Result of FASTA (omim) for
pF1KB9864
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9864, 422 aa
1>>>pF1KB9864 422 - 422 aa - 422 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1174+/-0.000351; mu= 19.0459+/- 0.022
mean_var=89.8302+/-20.647, 0's: 0 Z-trim(115.8): 601 B-trim: 2601 in 2/51
Lambda= 0.135320
statistics sampled from 25656 (26430) to 25656 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.664), E-opt: 0.2 (0.31), width: 16
Scan time: 6.360
The best scores are: opt bits E(85289)
NP_000515 (OMIM: 109760,614674) 5-hydroxytryptamin ( 422) 2821 560.9 2.1e-159
NP_057658 (OMIM: 126450,159900) D(2) dopamine rece ( 414) 753 157.2 7.1e-38
NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 721 150.9 5.2e-36
NP_000788 (OMIM: 126452,143465,601696) D(4) dopami ( 419) 709 148.6 2.8e-35
NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 659 138.8 2.2e-32
XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365) 648 136.6 9.6e-32
NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365) 648 136.6 9.6e-32
NP_001309138 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 646 136.3 1.3e-31
XP_005264808 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 646 136.3 1.3e-31
XP_011531966 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 646 136.3 1.3e-31
NP_001309137 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 646 136.3 1.3e-31
NP_001309139 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 646 136.3 1.3e-31
NP_000857 (OMIM: 182134) 5-hydroxytryptamine recep ( 366) 646 136.3 1.3e-31
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 582 124.0 9.9e-28
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 568 121.0 4.3e-27
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 568 121.0 4.4e-27
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 568 121.0 4.5e-27
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 568 121.0 4.6e-27
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 568 121.0 4.9e-27
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 568 121.0 4.9e-27
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 568 121.1 5.4e-27
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 568 121.1 5.4e-27
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 568 121.1 5.6e-27
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 568 121.1 5.7e-27
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 568 121.1 5.8e-27
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 568 121.1 5.8e-27
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 568 121.1 5.8e-27
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 568 121.1 5.8e-27
NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 567 120.9 6.5e-27
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 558 119.0 1.7e-26
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 558 119.0 1.7e-26
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 558 119.1 1.9e-26
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 558 119.1 2e-26
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 558 119.1 2e-26
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 558 119.2 2.4e-26
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 558 119.3 2.5e-26
NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 550 117.6 6.5e-26
NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 541 115.8 2.1e-25
NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 541 115.8 2.1e-25
NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 541 115.9 2.3e-25
NP_000673 (OMIM: 104260,607876) alpha-2B adrenergi ( 450) 528 113.3 1.3e-24
NP_076917 (OMIM: 601305) 5-hydroxytryptamine recep ( 357) 520 111.7 3.2e-24
XP_016872785 (OMIM: 126450,159900) PREDICTED: D(2) ( 443) 491 106.1 1.9e-22
NP_000786 (OMIM: 126450,159900) D(2) dopamine rece ( 443) 491 106.1 1.9e-22
NP_387512 (OMIM: 126451,181500,190300) D(3) dopami ( 367) 487 105.2 2.8e-22
NP_001277738 (OMIM: 126451,181500,190300) D(3) dop ( 400) 487 105.3 3e-22
NP_000787 (OMIM: 126451,181500,190300) D(3) dopami ( 400) 487 105.3 3e-22
NP_001269492 (OMIM: 126451,181500,190300) D(3) dop ( 400) 487 105.3 3e-22
XP_016861318 (OMIM: 126451,181500,190300) PREDICTE ( 400) 487 105.3 3e-22
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 486 105.1 3.8e-22
>>NP_000515 (OMIM: 109760,614674) 5-hydroxytryptamine re (422 aa)
initn: 2821 init1: 2821 opt: 2821 Z-score: 2982.8 bits: 560.9 E(85289): 2.1e-159
Smith-Waterman score: 2821; 100.0% identity (100.0% similar) in 422 aa overlap (1-422:1-422)
10 20 30 40 50 60
pF1KB9 MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
370 380 390 400 410 420
pF1KB9 RQ
::
NP_000 RQ
>>NP_057658 (OMIM: 126450,159900) D(2) dopamine receptor (414 aa)
initn: 685 init1: 345 opt: 753 Z-score: 801.0 bits: 157.2 E(85289): 7.1e-38
Smith-Waterman score: 753; 33.2% identity (66.6% similar) in 386 aa overlap (42-417:40-414)
20 30 40 50 60 70
pF1KB9 TTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVA
:: :: :.::. : :.. :..::...
