FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9855, 390 aa 1>>>pF1KB9855 390 - 390 aa - 390 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5976+/-0.000403; mu= 14.6018+/- 0.025 mean_var=60.4468+/-12.461, 0's: 0 Z-trim(110.2): 71 B-trim: 0 in 0/55 Lambda= 0.164963 statistics sampled from 18445 (18518) to 18445 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.584), E-opt: 0.2 (0.217), width: 16 Scan time: 6.950 The best scores are: opt bits E(85289) NP_000516 (OMIM: 125853,600937,601820,606176,61058 ( 390) 2562 618.6 8.1e-177 XP_016873169 (OMIM: 125853,600937,601820,606176,61 ( 303) 1978 479.5 4.4e-135 XP_006718289 (OMIM: 125853,600937,601820,606176,61 ( 303) 1978 479.5 4.4e-135 NP_001159762 (OMIM: 125853,600937,601820,606176,61 ( 303) 1978 479.5 4.4e-135 XP_005253415 (OMIM: 600935) PREDICTED: ATP-sensiti ( 424) 1277 312.8 1e-84 XP_016874772 (OMIM: 600935) PREDICTED: ATP-sensiti ( 424) 1277 312.8 1e-84 XP_016874773 (OMIM: 600935) PREDICTED: ATP-sensiti ( 424) 1277 312.8 1e-84 NP_004973 (OMIM: 600935) ATP-sensitive inward rect ( 424) 1277 312.8 1e-84 NP_004974 (OMIM: 600932) G protein-activated inwar ( 393) 1198 293.9 4.3e-79 XP_016856736 (OMIM: 600932) PREDICTED: G protein-a ( 450) 1198 294.0 4.8e-79 XP_011522133 (OMIM: 602323) PREDICTED: ATP-sensiti ( 433) 1164 285.9 1.3e-76 XP_005256682 (OMIM: 602323) PREDICTED: ATP-sensiti ( 433) 1164 285.9 1.3e-76 NP_066292 (OMIM: 602323) ATP-sensitive inward rect ( 433) 1164 285.9 1.3e-76 NP_002231 (OMIM: 600877,614098) G protein-activate ( 423) 1159 284.7 2.8e-76 NP_001181887 (OMIM: 613236,613239) inward rectifie ( 433) 1154 283.5 6.6e-76 XP_005276976 (OMIM: 613236,613239) PREDICTED: inwa ( 535) 1154 283.5 8.1e-76 NP_000882 (OMIM: 170390,600681,609622,613980) inwa ( 427) 1135 279.0 1.5e-74 NP_002230 (OMIM: 601534) G protein-activated inwar ( 501) 1135 279.0 1.7e-74 XP_011541112 (OMIM: 600734,613485,613677) PREDICTE ( 419) 1124 276.3 9.1e-74 XP_011541111 (OMIM: 600734,613485,613677) PREDICTE ( 419) 1124 276.3 9.1e-74 NP_000881 (OMIM: 600734,613485,613677) G protein-a ( 419) 1124 276.3 9.1e-74 NP_037480 (OMIM: 603953) ATP-sensitive inward rect ( 436) 1056 260.2 7e-69 NP_722450 (OMIM: 241200,600359) ATP-sensitive inwa ( 372) 1015 250.4 5.2e-66 NP_722448 (OMIM: 241200,600359) ATP-sensitive inwa ( 372) 1015 250.4 5.2e-66 NP_722451 (OMIM: 241200,600359) ATP-sensitive inwa ( 372) 1015 250.4 5.2e-66 NP_722449 (OMIM: 241200,600359) ATP-sensitive inwa ( 389) 1015 250.4 5.5e-66 NP_000211 (OMIM: 241200,600359) ATP-sensitive inwa ( 391) 1015 250.4 5.5e-66 NP_001247438 (OMIM: 601534) G protein-activated in ( 308) 925 228.9 1.2e-59 NP_001278553 (OMIM: 605722) inward rectifier potas ( 418) 894 221.6 2.7e-57 NP_001278554 (OMIM: 605722) inward rectifier potas ( 418) 894 221.6 2.7e-57 XP_011523083 (OMIM: 605722) PREDICTED: inward rect ( 418) 894 221.6 2.7e-57 NP_001257351 (OMIM: 605722) inward rectifier potas ( 418) 894 221.6 2.7e-57 XP_016880102 (OMIM: 605722) PREDICTED: inward rect ( 418) 894 221.6 2.7e-57 NP_061128 (OMIM: 605722) inward rectifier potassiu ( 453) 894 221.6 2.9e-57 XP_016880099 (OMIM: 605722) PREDICTED: inward rect ( 453) 894 221.6 2.9e-57 XP_016880100 (OMIM: 605722) PREDICTED: inward rect ( 453) 894 221.6 2.9e-57 XP_006721950 (OMIM: 605722) PREDICTED: inward rect ( 453) 894 221.6 2.9e-57 XP_016880098 (OMIM: 605722) PREDICTED: inward rect ( 453) 894 221.6 2.9e-57 NP_001278552 (OMIM: 605722) inward rectifier potas ( 453) 894 221.6 2.9e-57 XP_016880101 (OMIM: 605722) PREDICTED: inward rect ( 453) 894 221.6 2.9e-57 XP_006721949 (OMIM: 605722) PREDICTED: inward rect ( 453) 894 221.6 2.9e-57 NP_733938 (OMIM: 605722) inward rectifier potassiu ( 453) 894 221.6 2.9e-57 XP_005257394 (OMIM: 605722) PREDICTED: inward rect ( 453) 894 221.6 2.9e-57 XP_006721948 (OMIM: 605722) PREDICTED: inward rect ( 453) 894 221.6 2.9e-57 NP_733937 (OMIM: 605722) inward rectifier potassiu ( 453) 894 221.6 2.9e-57 NP_001278551 (OMIM: 605722) inward rectifier potas ( 453) 894 221.6 2.9e-57 NP_004972 (OMIM: 600504) inward rectifier potassiu ( 445) 885 219.5 1.3e-56 NP_690607 (OMIM: 600504) inward rectifier potassiu ( 445) 885 219.5 1.3e-56 NP_002232 (OMIM: 274600,600791,602208,612780) ATP- ( 379) 884 219.2 1.3e-56 XP_016883833 (OMIM: 602106) PREDICTED: ATP-sensiti ( 375) 838 208.3 2.5e-53 >>NP_000516 (OMIM: 125853,600937,601820,606176,610582,61 (390 aa) initn: 2562 init1: 2562 opt: 2562 Z-score: 3295.5 bits: 618.6 E(85289): 8.1e-177 Smith-Waterman score: 2562; 99.5% identity (100.0% similar) in 390 aa overlap (1-390:1-390) 10 20 30 40 50 60 pF1KB9 MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVF ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: NP_000 MLSRKGIIPEEYVLTRLAEDPAKPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 TTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 FLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAET 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 LIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 ENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 RTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALT ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: NP_000 RTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTVKVPTPLCTARQLDEDHSLLEALT 310 320 330 340 350 360 370 380 390 pF1KB9 LASARGPLRKRSVPMAKAKPKFSISPDSLS :::::::::::::::::::::::::::::: NP_000 LASARGPLRKRSVPMAKAKPKFSISPDSLS 370 380 390 >>XP_016873169 (OMIM: 125853,600937,601820,606176,610582 (303 aa) initn: 1978 init1: 1978 opt: 1978 Z-score: 2546.1 bits: 479.5 E(85289): 4.4e-135 Smith-Waterman score: 1978; 99.7% identity (100.0% similar) in 303 aa overlap (88-390:1-303) 60 70 80 90 100 110 pF1KB9 DVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSF :::::::::::::::::::::::::::::: XP_016 MAWWLIAFAHGDLAPSEGTAEPCVTSIHSF 10 20 30 120 130 140 150 160 170 pF1KB9 SSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRR 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB9 AETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVD 100 110 120 130 140 150 240 250 260 270 280 290 pF1KB9 IPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGIT 160 170 180 190 200 210 300 310 320 330 340 350 pF1KB9 TQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLE :::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::: XP_016 TQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTVKVPTPLCTARQLDEDHSLLE 220 230 240 250 260 270 360 370 380 390 pF1KB9 ALTLASARGPLRKRSVPMAKAKPKFSISPDSLS ::::::::::::::::::::::::::::::::: XP_016 ALTLASARGPLRKRSVPMAKAKPKFSISPDSLS 280 290 300 >>XP_006718289 (OMIM: 125853,600937,601820,606176,610582 (303 aa) initn: 1978 init1: 1978 opt: 1978 Z-score: 2546.1 bits: 479.5 E(85289): 4.4e-135 Smith-Waterman score: 1978; 99.7% identity (100.0% similar) in 303 aa overlap (88-390:1-303) 