FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9854, 389 aa 1>>>pF1KB9854 389 - 389 aa - 389 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6899+/-0.000876; mu= 15.0464+/- 0.053 mean_var=68.1756+/-13.397, 0's: 0 Z-trim(106.0): 13 B-trim: 0 in 0/50 Lambda= 0.155332 statistics sampled from 8729 (8733) to 8729 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.642), E-opt: 0.2 (0.268), width: 16 Scan time: 2.750 The best scores are: opt bits E(32554) CCDS14446.1 FAM46D gene_id:169966|Hs108|chrX ( 389) 2616 595.2 3.3e-170 CCDS34489.1 FAM46A gene_id:55603|Hs108|chr6 ( 442) 1544 355.0 7.7e-98 CCDS896.1 FAM46C gene_id:54855|Hs108|chr1 ( 391) 1502 345.6 4.7e-95 CCDS294.2 FAM46B gene_id:115572|Hs108|chr1 ( 425) 1282 296.3 3.5e-80 >>CCDS14446.1 FAM46D gene_id:169966|Hs108|chrX (389 aa) initn: 2616 init1: 2616 opt: 2616 Z-score: 3169.2 bits: 595.2 E(32554): 3.3e-170 Smith-Waterman score: 2616; 99.7% identity (100.0% similar) in 389 aa overlap (1-389:1-389) 10 20 30 40 50 60 pF1KB9 MSEIRFTNLTWDQVITLDQVLDEVIPIHGKGNFPTMEVKPKDIIHVVKDQLIGQGIIVKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 MSEIRFTNLTWDQVITLDQVLDEVIPIHGKGNFPTMEVKPKDIIHVVKDQLIGQGIIVKD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 ARLNGSVASYILASHNGISYKDLDVIFGVELPGNEEFQVVKDAVLDCLLDFLPKDVKKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 ARLNGSVASYILASHNGISYKDLDVIFGVELPGNEEFQVVKDAVLDCLLDFLPKDVKKEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LSPDIMKDAYVQKLVKVCNGHDCWSLISLSNNTGKNLELKFVSSLRRQFEFSVDSFQIVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 LSPDIMKDAYVQKLVKVCNGHDCWSLISLSNNTGKNLELKFVSSLRRQFEFSVDSFQIVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 DPMLEFYSDKNAKLTKESYPVVVAESMYGDFQEAMTHLQHKLICTRKPEEIRGGGLLKYC ::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 DPMLDFYSDKNAKLTKESYPVVVAESMYGDFQEAMTHLQHKLICTRKPEEIRGGGLLKYC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 SLLVHGFKPACMSEIKNLERYMCSRFFIDFPHIEEQQKKIESYLHNHFIGEGMTKYDYLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 SLLVHGFKPACMSEIKNLERYMCSRFFIDFPHIEEQQKKIESYLHNHFIGEGMTKYDYLM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 TLHGVVNESTVCLMSYERRQILHLITMMALKVLGELNILPNTQKVTCFYQPAPYFAAEAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 TLHGVVNESTVCLMSYERRQILHLITMMALKVLGELNILPNTQKVTCFYQPAPYFAAEAR 310 320 330 340 350 360 370 380 pF1KB9 YPIYVIPEPPPVSFQPYHPLHFRGSNGMS ::::::::::::::::::::::::::::: CCDS14 YPIYVIPEPPPVSFQPYHPLHFRGSNGMS 370 380 >>CCDS34489.1 FAM46A gene_id:55603|Hs108|chr6 (442 aa) initn: 1524 init1: 1034 opt: 1544 Z-score: 1870.0 bits: 355.0 E(32554): 7.7e-98 Smith-Waterman score: 1544; 62.9% identity (85.7% similar) in 364 aa overlap (9-372:66-427) 