FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9866, 435 aa 1>>>pF1KB9866 435 - 435 aa - 435 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.8005+/-0.00031; mu= 3.7946+/- 0.020 mean_var=238.2198+/-49.014, 0's: 0 Z-trim(124.1): 51 B-trim: 0 in 0/55 Lambda= 0.083097 statistics sampled from 44984 (45043) to 44984 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.81), E-opt: 0.2 (0.528), width: 16 Scan time: 11.160 The best scores are: opt bits E(85289) NP_068773 (OMIM: 121015,601885) gap junction alpha ( 435) 2966 368.0 2.7e-101 XP_011533350 (OMIM: 121015,601885) PREDICTED: gap ( 435) 2966 368.0 2.7e-101 NP_005258 (OMIM: 116200,600897,612474) gap junctio ( 433) 1176 153.4 1.1e-36 XP_011507718 (OMIM: 116200,600897,612474) PREDICTE ( 433) 1176 153.4 1.1e-36 XP_011507719 (OMIM: 116200,600897,612474) PREDICTE ( 427) 1158 151.2 4.7e-36 XP_005273008 (OMIM: 108770,121013,612474,614049) P ( 358) 1023 135.0 3.1e-31 XP_016856533 (OMIM: 108770,121013,612474,614049) P ( 358) 1023 135.0 3.1e-31 NP_859054 (OMIM: 108770,121013,612474,614049) gap ( 358) 1023 135.0 3.1e-31 NP_005257 (OMIM: 108770,121013,612474,614049) gap ( 358) 1023 135.0 3.1e-31 XP_005270807 (OMIM: 121012) PREDICTED: gap junctio ( 333) 989 130.9 4.9e-30 NP_002051 (OMIM: 121012) gap junction alpha-4 prot ( 333) 989 130.9 4.9e-30 XP_016856532 (OMIM: 121012) PREDICTED: gap junctio ( 333) 989 130.9 4.9e-30 NP_115991 (OMIM: 611924) gap junction alpha-10 pro ( 543) 955 127.0 1.2e-28 NP_110399 (OMIM: 611923) gap junction alpha-9 prot ( 515) 949 126.3 1.9e-28 NP_000156 (OMIM: 104100,121014,133200,164200,18610 ( 382) 942 125.3 2.7e-28 NP_699199 (OMIM: 611922) gap junction delta-4 prot ( 370) 534 76.4 1.4e-13 NP_003995 (OMIM: 121011,124500,148210,148350,14920 ( 226) 477 69.3 1.1e-11 XP_011533351 (OMIM: 121011,124500,148210,148350,14 ( 226) 477 69.3 1.1e-11 NP_065168 (OMIM: 608803,608804,613206,613480) gap ( 439) 471 68.9 3e-11 XP_016875849 (OMIM: 129500,220290,304400,604418,61 ( 261) 466 68.1 3.1e-11 NP_001103690 (OMIM: 129500,220290,304400,604418,61 ( 261) 466 68.1 3.1e-11 NP_006774 (OMIM: 129500,220290,304400,604418,61264 ( 261) 466 68.1 3.1e-11 NP_001103689 (OMIM: 129500,220290,304400,604418,61 ( 261) 466 68.1 3.1e-11 XP_016875847 (OMIM: 129500,220290,304400,604418,61 ( 261) 466 68.1 3.1e-11 XP_016875848 (OMIM: 129500,220290,304400,604418,61 ( 261) 466 68.1 3.1e-11 XP_016875846 (OMIM: 129500,220290,304400,604418,61 ( 261) 466 68.1 3.1e-11 NP_001103691 (OMIM: 129500,220290,304400,604418,61 ( 261) 466 68.1 3.1e-11 XP_005256978 (OMIM: 608655) PREDICTED: gap junctio ( 396) 462 67.8 5.8e-11 XP_005256977 (OMIM: 608655) PREDICTED: gap junctio ( 396) 462 67.8 5.8e-11 NP_005488 (OMIM: 608655) gap junction gamma-1 prot ( 396) 462 67.8 5.8e-11 NP_001073852 (OMIM: 608655) gap junction gamma-1 p ( 396) 462 67.8 5.8e-11 NP_000157 (OMIM: 302800,304040) gap junction beta- ( 283) 447 65.8 1.6e-10 XP_011529209 (OMIM: 302800,304040) PREDICTED: gap ( 283) 447 65.8 1.6e-10 XP_016884897 (OMIM: 302800,304040) PREDICTED: gap ( 283) 447 65.8 1.6e-10 NP_001091111 (OMIM: 302800,304040) gap junction be ( 283) 447 65.8 1.6e-10 NP_694944 (OMIM: 133200,605425) gap junction beta- ( 266) 446 65.7 1.7e-10 XP_011538981 (OMIM: 133200,605425) PREDICTED: gap ( 266) 446 65.7 1.7e-10 NP_001005752 (OMIM: 133200,220290,603324,612644) g ( 270) 443 65.3 2.1e-10 NP_076872 (OMIM: 133200,220290,603324,612644) gap ( 270) 443 65.3 2.1e-10 NP_689343 (OMIM: 607425) gap junction delta-3 prot ( 294) 426 63.3 9.4e-10 NP_065711 (OMIM: 607058) gap junction delta-2 prot ( 321) 422 62.9 1.4e-09 NP_005259 (OMIM: 604493) gap junction beta-5 prote ( 273) 406 60.9 4.7e-09 XP_005270808 (OMIM: 604493) PREDICTED: gap junctio ( 273) 406 60.9 4.7e-09 XP_005248773 (OMIM: 611921) PREDICTED: gap junctio ( 223) 399 60.0 7.2e-09 NP_940970 (OMIM: 611921) gap junction beta-7 prote ( 223) 399 60.0 7.2e-09 XP_016877927 (OMIM: 607058) PREDICTED: gap junctio ( 270) 385 58.4 2.7e-08 NP_853516 (OMIM: 611925) gap junction gamma-3 prot ( 279) 346 53.7 6.9e-07 >>NP_068773 (OMIM: 121015,601885) gap junction alpha-3 p (435 aa) initn: 2966 init1: 2966 opt: 2966 Z-score: 1939.6 bits: 368.0 E(85289): 2.7e-101 Smith-Waterman score: 2966; 99.8% identity (100.0% similar) in 435 aa overlap (1-435:1-435) 10 20 30 40 50 60 pF1KB9 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 SPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 SPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 CDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRLGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 CDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRLGP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 DASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADFKML ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.: NP_068 DASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADFKLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 ALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQPPALKAYPAASTPAAPSPVGSSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 ALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQPPALKAYPAASTPAAPSPVGSSSP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 PLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQPPLPLGDPGRASKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 PLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQPPLPLGDPGRASKA 370 380 390 400 410 420 430 pF1KB9 SRASSGRARPEDLAI ::::::::::::::: NP_068 SRASSGRARPEDLAI 430 >>XP_011533350 (OMIM: 121015,601885) PREDICTED: gap junc (435 aa) initn: 2966 init1: 2966 opt: 2966 Z-score: 1939.6 bits: 368.0 E(85289): 2.7e-101 Smith-Waterman score: 2966; 99.8% identity (100.0% similar) in 435 aa overlap (1-435:1-435) 10 20 30 40 50 60 pF1KB9 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 SPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 CDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRLGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRLGP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 DASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADFKML ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.: XP_011 DASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADFKLL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 ALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQPPALKAYPAASTPAAPSPVGSSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQPPALKAYPAASTPAAPSPVGSSSP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 PLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQPPLPLGDPGRASKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQPPLPLGDPGRASKA 370 380 390 400 410 420 430 pF1KB9 SRASSGRARPEDLAI ::::::::::::::: XP_011 SRASSGRARPEDLAI 430 >>NP_005258 (OMIM: 116200,600897,612474) gap junction al (433 aa) initn: 1171 init1: 657 opt: 1176 Z-score: 779.8 bits: 153.4 E(85289): 1.1e-36 Smith-Waterman score: 1176; 45.5% identity (66.4% similar) in 446 aa overlap (1-435:1-433) 10 20 30 40 50 60 pF1KB9 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG :::::::: .::...:::::::.::::::::::::.::.::: :::::::::.::::::: NP_005 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP :::::::.::::::::.:.:::::::::.:.:.::..: ::::::.: :: :: : ... NP_005 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEE-LGQQAG 70 80 90 100 110 130 140 150 160 170 pF1KB9 SPKEPPQDN-PSSRDDRG--RVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKP . : : . .: ..: . :. :.:::::. .::::::::::::.:.::::::.. : NP_005 TNGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILP 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 LYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSR ::::.::::::.::::.::::::::::.:::.:: .::.::..:. ::: : ..... NP_005 LYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKRP 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB9 LGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADF . .: : . . .. . . . :: .. : .: :: : NP_005 VEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMV--ETSPLPAKPF 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 KMLALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQ-PPALKAYPAASTPAAPSPVG ... : . : . : :... : . . . : .: . ::: .. . : . NP_005 NQFE--EKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEG----AEPEVGEKKE 300 310 320 330 340 350 360 370 380 390 400 pF1KB9 SSSPPLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQ-------PPL . ..: : :.: .: : : :: .. .. . : : NP_005 EAERLTTEEQEKVAVP---EGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPEL 360 370 380 390 400 410 420 430 pF1KB9 PLGDPGRASKASRASSGRARPEDLAI : :. :.::: ::: .::.. NP_005 TTDDARPLSRLSKASS-RARSDDLTV 410 420 430 >>XP_011507718 (OMIM: 116200,600897,612474) PREDICTED: g (433 aa) initn: 1171 init1: 657 opt: 1176 Z-score: 779.8 bits: 153.4 E(85289): 1.1e-36 Smith-Waterman score: 1176; 45.5% identity (66.4% similar) in 446 aa overlap (1-435:1-433) 10 20 30 40 50 60 pF1KB9 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG :::::::: .::...:::::::.::::::::::::.::.::: :::::::::.::::::: XP_011 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP :::::::.::::::::.:.:::::::::.:.:.::..: ::::::.: :: :: : ... XP_011 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEE-LGQQAG 70 80 90 100 110 130 140 150 160 170 pF1KB9 SPKEPPQDN-PSSRDDRG--RVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKP . : : . .: ..: . :. :.:::::. .::::::::::::.:.::::::.. : XP_011 TNGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILP 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 LYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSR ::::.::::::.::::.::::::::::.:::.:: .::.::..:. ::: : ..... XP_011 LYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKRP 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB9 LGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADF . .: : . . .. . . . :: .. : .: :: : XP_011 VEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMV--ETSPLPAKPF 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 KMLALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQ-PPALKAYPAASTPAAPSPVG ... : . : . : :... : . . . : .: . ::: .. . : . XP_011 NQFE--EKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEG----AEPEVGEKKE 300 310 320 330 340 350 360 370 380 390 400 pF1KB9 SSSPPLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQ-------PPL . ..: : :.: .: : : :: .. .. . : : XP_011 EAERLTTEEQEKVAVP---EGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPEL 360 370 380 390 400 410 420 430 pF1KB9 PLGDPGRASKASRASSGRARPEDLAI : :. :.::: ::: .::.. XP_011 TTDDARPLSRLSKASS-RARSDDLTV 410 420 430 >>XP_011507719 (OMIM: 116200,600897,612474) PREDICTED: g (427 aa) initn: 1148 init1: 657 opt: 1158 Z-score: 768.3 bits: 151.2 E(85289): 4.7e-36 Smith-Waterman score: 1158; 45.7% identity (66.1% similar) in 440 aa overlap (1-429:1-427) 10 20 30 40 50 60 pF1KB9 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG :::::::: .::...:::::::.::::::::::::.::.::: :::::::::.::::::: XP_011 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP :::::::.::::::::.:.:::::::::.:.:.::..: ::::::.: :: :: : ... XP_011 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEE-LGQQAG 