FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9848, 376 aa 1>>>pF1KB9848 376 - 376 aa - 376 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.6895+/-0.000365; mu= 4.0290+/- 0.023 mean_var=445.2523+/-102.847, 0's: 0 Z-trim(123.8): 1078 B-trim: 0 in 0/57 Lambda= 0.060781 statistics sampled from 42471 (44149) to 42471 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.821), E-opt: 0.2 (0.518), width: 16 Scan time: 10.360 The best scores are: opt bits E(85289) XP_006722178 (OMIM: 608613) PREDICTED: transcripti ( 376) 2728 253.2 7.1e-67 NP_954871 (OMIM: 608613) transcription factor Sp6 ( 376) 2728 253.2 7.1e-67 NP_001245177 (OMIM: 608613) transcription factor S ( 376) 2728 253.2 7.1e-67 XP_011536202 (OMIM: 606633,613849) PREDICTED: tran ( 413) 813 85.4 2.6e-16 NP_001287766 (OMIM: 606633,613849) transcription f ( 413) 813 85.4 2.6e-16 NP_001166938 (OMIM: 606633,613849) transcription f ( 431) 813 85.4 2.7e-16 NP_690599 (OMIM: 606633,613849) transcription fact ( 431) 813 85.4 2.7e-16 NP_945194 (OMIM: 608306) transcription factor Sp8 ( 490) 757 80.6 8.7e-15 NP_874359 (OMIM: 608306) transcription factor Sp8 ( 508) 757 80.6 8.9e-15 NP_001003845 (OMIM: 609391) transcription factor S ( 398) 649 71.0 5.5e-12 XP_005246599 (OMIM: 609391) PREDICTED: transcripti ( 442) 649 71.0 5.8e-12 XP_011509461 (OMIM: 609391) PREDICTED: transcripti ( 454) 649 71.1 5.9e-12 NP_001017371 (OMIM: 601804) transcription factor S ( 713) 596 66.7 1.9e-10 NP_001166183 (OMIM: 601804) transcription factor S ( 778) 596 66.8 2e-10 NP_003102 (OMIM: 601804) transcription factor Sp3 ( 781) 596 66.8 2e-10 NP_001313472 (OMIM: 600540) transcription factor S ( 471) 582 65.2 3.5e-10 NP_001238754 (OMIM: 189906) transcription factor S ( 737) 584 65.7 4e-10 XP_011536998 (OMIM: 189906) PREDICTED: transcripti ( 778) 584 65.7 4.1e-10 NP_003100 (OMIM: 189906) transcription factor Sp1 ( 778) 584 65.7 4.1e-10 NP_612482 (OMIM: 189906) transcription factor Sp1 ( 785) 584 65.7 4.1e-10 NP_001313471 (OMIM: 600540) transcription factor S ( 767) 582 65.5 4.6e-10 XP_005249885 (OMIM: 600540) PREDICTED: transcripti ( 767) 582 65.5 4.6e-10 NP_003103 (OMIM: 600540) transcription factor Sp4 ( 784) 582 65.6 4.6e-10 XP_006722088 (OMIM: 601801) PREDICTED: transcripti ( 660) 532 61.1 8.8e-09 XP_006722089 (OMIM: 601801) PREDICTED: transcripti ( 660) 532 61.1 8.8e-09 XP_011523444 (OMIM: 601801) PREDICTED: transcripti ( 660) 532 61.1 8.8e-09 XP_016880458 (OMIM: 601801) PREDICTED: transcripti ( 660) 532 61.1 8.8e-09 XP_016880457 (OMIM: 601801) PREDICTED: transcripti ( 660) 532 61.1 8.8e-09 XP_011523445 (OMIM: 601801) PREDICTED: transcripti ( 660) 532 61.1 8.8e-09 XP_006722090 (OMIM: 601801) PREDICTED: transcripti ( 660) 532 61.1 8.8e-09 XP_006722086 (OMIM: 601801) PREDICTED: transcripti ( 667) 532 61.1 8.9e-09 XP_011523441 (OMIM: 601801) PREDICTED: transcripti ( 727) 532 61.1 9.3e-09 XP_011523440 (OMIM: 601801) PREDICTED: transcripti ( 760) 532 61.2 9.5e-09 XP_011523439 (OMIM: 601801) PREDICTED: transcripti ( 768) 532 61.2 9.6e-09 XP_011523438 (OMIM: 601801) PREDICTED: transcripti ( 771) 532 61.2 9.6e-09 NP_003101 (OMIM: 601801) transcription factor Sp2 ( 613) 528 60.7 1.1e-08 XP_011523442 (OMIM: 601801) PREDICTED: transcripti ( 717) 528 60.8 1.2e-08 NP_057354 (OMIM: 602016) Krueppel-like factor 2 [H ( 355) 472 55.4 2.4e-07 XP_011513788 (OMIM: 600540) PREDICTED: transcripti ( 711) 451 54.0 1.3e-06 XP_011539002 (OMIM: 609602) PREDICTED: Krueppel-li ( 352) 442 52.7 1.5e-06 NP_775755 (OMIM: 609602) Krueppel-like factor 17 [ ( 389) 442 52.8 1.6e-06 NP_057079 (OMIM: 605328,612001) Krueppel-like fact ( 288) 435 52.0 2.1e-06 XP_011525944 (OMIM: 111150,600599,613566,613673) P ( 324) 436 52.2 2.1e-06 NP_006554 (OMIM: 111150,600599,613566,613673) Krue ( 362) 436 52.2 2.2e-06 XP_005249886 (OMIM: 600540) PREDICTED: transcripti ( 706) 436 52.7 3.1e-06 NP_619638 (OMIM: 609393) Krueppel-like factor 14 [ ( 323) 426 51.3 3.8e-06 NP_114124 (OMIM: 606139) Krueppel-like factor 16 [ ( 252) 422 50.8 4.3e-06 NP_001027453 (OMIM: 601878) Krueppel-like factor 1 ( 469) 416 50.6 8.5e-06 NP_005646 (OMIM: 601878) Krueppel-like factor 10 i ( 480) 416 50.7 8.6e-06 NP_001171187 (OMIM: 603301,610508) Krueppel-like f ( 495) 416 50.7 8.8e-06 >>XP_006722178 (OMIM: 608613) PREDICTED: transcription f (376 aa) initn: 2728 init1: 2728 opt: 2728 Z-score: 1321.6 bits: 253.2 E(85289): 7.1e-67 Smith-Waterman score: 2728; 100.0% identity (100.0% similar) in 376 aa overlap (1-376:1-376) 10 20 30 40 50 60 pF1KB9 MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 VDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPTHPGAEDGSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPTHPGAEDGSW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 WDLHPGTSWMDLPHTQGALTSPGHPGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WDLHPGTSWMDLPHTQGALTSPGHPGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 HLLGPPDGAKALEVAAPESQGLDSSLDGAARPKGSRRSVPRSSGQTVCRCPNCLEAERLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HLLGPPDGAKALEVAAPESQGLDSSLDGAARPKGSRRSVPRSSGQTVCRCPNCLEAERLG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 APCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 APCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 LQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGAKEEAAGAASGEGKAGGAVEPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGAKEEAAGAASGEGKAGGAVEPP 310 320 330 340 350 360 370 pF1KB9 GGKGKREAEGSVAPSN :::::::::::::::: XP_006 GGKGKREAEGSVAPSN 370 >>NP_954871 (OMIM: 608613) transcription factor Sp6 [Hom (376 aa) initn: 2728 init1: 2728 opt: 2728 Z-score: 1321.6 bits: 253.2 E(85289): 7.1e-67 Smith-Waterman score: 2728; 100.0% identity (100.0% similar) in 376 aa overlap (1-376:1-376) 10 20 30 40 50 60 pF1KB9 MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_954 MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 VDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPTHPGAEDGSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_954 VDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPTHPGAEDGSW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 