FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9816, 300 aa 1>>>pF1KB9816 300 - 300 aa - 300 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6647+/-0.000336; mu= 19.6994+/- 0.021 mean_var=87.7428+/-21.139, 0's: 0 Z-trim(115.3): 347 B-trim: 1434 in 1/55 Lambda= 0.136921 statistics sampled from 25184 (25638) to 25184 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.659), E-opt: 0.2 (0.301), width: 16 Scan time: 7.930 The best scores are: opt bits E(85289) NP_005294 (OMIM: 603820) free fatty acid receptor ( 300) 2046 414.0 1.8e-115 NP_005295 (OMIM: 603821) free fatty acid receptor ( 346) 447 98.2 2.3e-20 XP_011525160 (OMIM: 603821) PREDICTED: free fatty ( 383) 447 98.3 2.5e-20 XP_016882198 (OMIM: 603823) PREDICTED: free fatty ( 330) 424 93.7 5.3e-19 XP_016882199 (OMIM: 603823) PREDICTED: free fatty ( 330) 424 93.7 5.3e-19 XP_016882200 (OMIM: 603823) PREDICTED: free fatty ( 330) 424 93.7 5.3e-19 NP_005297 (OMIM: 603823) free fatty acid receptor ( 330) 424 93.7 5.3e-19 NP_001983 (OMIM: 187930) proteinase-activated rece ( 425) 313 71.9 2.5e-12 XP_011543934 (OMIM: 300525) PREDICTED: P2Y purinoc ( 359) 300 69.2 1.3e-11 XP_005274835 (OMIM: 300525) PREDICTED: P2Y purinoc ( 359) 300 69.2 1.3e-11 NP_835230 (OMIM: 300525) P2Y purinoceptor 8 [Homo ( 359) 300 69.2 1.3e-11 XP_011543933 (OMIM: 300525) PREDICTED: P2Y purinoc ( 359) 300 69.2 1.3e-11 XP_005274486 (OMIM: 300525) PREDICTED: P2Y purinoc ( 359) 300 69.2 1.3e-11 XP_011544481 (OMIM: 300525) PREDICTED: P2Y purinoc ( 359) 300 69.2 1.3e-11 XP_011544480 (OMIM: 300525) PREDICTED: P2Y purinoc ( 359) 300 69.2 1.3e-11 XP_006724927 (OMIM: 300525) PREDICTED: P2Y purinoc ( 548) 300 69.5 1.7e-11 XP_006724506 (OMIM: 300525) PREDICTED: P2Y purinoc ( 548) 300 69.5 1.7e-11 NP_003941 (OMIM: 602779) proteinase-activated rece ( 385) 287 66.7 8.2e-11 NP_001136433 (OMIM: 606926) lysophosphatidic acid ( 372) 276 64.5 3.6e-10 NP_065133 (OMIM: 606926) lysophosphatidic acid rec ( 372) 276 64.5 3.6e-10 NP_001298242 (OMIM: 187930) proteinase-activated r ( 304) 275 64.2 3.7e-10 XP_011510478 (OMIM: 604107) PREDICTED: G-protein c ( 319) 244 58.1 2.6e-08 XP_005247009 (OMIM: 604107) PREDICTED: G-protein c ( 319) 244 58.1 2.6e-08 XP_011510477 (OMIM: 604107) PREDICTED: G-protein c ( 319) 244 58.1 2.6e-08 NP_005674 (OMIM: 604107) G-protein coupled recepto ( 319) 244 58.1 2.6e-08 XP_005260196 (OMIM: 602779) PREDICTED: proteinase- ( 273) 241 57.4 3.6e-08 NP_004063 (OMIM: 602351) chemokine-like receptor 1 ( 371) 242 57.8 3.8e-08 XP_016874309 (OMIM: 602351) PREDICTED: chemokine-l ( 371) 242 57.8 3.8e-08 NP_001135816 (OMIM: 602351) chemokine-like recepto ( 373) 242 57.8 3.8e-08 NP_001135815 (OMIM: 602351) chemokine-like recepto ( 373) 242 57.8 3.8e-08 NP_001135817 (OMIM: 602351) chemokine-like recepto ( 373) 242 57.8 3.8e-08 NP_001043 (OMIM: 182454) somatostatin receptor typ ( 388) 239 57.2 5.9e-08 NP_001243495 (OMIM: 601919) proteinase-activated r ( 352) 238 57.0 6.4e-08 NP_004092 (OMIM: 601919) proteinase-activated rece ( 374) 238 57.0 6.6e-08 NP_005758 (OMIM: 278150,609239) lysophosphatidic a ( 344) 237 56.8 7.2e-08 NP_001155969 (OMIM: 278150,609239) lysophosphatidi ( 344) 237 56.8 7.2e-08 NP_001155970 (OMIM: 278150,609239) lysophosphatidi ( 344) 237 56.8 7.2e-08 NP_004769 (OMIM: 604837) prostaglandin D2 receptor ( 395) 237 56.8 7.9e-08 XP_016875894 (OMIM: 605741) PREDICTED: G-protein c ( 361) 228 55.0 2.5e-07 NP_004942 (OMIM: 605741) G-protein coupled recepto ( 361) 228 55.0 2.5e-07 NP_789766 (OMIM: 602451) P2Y purinoceptor 6 isofor ( 328) 220 53.4 7.2e-07 XP_005274079 (OMIM: 602451) PREDICTED: P2Y purinoc ( 328) 220 53.4 7.2e-07 NP_001264136 (OMIM: 602451) P2Y purinoceptor 6 iso ( 328) 220 53.4 7.2e-07 