10 20 30 pF1KB9 MSEIRFTNLTWDQVITLDQVLDEVIPIHGKGNFPTMEV :.:.:: :: .:.:.:::::.:::::.:. CCDS34 DFGGGDFGGGGSFGGHCLDYCESPTAHCNVLNWEQVQRLDGILSETIPIHGRGNFPTLEL 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB9 KPKDIIHVVKDQLIGQGIIVKDARLNGSVASYILASHNGISYKDLDVIFGVELPGNEEFQ .:. :..::. .: . : :.:.:::::.::..: . .:..:::::.:: ..: :. ::: CCDS34 QPSLIVKVVRRRLAEKRIGVRDVRLNGSAASHVLHQDSGLGYKDLDLIFCADLRGEGEFQ 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB9 VVKDAVLDCLLDFLPKDVKKEKLSPDIMKDAYVQKLVKVCNGHDCWSLISLSNNTGKNLE .:::.::::::::::. :.:::..: .:.:::::.::::: : :::::::::.:::.: CCDS34 TVKDVVLDCLLDFLPEGVNKEKITPLTLKEAYVQKMVKVCNDSDRWSLISLSNNSGKNVE 160 170 180 190 200 210 160 170 180 190 200 210 pF1KB9 LKFVSSLRRQFEFSVDSFQIVLDPMLEFYSDKNAKLTKESYPVVVAESMYGDFQEAMTHL ::::.::::::::::::::: :: .: :: .. .:. .:....::.:::::::. :: CCDS34 LKFVDSLRRQFEFSVDSFQIKLDSLLLFYECSENPMTETFHPTIIGESVYGDFQEAFDHL 220 230 240 250 260 270 220 230 240 250 260 270 pF1KB9 QHKLICTRKPEEIRGGGLLKYCSLLVHGFKPACMSEIKNLERYMCSRFFIDFPHIEEQQK .:.: ::.:::::::::::::.:::.::.:: .:::.:.::::::::::: : :::. CCDS34 CNKIIATRNPEEIRGGGLLKYCNLLVRGFRPAS-DEIKTLQRYMCSRFFIDFSDIGEQQR 280 290 300 310 320 330 280 290 300 310 320 330 pF1KB9 KIESYLHNHFIGEGMTKYDYLMTLHGVVNESTVCLMSYERRQILHLITMMALKVLGELNI :.::::.:::.: ::.:::::::::::::::::..:::: :.::::.:..::.. :. CCDS34 KLESYLQNHFVGLEDRKYEYLMTLHGVVNESTVCLMGHERRQTLNLITMLAIRVLADQNV 340 350 360 370 380 390 340 350 360 370 380 pF1KB9 LPNTQKVTCFYQPAPYFAAEARYPIYVIPEPPPVSFQPYHPLHFRGSNGMS .::. .:::.:::::: .:.: . : : . :: CCDS34 IPNVANVTCYYQPAPY-VADANFSNYYIAQVQPVFTCQQQTYSTWLPCN 400 410 420 430 440 >>CCDS896.1 FAM46C gene_id:54855|Hs108|chr1 (391 aa) initn: 1490 init1: 1465 opt: 1502 Z-score: 1820.0 bits: 345.6 E(32554): 4.7e-95 Smith-Waterman score: 1502; 59.6% identity (84.2% similar) in 374 aa overlap (4-377:12-384) 10 20 30 40 50 pF1KB9 MSEIRFTNLTWDQVITLDQVLDEVIPIHGKGNFPTMEVKPKDIIHVVKDQLI . :. :.:::: : .:: ::.::::.:::::.:. :::...:...: CCDS89 MAEESSCTRDCMSFSVLNWDQVSRLHEVLTEVVPIHGRGNFPTLEITLKDIVQTVRSRLE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 GQGIIVKDARLNGSVASYILASHNGISYKDLDVIFGVELPGNEEFQVVKDAVLDCLLDFL :: :.:.:::::.:...:.. ::.. ::::.:: : :: . :::.:.:.:: ::.:: CCDS89 EAGIKVHDVRLNGSAAGHVLVKDNGLGCKDLDLIFHVALPTEAEFQLVRDVVLCSLLNFL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 PKDVKKEKLSPDIMKDAYVQKLVKVCNGHDCWSLISLSNNTGKNLELKFVSSLRRQFEFS :. :.: :.:: .:.::::::::::. : ::::::::..:::.:::::.:.::::::: CCDS89 PEGVNKLKISPVTLKEAYVQKLVKVCTDTDRWSLISLSNKNGKNVELKFVDSIRRQFEFS 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 VDSFQIVLDPMLEFYSDKNAKLTKESYPVVVAESMYGDFQEAMTHLQHKLICTRKPEEIR ::::::.:: .: ::. .: .... .:.:..:::::::.::. :::..:: :..::::: CCDS89 