60 70 80 90 100 110 pF1KB9 DVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSF :::::::::::::::::::::::::::::: XP_006 MAWWLIAFAHGDLAPSEGTAEPCVTSIHSF 10 20 30 120 130 140 150 160 170 pF1KB9 SSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRR 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB9 AETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVD 100 110 120 130 140 150 240 250 260 270 280 290 pF1KB9 IPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGIT 160 170 180 190 200 210 300 310 320 330 340 350 pF1KB9 TQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLE :::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::: XP_006 TQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTVKVPTPLCTARQLDEDHSLLE 220 230 240 250 260 270 360 370 380 390 pF1KB9 ALTLASARGPLRKRSVPMAKAKPKFSISPDSLS ::::::::::::::::::::::::::::::::: XP_006 ALTLASARGPLRKRSVPMAKAKPKFSISPDSLS 280 290 300 >>NP_001159762 (OMIM: 125853,600937,601820,606176,610582 (303 aa) initn: 1978 init1: 1978 opt: 1978 Z-score: 2546.1 bits: 479.5 E(85289): 4.4e-135 Smith-Waterman score: 1978; 99.7% identity (100.0% similar) in 303 aa overlap (88-390:1-303) 60 70 80 90 100 110 pF1KB9 DVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSF :::::::::::::::::::::::::::::: NP_001 MAWWLIAFAHGDLAPSEGTAEPCVTSIHSF 10 20 30 120 130 140 150 160 170 pF1KB9 SSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRR 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB9 AETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVD 100 110 120 130 140 150 240 250 260 270 280 290 pF1KB9 IPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGIT 160 170 180 190 200 210 300 310 320 330 340 350 pF1KB9 TQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLE :::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::: NP_001 TQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTVKVPTPLCTARQLDEDHSLLE 220 230 240 250 260 270 360 370 380 390 pF1KB9 ALTLASARGPLRKRSVPMAKAKPKFSISPDSLS ::::::::::::::::::::::::::::::::: NP_001 ALTLASARGPLRKRSVPMAKAKPKFSISPDSLS 280 290 300 >>XP_005253415 (OMIM: 600935) PREDICTED: ATP-sensitive i (424 aa) initn: 1713 init1: 892 opt: 1277 Z-score: 1642.1 bits: 312.8 E(85289): 1e-84 Smith-Waterman score: 1768; 70.6% identity (87.8% similar) in 385 aa overlap (1-372:1-384) 10 20 30 40 50 pF1KB9 MLSRKGIIPEEYVLTRLA-EDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDV ::.::.::::::::.:.: :. .:: : : .:::..:.: ::.::::::::::::::. XP_005 MLARKSIIPEEYVLARIAAENLRKPRIRDRLPKARFIAKSGACNLAHKNIREQGRFLQDI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 FTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDL-APSEGTAEP--------C ::::::::: :::.::::::::::::::. :::.::::::. : : .. : XP_005 FTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIYAYMEKSGMEKSGLESTVC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 VTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMK ::...::.:::::::::::::::::::.:::::::: .::.::::::.:::.:::::::: XP_005 VTNVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQNIVGLIINAVMLGCIFMK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 TAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEV ::::::::::::::.:::::.:.:.::::.:::::::::::::....:::.:::.::::: XP_005 TAQAHRRAETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQVVKKTTTPEGEV 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 VPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGV ::.::.:::..: . .:.::::::::: :::: :::::.. .:: . ::::.::::::: XP_005 VPIHQLDIPVDNPIESNNIFLVAPLIICHVIDKRSPLYDISATDLAN-QDLEVIVILEGV 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 VETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLD ::::::::::::::.:.:: ::.::: ::.::.: :::::::::::.:: .: :.::.:: XP_005 VETTGITTQARTSYIAEEIQWGHRFVSIVTEEEGVYSVDYSKFGNTVKVAAPRCSARELD 300 310 320 330 340 350 360 370 380 390 pF1KB9 EDHSLL-EALTLA--SARGPLRKRSVPMAKAKPKFSISPDSLS : :.: ..: . : .. ::::. XP_005 EKPSILIQTLQKSELSHQNSLRKRNSMRRNNSMRRNNSIRRNNSSLMVPKVQFMTPEGNQ 360 370 380 390 400 410 >>XP_016874772 (OMIM: 600935) PREDICTED: ATP-sensitive i (424 aa) initn: 1713 init1: 892 opt: 1277 Z-score: 1642.1 bits: 312.8 E(85289): 1e-84 Smith-Waterman score: 1768; 70.6% identity (87.8% similar) in 385 aa overlap (1-372:1-384) 10 20 30 40 50 pF1KB9 MLSRKGIIPEEYVLTRLA-EDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDV ::.::.::::::::.:.: :. .:: : : .:::..:.: ::.::::::::::::::. XP_016 MLARKSIIPEEYVLARIAAENLRKPRIRDRLPKARFIAKSGACNLAHKNIREQGRFLQDI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 FTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDL-APSEGTAEP--------C ::::::::: :::.::::::::::::::. :::.::::::. : : .. : XP_016 FTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIYAYMEKSGMEKSGLESTVC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 VTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMK ::...::.:::::::::::::::::::.:::::::: .::.::::::.:::.:::::::: XP_016 VTNVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQNIVGLIINAVMLGCIFMK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 TAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEV ::::::::::::::.:::::.:.:.::::.:::::::::::::....:::.:::.::::: XP_016 TAQAHRRAETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQVVKKTTTPEGEV 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 VPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGV ::.::.:::..: . .:.::::::::: :::: :::::.. .:: . ::::.::::::: XP_016 VPIHQLDIPVDNPIESNNIFLVAPLIICHVIDKRSPLYDISATDLAN-QDLEVIVILEGV 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 VETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLD ::::::::::::::.:.:: ::.::: ::.::.: :::::::::::.:: .: :.::.:: XP_016 VETTGITTQARTSYIAEEIQWGHRFVSIVTEEEGVYSVDYSKFGNTVKVAAPRCSARELD 300 310 320 330 340 350 360 370 380 390 pF1KB9 EDHSLL-EALTLA--SARGPLRKRSVPMAKAKPKFSISPDSLS : :.: ..: . : .. ::::. XP_016 EKPSILIQTLQKSELSHQNSLRKRNSMRRNNSMRRNNSIRRNNSSLMVPKVQFMTPEGNQ 360 370 380 390 400 410 >>XP_016874773 (OMIM: 600935) PREDICTED: ATP-sensitive i (424 aa) initn: 1713 init1: 892 opt: 1277 Z-score: 1642.1 bits: 312.8 E(85289): 1e-84 Smith-Waterman score: 1768; 70.6% identity (87.8% similar) in 385 aa overlap (1-372:1-384) 10 20 30 40 50 pF1KB9 MLSRKGIIPEEYVLTRLA-EDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDV ::.::.::::::::.:.: :. .:: : : .:::..:.: ::.::::::::::::::. XP_016 MLARKSIIPEEYVLARIAAENLRKPRIRDRLPKARFIAKSGACNLAHKNIREQGRFLQDI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 FTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDL-APSEGTAEP--------C ::::::::: :::.::::::::::::::. :::.::::::. : : .. : XP_016 FTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIYAYMEKSGMEKSGLESTVC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 VTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMK ::...::.:::::::::::::::::::.:::::::: .::.::::::.:::.:::::::: XP_016 VTNVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQNIVGLIINAVMLGCIFMK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 TAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEV ::::::::::::::.:::::.:.:.::::.:::::::::::::....:::.:::.::::: XP_016 TAQAHRRAETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQVVKKTTTPEGEV 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 VPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGV ::.::.:::..: . .:.::::::::: :::: :::::.. .:: . ::::.::::::: XP_016 VPIHQLDIPVDNPIESNNIFLVAPLIICHVIDKRSPLYDISATDLAN-QDLEVIVILEGV 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 VETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLD ::::::::::::::.:.:: ::.::: ::.::.: :::::::::::.:: .: :.::.:: XP_016 VETTGITTQARTSYIAEEIQWGHRFVSIVTEEEGVYSVDYSKFGNTVKVAAPRCSARELD 300 310 320 330 340 350 360 370 380 390 pF1KB9 EDHSLL-EALTLA--SARGPLRKRSVPMAKAKPKFSISPDSLS : :.: ..: . : .. ::::. XP_016 EKPSILIQTLQKSELSHQNSLRKRNSMRRNNSMRRNNSIRRNNSSLMVPKVQFMTPEGNQ 360 370 380 390 400 410 >>NP_004973 (OMIM: 600935) ATP-sensitive inward rectifie (424 aa) initn: 1713 init1: 892 opt: 1277 Z-score: 1642.1 bits: 312.8 E(85289): 1e-84 Smith-Waterman score: 1768; 70.6% identity (87.8% similar) in 385 aa overlap (1-372:1-384) 10 20 30 40 50 pF1KB9 MLSRKGIIPEEYVLTRLA-EDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDV ::.::.::::::::.:.: :. .:: : : .:::..:.: ::.::::::::::::::. NP_004 MLARKSIIPEEYVLARIAAENLRKPRIRDRLPKARFIAKSGACNLAHKNIREQGRFLQDI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 FTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDL-APSEGTAEP--------C ::::::::: :::.::::::::::::::. :::.::::::. : : .. : NP_004 FTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIYAYMEKSGMEKSGLESTVC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 VTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMK ::...::.:::::::::::::::::::.:::::::: .::.::::::.:::.:::::::: NP_004 VTNVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQNIVGLIINAVMLGCIFMK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 TAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEV ::::::::::::::.:::::.:.:.::::.:::::::::::::....:::.:::.::::: NP_004 TAQAHRRAETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQVVKKTTTPEGEV 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 VPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGV ::.::.:::..: . .:.::::::::: :::: :::::.. .:: . ::::.::::::: NP_004 VPIHQLDIPVDNPIESNNIFLVAPLIICHVIDKRSPLYDISATDLAN-QDLEVIVILEGV 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 VETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLD ::::::::::::::.:.:: ::.::: ::.::.: :::::::::::.:: .: :.::.:: NP_004 VETTGITTQARTSYIAEEIQWGHRFVSIVTEEEGVYSVDYSKFGNTVKVAAPRCSARELD 300 310 320 330 340 350 360 370 380 390 pF1KB9 EDHSLL-EALTLA--SARGPLRKRSVPMAKAKPKFSISPDSLS : :.: ..: . : .. ::::. NP_004 EKPSILIQTLQKSELSHQNSLRKRNSMRRNNSMRRNNSIRRNNSSLMVPKVQFMTPEGNQ 360 370 380 390 400 410 >>NP_004974 (OMIM: 600932) G protein-activated inward re (393 aa) initn: 1015 init1: 605 opt: 1198 Z-score: 1541.0 bits: 293.9 E(85289): 4.3e-79 Smith-Waterman score: 1198; 50.7% identity (80.4% similar) in 341 aa overlap (19-358:13-347) 10 20 30 40 50 60 pF1KB9 MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVF :.: :: :.:: :.: : : ::: . :.:: :.: :.: NP_004 MAQENAAFSPGQEEP--PRRRGRQ---RYVEKDGRCNVQQGNVRETYRYLTDLF 