XP_011543381 (OMIM: 602451) PREDICTED: P2Y purinoc ( 328) 220 53.4 7.2e-07 XP_011543379 (OMIM: 602451) PREDICTED: P2Y purinoc ( 328) 220 53.4 7.2e-07 NP_001264133 (OMIM: 602451) P2Y purinoceptor 6 iso ( 328) 220 53.4 7.2e-07 NP_789767 (OMIM: 602451) P2Y purinoceptor 6 isofor ( 328) 220 53.4 7.2e-07 XP_006718634 (OMIM: 602451) PREDICTED: P2Y purinoc ( 328) 220 53.4 7.2e-07 NP_789768 (OMIM: 602451) P2Y purinoceptor 6 isofor ( 328) 220 53.4 7.2e-07 NP_001264135 (OMIM: 602451) P2Y purinoceptor 6 iso ( 328) 220 53.4 7.2e-07 >>NP_005294 (OMIM: 603820) free fatty acid receptor 1 [H (300 aa) initn: 2046 init1: 2046 opt: 2046 Z-score: 2194.2 bits: 414.0 E(85289): 1.8e-115 Smith-Waterman score: 2046; 100.0% identity (100.0% similar) in 300 aa overlap (1-300:1-300) 10 20 30 40 50 60 pF1KB9 MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 CYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 CYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 PARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 NASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK 250 260 270 280 290 300 >>NP_005295 (OMIM: 603821) free fatty acid receptor 3 [H (346 aa) initn: 383 init1: 215 opt: 447 Z-score: 486.4 bits: 98.2 E(85289): 2.3e-20 Smith-Waterman score: 461; 33.9% identity (62.5% similar) in 277 aa overlap (9-282:18-282) 10 20 30 40 50 pF1KB9 MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCS :..:. .: .:.:::.::. ... . : . : ::: : NP_005 MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLQRRPVAVDVLLLNLTAS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 DLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFP :::: . ::.. ::: . :::: :::. . : .: . ::::.: :.:..: : NP_005 DLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAHP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 LGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVC- : :.. : . : .: : :. : ..:. .: : ..::. . ::. : NP_005 LWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGD-ISHSQGT-------NGT--CY 130 140 150 160 170 180 190 200 210 220 pF1KB9 LEAWDPASAG--PARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGG :: : :.:. ....:: .:: ::..:: . :.:.: .:::. :.: . .. NP_005 LEFRKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRGG-SHRRQRRVAGLLAA 180 190 200 210 220 230 240 250 260 270 280 pF1KB9 ALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTV .::..:.: ::::.:.:.... . . .:: . .. . ..:.: . . : NP_005 TLLNFLVCFGPYNVSHVVGYICGE-SPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFH 230 240 250 260 270 280 290 300 pF1KB9 CAARTQGGKSQK NP_005 ELLRRLCGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAES 290 300 310 320 330 340 >>XP_011525160 (OMIM: 603821) PREDICTED: free fatty acid (383 aa) initn: 383 init1: 215 opt: 447 Z-score: 485.9 bits: 98.3 E(85289): 2.5e-20 Smith-Waterman score: 461; 33.9% identity (62.5% similar) in 277 aa overlap (9-282:55-319) 10 20 30 pF1KB9 MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRL :..:. .: .:.:::.::. ... . : XP_011 QGIYVPLLNMATTMDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLQRRP 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB9 TPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLA . : ::: ::::: . ::.. ::: . :::: :::. . : .: . ::: XP_011 VAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLA 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB9 ALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSL :.: :.:..: :: :.. : . : .: : :. : ..:. .: : ..::. . XP_011 AVSIERFLSVAHPLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGD-ISHSQGT- 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB9 GINTPVNGSPVC-LEAWDPASAG--PARFSLSLLLFFLPLAITAFCYVGCLRALARSGLT ::. : :: : :.:. ....:: .:: ::..:: . :.:.: . XP_011 ------NGT--CYLEFRKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRGG-S 210 220 230 240 250 220 230 240 250 260 270 pF1KB9 HRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLV :::. :.: . ...::..:.: ::::.:.:.... . . .:: . .. . ..:.: XP_011 HRRQRRVAGLLAATLLNFLVCFGPYNVSHVVGYICGE-SPAWRIYVTLLSTLNSCVDPFV 260 270 280 290 300 310 280 290 300 pF1KB9 TGYLGRGPGLKTVCAARTQGGKSQK . . : XP_011 YYFSSSGFQADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQGC 320 330 340 350 360 370 >>XP_016882198 (OMIM: 603823) PREDICTED: free fatty acid (330 aa) initn: 345 init1: 213 opt: 424 Z-score: 462.1 bits: 93.7 E(85289): 5.3e-19 Smith-Waterman score: 438; 30.5% identity (60.7% similar) in 308 aa overlap (2-295:4-295) 10 20 30 40 50 pF1KB9 MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARL-RLTPSLVYALNLGCSDLLLTV : .: . :. : :.: :.::.:. ... : . .: . :.: .:::: . XP_016 MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 SLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAF ::.: .:: .. : :: .: . . . . .: . .::..: ::::.:::. :. XP_016 LLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 RRPCYSWGVCAAI--WALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPV-CLEAW ::: : :: ::. :.. . : .:. .. . ::. . . :. . : : . XP_016 RRPLY--GVIAALVAWVMSFGHCTIVIIVQ-------YLNTTEQVRS---GNEITCYENF 130 140 150 160 180 190 200 210 220 230 pF1KB9 DPASAG---PARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTH-RRKLRAAWVAGGAL . :.:. : :.:::.:.:.: ::: . . . :. .:. ::. .: .: XP_016 TDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTL 170 180 190 200 210 220 240 250 260 270 280 pF1KB9 LTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLV----TGYLGR--GPG :..:.: ::::.:..... . . ::..... .. .. :.::. .. . : : : XP_016 LNFLVCFGPYNVSHLVGY-HQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRG 230 240 250 260 270 280 290 300 pF1KB9 LKTVCAARTQGGKSQK :... :.:: XP_016 LQVL---RNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE 290 300 310 320 330 >>XP_016882199 (OMIM: 603823) PREDICTED: free fatty acid (330 aa) initn: 345 init1: 213 opt: 424 Z-score: 462.1 bits: 93.7 E(85289): 5.3e-19 Smith-Waterman score: 438; 30.5% identity (60.7% similar) in 308 aa overlap (2-295:4-295) 10 20 30 40 50 pF1KB9 MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARL-RLTPSLVYALNLGCSDLLLTV : .: . :. : :.: :.::.:. ... : . .: . :.: .:::: . XP_016 MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 SLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAF ::.: .:: .. : :: .: . . . . .: . .::..: ::::.:::. :. XP_016 LLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 RRPCYSWGVCAAI--WALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPV-CLEAW ::: : :: ::. :.. . : .:. .. . ::. . . :. . : : . XP_016 RRPLY--GVIAALVAWVMSFGHCTIVIIVQ-------YLNTTEQVRS---GNEITCYENF 130 140 150 160 180 190 200 210 220 230 pF1KB9 DPASAG---PARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTH-RRKLRAAWVAGGAL . :.:. : :.:::.:.:.: ::: . . . :. .:. ::. .: .: XP_016 TDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTL 170 180 190 200 210 220 240 250 260 270 280 pF1KB9 LTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLV----TGYLGR--GPG :..:.: ::::.:..... . . ::..... .. .. :.::. .. . : : : XP_016 LNFLVCFGPYNVSHLVGY-HQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRG 230 240 250 260 270 280 290 300 pF1KB9 LKTVCAARTQGGKSQK :... :.:: XP_016 LQVL---RNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE 290 300 310 320 330 >>XP_016882200 (OMIM: 603823) PREDICTED: free fatty acid (330 aa) initn: 345 init1: 213 opt: 424 Z-score: 462.1 bits: 93.7 E(85289): 5.3e-19 Smith-Waterman score: 438; 30.5% identity (60.7% similar) in 308 aa overlap (2-295:4-295) 