WDLHPGTSWMDLPHTQGALTSPGHPGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_954 WDLHPGTSWMDLPHTQGALTSPGHPGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 HLLGPPDGAKALEVAAPESQGLDSSLDGAARPKGSRRSVPRSSGQTVCRCPNCLEAERLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_954 HLLGPPDGAKALEVAAPESQGLDSSLDGAARPKGSRRSVPRSSGQTVCRCPNCLEAERLG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 APCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_954 APCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 LQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGAKEEAAGAASGEGKAGGAVEPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_954 LQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGAKEEAAGAASGEGKAGGAVEPP 310 320 330 340 350 360 370 pF1KB9 GGKGKREAEGSVAPSN :::::::::::::::: NP_954 GGKGKREAEGSVAPSN 370 >>NP_001245177 (OMIM: 608613) transcription factor Sp6 [ (376 aa) initn: 2728 init1: 2728 opt: 2728 Z-score: 1321.6 bits: 253.2 E(85289): 7.1e-67 Smith-Waterman score: 2728; 100.0% identity (100.0% similar) in 376 aa overlap (1-376:1-376) 10 20 30 40 50 60 pF1KB9 MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 VDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPTHPGAEDGSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPTHPGAEDGSW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 WDLHPGTSWMDLPHTQGALTSPGHPGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WDLHPGTSWMDLPHTQGALTSPGHPGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 HLLGPPDGAKALEVAAPESQGLDSSLDGAARPKGSRRSVPRSSGQTVCRCPNCLEAERLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLLGPPDGAKALEVAAPESQGLDSSLDGAARPKGSRRSVPRSSGQTVCRCPNCLEAERLG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 APCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 LQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGAKEEAAGAASGEGKAGGAVEPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGAKEEAAGAASGEGKAGGAVEPP 310 320 330 340 350 360 370 pF1KB9 GGKGKREAEGSVAPSN :::::::::::::::: NP_001 GGKGKREAEGSVAPSN 370 >>XP_011536202 (OMIM: 606633,613849) PREDICTED: transcri (413 aa) initn: 700 init1: 526 opt: 813 Z-score: 413.7 bits: 85.4 E(85289): 2.6e-16 Smith-Waterman score: 857; 40.7% identity (59.0% similar) in 398 aa overlap (8-376:41-409) 10 20 30 pF1KB9 MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTS ..:. . :: .: : :.: . . :: XP_011 GSSPLRDSTTLGKAGTKKPYSVGSDLSASKTMGDAYP-APFTSTNGL-LSPAGSPPAPTS 20 30 40 50 60 40 50 60 70 80 90 pF1KB9 PEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQ :.::: :.. .:.: :: . : .: . : : :. ...: XP_011 GYANDYP-PFS----HSFP-GPTGTQDPGLLVPKGHSSSDC---------LPSVYTSL-- 70 80 90 100 110 100 110 120 130 140 pF1KB9 PDMSHHYESWFRP-TH------PGAEDGSWWDLHPGTSWMDLPH-----TQGAL-TSPGH ::.: : ::.. : :: :::.::: .:. . ::.: :.:.. XP_011 -DMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQGTLPTGPAQ 120 130 140 150 160 170 150 160 170 180 190 200 pF1KB9 PGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQHLLGPPDGAKALEVAAPESQGLDS : :. : : .: : :.: : : : : ::.: : : : :. .: :.. XP_011 P-PLNPQLPTYPSDFAPLNPAPYPAPHLLQP--GPQHVL-PQDVYKPKAVG--NSGQLEG 180 190 200 210 220 210 220 230 240 250 pF1KB9 SLDGAARPKGSRRSVP-----RSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIP : :: :.:. . ..:.. : :::: : ::::: . : .:: .:.:::: XP_011 S-GGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAA--GLRKKPIHSCHIP 230 240 250 260 270 280 260 270 280 290 300 310 pF1KB9 GCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVC ::::.:.:.::::::::::.:.::::::::::::::::::::.::..::: ::: : .: XP_011 GCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLC 290 300 310 320 330 340 320 330 340 350 360 pF1KB9 SRVFMRSDHLAKHMKTH---------EGAKEEAAGAASGEGKAGGAVEPPGGKGKREAE- :. : :::::.::..:: : :: . : ..:: .:. . .: .. . : XP_011 SKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAP 350 360 370 380 390 400 370 pF1KB9 -GSVAPSN :: :: XP_011 GGSPEQSNLLEI 410 >>NP_001287766 (OMIM: 606633,613849) transcription facto (413 aa) initn: 700 init1: 526 opt: 813 Z-score: 413.7 bits: 85.4 E(85289): 2.6e-16 Smith-Waterman score: 857; 40.7% identity (59.0% similar) in 398 aa overlap (8-376:41-409) 10 20 30 pF1KB9 MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTS ..:. . :: .: : :.: . . :: NP_001 GSSPLRDSTTLGKAGTKKPYSVGSDLSASKTMGDAYP-APFTSTNGL-LSPAGSPPAPTS 20 30 40 50 60 40 50 60 70 80 90 pF1KB9 PEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQ :.::: :.. .:.: :: . : .: . : : :. ...: NP_001 GYANDYP-PFS----HSFP-GPTGTQDPGLLVPKGHSSSDC---------LPSVYTSL-- 70 80 90 100 110 100 110 120 130 140 pF1KB9 PDMSHHYESWFRP-TH------PGAEDGSWWDLHPGTSWMDLPH-----TQGAL-TSPGH ::.: : ::.. : :: :::.::: .:. . ::.: :.:.. NP_001 -DMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQGTLPTGPAQ 120 130 140 150 160 170 150 160 170 180 190 200 pF1KB9 PGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQHLLGPPDGAKALEVAAPESQGLDS : :. : : .: : :.: : : : : ::.: : : : :. .: :.. NP_001 P-PLNPQLPTYPSDFAPLNPAPYPAPHLLQP--GPQHVL-PQDVYKPKAVG--NSGQLEG 180 190 200 210 220 210 220 230 240 250 pF1KB9 SLDGAARPKGSRRSVP-----RSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIP : :: :.:. . ..:.. : :::: : ::::: . : .:: .:.:::: NP_001 S-GGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAA--GLRKKPIHSCHIP 230 240 250 260 270 280 260 270 280 290 300 310 pF1KB9 GCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVC ::::.:.:.::::::::::.:.::::::::::::::::::::.::..::: ::: : .: NP_001 GCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLC 290 300 310 320 330 340 320 330 340 350 360 pF1KB9 SRVFMRSDHLAKHMKTH---------EGAKEEAAGAASGEGKAGGAVEPPGGKGKREAE- :. : :::::.::..:: : :: . : ..:: .:. . .: .. . : NP_001 SKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAP 350 360 370 380 390 400 370 pF1KB9 -GSVAPSN :: :: NP_001 GGSPEQSNLLEI 410 >>NP_001166938 (OMIM: 606633,613849) transcription facto (431 aa) initn: 700 init1: 526 opt: 813 Z-score: 413.5 bits: 85.4 E(85289): 2.7e-16 Smith-Waterman score: 857; 40.7% identity (59.0% similar) in 398 aa overlap (8-376:59-427) 10 20 30 pF1KB9 MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTS ..:. . :: .: : :.: . . :: NP_001 GSSPLRDSTTLGKAGTKKPYSVGSDLSASKTMGDAYP-APFTSTNGL-LSPAGSPPAPTS 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB9 PEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQ :.::: :.. .:.: :: . : .: . : : :. ...: NP_001 GYANDYP-PFS----HSFP-GPTGTQDPGLLVPKGHSSSDC---------LPSVYTSL-- 90 100 110 120 100 110 120 130 140 pF1KB9 PDMSHHYESWFRP-TH------PGAEDGSWWDLHPGTSWMDLPH-----TQGAL-TSPGH ::.: : ::.. : :: :::.::: .:. . ::.: :.:.. NP_001 -DMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQGTLPTGPAQ 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB9 PGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQHLLGPPDGAKALEVAAPESQGLDS : :. : : .: : :.: : : : : ::.: : : : :. .: :.. NP_001 P-PLNPQLPTYPSDFAPLNPAPYPAPHLLQP--GPQHVL-PQDVYKPKAVG--NSGQLEG 190 200 210 220 230 240 210 220 230 240 250 pF1KB9 SLDGAARPKGSRRSVP-----RSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIP : :: :.:. . ..:.. : :::: : ::::: . : .:: .:.:::: NP_001 S-GGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAA--GLRKKPIHSCHIP 250 260 270 280 290 260 270 280 290 300 310 pF1KB9 GCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVC ::::.:.:.::::::::::.:.::::::::::::::::::::.::..::: ::: : .: NP_001 GCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLC 300 310 320 330 340 350 320 330 340 350 360 pF1KB9 SRVFMRSDHLAKHMKTH---------EGAKEEAAGAASGEGKAGGAVEPPGGKGKREAE- :. : :::::.::..:: : :: . : ..:: .:. . .: .. . : NP_001 SKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAP 360 370 380 390 400 410 370 pF1KB9 -GSVAPSN :: :: NP_001 GGSPEQSNLLEI 420 430 >>NP_690599 (OMIM: 606633,613849) transcription factor S (431 aa) initn: 700 init1: 526 opt: 813 Z-score: 413.5 bits: 85.4 E(85289): 2.7e-16 Smith-Waterman score: 857; 40.7% identity (59.0% similar) in 398 aa overlap (8-376:59-427) 10 20 30 pF1KB9 MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTS ..:. . :: .: : :.: . . :: NP_690 GSSPLRDSTTLGKAGTKKPYSVGSDLSASKTMGDAYP-APFTSTNGL-LSPAGSPPAPTS 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB9 PEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQ :.::: :.. .:.: :: . : .: . : : :. ...: NP_690 GYANDYP-PFS----HSFP-GPTGTQDPGLLVPKGHSSSDC---------LPSVYTSL-- 90 100 110 120 100 110 120 130 140 pF1KB9 PDMSHHYESWFRP-TH------PGAEDGSWWDLHPGTSWMDLPH-----TQGAL-TSPGH ::.: : ::.. : :: :::.::: .:. . ::.: :.:.. NP_690 -DMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQGTLPTGPAQ 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB9 PGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQHLLGPPDGAKALEVAAPESQGLDS : :. : : .: : :.: : : : : ::.: : : : :. .: :.. NP_690 P-PLNPQLPTYPSDFAPLNPAPYPAPHLLQP--GPQHVL-PQDVYKPKAVG--NSGQLEG 190 200 210 220 230 240 210 220 230 240 250 pF1KB9 SLDGAARPKGSRRSVP-----RSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIP : :: :.:. . ..:.. : :::: : ::::: . : .:: .:.:::: NP_690 S-GGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAA--GLRKKPIHSCHIP 250 260 270 280 290 260 270 280 290 300 310 