FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9841, 358 aa 1>>>pF1KB9841 358 - 358 aa - 358 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1770+/-0.00035; mu= 17.7826+/- 0.022 mean_var=78.0107+/-15.392, 0's: 0 Z-trim(115.9): 49 B-trim: 0 in 0/52 Lambda= 0.145210 statistics sampled from 26558 (26617) to 26558 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.694), E-opt: 0.2 (0.312), width: 16 Scan time: 8.270 The best scores are: opt bits E(85289) XP_016856533 (OMIM: 108770,121013,612474,614049) P ( 358) 2469 526.6 3.2e-149 XP_005273008 (OMIM: 108770,121013,612474,614049) P ( 358) 2469 526.6 3.2e-149 NP_005257 (OMIM: 108770,121013,612474,614049) gap ( 358) 2469 526.6 3.2e-149 NP_859054 (OMIM: 108770,121013,612474,614049) gap ( 358) 2469 526.6 3.2e-149 XP_011507719 (OMIM: 116200,600897,612474) PREDICTE ( 427) 1032 225.6 1.6e-58 XP_011507718 (OMIM: 116200,600897,612474) PREDICTE ( 433) 1032 225.6 1.6e-58 NP_005258 (OMIM: 116200,600897,612474) gap junctio ( 433) 1032 225.6 1.6e-58 XP_011533350 (OMIM: 121015,601885) PREDICTED: gap ( 435) 1023 223.8 5.8e-58 NP_068773 (OMIM: 121015,601885) gap junction alpha ( 435) 1023 223.8 5.8e-58 NP_002051 (OMIM: 121012) gap junction alpha-4 prot ( 333) 940 206.3 8.2e-53 XP_005270807 (OMIM: 121012) PREDICTED: gap junctio ( 333) 940 206.3 8.2e-53 XP_016856532 (OMIM: 121012) PREDICTED: gap junctio ( 333) 940 206.3 8.2e-53 NP_115991 (OMIM: 611924) gap junction alpha-10 pro ( 543) 916 201.4 3.8e-51 NP_110399 (OMIM: 611923) gap junction alpha-9 prot ( 515) 909 199.9 1e-50 NP_000156 (OMIM: 104100,121014,133200,164200,18610 ( 382) 883 194.4 3.6e-49 XP_011533351 (OMIM: 121011,124500,148210,148350,14 ( 226) 471 107.9 2.3e-23 NP_003995 (OMIM: 121011,124500,148210,148350,14920 ( 226) 471 107.9 2.3e-23 NP_001103690 (OMIM: 129500,220290,304400,604418,61 ( 261) 466 106.9 5.3e-23 XP_016875847 (OMIM: 129500,220290,304400,604418,61 ( 261) 466 106.9 5.3e-23 NP_001103689 (OMIM: 129500,220290,304400,604418,61 ( 261) 466 106.9 5.3e-23 XP_016875848 (OMIM: 129500,220290,304400,604418,61 ( 261) 466 106.9 5.3e-23 NP_006774 (OMIM: 129500,220290,304400,604418,61264 ( 261) 466 106.9 5.3e-23 XP_016875846 (OMIM: 129500,220290,304400,604418,61 ( 261) 466 106.9 5.3e-23 XP_016875849 (OMIM: 129500,220290,304400,604418,61 ( 261) 466 106.9 5.3e-23 NP_001103691 (OMIM: 129500,220290,304400,604418,61 ( 261) 466 106.9 5.3e-23 NP_001073852 (OMIM: 608655) gap junction gamma-1 p ( 396) 449 103.5 8.6e-22 XP_005256977 (OMIM: 608655) PREDICTED: gap junctio ( 396) 449 103.5 8.6e-22 XP_005256978 (OMIM: 608655) PREDICTED: gap junctio ( 396) 449 103.5 8.6e-22 NP_005488 (OMIM: 608655) gap junction gamma-1 prot ( 396) 449 103.5 8.6e-22 NP_065168 (OMIM: 608803,608804,613206,613480) gap ( 439) 446 102.9 1.4e-21 NP_000157 (OMIM: 302800,304040) gap junction beta- ( 283) 436 100.6 4.4e-21 NP_001091111 (OMIM: 302800,304040) gap junction be ( 283) 436 100.6 4.4e-21 XP_011529209 (OMIM: 302800,304040) PREDICTED: gap ( 283) 436 100.6 4.4e-21 XP_016884897 (OMIM: 302800,304040) PREDICTED: gap ( 283) 436 100.6 4.4e-21 XP_011538981 (OMIM: 133200,605425) PREDICTED: gap ( 266) 414 96.0 1e-19 NP_694944 (OMIM: 133200,605425) gap junction beta- ( 266) 414 96.0 1e-19 NP_001005752 (OMIM: 133200,220290,603324,612644) g ( 270) 414 96.0 1e-19 NP_076872 (OMIM: 133200,220290,603324,612644) gap ( 270) 414 96.0 1e-19 NP_065711 (OMIM: 607058) gap junction delta-2 prot ( 321) 403 93.8 5.8e-19 XP_005248773 (OMIM: 611921) PREDICTED: gap junctio ( 223) 394 91.7 1.6e-18 NP_940970 (OMIM: 611921) gap junction beta-7 prote ( 223) 394 91.7 1.6e-18 NP_005259 (OMIM: 604493) gap junction beta-5 prote ( 273) 392 91.4 2.5e-18 XP_005270808 (OMIM: 604493) PREDICTED: gap junctio ( 273) 392 91.4 2.5e-18 NP_689343 (OMIM: 607425) gap junction delta-3 prot ( 294) 387 90.4 5.6e-18 XP_016877927 (OMIM: 607058) PREDICTED: gap junctio ( 270) 342 80.9 3.6e-15 NP_853516 (OMIM: 611925) gap junction gamma-3 prot ( 279) 318 75.9 1.2e-13 NP_699199 (OMIM: 611922) gap junction delta-4 prot ( 370) 286 69.3 1.5e-11 >>XP_016856533 (OMIM: 108770,121013,612474,614049) PREDI (358 aa) initn: 2469 init1: 2469 opt: 2469 Z-score: 2799.9 bits: 526.6 E(85289): 3.2e-149 Smith-Waterman score: 2469; 100.0% identity (100.0% similar) in 358 aa overlap (1-358:1-358) 10 20 30 40 50 60 pF1KB9 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 VRGQEQTPGEGFIQVRYGQKPEVPNGVSPGHRLPHGYHSDKRRLSKASSKARSDDLSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VRGQEQTPGEGFIQVRYGQKPEVPNGVSPGHRLPHGYHSDKRRLSKASSKARSDDLSV 310 320 330 340 350 >>XP_005273008 (OMIM: 108770,121013,612474,614049) PREDI (358 aa) initn: 2469 init1: 2469 opt: 2469 Z-score: 2799.9 bits: 526.6 E(85289): 3.2e-149 Smith-Waterman score: 2469; 100.0% identity (100.0% similar) in 358 aa overlap (1-358:1-358) 10 20 30 40 50 60 pF1KB9 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 VRGQEQTPGEGFIQVRYGQKPEVPNGVSPGHRLPHGYHSDKRRLSKASSKARSDDLSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VRGQEQTPGEGFIQVRYGQKPEVPNGVSPGHRLPHGYHSDKRRLSKASSKARSDDLSV 310 320 330 340 350 >>NP_005257 (OMIM: 108770,121013,612474,614049) gap junc (358 aa) initn: 2469 init1: 2469 opt: 2469 Z-score: 2799.9 bits: 526.6 E(85289): 3.2e-149 Smith-Waterman score: 2469; 100.0% identity (100.0% similar) in 358 aa overlap (1-358:1-358) 10 20 30 40 50 60 pF1KB9 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 VRGQEQTPGEGFIQVRYGQKPEVPNGVSPGHRLPHGYHSDKRRLSKASSKARSDDLSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VRGQEQTPGEGFIQVRYGQKPEVPNGVSPGHRLPHGYHSDKRRLSKASSKARSDDLSV 310 320 330 340 350 >>NP_859054 (OMIM: 108770,121013,612474,614049) gap junc (358 aa) initn: 2469 init1: 2469 opt: 2469 Z-score: 2799.9 bits: 526.6 E(85289): 3.2e-149 Smith-Waterman score: 2469; 100.0% identity (100.0% similar) in 358 aa overlap (1-358:1-358) 10 20 30 40 50 60 pF1KB9 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 VRGQEQTPGEGFIQVRYGQKPEVPNGVSPGHRLPHGYHSDKRRLSKASSKARSDDLSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_859 VRGQEQTPGEGFIQVRYGQKPEVPNGVSPGHRLPHGYHSDKRRLSKASSKARSDDLSV 310 320 330 340 350 >>XP_011507719 (OMIM: 116200,600897,612474) PREDICTED: g (427 aa) initn: 1071 init1: 649 opt: 1032 Z-score: 1171.9 bits: 225.6 E(85289): 1.6e-58 Smith-Waterman score: 1032; 61.8% identity (83.8% similar) in 241 aa overlap (1-241:1-239) 10 20 30 40 50 60 pF1KB9 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG :::::::::.::::..::::.:.::::::::::.:.:::::: :::::.:: :.: ::: XP_011 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS :.:::::.:::::::: :::::::::::::.:.:::.: :::.:::: ::::. . :. XP_011 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT .. : ... : .:. .. :.:::: ::.: :...: .:::::::.::.::. . XP_011 NGG--PDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRIL 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK :. : : :::. :.:.:::::::..::.:::.::..::.:.. :: ::: : ::. . . XP_011 PLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB9 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ : XP_011 PVEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFN 240 250 260 270 280 290 >>XP_011507718 (OMIM: 116200,600897,612474) PREDICTED: g (433 aa) initn: 1104 init1: 649 opt: 1032 Z-score: 1171.8 bits: 225.6 E(85289): 1.6e-58 Smith-Waterman score: 1032; 61.8% identity (83.8% similar) in 241 aa overlap (1-241:1-239) 10 20 30 40 50 60 pF1KB9 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG :::::::::.::::..::::.:.::::::::::.:.:::::: :::::.:: :.: ::: XP_011 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS :.:::::.:::::::: :::::::::::::.:.:::.: :::.:::: ::::. . :. XP_011 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT .. : ... : .:. .. :.:::: ::.: :...: .:::::::.::.::. . XP_011 NGG--PDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRIL 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK :. : : :::. :.:.:::::::..::.:::.::..::.:.. :: ::: : ::. . . XP_011 PLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB9 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ : XP_011 PVEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFN 240 250 260 270 280 290 >>NP_005258 (OMIM: 116200,600897,612474) gap junction al (433 aa) initn: 1104 init1: 649 opt: 1032 Z-score: 1171.8 bits: 225.6 E(85289): 1.6e-58 Smith-Waterman score: 1032; 61.8% identity (83.8% similar) in 241 aa overlap (1-241:1-239) 10 20 30 40 50 60 pF1KB9 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG :::::::::.::::..::::.:.::::::::::.:.:::::: :::::.:: :.: ::: NP_005 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS :.:::::.:::::::: :::::::::::::.:.:::.: :::.:::: ::::. . :. NP_005 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT .. : ... : .:. .. :.:::: ::.: :...: .:::::::.::.::. . NP_005 NGG--PDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRIL 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK :. : : :::. :.:.:::::::..::.:::.::..::.:.. :: ::: : ::. . . NP_005 PLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB9 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ : NP_005 PVEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFN 240 250 260 270 280 290 >>XP_011533350 (OMIM: 121015,601885) PREDICTED: gap junc (435 aa) initn: 1032 init1: 627 opt: 1023 Z-score: 1161.6 bits: 223.8 E(85289): 5.8e-58 Smith-Waterman score: 1023; 61.0% identity (83.5% similar) in 236 aa overlap (1-236:1-232) 10 20 30 40 50 60 pF1KB9 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG :::::::: .::....::::.::::::::::::.::::.:::. :::::.:: :.: ::: XP_011 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS :.:::::.::::::::.:.:::::::::.:.:.::..: :::.::.: :: :. . : : XP_011 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLK-RES 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT : . : .. .. ::. . :.:: ::: .:...: .:::::.::::.::. : XP_011 PSPKEPPQDNPSS---RDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK :. : : :::. :.:..::::::..::.:::::: ::::.. :.:::::::..: XP_011 PLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTS 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB9 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ XP_011 RLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAAD 240 250 260 270 280 290 >>NP_068773 (OMIM: 121015,601885) gap junction alpha-3 p (435 aa) initn: 1032 init1: 627 opt: 1023 Z-score: 1161.6 bits: 223.8 E(85289): 5.8e-58 Smith-Waterman score: 1023; 61.0% identity (83.5% similar) in 236 aa overlap (1-236:1-232) 10 20 30 40 50 60 pF1KB9 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG :::::::: .::....::::.::::::::::::.::::.:::. :::::.:: :.: ::: NP_068 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS :.:::::.::::::::.:.:::::::::.:.:.::..: :::.::.: :: :. . : : NP_068 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLK-RES 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT : . : .. .. ::. . :.:: ::: .:...: .:::::.::::.::. : NP_068 PSPKEPPQDNPSS---RDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK :. : : :::. :.:..::::::..::.:::::: ::::.. :.:::::::..: NP_068 PLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTS 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB9 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ NP_068 RLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAAD 240 250 260 270 280 290 >>NP_002051 (OMIM: 121012) gap junction alpha-4 protein (333 aa) initn: 951 init1: 579 opt: 940 Z-score: 1069.2 bits: 206.3 E(85289): 8.2e-53 Smith-Waterman score: 940; 46.2% identity (72.0% similar) in 329 aa overlap (1-321:1-319) 10 20 30 40 50 60 pF1KB9 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG ::::.:: ..:..:..:::::::.:::::::::.:.:: :.:: :::::.::.:.: ::: NP_002 MGDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPG 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAE-RAKEVRG : :::::::::::::::::::..:::::.:::.::... : .:. . .:.: :: .. NP_002 CTNVCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREERLRQKEGELRALPAKD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 SGSYEYPVA----EKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIY . : .: . :..: :. ::. ..:.:..::: :.: ....:.::. ::. .: NP_002 P-QVERALAAVERQMAKISVAED--GRLRIRGALMGTYVASVLCKSVLEAGFLYGQWRLY 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 GIFLTTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIR : . . ::.:.:::. :.:.:::::::..::.:::.:. .::.:.: :: :: . NP_002 GWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHL-LCRCL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB9 QRFVKPRQHMAKCQLSGPSVGIVQSCTPPPD---FNQCLENGPGGKFFNPFSNNMASQQN .: .. :: : . :. : : : : : . .::.. ... .:.:: NP_002 SRGMRARQG----QDAPPTQGT--SSDPYTDQVFFYLPVGQGPSSPPCPTYNGLSSSEQN 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 TDNLVTEQVRGQEQTPGEGFIQVRYGQKPEVPNGVSPGHRLPHGYHSDKRRLSKASSKAR ::.::. .. . : . :::: NP_002 WANLTTEERLASSRPPLFLDPPPQNGQKPPSRPSSSASKKQYV 300 310 320 330 358 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 19:39:37 2016 done: Fri Nov 4 19:39:38 2016 Total Scan time: 8.270 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]