10 20 30 40 50 pF1KB9 MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARL-RLTPSLVYALNLGCSDLLLTV : .: . :. : :.: :.::.:. ... : . .: . :.: .:::: . XP_016 MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 SLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAF ::.: .:: .. : :: .: . . . . .: . .::..: ::::.:::. :. XP_016 LLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 RRPCYSWGVCAAI--WALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPV-CLEAW ::: : :: ::. :.. . : .:. .. . ::. . . :. . : : . XP_016 RRPLY--GVIAALVAWVMSFGHCTIVIIVQ-------YLNTTEQVRS---GNEITCYENF 130 140 150 160 180 190 200 210 220 230 pF1KB9 DPASAG---PARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTH-RRKLRAAWVAGGAL . :.:. : :.:::.:.:.: ::: . . . :. .:. ::. .: .: XP_016 TDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTL 170 180 190 200 210 220 240 250 260 270 280 pF1KB9 LTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLV----TGYLGR--GPG :..:.: ::::.:..... . . ::..... .. .. :.::. .. . : : : XP_016 LNFLVCFGPYNVSHLVGY-HQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRG 230 240 250 260 270 280 290 300 pF1KB9 LKTVCAARTQGGKSQK :... :.:: XP_016 LQVL---RNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE 290 300 310 320 330 >>NP_005297 (OMIM: 603823) free fatty acid receptor 2 [H (330 aa) initn: 345 init1: 213 opt: 424 Z-score: 462.1 bits: 93.7 E(85289): 5.3e-19 Smith-Waterman score: 438; 30.5% identity (60.7% similar) in 308 aa overlap (2-295:4-295) 10 20 30 40 50 pF1KB9 MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARL-RLTPSLVYALNLGCSDLLLTV : .: . :. : :.: :.::.:. ... : . .: . :.: .:::: . NP_005 MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 SLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAF ::.: .:: .. : :: .: . . . . .: . .::..: ::::.:::. :. NP_005 LLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 RRPCYSWGVCAAI--WALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPV-CLEAW ::: : :: ::. :.. . : .:. .. . ::. . . :. . : : . NP_005 RRPLY--GVIAALVAWVMSFGHCTIVIIVQ-------YLNTTEQVRS---GNEITCYENF 130 140 150 160 180 190 200 210 220 230 pF1KB9 DPASAG---PARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTH-RRKLRAAWVAGGAL . :.:. : :.:::.:.:.: ::: . . . :. .:. ::. .: .: NP_005 TDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTL 170 180 190 200 210 220 240 250 260 270 280 pF1KB9 LTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLV----TGYLGR--GPG :..:.: ::::.:..... . . ::..... .. .. :.::. .. . : : : NP_005 LNFLVCFGPYNVSHLVGY-HQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRG 230 240 250 260 270 280 290 300 pF1KB9 LKTVCAARTQGGKSQK :... :.:: NP_005 LQVL---RNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE 290 300 310 320 330 >>NP_001983 (OMIM: 187930) proteinase-activated receptor (425 aa) initn: 287 init1: 164 opt: 313 Z-score: 342.4 bits: 71.9 E(85289): 2.5e-12 Smith-Waterman score: 314; 26.0% identity (62.4% similar) in 242 aa overlap (11-250:108-339) 10 20 30 40 pF1KB9 MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTP .:...:....:::..:: . ... : NP_001 SPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVK-KP 80 90 100 110 120 130 50 60 70 80 90 100 pF1KB9 SLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAAL ..:: :.:. .:.:.. ::.: .... : . . :: ..: . .::. ..... NP_001 AVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVI 140 150 160 170 180 190 110 120 130 140 150 160 pF1KB9 SAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGI : :.:....:. ..: . .: :::::.. :.: : ... :. NP_001 SIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIA--GVV-----PLLLKEQTIQVPGL 200 210 220 230 240 170 180 190 200 210 pF1KB9 NTPVNGSPVCLEAWDPASAGPARFS-LSLLLFFLPLAITAFCYVGCLRALARSGLTHR-R : . . . . : :: .: ..::.:: :.. :::. .: :. :....: . NP_001 NITTCHDVLNETLLEGYYA--YYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSK 250 260 270 280 290 300 220 230 240 250 260 270 pF1KB9 KLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGY : :: ....... ...: :: :. .: . . NP_001 KSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCID 310 320 330 340 350 360 280 290 300 pF1KB9 LGRGPGLKTVCAARTQGGKSQK NP_001 PLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT 370 380 390 400 410 420 >>XP_011543934 (OMIM: 300525) PREDICTED: P2Y purinocepto (359 aa) initn: 256 init1: 201 opt: 300 Z-score: 329.3 bits: 69.2 E(85289): 1.3e-11 Smith-Waterman score: 305; 27.2% identity (56.9% similar) in 283 aa overlap (11-281:29-298) 10 20 30 40 pF1KB9 MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSL .: . :...: :.... . : .::. XP_011 MQVPNSTGPDNATLQMLRNPAIAVALPVVYSLVAAVSIPGNLFSLWVLCRRMGPR-SPSV 10 20 30 40 50 50 60 70 80 90 100 pF1KB9 VYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSA .. .::. .::.:. ::.. : . . :: : .:: . .:.. .. .:. XP_011 IFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISV 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB9 GRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINT :.::. .::. . .:: :. ..::. : :.: :. . . : . .::: : XP_011 ERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTD-----LTYPVHALGIIT 120 130 140 150 160 170 170 180 190 200 210 pF1KB9 PVNGSPVCLEA--WD--PASAGPARF--SLSLLLFFLPLAITAFCYVGCLRALARSGLTH :... : :. : : : .. .:::..:..::. ::.. . : :. .: XP_011 -------CFDVLKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAH 180 190 200 210 220 220 230 240 250 260 270 pF1KB9 RR--KLRAAWVAGGALLTLLLCVGPYN----ASNVASFLYPNLGGSWRKLGLITGAWSVV : . ::. .:. .::... : .: : : :. ..: . :: : . . XP_011 GREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNC 230 240 250 260 270 280 280 290 300 pF1KB9 LNPLVTGYLGRGPGLKTVCAARTQGGKSQK :.:.: . .: XP_011 LDPFVYYFASREFQLRLREYLGCRRVPRDTLDTRRESLFSARTTSVRSEAGAHPEGMEGA 290 300 310 320 330 340 >>XP_005274835 (OMIM: 300525) PREDICTED: P2Y purinocepto (359 aa) initn: 256 init1: 201 opt: 300 Z-score: 329.3 bits: 69.2 E(85289): 1.3e-11 Smith-Waterman score: 305; 27.2% identity (56.9% similar) in 283 aa overlap (11-281:29-298) 10 20 30 40 pF1KB9 MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSL .: . :...: :.... . : .::. XP_005 MQVPNSTGPDNATLQMLRNPAIAVALPVVYSLVAAVSIPGNLFSLWVLCRRMGPR-SPSV 10 20 30 40 50 50 60 70 80 90 100 pF1KB9 VYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSA .. .::. .::.:. ::.. : . . :: : .:: . .:.. .. .:. XP_005 IFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISV 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB9 GRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINT :.::. .::. . .:: :. ..::. : :.: :. . . : . .::: : XP_005 ERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTD-----LTYPVHALGIIT 120 130 140 150 160 170 170 180 190 200 210 pF1KB9 PVNGSPVCLEA--WD--PASAGPARF--SLSLLLFFLPLAITAFCYVGCLRALARSGLTH :... : :. : : : .. .:::..:..::. ::.. . : :. .: XP_005 -------CFDVLKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAH 180 190 200 210 220 220 230 240 250 260 270 pF1KB9 RR--KLRAAWVAGGALLTLLLCVGPYN----ASNVASFLYPNLGGSWRKLGLITGAWSVV : . ::. .:. .::... : .: : : :. ..: . :: : . . XP_005 GREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNC 230 240 250 260 270 280 280 290 300 pF1KB9 LNPLVTGYLGRGPGLKTVCAARTQGGKSQK :.:.: . .: XP_005 LDPFVYYFASREFQLRLREYLGCRRVPRDTLDTRRESLFSARTTSVRSEAGAHPEGMEGA 290 300 310 320 330 340 300 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 19:12:41 2016 done: Fri Nov 4 19:12:42 2016 Total Scan time: 7.930 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]