10 20 30 40 70 80 90 100 110 pF1KB9 TTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTA-EPCVTSIHSFSS ::::::.: .::.:.... .::.:. :::::...::: : :: :::.....: . NP_004 TTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGFVA 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB9 AFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAE :::::::...:::.: :..:..:: .:..:..: :.: :.::.:.::.:.: .: ..:: NP_004 AFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKRAA 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB9 TLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIP ::.::.:::..:: ::::.:.::::::.: :. :.:. ...:. . ::: .::::.:. NP_004 TLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTDLS 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB9 MENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQ . .: . .:::.::.: : ::: ::... . :.. .:.::.:::::.::.::.: : NP_004 VGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALER-DDFEIVVILEGMVEATGMTCQ 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB9 ARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEAL ::.:::.::.:::.::. ... ::: : :::..: .:..:::: :.::.: : . :.: NP_004 ARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDAH 290 300 310 320 330 340 360 370 380 390 pF1KB9 TLASARGPLRKRSVPMAKAKPKFSISPDSLS NP_004 LYWSIPSRLDEKVEEEGAGEGAGGEAGADKEQNGCLPPPESESKV 350 360 370 380 390 >>XP_016856736 (OMIM: 600932) PREDICTED: G protein-activ (450 aa) initn: 1015 init1: 605 opt: 1198 Z-score: 1540.0 bits: 294.0 E(85289): 4.8e-79 Smith-Waterman score: 1198; 50.7% identity (80.4% similar) in 341 aa overlap (19-358:70-404) 10 20 30 40 pF1KB9 MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKN :.: :: :.:: :.: : : ::: . : XP_016 SGPRRTPGARSARPDAAAMAQENAAFSPGQEEP--PRRRGRQ---RYVEKDGRCNVQQGN 40 50 60 70 80 90 50 60 70 80 90 100 pF1KB9 IREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTA- .:: :.: :.:::::::.: .::.:.... .::.:. :::::...::: : :: XP_016 VRETYRYLTDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAW 100 110 120 130 140 150 110 120 130 140 150 160 pF1KB9 EPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCI :::.....: .:::::::...:::.: :..:..:: .:..:..: :.: :.::.:.::. XP_016 TPCVNNLNGFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCM 160 170 180 190 200 210 170 180 190 200 210 220 pF1KB9 FMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPE :.: .: ..:: ::.::.:::..:: ::::.:.::::::.: :. :.:. ...:. . : XP_016 FVKISQPNKRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLE 220 230 240 250 260 270 230 240 250 260 270 280 pF1KB9 GEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVIL :: .::::.:. . .: . .:::.::.: : ::: ::... . :.. .:.::.::: XP_016 GEFIPLHQTDLSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALER-DDFEIVVIL 280 290 300 310 320 330 290 300 310 320 330 340 pF1KB9 EGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTAR ::.::.::.: :::.:::.::.:::.::. ... ::: : :::..: .:..:::: :.:: XP_016 EGMVEATGMTCQARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSAR 340 350 360 370 380 390 350 360 370 380 390 pF1KB9 QLDEDHSLLEALTLASARGPLRKRSVPMAKAKPKFSISPDSLS .: : . :.: XP_016 ELAEAAARLDAHLYWSIPSRLDEKVEEEGAGEGAGGEAGADKEQNGCLPPPESESKV 400 410 420 430 440 450 390 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 09:18:47 2016 done: Sat Nov 5 09:18:49 2016 Total Scan time: 6.950 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]