NP_057 DDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTT
10 20 30 40 50 60
80 90 100 110 120 130
pF1KB9 NYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIA
:::: ::::.::.:..::.: .. .:...: .... ::.:..:::. ::.:::.::::.
NP_057 NYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAIS
70 80 90 100 110 120
140 150 160 170 180
pF1KB9 LDRYWAITDPIDYVNKR--TPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTI
.::: :.. :. : : : . ::....::..:...: :: : ..: . .: . : :
NP_057 IDRYTAVAMPMLY-NTRYSSKRRVTVMISIVWVLSFTISCPLLFGL----NNADQNECII
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 SKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQ
. . ....::.. .::.:... :..: .:. . : : :: :. ... : : .: .
NP_057 A-NPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRR-RKRVNTKRSSRAFRAHLRAPLKE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 PKKS--------VNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNS
. ... : . : . . : ..: .. . .. :..
NP_057 AARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 KEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPF
:.: : .. : . : . .. ..::.. .:.:... :.:..:.::.:::::
NP_057 KDH-PKIAKIFEIQTMPNGKTRTSLKTM-SRRKLSQQKEKKATQMLAIVLGVFIICWLPF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 FIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCR
::. .. :. :..: .: . ..:::: :: .::.::. :: .:..:: ::..:
NP_057 FITHILNIHCD--CNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
370 380 390 400 410
pF1KB9 Q
>>NP_000854 (OMIM: 182131) 5-hydroxytryptamine receptor (390 aa)
initn: 988 init1: 662 opt: 721 Z-score: 767.5 bits: 150.9 E(85289): 5.2e-36
Smith-Waterman score: 999; 40.0% identity (69.6% similar) in 415 aa overlap (11-420:24-388)
10 20 30 40
pF1KB9 MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLI
: .: :. .. . ..... ..:. .::. .
NP_000 MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALIT
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB9 FCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQV
. ..:.:: :.:.. :.:.. :::::.:::::::.::.::.:....: : ..::::::
NP_000 LATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQV
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB9 TCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLI
.::.... :. :::.::::::.::::::::::: ..: ::::.:::..:.:.:.... :
NP_000 VCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISI
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB9 SIPPMLGWRTPEDRSDPDACTISKDHG-YTIYSTFGAFYIPLLLMLVLYGRIFRAARFRI
:.::.. :: . . . . :... :: ::.::: ::::.: ::...:::::. :: ::
NP_000 SLPPFF-WRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRI
190 200 210 220 230
230 240 250 260 270 280
pF1KB9 RKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDD
: . :... :.: : . . . :. . ..
NP_000 LKQT-------------------PNRT-----GKRLTRAQLITDSPGSTSSVTSI-----
240 250 260 270
290 300 310 320 330 340
pF1KB9 GAALEVIEVHRVGNSKEHLP-LPSEAGPTPCAPASFERKNERNAEA---KRKMALARERK
::. .: .:::.: .:. .. . : ..: :.:. :::::
NP_000 -------------NSR--VPDVPSESG----SPVYVNQVKVRVSDALLEKKKLMAARERK
280 290 300 310
350 360 370 380 390 400
pF1KB9 TVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAY
..::::::.:.::.:::::::..::.:.:...: . . ...:::: :::.::.::..
NP_000 ATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTM
320 330 340 350 360 370
410 420
pF1KB9 FNKDFQNAFKKIIKCKFCRQ
:.::..::.:.:. : :
NP_000 SNEDFKQAFHKLIRFK-CTS
380 390
>>NP_000788 (OMIM: 126452,143465,601696) D(4) dopamine r (419 aa)
initn: 651 init1: 195 opt: 709 Z-score: 754.5 bits: 148.6 E(85289): 2.8e-35
Smith-Waterman score: 709; 32.5% identity (62.0% similar) in 418 aa overlap (16-417:18-418)
10 20 30 40 50
pF1KB9 MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVL-GNACV
:: ..: ..:.. : ..:. :.:.. ::: ::. :
NP_000 MGNRSTADADGLLAGRGPAAGASAGASAGLAG-----QGAAALVGGVLLIGAVLAGNSLV
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 VAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLN-KWTLGQVTCDLFIALD
...: ::.::. .: .: :::..::....::::. . .: . : :. :: ..:.:
NP_000 CVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMD
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 VLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWR
:. ::.::..::::..::. :.. :. : . :: ::. :::.. .. : . :
NP_000 VMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLN
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 TPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRA-ARFRIRKTVK---K
. : :: .: . .:. :..::. .:..: :::.:: ::. :... . .: .