pF1KB9 GCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVC ::::.:.:.::::::::::.:.::::::::::::::::::::.::..::: ::: : .: NP_690 GCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLC 300 310 320 330 340 350 320 330 340 350 360 pF1KB9 SRVFMRSDHLAKHMKTH---------EGAKEEAAGAASGEGKAGGAVEPPGGKGKREAE- :. : :::::.::..:: : :: . : ..:: .:. . .: .. . : NP_690 SKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSTGEEEASQTPRPSASPATPEKAP 360 370 380 390 400 410 370 pF1KB9 -GSVAPSN :: :: NP_690 GGSPEQSNLLEI 420 430 >>NP_945194 (OMIM: 608306) transcription factor Sp8 isof (490 aa) initn: 920 init1: 571 opt: 757 Z-score: 386.5 bits: 80.6 E(85289): 8.7e-15 Smith-Waterman score: 884; 45.0% identity (64.3% similar) in 353 aa overlap (36-356:118-458) 10 20 30 40 50 60 pF1KB9 CGSLGSQHTEAPHASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGEL--QSLPLGPEVDF .:: :.:: :: .. : NP_945 SCGGSPGSSAFSLTSSSAAAAAAAAAAAASSSPFANDYSVFQAPGVSGGSGGGGGGGGGG 90 100 110 120 130 140 70 80 90 100 110 pF1KB9 SQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPTHPG----AEDGS :... :. . : .... : . .. :.: :::::.:.::: .: :: NP_945 SSAHSQDGSHQPVFISKVHTSVDGLQGIYPRV---GMAHPYESWFKPSHPGLGAAGEVGS 150 160 170 180 190 200 120 130 140 150 160 pF1KB9 -----WWDLHPGTSWMDLPHTQGALTSPG--HP--GALQAGL----GGYVGDHQ---LCA :::. :..:.:. . ..: . :: :: :.::..: ::: .:.. : NP_945 AGASSWWDV--GAGWIDVQNPNSAAALPGSLHPAAGGLQTSLHSPLGGYNSDYSGLSHSA 210 220 230 240 250 260 170 180 190 200 210 pF1KB9 PPPHPHAHHLLPAAGGQHLLGPPDGAK-ALEVAAPESQ-----GLDSSL--DGAARPKGS .: : :: ::::. :: : .: . :.: : .:. : . : :. NP_945 FSSGASSHLLSPA--GQHLM---DGFKPVLPGSYPDSAPSPLAGAGGSMLSAGPSAPLGG 270 280 290 300 310 220 230 240 250 260 270 pF1KB9 --RRSVPRSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKA : :. : ::...: :::: :::::: : : . ..: ::.::::::::.:.::::::: NP_945 SPRSSARRYSGRATCDCPNCQEAERLG-PAGASL-RRKGLHSCHIPGCGKVYGKTSHLKA 320 330 340 350 360 370 280 290 300 310 320 330 pF1KB9 HLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHM :::::.:.::::::::::::::::::::::::.:::: :.: : ::.. :::::::.::. NP_945 HLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHV 380 390 400 410 420 430 340 350 360 370 pF1KB9 KTHEGAKEEAAGAASGEGKAGGAVEPPGGKGKREAEGSVAPSN ::: :. ...:.:: : :. NP_945 KTHSGGGGGGGSAGSGSGGKKGSDTDSEHSAAGSPPCHSPELLQPPEPGHRNGLE 440 450 460 470 480 490 >>NP_874359 (OMIM: 608306) transcription factor Sp8 isof (508 aa) initn: 920 init1: 571 opt: 757 Z-score: 386.3 bits: 80.6 E(85289): 8.9e-15 Smith-Waterman score: 884; 45.0% identity (64.3% similar) in 353 aa overlap (36-356:136-476) 10 20 30 40 50 60 pF1KB9 CGSLGSQHTEAPHASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGEL--QSLPLGPEVDF .:: :.:: :: .. : NP_874 SCGGSPGSSAFSLTSSSAAAAAAAAAAAASSSPFANDYSVFQAPGVSGGSGGGGGGGGGG 110 120 130 140 150 160 70 80 90 100 110 pF1KB9 SQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPTHPG----AEDGS :... :. . : .... : . .. :.: :::::.:.::: .: :: NP_874 SSAHSQDGSHQPVFISKVHTSVDGLQGIYPRV---GMAHPYESWFKPSHPGLGAAGEVGS 170 180 190 200 210 220 120 130 140 150 160 pF1KB9 -----WWDLHPGTSWMDLPHTQGALTSPG--HP--GALQAGL----GGYVGDHQ---LCA :::. :..:.:. . ..: . :: :: :.::..: ::: .:.. : NP_874 AGASSWWDV--GAGWIDVQNPNSAAALPGSLHPAAGGLQTSLHSPLGGYNSDYSGLSHSA 230 240 250 260 270 280 170 180 190 200 210 pF1KB9 PPPHPHAHHLLPAAGGQHLLGPPDGAK-ALEVAAPESQ-----GLDSSL--DGAARPKGS .: : :: ::::. :: : .: . :.: : .:. : . : :. NP_874 FSSGASSHLLSPA--GQHLM---DGFKPVLPGSYPDSAPSPLAGAGGSMLSAGPSAPLGG 290 300 310 320 330 220 230 240 250 260 270 pF1KB9 --RRSVPRSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKA : :. : ::...: :::: :::::: : : . ..: ::.::::::::.:.::::::: NP_874 SPRSSARRYSGRATCDCPNCQEAERLG-PAGASL-RRKGLHSCHIPGCGKVYGKTSHLKA 340 350 360 370 380 390 280 290 300 310 320 330 pF1KB9 HLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHM :::::.:.::::::::::::::::::::::::.:::: :.: : ::.. :::::::.::. NP_874 HLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHV 400 410 420 430 440 450 340 350 360 370 pF1KB9 KTHEGAKEEAAGAASGEGKAGGAVEPPGGKGKREAEGSVAPSN ::: :. ...:.:: : :. NP_874 KTHSGGGGGGGSAGSGSGGKKGSDTDSEHSAAGSPPCHSPELLQPPEPGHRNGLE 460 470 480 490 500 >>NP_001003845 (OMIM: 609391) transcription factor Sp5 [ (398 aa) initn: 872 init1: 546 opt: 649 Z-score: 336.1 bits: 71.0 E(85289): 5.5e-12 Smith-Waterman score: 722; 39.8% identity (55.6% similar) in 392 aa overlap (1-346:35-388) 10 pF1KB9 MLTAVCGSLGSQHTEAPH-----------A .:.:.:. .:. . :: . NP_001 AVLRNDSLQAFLQDRTPSASPDLGKHSPLALLAATCSRIGQPGAAAPPDFLQVPYDPALG 10 20 30 40 50 60 20 30 40 50 60 pF1KB9 SPPRLDLQPLQTYQGHTSPEAGDYPSP----------LQP--GELQSLPLGPEVDFSQGY :: :: ..: . . :: : : : ::: : . ::: : .: : : NP_001 SPSRL-FHPWTADMPAHSPGALPPPHPSLGLTPQKTHLQPSFGAAHELPLTPPADPSYPY 70 80 90 100 110 120 70 80 90 100 110 pF1KB9 E------LPG--ASSRVTCED----LESDSPLAPGPFSKLLQPDMSHHYESWFRPT--HP : ::. :. ..: ... : :: .:.:: : : .: NP_001 EFSPVKMLPSSMAALPASCAPAYVPYAAQAALPPG-YSNLLPPPPPPPPPPTCRQLSPNP 130 140 150 160 170 180 120 130 140 150 160 pF1KB9 GAEDGSWWDLHPGTSWMDLPHTQGALTSPGHPGALQAGLGGYVGDHQLCAPPPH-PH--- . .: ::.. :.. :: .:: :. .::.: :: :: :. NP_001 APDDLPWWSI---------PQA-GA--GPGASGVPGSGLSGA------CAGAPHAPRFPA 190 200 210 220 170 180 190 200 210 220 pF1KB9 --AHHLLPAAGGQH--LLGPPDGAKAL-EVAAPESQGLDSSLDGAARPKGSRRSVPRSSG : ::. :. .::: : :. ..:: :... :: . :: NP_001 SAAAAAAAAAALQRGLVLGPSDFAQYQSQIAAL----LQTKAPLAATARRCRR------- 230 240 250 260 270 230 240 250 260 270 280 pF1KB9 QTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPF :::::: : ::: . : ::.:. ::.:::::.:.::::::::::::.:.::: NP_001 ---CRCPNCQAAG--GAPEAEPGKKKQHV--CHVPGCGKVYGKTSHLKAHLRWHTGERPF 280 290 300 310 320 290 300 310 320 330 340 pF1KB9 VCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGAKEEAA ::::::::: :::::::::::.:::: :.: : :.. ::::::::::.:::.. : ..: NP_001 VCNWLFCGKSFTRSDELQRHLRTHTGEKRFACPECGKRFMRSDHLAKHVKTHQNKKLKVA 330 340 350 360 370 380 350 360 370 pF1KB9 GAASGEGKAGGAVEPPGGKGKREAEGSVAPSN : NP_001 EAGVKREDARDL 390 376 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 19:44:30 2016 done: Fri Nov 4 19:44:32 2016 Total Scan time: 10.360 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]