FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9821, 312 aa 1>>>pF1KB9821 312 - 312 aa - 312 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.3493+/-0.000548; mu= 4.2649+/- 0.035 mean_var=407.9582+/-83.863, 0's: 0 Z-trim(118.9): 192 B-trim: 1815 in 2/54 Lambda= 0.063499 statistics sampled from 32078 (32337) to 32078 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.645), E-opt: 0.2 (0.379), width: 16 Scan time: 5.910 The best scores are: opt bits E(85289) NP_000418 (OMIM: 152445,604117) loricrin [Homo sap ( 312) 2298 224.5 2.1e-58 NP_000217 (OMIM: 144200,607606) keratin, type I cy ( 623) 467 57.3 9.5e-08 XP_005257400 (OMIM: 113800,148080,607602,609165) P ( 624) 458 56.4 1.7e-07 NP_000412 (OMIM: 113800,148080,607602,609165) kera ( 584) 456 56.2 1.9e-07 NP_001005922 (OMIM: 148022) keratin-associated pro ( 278) 449 55.1 2e-07 XP_016880670 (OMIM: 601574,612237) PREDICTED: TATA ( 323) 434 53.8 5.5e-07 XP_011523617 (OMIM: 601574,612237) PREDICTED: TATA ( 501) 434 54.1 6.9e-07 NP_003478 (OMIM: 601574,612237) TATA-binding prote ( 589) 434 54.2 7.5e-07 NP_631961 (OMIM: 601574,612237) TATA-binding prote ( 592) 434 54.2 7.5e-07 XP_005268883 (OMIM: 164017,615424,615426) PREDICTE ( 372) 415 52.2 2e-06 NP_112420 (OMIM: 164017,615424,615426) heterogeneo ( 372) 415 52.2 2e-06 NP_001014364 (OMIM: 616284) filaggrin-2 [Homo sapi (2391) 407 52.7 8.8e-06 NP_006112 (OMIM: 113800,139350,144200,146590,60096 ( 644) 393 50.5 1.1e-05 NP_001009931 (OMIM: 616293) hornerin [Homo sapiens (2850) 402 52.3 1.3e-05 NP_001317176 (OMIM: 605372) heterogeneous nuclear ( 356) 383 49.2 1.5e-05 NP_001317177 (OMIM: 605372) heterogeneous nuclear ( 356) 383 49.2 1.5e-05 NP_919223 (OMIM: 605372) heterogeneous nuclear rib ( 378) 383 49.2 1.5e-05 NP_001317178 (OMIM: 605372) heterogeneous nuclear ( 378) 383 49.2 1.5e-05 NP_775882 (OMIM: 616142) protein FAM98B [Homo sapi ( 433) 384 49.4 1.5e-05 NP_000414 (OMIM: 146800,600194) keratin, type II c ( 639) 370 48.4 4.6e-05 XP_011544083 (OMIM: 137070,608030,614782) PREDICTE ( 524) 352 46.6 0.00013 NP_001164408 (OMIM: 137070,608030,614782) RNA-bind ( 522) 347 46.2 0.00018 NP_001164105 (OMIM: 137070,608030,614782) RNA-bind ( 525) 346 46.1 0.00019 NP_004951 (OMIM: 137070,608030,614782) RNA-binding ( 526) 346 46.1 0.00019 XP_011507833 (OMIM: 616284) PREDICTED: filaggrin-2 (2239) 350 47.4 0.00032 NP_006796 (OMIM: 609409) heterogeneous nuclear rib ( 305) 332 44.4 0.00035 XP_016867598 (OMIM: 600124,615422) PREDICTED: hete ( 341) 318 43.2 0.00089 XP_016867599 (OMIM: 600124,615422) PREDICTED: hete ( 341) 