NP_000 DVRGR-DPAVCRL-EDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGR
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB9 VEK--TGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAAL
. . .: . :::. .. : . . :. : :: .: .: .
NP_000 APRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAP-GLPRGPCGPDCAPAAPSLPQDPCGP
240 250 260 270 280 290
300 310 320 330 340
pF1KB9 EVIEVHRVGNSKEHLPLPSEAGPTPCAP------ASFERKNERNAEAKRKMALA-RERKT
. . :: :. : . ::: :.. .. ... .:. .. ::::.
NP_000 D------CAPPAPGLP-PDPCG-SNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKA
300 310 320 330 340
350 360 370 380 390 400
pF1KB9 VKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYF
...: ...:.:.::: :::.: .. .: . : .: : . ..:::: :: ::::::. :
NP_000 MRVLPVVVGAFLLCWTPFFVVHITQALCPA-CSVPPRLVSAVTWLGYVNSALNPVIYTVF
350 360 370 380 390 400
410 420
pF1KB9 NKDFQNAFKKIIK-CKFCRQ
: .:.:.:.: .. :
NP_000 NAEFRNVFRKALRACC
410
>>NP_000855 (OMIM: 182133) 5-hydroxytryptamine receptor (377 aa)
initn: 968 init1: 637 opt: 659 Z-score: 702.3 bits: 138.8 E(85289): 2.2e-32
Smith-Waterman score: 950; 40.8% identity (70.7% similar) in 382 aa overlap (36-415:38-371)
10 20 30 40 50 60
pF1KB9 PGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALER
.. ...:... . .::.:: :...: : :
NP_000 AEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 SLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSIL
.:.. :::::::::.:::.::.::.:.. : . . :..::. ::.... :. :::.:::
NP_000 KLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 HLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPD
:::.::::::::::: ..: ..:: .::..:...: :.. :::::.. :: . . . .
NP_000 HLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLF-WRQAKAQEEMS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 ACTISKDH-GYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGA
: .. .. .:::::: :::::: .:...:::::.:::: :: .
NP_000 DCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNP---------------
190 200 210 220 230
250 260 270 280 290 300
pF1KB9 SPAPQPKKSVNGESGSRNWRLGVESKAGGALCA-NGAVRQGDDGAALEVIEVHRVGNSKE
:. :. .... . ..::..::. :.....: . : .:.
NP_000 -PSLYGKRFTTAHL--------ITGSAGSSLCSLNSSLHEGHS---------HSAGS---
240 250 260 270
310 320 330 340 350 360
pF1KB9 HLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFI
:: . : ...::: ... :::::..: ::::.:.::.::::::.
NP_000 --PLFFNHVKIKLADSALERK---------RISAARERKATKILGIILGAFIICWLPFFV
280 290 300 310
370 380 390 400 410 420
pF1KB9 VALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
:.::::.:..:: . : ...:::: :::.::.::. ::..:..::.::.
NP_000 VSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
320 330 340 350 360 370
>>XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytrypta (365 aa)
initn: 878 init1: 487 opt: 648 Z-score: 690.9 bits: 136.6 E(85289): 9.6e-32
Smith-Waterman score: 845; 37.6% identity (67.2% similar) in 396 aa overlap (25-418:11-362)
10 20 30 40 50 60
pF1KB9 MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
. .: :.. ... . : .. ..: : :. :
XP_011 MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMA
10 20 30 40
70 80 90 100 110 120
pF1KB9 IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
:. ..:.. ::::: :::::::.:.:::.:.. .: :...: :: :......:. ::
XP_011 IGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCC
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB9 TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
: ::::::.::::::::::. :.:. ::: .::: .: .: :...::.::.. ::. .