VDSFQIILDSLLFFYDCSNNPISEHFHPTVIGESMYGDFEEAFDHLQNRLIATKNPEEIR 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 GGGLLKYCSLLVHGFKPACMSEIKNLERYMCSRFFIDFPHIEEQQKKIESYLHNHFIGEG ::::::: .:::. :.:. . :::.:::::::::::::: : :::.:.:.::.::: : CCDS89 GGGLLKYSNLLVRDFRPTDQEEIKTLERYMCSRFFIDFPDILEQQRKLETYLQNHFAEEE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB9 MTKYDYLMTLHGVVNESTVCLMSYERRQILHLITMMALKVLGELNILPNTQKVTCFYQPA .:::::: :. ::::::::::..:::: :.::...::.::.: ::.:.. .:::.:::: CCDS89 RSKYDYLMILRRVVNESTVCLMGHERRQTLNLISLLALRVLAEQNIIPSATNVTCYYQPA 310 320 330 340 350 360 360 370 380 pF1KB9 PYFAAEARYPIYVIPEPPPVSFQPYHPLHFRGSNGMS :: .... . : . .:: . ::: CCDS89 PY-VSDGNFSNYYVAHPPVTYSQPYPTWLPCN 370 380 390 >>CCDS294.2 FAM46B gene_id:115572|Hs108|chr1 (425 aa) initn: 1227 init1: 1093 opt: 1282 Z-score: 1553.0 bits: 296.3 E(32554): 3.5e-80 Smith-Waterman score: 1282; 52.5% identity (79.0% similar) in 366 aa overlap (6-370:49-412) 10 20 30 pF1KB9 MSEIRFTNLTWDQVITLDQVLDEVIPIHGKGNFPT ...:.: :: :: .:.: :::::.::::: CCDS29 GTAAATAVATAAPAGGGPDPEALSAFPGRHLSGLSWPQVKRLDALLSEPIPIHGRGNFPT 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB9 MEVKPKDIIHVVKDQLIGQGIIVKDARLNGSVASYILASHNGISYKDLDVIFGVELPGNE . :.:..:..::.. : ::. :...::.::.::..: ..:..:::::..: :.: .. CCDS29 LSVQPRQIVQVVRSTLEEQGLHVHSVRLHGSAASHVLHPESGLGYKDLDLVFRVDLRSEA 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB9 EFQVVKDAVLDCLLDFLPKDVKKEKLSPDIMKDAYVQKLVKVCNGHDCWSLISLSNNTGK ::..: .:: ::::::: :.. :..: .:.::::::::::. : ::::::::..:: CCDS29 SFQLTKAVVLACLLDFLPAGVSRAKITPLTLKEAYVQKLVKVCTDSDRWSLISLSNKSGK 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB9 NLELKFVSSLRRQFEFSVDSFQIVLDPMLEFYSDKNAKLTKESYPVVVAESMYGDFQEAM :.:::::.:.:::::::.:::::.:: .: : . ... ... .:.:..::.:::: ::. CCDS29 NVELKFVDSVRRQFEFSIDSFQIILDSLLLFGQCSSTPMSEAFHPTVTGESLYGDFTEAL 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB9 THLQHKLICTRKPEEIRGGGLLKYCSLLVHGFKPACMSEIKNLERYMCSRFFIDFPHIEE ::.:..: ::.::::::::::::: :::.::.: .... :.:::::::::::: . : CCDS29 EHLRHRVIATRSPEEIRGGGLLKYCHLLVRGFRPRPSTDVRALQRYMCSRFFIDFPDLVE 260 270 280 290 300 310 280 290 300 310 320 330 pF1KB9 QQKKIESYLHNHFIG-EGMTKYDYLMTLHGVVNESTVCLMSYERRQILHLITMMALKVLG :.. .: ::. :: : .. .: :.::: ::::::::::..:::: : ::. .::..:. CCDS29 QRRTLERYLEAHFGGADAARRYACLVTLHRVVNESTVCLMNHERRQTLDLIAALALQALA 320 330 340 350 360 370 340 350 360 370 380 pF1KB9 ELNILPNTQKVTCFYQPAPYFAAEARYPIYVIPEPPPVSFQPYHPLHFRGSNGMS : . : . . . :. .. : :: : : CCDS29 EQG--PAATAALAWRPPGTDGVVPATVNYYVTPVQPLLAHAYPTWLPCN 380 390 400 410 420 389 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 19:48:10 2016 done: Fri Nov 4 19:48:10 2016 Total Scan time: 2.750 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]