: 126.2 E(32554): 2.8e-29 Smith-Waterman score: 582; 45.5% identity (74.2% similar) in 209 aa overlap (60-256:122-329) 30 40 50 60 70 80 pF1KB9 SLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPA-KSAFQPVIA- ..:: ....:. :: . ..:. :: CCDS44 ISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIEE 100 110 120 130 140 150 90 100 110 120 130 pF1KB9 -MDTEL-LRQQRRYN------SPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRY .: . .: ... : . ::.::...::::: :.:.:.: . .:: . : .:. CCDS44 LLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRH 160 170 180 190 200 210 140 150 160 170 180 190 pF1KB9 AEHKSHRGEYSVCDSESLWVT--DKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKE .. ..::: ::::: : ::: ::..:.:. : :::: .. .... .:::::::.:. CCDS44 SD-PARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNP 220 230 240 250 260 270 200 210 220 230 240 250 pF1KB9 ARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT .:.:::::: .::::::.:.:.:::::: ...: .:::.:::::::::.:. : :: CCDS44 MGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR 280 290 300 310 320 >>CCDS12754.1 NTF4 gene_id:4909|Hs108|chr19 (210 aa) initn: 602 init1: 268 opt: 502 Z-score: 562.7 bits: 111.4 E(32554): 5.1e-25 Smith-Waterman score: 578; 46.3% identity (69.2% similar) in 201 aa overlap (69-256:18-209) 40 50 60 70 80 90 pF1KB9 IQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRR : : .. : :.. : .: . .:: CCDS12 MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLL----- 10 20 30 40 100 110 120 130 140 150 pF1KB9 YNSPRVLLSDSTPLEPPPLYLME-----DYVGSPVVANRTSRRKRYAEHKSHRGEYSVCD ::::.:: ..: :: :.:.: . .:.: :::. : . :.::: .::: CCDS12 --SPRVVLSRGAPAGPPLLFLLEAGAFRESAGAP--ANRSRRGVSETAPASRRGELAVCD 50 60 70 80 90 160 170 180 190 200 pF1KB9 SESLWVTDKSSAIDIRGHQVTVLGEIKT-GNSPVKQYFYETRCK-----EARPVKNG--C . : ::::. .:.:.::..: ::::. . :.::..:::.::::: :. : .: : CCDS12 AVSGWVTDRRTAVDLRGREVEVLGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGC 100 110 120 130 140 150 210 220 230 240 250 pF1KB9 RGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT ::.: .:: :.::..:.::::::.. . ::::::::::.:::.: . :: CCDS12 RGVDRRHWVSECKAKQSYVRALTADAQGRVGWRWIRIDTACVCTLLSRTGRA 160 170 180 190 200 210 257 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 19:10:59 2016 done: Fri Nov 4 19:11:00 2016 Total Scan time: 2.090 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]