XP_011 TCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLF-WRSHRR
110 120 130 140 150 160
190 200 210 220 230
pF1KB9 RSDPDA-CTISKDHG-YTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGA
: : . :::..:: ::::::.::::::: :.:.:: ::..::. . .: :.
XP_011 LSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAK-------SLYQKRGS
170 180 190 200 210
240 250 260 270 280 290
pF1KB9 DTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRV
.:: .. . . ..: . : ..:.. : ... . : ..
XP_011 -SRHLSNRSTDSQNSFAS------------CKLTQTFCVS------DFSTSDPTTEFEKF
220 230 240 250
300 310 320 330 340 350
pF1KB9 GNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCW
: . :. .. ... .:: .... .::::... ::.:.:.::: :
XP_011 HASIRIPPFDND----------LDHPGER-----QQISSTRERKAARILGLILGAFILSW
260 270 280 290 300
360 370 380 390 400 410
pF1KB9 LPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCK
::::: :.. . : . . .. ...:::: :::.::..:. ::.::. ::::.:.:.
XP_011 LPFFIKELIVGL--SIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCR
310 320 330 340 350 360
420
pF1KB9 FCRQ
XP_011 EHT
>>NP_000856 (OMIM: 182132) 5-hydroxytryptamine receptor (365 aa)
initn: 878 init1: 487 opt: 648 Z-score: 690.9 bits: 136.6 E(85289): 9.6e-32
Smith-Waterman score: 845; 37.6% identity (67.2% similar) in 396 aa overlap (25-418:11-362)
10 20 30 40 50 60
pF1KB9 MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
. .: :.. ... . : .. ..: : :. :
NP_000 MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMA
10 20 30 40
70 80 90 100 110 120
pF1KB9 IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
:. ..:.. ::::: :::::::.:.:::.:.. .: :...: :: :......:. ::
NP_000 IGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCC
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB9 TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
: ::::::.::::::::::. :.:. ::: .::: .: .: :...::.::.. ::. .
NP_000 TCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLF-WRSHRR
110 120 130 140 150 160
190 200 210 220 230
pF1KB9 RSDPDA-CTISKDHG-YTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGA
: : . :::..:: ::::::.::::::: :.:.:: ::..::. . .: :.
NP_000 LSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAK-------SLYQKRGS
170 180 190 200 210
240 250 260 270 280 290
pF1KB9 DTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRV
.:: .. . . ..: . : ..:.. : ... . : ..
NP_000 -SRHLSNRSTDSQNSFAS------------CKLTQTFCVS------DFSTSDPTTEFEKF
220 230 240 250
300 310 320 330 340 350
pF1KB9 GNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCW
: . :. .. ... .:: .... .::::... ::.:.:.::: :
NP_000 HASIRIPPFDND----------LDHPGER-----QQISSTRERKAARILGLILGAFILSW
260 270 280 290 300
360 370 380 390 400 410
pF1KB9 LPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCK
::::: :.. . : . . .. ...:::: :::.::..:. ::.::. ::::.:.:.
NP_000 LPFFIKELIVGL--SIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCR
310 320 330 340 350 360
420
pF1KB9 FCRQ
NP_000 EHT
>>NP_001309138 (OMIM: 182134) 5-hydroxytryptamine recept (366 aa)
initn: 904 init1: 484 opt: 646 Z-score: 688.8 bits: 136.3 E(85289): 1.3e-31
Smith-Waterman score: 901; 40.2% identity (69.7% similar) in 386 aa overlap (36-420:23-366)
10 20 30 40 50 60
pF1KB9 PGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALER
....:: :. : . .. :. :.::: . :
NP_001 MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTR
10 20 30 40 50
70 80 90 100 110 120
pF1KB9 SLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSIL
.:.. ::::: ::::::..:.:::.:.. .: : ..: .:::.::.....:. ::: :::
NP_001 KLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSIL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB9 HLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPD
:: ::::::: :::: ..:. ::::..:. .:...:.:. .::.::.. :: . : :
NP_001 HLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLF-WRH-QGTSRDD
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB9 ACTISKDHGY-TIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGA
: :..:: ::::::::::::: :.:.:: .:.:::. .: :...
NP_001 ECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHK------------RQAS
180 190 200 210
250 260 270 280 290 300
pF1KB9 SPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEH
: :. :::. : :. .. .. ..... . . . ..: . :
NP_001 RIA---KEEVNGQV-----LLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRS---
220 230 240 250 260
310 320 330 340 350 360
pF1KB9 LPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIV
: :: : :.:.. . ..:.. .::::.. :::.:.:.:..::::::.