318 43.2 0.00089 NP_002128 (OMIM: 600124,615422) heterogeneous nucl ( 341) 318 43.2 0.00089 NP_112533 (OMIM: 600124,615422) heterogeneous nucl ( 353) 318 43.2 0.00091 XP_005249786 (OMIM: 600124,615422) PREDICTED: hete ( 353) 318 43.2 0.00091 NP_476429 (OMIM: 122100,148043) keratin, type II c ( 628) 315 43.4 0.0015 NP_001258112 (OMIM: 300132) trophinin isoform 6 [H ( 962) 310 43.2 0.0026 NP_001258113 (OMIM: 300132) trophinin isoform 7 [H (1034) 310 43.2 0.0027 XP_011529116 (OMIM: 300132) PREDICTED: trophinin i (1387) 310 43.4 0.0031 XP_016885257 (OMIM: 300132) PREDICTED: trophinin i (1387) 310 43.4 0.0031 NP_001034794 (OMIM: 300132) trophinin isoform 5 [H (1431) 310 43.5 0.0032 XP_011529114 (OMIM: 300132) PREDICTED: trophinin i (1431) 310 43.5 0.0032 XP_016885256 (OMIM: 300132) PREDICTED: trophinin i (1431) 310 43.5 0.0032 XP_011529111 (OMIM: 300132) PREDICTED: trophinin i (1431) 310 43.5 0.0032 XP_011529110 (OMIM: 300132) PREDICTED: trophinin i (1431) 310 43.5 0.0032 XP_011529115 (OMIM: 300132) PREDICTED: trophinin i (1431) 310 43.5 0.0032 XP_011529113 (OMIM: 300132) PREDICTED: trophinin i (1431) 310 43.5 0.0032 XP_006724663 (OMIM: 300132) PREDICTED: trophinin i (1431) 310 43.5 0.0032 XP_016882254 (OMIM: 603182) PREDICTED: interleukin ( 563) 299 41.8 0.0039 XP_011526289 (OMIM: 603182) PREDICTED: interleukin ( 563) 299 41.8 0.0039 XP_016882253 (OMIM: 603182) PREDICTED: interleukin ( 633) 299 41.9 0.0041 NP_002705 (OMIM: 603771) serine/threonine-protein ( 940) 302 42.4 0.0042 XP_011513024 (OMIM: 603771) PREDICTED: serine/thre ( 940) 302 42.4 0.0042 XP_016866484 (OMIM: 603771) PREDICTED: serine/thre ( 940) 302 42.4 0.0042 >>NP_000418 (OMIM: 152445,604117) loricrin [Homo sapiens (312 aa) initn: 2298 init1: 2298 opt: 2298 Z-score: 1169.4 bits: 224.5 E(85289): 2.1e-58 Smith-Waterman score: 2298; 100.0% identity (100.0% similar) in 312 aa overlap (1-312:1-312) 10 20 30 40 50 60 pF1KB9 MSYQKKQPTPQPPVDCVKTSGGGGGGGGSGGGGCGFFGGGGSGGGSSGSGCGYSGGGGYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MSYQKKQPTPQPPVDCVKTSGGGGGGGGSGGGGCGFFGGGGSGGGSSGSGCGYSGGGGYS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 GGGCGGGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSGGGGSGCFSSGGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GGGCGGGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSGGGGSGCFSSGGGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 SSGGGSGCFSSGGGGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSSGGGSGCFSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SSGGGSGCFSSGGGGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSSGGGSGCFSSG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 GGGGSVCGYSGGGSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSGGSGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GGGGSVCGYSGGGSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSGGSGC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 FSSGGGGGSSGCGGGSSGIGSGCIISGGGSVCGGGSSGGGGGGSSVGGSGSGKGVPICHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FSSGGGGGSSGCGGGSSGIGSGCIISGGGSVCGGGSSGGGGGGSSVGGSGSGKGVPICHQ 250 260 270 280 290 300 310 pF1KB9 TQQKQAPTWPSK :::::::::::: NP_000 TQQKQAPTWPSK 310 >>NP_000217 (OMIM: 144200,607606) keratin, type I cytosk (623 aa) initn: 1048 init1: 393 opt: 467 Z-score: 260.1 bits: 57.3 E(85289): 9.5e-08 Smith-Waterman score: 489; 53.5% identity (67.4% similar) in 187 aa overlap (21-205:460-618) 10 20 30 40 50 pF1KB9 MSYQKKQPTPQPPVDCVKTSGGGGGGGGSGGGGCGFFGGGGSGGGSSGSG :: .::.: :. : ::::: : : : NP_000 IECQNQEYSLLLSIKMRLEKEIETYHNLLEGGQEDFESSGAGKIGLGGRGGSGG-SYGRG 430 440 450 460 470 480 60 70 80 90 100 110 pF1KB9 CGYSGGGGYSGGGCGGGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSGGGG : :: :::. :::.:::: ::: .: :::::: :::..:::::: :: : NP_000 ---SRGG--SGGSYGGGGSGGGYGGG-SGSRGGSGGSY---GGGSGSGGGSG----GGYG 490 500 510 520 530 120 130 140 150 160 170 pF1KB9 SGCFSSGGGGSSGGGSGCFSSGGGGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSS .: .::: :::..: :.:.::. ::::: ...:::..: . : :: :::: NP_000 GG----SGGGHSGGSGGGHSGGSGGNYGGGSGSGGGSGGGYGGGS---GSRGG--SGGSH 540 550 560 570 580 180 190 200 210 220 pF1KB9 GGGSGCFSSGGGGGSVCGYSGG--GSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGG ::::: :. : .::: :.:: .:: ::: .:::: NP_000 GGGSG-FG-GESGGS---YGGGEEASGSGGGYGGGSGKSSHS 590 600 610 620 230 240 250 260 270 280 pF1KB9 SSGGGGSGGSGCFSSGGGGGSSGCGGGSSGIGSGCIISGGGSVCGGGSSGGGGGGSSVGG >-- initn: 858 init1: 320 opt: 370 Z-score: 212.0 bits: 48.4 E(85289): 4.5e-05 Smith-Waterman score: 387; 53.1% identity (68.7% similar) in 147 aa overlap (29-171:14-147) 10 20 30 40 50 60 pF1KB9 MSYQKKQPTPQPPVDCVKTSGGGGGGGGSGGGGCGFFGGGGSGGGSSGSGCGYSGGGGYS ::::: : .:.::: :: : . ::::: NP_000 MSCRQFSSSYLSRSGGGGGGGLGSGGSIR-SSYSRFSSSGGGG-- 10 20 30 40 70 80 90 100 110 120 pF1KB9 GGGCGGGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSGGGGSGCFSSGGGG ::: ..::: :::.. :: :.::: :: ::::.:: :. :: ::: : : : :: NP_000 GGGRFSSSSGYGGGSS-RVCGRGGGGSFGYSYGGGSGGGFSA--SSLGGGFGGGSRGFGG 50 60 70 80 90 130 140 150 160 170 pF1KB9 SSGGG---SGCFSSGGGGSSGGG-SGCFSSGGGGFSGQAVQCQSYGGVSSGGSSGGGSGC .:::: :: :..: ::.:::: .: ..:: :::.: .:: ..::..: NP_000 ASGGGYSSSGGFGGGFGGGSGGGFGGGYGSGFGGFGG-------FGGGAGGGDGGILTAN 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB9 FSSGGGGGSVCGYSGGGSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSG NP_000 EKSTMQELNSRLASYLDKVQALEEANNDLENKIQDWYDKKGPAAIQKNYSPYYNTIDDLK 160 170 180 190 200 210 >>XP_005257400 (OMIM: 113800,148080,607602,609165) PREDI (624 aa) initn: 1402 init1: 394 opt: 458 Z-score: 255.6 bits: 56.4 E(85289): 1.7e-07 Smith-Waterman score: 466; 62.2% identity (73.3% similar) in 135 aa overlap (19-152:458-577) 10 20 30 40 pF1KB9 MSYQKKQPTPQPPVDCVKTSGGGGGGGGSGGGGCGFFGGGGSGGGSSG .::::: :::: ::: .:::.::::::: XP_005 QNTEYQQLLDIKIRLENEIQTYRSLLEGEGSSGGGGRGGGSFGGG---YGGGSSGGGSSG 430 440 450 460 470 480 50 60 70 80 90 100 pF1KB9 SGCGYSGGGGYSGGGCGGGSSGGGGGGGIGGCGGGSGGSVKYSGG-GGSSGGGSGCFSSG .: : .: :: :::: ::::::::..:: : ::::. ::: ::::.:: : ::: XP_005 GGHG-GGHGGSSGGGYGGGSSGGGSSGG--GYGGGSS-----SGGHGGSSSGGYGGGSSG 490 500 510 520 530 110 120 130 140 150 160 pF1KB9 GGGSGCFSSGGGGSSGGGSGCFSSGGGGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSG :::.: :::::::::. .. :::::.:: :::. : : XP_005 GGGGGY----GGGSSGGGSSSGGGYGGGSSSGGHKSSSSGSVGESSSKGPRSAETSWDTN 540 550 560 570 580 590 170 180 190 200 210 220 pF1KB9 GSSGGGSGCFSSGGGGGSVCGYSGGGSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGG XP_005 KTRVIKTIIEEVAPDGRVLSSMVESETKKHYY 600 610 620 >-- initn: 296 init1: 296 opt: 382 Z-score: 218.0 bits: 49.5 E(85289): 2.1e-05 Smith-Waterman score: 397; 48.8% identity (69.8% similar) in 162 aa overlap (59-215:5-149) 30 40 50 60 70 80 pF1KB9 SGGGGCGFFGGGGSGGGSSGSGCGYSGGGGYSGGGCGGGSSGGGGGGGIGGCGGGSG-GS ::.. ..: .:::::: ::::::.: .: XP_005 MSVRYSSSKHYSSSRSGGGGGG-GGCGGGGGVSS 10 20 30 90 100 110 120 130 140 pF1KB9 VKYSGGGGSSGGGSGCFSSGGGGSGCFSSGGGGSSGGGSGCFSSGGGGSSGGGSGCFSSG .. :.. :: ::: ::::: ..: :: : :::: ::: :::::: .: . : XP_005 LRISSSKGSLGGG---FSSGGFSGGSFSRG---SSGG--GCF----GGSSGGYGGLGGFG 40 50 60 70 80 150 160 170 180 190 200 pF1KB9 GGGFSGQAVQCQ---SYGGVSSGGSSGGGSGCFSSGGGGGSVCGYSGGGSGCG-GGSSGG ::.: :. . . ::::. .::: :::: :..:. ::. :..::: : : ::. :: XP_005 GGSFRGSYGSSSFGGSYGGIFGGGSFGGGS--FGGGSFGGG--GFGGGGFGGGFGGGFGG 90 100 110 120 130 210 220 230 240 250 260 pF1KB9 SGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGCGGGSSGIGSGC .:. ....:: XP_005 DGGLLSGNEKVTMQNLNDRLASYLDKVRALEESNYELEGKIKEWYEKHGNSHQGEPRDYS 140 150 160 170 180 190 >>NP_000412 (OMIM: 113800,148080,607602,609165) keratin, (584 aa) initn: 1698 init1: 394 opt: 456 Z-score: 254.9 bits: 56.2 E(85289): 1.9e-07 Smith-Waterman score: 466; 62.2% identity (73.3% similar) in 135 aa overlap (19-152:458-577) 10 20 30 40 pF1KB9 MSYQKKQPTPQPPVDCVKTSGGGGGGGGSGGGGCGFFGGGGSGGGSSG .::::: :::: ::: .:::.::::::: NP_000 QNTEYQQLLDIKIRLENEIQTYRSLLEGEGSSGGGGRGGGSFGGG---YGGGSSGGGSSG 430 440 450 460 470 480 50 60 70 80 90 100 pF1KB9 SGCGYSGGGGYSGGGCGGGSSGGGGGGGIGGCGGGSGGSVKYSGG-GGSSGGGSGCFSSG .: : .: :: :::: ::::::::..:: : ::::. ::: ::::.:: : ::: NP_000 GGHG-GGHGGSSGGGYGGGSSGGGSSGG--GYGGGSS-----SGGHGGSSSGGYGGGSSG 490 500 510 520 530 110 120 130 140 150 160 pF1KB9 GGGSGCFSSGGGGSSGGGSGCFSSGGGGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSG :::.: :::::::::. .. :::::.:: :::. : : NP_000 GGGGGY----GGGSSGGGSSSGGGYGGGSSSGGHKSSSSGSVGESSSKGPRY 540 550 560 570 580 170 180 190 200 210 220 pF1KB9 GSSGGGSGCFSSGGGGGSVCGYSGGGSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGG >-- initn: 293 init1: 293 opt: 384 Z-score: 219.2 bits: 49.6 E(85289): 1.8e-05 Smith-Waterman score: 396; 49.4% identity (69.1% similar) in 162 aa overlap (59-215:5-149) 30 40 50 60 70 80 pF1KB9 SGGGGCGFFGGGGSGGGSSGSGCGYSGGGGYSGGGCGGGSSGGGGGGGIGGCGGGSG-GS ::.. ..: .:::::: ::::::.: .: NP_000 MSVRYSSSKHYSSSRSGGGGGG-GGCGGGGGVSS 10 20 30 90 100 110 120 130 140 pF1KB9 VKYSGGGGSSGGGSGCFSSGGGGSGCFSSGGGGSSGGGSGCFSSGGGGSSGGGSGCFSSG .. :.. :: ::: ::::: ..: :: : :::: ::: :::::: .: . : NP_000 LRISSSKGSLGGG---FSSGGFSGGSFSRG---SSGG--GCF----GGSSGGYGGLGGFG 40 50 60 70 80 150 160 170 180 190 200 pF1KB9 GGGFSGQAVQCQSYGGVSSGGSSGGGS---GCFSSGGGGGSVCGYSGGGSGCG-GGSSGG ::.: : . .:.:: : ::: :::: : :..:. ::. :..::: : : ::. :: NP_000 GGSFRG-SYGSSSFGG-SYGGSFGGGSFGGGSFGGGSFGGG--GFGGGGFGGGFGGGFGG 90 100 110 120 130 210 220 230 240 250 260 pF1KB9 SGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGCGGGSSGIGSGC .:. ....:: NP_000 DGGLLSGNEKVTMQNLNDRLASYLDKVRALEESNYELEGKIKEWYEKHGNSHQGEPRDYS 140 150 160 170 180 190 >>NP_001005922 (OMIM: 148022) keratin-associated protein (278 aa) initn: 923 init1: 295 opt: 449 Z-score: 254.5 bits: 55.1 E(85289): 2e-07 Smith-Waterman score: 518; 44.2% identity (56.2% similar) in 251 aa overlap (51-298:4-213) 30 40 50 60 70 80 pF1KB9 GGGGGGGGSGGGGCGFFGGGGSGGGSSGSGCGYSGGGGYSGGGCGGGSSGGGGGGGIGGC :: ::: : : ::::.: :: :.: ::: NP_001 MGCCGCSGGCGSSCGGCGSGC--GGCGSGCGGC 10 20 30 90 100 110 120 130 140 pF1KB9 GGGSGGSVKYSGGGGSSGGGSGCFSSGGGGSGCFSSGGGGSSGGGSGCFSSGGGGSSGGG :.: ::: ::: : . : . :: : .:: :::: :.:: NP_001 GSGCGGS-------GSSCCVPVCCCKP---VCCRVPTCSCSSCGKGGCGSSGG--SKGG- 40 50 60 70 150 160 170 180 190 pF1KB9 SGCFSSGGGGFSGQAVQCQSYGGVSS-GGSSGGGSGCFSSGGGGGSVCGYSGGGSGCGGG : : :: :. :: .: :::.:: ..: .: :: :: :: : :: ::.: NP_001 --CGSCGG---------CK--GGCGSCGGSKGGCGSCGGSKGGCGS-CGGSKGG--CGSG 80 90 100 110 120 200 210 220 230 240 250 pF1KB9 SSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGCGGGSSGI :: ::. . : :. . .: : :: :. :: : :. :: :::...: NP_001 C-GGCGSSCCVPVCCCKPMCCCVPACSCSSCGKGGCGSCGC--SKGACGS--CGGSKGGC 130 140 150 160 170 260 270 280 290 300 310 pF1KB9 GS--GCIISGGGSVCGGGSSGGGGGGSSVGGSGSGKGVPICHQTQQKQAPTWPSK :: :: .:: . :::.. :: ::. :: ::: :::.: NP_001 GSCGGC--KGGCGSCGGSK---GGCGSGCGGCGSGCGVPVCCCSCSSCGSCAGSKGGCGS 180 190 200 210 220 230 NP_001 SCSQCSCCKPCCCSSGCGSSCCQSSCCKPCCSQSSCCVPVCCQCKI 240 250 260 270 >>XP_016880670 (OMIM: 601574,612237) PREDICTED: TATA-bin (323 aa) initn: 1112 init1: 331 opt: 434 Z-score: 246.4 bits: 53.8 E(85289): 5.5e-07 Smith-Waterman score: 438; 39.1% identity (50.4% similar) in 258 aa overlap (4-258:109-309) 10 20 30 pF1KB9 MSYQKKQPTPQPPVDCVKTSGGGGGGGGSGGGG : ..: :. . ::: : : :: XP_016 GRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDS----RPSGGDFRGRGYGGER 80 90 100 110 120 130 40 50 60 70 80 90 pF1KB9 CGFFGGGGSGGGSSGSGCGYSGGGGYSGG-GCGGGSSGGGGGGGIGG--CGGGSGGSVKY :. : :: :: .: : : .::::.: . ::: :: .::: :: ::: ::. . XP_016 -GYRGRGGRGGDRGGYG-GDRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGD-RG 140 150 160 170 180 190 100 110 120 130 140 150 pF1KB9 SGGGGSSGGGSGCFSSGGGGSGCFSSGGGGSSGGGSGCFSSGGGGSSGGGSGCFSSGGGG .: ::. ::: : .. ::: : .: ::. ::: : : :. :: : ... :: XP_016 GGYGGDRGGGYG--GDRGGGYGGDRGGYGGDRGGGYG----GDRGGYGGDRGGYGGDRGG 200 210 220 230 240 160 170 180 190 200 210 pF1KB9 FSGQAVQCQSYGGVSSGGSSGGGSGCFSSGGGGGSVCGYSGGGSGCGGGSSGGSGSGYVS . ::. :: .: : :: ::. ::::: :: ::: XP_016 Y---------------GGDRGGYGGDRSRGGYGGD----RGGGSGYGGDRSGG------- 250 260 270 220 230 240 250 260 270 pF1KB9 SQQVTQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGCGGGSSGIGSGCIISGGGS ::: :::: .: : :: ::. : ::. : XP_016 --------------YGGDRSGGGYGGDRG----GGYGGDRGGYGGKMGGRNDYRNDQRNR 280 290 300 310 320 280 290 300 310 pF1KB9 VCGGGSSGGGGGGSSVGGSGSGKGVPICHQTQQKQAPTWPSK XP_016 PY >>XP_011523617 (OMIM: 601574,612237) PREDICTED: TATA-bin (501 aa) initn: 1112 init1: 331 opt: 434 Z-score: 244.6 bits: 54.1 E(85289): 6.9e-07 Smith-Waterman score: 438; 39.1% identity (50.4% similar) in 258 aa overlap (4-258:287-487) 10 20 30 pF1KB9 MSYQKKQPTPQPPVDCVKTSGGGGGGGGSGGGG : ..: :. . ::: : : :: XP_011 GRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDS----RPSGGDFRGRGYGGER 260 270 280 290 300 310 40 50 60 70 80 90 pF1KB9 CGFFGGGGSGGGSSGSGCGYSGGGGYSGG-GCGGGSSGGGGGGGIGG--CGGGSGGSVKY :. : :: :: .: : : .::::.: . ::: :: .::: :: ::: ::. . XP_011 -GYRGRGGRGGDRGGYG-GDRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGD-RG 320 330 340 350 360 100 110 120 130 140 150 pF1KB9 SGGGGSSGGGSGCFSSGGGGSGCFSSGGGGSSGGGSGCFSSGGGGSSGGGSGCFSSGGGG .: ::. ::: : .. ::: : .: ::. ::: : : :. :: : ... :: XP_011 GGYGGDRGGGYG--GDRGGGYGGDRGGYGGDRGGGYG----GDRGGYGGDRGGYGGDRGG 370 380 390 400 410 420 160 170 180 190 200 210 pF1KB9 FSGQAVQCQSYGGVSSGGSSGGGSGCFSSGGGGGSVCGYSGGGSGCGGGSSGGSGSGYVS . ::. :: .: : :: ::. ::::: :: ::: XP_011 Y---------------GGDRGGYGGDRSRGGYGGD----RGGGSGYGGDRSGG------- 430 440 450 220 230 240 250 260 270 pF1KB9 SQQVTQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGCGGGSSGIGSGCIISGGGS ::: :::: .: : :: ::. : ::. : XP_011 --------------YGGDRSGGGYGGDRG----GGYGGDRGGYGGKMGGRNDYRNDQRNR 460 470 480 490 280 290 300 310 pF1KB9 VCGGGSSGGGGGGSSVGGSGSGKGVPICHQTQQKQAPTWPSK XP_011 PY 500 >>NP_003478 (OMIM: 601574,612237) TATA-binding protein-a (589 aa) initn: 1112 init1: 331 opt: 434 Z-score: 244.0 bits: 54.2 E(85289): 7.5e-07 Smith-Waterman score: 438; 39.1% identity (50.4% similar) in 258 aa overlap (4-258:375-575) 10 20 30 pF1KB9 MSYQKKQPTPQPPVDCVKTSGGGGGGGGSGGGG : ..: :. . ::: : : :: NP_003 GRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDS----RPSGGDFRGRGYGGER 350 360 370 380 390 400 40 50 60 70 80 90 pF1KB9 CGFFGGGGSGGGSSGSGCGYSGGGGYSGG-GCGGGSSGGGGGGGIGG--CGGGSGGSVKY :. : :: :: .: : : .::::.: . ::: :: .::: :: ::: ::. . NP_003 -GYRGRGGRGGDRGGYG-GDRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGD-RG 410 420 430 440 450 100 110 120 130 140 150 pF1KB9 SGGGGSSGGGSGCFSSGGGGSGCFSSGGGGSSGGGSGCFSSGGGGSSGGGSGCFSSGGGG .: ::. ::: : .. ::: : .: ::. ::: : : :. :: : ... :: NP_003 GGYGGDRGGGYG--GDRGGGYGGDRGGYGGDRGGGYG----GDRGGYGGDRGGYGGDRGG 460 470 480 490 500 510 160 170 180 190 200 210 pF1KB9 FSGQAVQCQSYGGVSSGGSSGGGSGCFSSGGGGGSVCGYSGGGSGCGGGSSGGSGSGYVS . ::. :: .: : :: ::. ::::: :: ::: NP_003 Y---------------GGDRGGYGGDRSRGGYGGD----RGGGSGYGGDRSGG------- 520 530 540 220 230 240 250 260 270 pF1KB9 SQQVTQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGCGGGSSGIGSGCIISGGGS ::: :::: .: : :: ::. : ::. : NP_003 --------------YGGDRSGGGYGGDRG----GGYGGDRGGYGGKMGGRNDYRNDQRNR 550 560 570 580 280 290 300 310 pF1KB9 VCGGGSSGGGGGGSSVGGSGSGKGVPICHQTQQKQAPTWPSK NP_003 PY >>NP_631961 (OMIM: 601574,612237) TATA-binding protein-a (592 aa) initn: 1112 init1: 331 opt: 434 Z-score: 243.9 bits: 54.2 E(85289): 7.5e-07 Smith-Waterman score: 438; 39.1% identity (50.4% similar) in 258 aa overlap (4-258:378-578) 10 20 30 pF1KB9 MSYQKKQPTPQPPVDCVKTSGGGGGGGGSGGGG : ..: :. . ::: : : :: NP_631 GRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDS----RPSGGDFRGRGYGGER 350 360 370 380 390 400 40 50 60 70 80 90 pF1KB9 CGFFGGGGSGGGSSGSGCGYSGGGGYSGG-GCGGGSSGGGGGGGIGG--CGGGSGGSVKY :. : :: :: .: : : .::::.: . ::: :: .::: :: ::: ::. . NP_631 -GYRGRGGRGGDRGGYG-GDRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGD-RG 410 420 430 440 450 460 100 110 120 130 140 150 pF1KB9 SGGGGSSGGGSGCFSSGGGGSGCFSSGGGGSSGGGSGCFSSGGGGSSGGGSGCFSSGGGG .: ::. ::: : .. ::: : .: ::. ::: : : :. :: : ... :: NP_631 GGYGGDRGGGYG--GDRGGGYGGDRGGYGGDRGGGYG----GDRGGYGGDRGGYGGDRGG 470 480 490 500 510 160 170 180 190 200 210 pF1KB9 FSGQAVQCQSYGGVSSGGSSGGGSGCFSSGGGGGSVCGYSGGGSGCGGGSSGGSGSGYVS . ::. :: .: : :: ::. ::::: :: ::: NP_631 Y---------------GGDRGGYGGDRSRGGYGGD----RGGGSGYGGDRSGG------- 520 530 540 220 230 240 250 260 270 pF1KB9 SQQVTQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGCGGGSSGIGSGCIISGGGS ::: :::: .: : :: ::. : ::. : NP_631 --------------YGGDRSGGGYGGDRG----GGYGGDRGGYGGKMGGRNDYRNDQRNR 550 560 570 580 590 280 290 300 310 pF1KB9 VCGGGSSGGGGGGSSVGGSGSGKGVPICHQTQQKQAPTWPSK NP_631 PY >>XP_005268883 (OMIM: 164017,615424,615426) PREDICTED: h (372 aa) initn: 529 init1: 324 opt: 415 Z-score: 236.4 bits: 52.2 E(85289): 2e-06 Smith-Waterman score: 415; 42.9% identity (66.5% similar) in 182 aa overlap (30-207:195-369) 10 20 30 40 50 pF1KB9 MSYQKKQPTPQPPVDCVKTSGGGGGGGGSGGGGCGFFGGGGSGGGSSGSGCGYSGGGGY : .: : :::: ::: .:. ... ::.. XP_005 QKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGG-RGGGFGGND-NFGRGGNF 170 180 190 200 210 220 60 70 80 90 100 110 pF1KB9 SGGGCGGGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSGGGGSGCFSSGGG :: : ::: :::: :: : .: :.. :.::: . .::: ..::: : : .:: : XP_005 SGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYG 230 240 250 260 270 280 120 130 140 150 160 170 pF1KB9 GSSGGGSGCFSSGGGGSSGGGSGCFSSGGGG---FSGQAVQCQSYGGVSSGGSSGGGSGC :: :. ...::::. ::::: .:::. :.. : ...: ...:. .: .:: XP_005 GS--GSYDSYNNGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGP 290 300 310 320 330 340 180 190 200 210 220 230 pF1KB9 FSSGGGGGSVCGYSGGGSGCGGGSSGGS-GSGYVSSQQVTQTSCAPQPSYGGGSSGGGGS . ::::. . . .: ::.::..: ::: XP_005 Y---GGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF 350 360 370 240 250 260 270 280 290 pF1KB9 GGSGCFSSGGGGGSSGCGGGSSGIGSGCIISGGGSVCGGGSSGGGGGGSSVGGSGSGKGV 312 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 19:27:28 2016 done: Fri Nov 4 19:27:29 2016 Total Scan time: 5.910 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]