NP_001 --LRSE----------F--KHEKSWR-RQKISGTRERKAATTLGLILGAFVICWLPFFVK
270 280 290 300 310
370 380 390 400 410 420
pF1KB9 ALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
::. :.. :.. .. .. :::: :::.::.::. ::.::..::.:...:. :
NP_001 ELVVNVCDK-CKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR-C
320 330 340 350 360
>>XP_005264808 (OMIM: 182134) PREDICTED: 5-hydroxytrypta (366 aa)
initn: 904 init1: 484 opt: 646 Z-score: 688.8 bits: 136.3 E(85289): 1.3e-31
Smith-Waterman score: 901; 40.2% identity (69.7% similar) in 386 aa overlap (36-420:23-366)
10 20 30 40 50 60
pF1KB9 PGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALER
....:: :. : . .. :. :.::: . :
XP_005 MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTR
10 20 30 40 50
70 80 90 100 110 120
pF1KB9 SLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSIL
.:.. ::::: ::::::..:.:::.:.. .: : ..: .:::.::.....:. ::: :::
XP_005 KLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSIL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB9 HLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPD
:: ::::::: :::: ..:. ::::..:. .:...:.:. .::.::.. :: . : :
XP_005 HLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLF-WRH-QGTSRDD
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB9 ACTISKDHGY-TIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGA
: :..:: ::::::::::::: :.:.:: .:.:::. .: :...
XP_005 ECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHK------------RQAS
180 190 200 210
250 260 270 280 290 300
pF1KB9 SPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEH
: :. :::. : :. .. .. ..... . . . ..: . :
XP_005 RIA---KEEVNGQV-----LLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRS---
220 230 240 250 260
310 320 330 340 350 360
pF1KB9 LPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIV
: :: : :.:.. . ..:.. .::::.. :::.:.:.:..::::::.
XP_005 --LRSE----------F--KHEKSWR-RQKISGTRERKAATTLGLILGAFVICWLPFFVK
270 280 290 300 310
370 380 390 400 410 420
pF1KB9 ALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
::. :.. :.. .. .. :::: :::.::.::. ::.::..::.:...:. :
XP_005 ELVVNVCDK-CKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR-C
320 330 340 350 360
>>XP_011531966 (OMIM: 182134) PREDICTED: 5-hydroxytrypta (366 aa)
initn: 904 init1: 484 opt: 646 Z-score: 688.8 bits: 136.3 E(85289): 1.3e-31
Smith-Waterman score: 901; 40.2% identity (69.7% similar) in 386 aa overlap (36-420:23-366)
10 20 30 40 50 60
pF1KB9 PGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALER
....:: :. : . .. :. :.::: . :
XP_011 MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTR
10 20 30 40 50
70 80 90 100 110 120
pF1KB9 SLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSIL
.:.. ::::: ::::::..:.:::.:.. .: : ..: .:::.::.....:. ::: :::
XP_011 KLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSIL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB9 HLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPD
:: ::::::: :::: ..:. ::::..:. .:...:.:. .::.::.. :: . : :
XP_011 HLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLF-WRH-QGTSRDD
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB9 ACTISKDHGY-TIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGA
: :..:: ::::::::::::: :.:.:: .:.:::. .: :...
XP_011 ECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHK------------RQAS
180 190 200 210
250 260 270 280 290 300
pF1KB9 SPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEH
: :. :::. : :. .. .. ..... . . . ..: . :
XP_011 RIA---KEEVNGQV-----LLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRS---
220 230 240 250 260
310 320 330 340 350 360
pF1KB9 LPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIV
: :: : :.:.. . ..:.. .::::.. :::.:.:.:..::::::.
XP_011 --LRSE----------F--KHEKSWR-RQKISGTRERKAATTLGLILGAFVICWLPFFVK
270 280 290 300 310
370 380 390 400 410 420
pF1KB9 ALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
::. :.. :.. .. .. :::: :::.::.::. ::.::..::.:...:. :
XP_011 ELVVNVCDK-CKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR-C
320 330 340 350 360
422 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 19:51:39 2016 done: Fri Nov 4 19:51:40 2016
Total Scan time: 6.360 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]