70 80 90 100 110 130 140 150 160 170 pF1KB9 SPKEPPQDN-PSSRDDRG--RVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKP . : : . .: ..: . :. :.:::::. .::::::::::::.:.::::::.. : XP_011 TNGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILP 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 LYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSR ::::.::::::.::::.::::::::::.:::.:: .::.::..:. ::: : ..... XP_011 LYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKRP 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB9 LGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADF . .: : . . .. . . . :: .. : .: :: : XP_011 VEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMV--ETSPLPAKPF 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 KMLALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQ-PPALKAYPAASTPAAPSPVG ... : . : . : :... : . . . : .: . ::: .. . : . XP_011 NQFE--EKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEG----AEPEVGEKKE 300 310 320 330 340 350 360 370 380 390 400 pF1KB9 SSSPPLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQ-------PPL . ..: : :.: .: : : :: .. .. . : : XP_011 EAERLTTEEQEKVAVP---EGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPEL 360 370 380 390 400 410 420 430 pF1KB9 PLGDPGRASKASRASSGRARPEDLAI : :. :.::: ::: XP_011 TTDDARPLSRLSKASS-RAR 410 420 >>XP_005273008 (OMIM: 108770,121013,612474,614049) PREDI (358 aa) initn: 1032 init1: 627 opt: 1023 Z-score: 681.8 bits: 135.0 E(85289): 3.1e-31 Smith-Waterman score: 1023; 61.0% identity (83.5% similar) in 236 aa overlap (1-232:1-236) 10 20 30 40 50 60 pF1KB9 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG :::::::: .::....::::.::::::::::::.::::.:::. :::::.:: :.: ::: XP_005 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLK-RES :.:::::.::::::::.:.:::::::::.:.:.::..: :::.::.: :: :. . : : XP_005 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 PSPKEPPQDNPSS---RDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELK : . : .. .. ::. . :.:: ::: .:...: .:::::.::::.::. : XP_005 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 PLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTS :. : : :::. :.:..::::::..::.:::::: ::::.. :.:::::::..: XP_005 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 RLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAAD XP_005 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ 250 260 270 280 290 300 >>XP_016856533 (OMIM: 108770,121013,612474,614049) PREDI (358 aa) initn: 1032 init1: 627 opt: 1023 Z-score: 681.8 bits: 135.0 E(85289): 3.1e-31 Smith-Waterman score: 1023; 61.0% identity (83.5% similar) in 236 aa overlap (1-232:1-236) 10 20 30 40 50 60 pF1KB9 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG :::::::: .::....::::.::::::::::::.::::.:::. :::::.:: :.: ::: XP_016 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLK-RES :.:::::.::::::::.:.:::::::::.:.:.::..: :::.::.: :: :. . : : XP_016 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 PSPKEPPQDNPSS---RDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELK : . : .. .. ::. . :.:: ::: .:...: .:::::.::::.::. : XP_016 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 PLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTS :. : : :::. :.:..::::::..::.:::::: ::::.. :.:::::::..: XP_016 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 RLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAAD XP_016 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ 250 260 270 280 290 300 >>NP_859054 (OMIM: 108770,121013,612474,614049) gap junc (358 aa) initn: 1032 init1: 627 opt: 1023 Z-score: 681.8 bits: 135.0 E(85289): 3.1e-31 Smith-Waterman score: 1023; 61.0% identity (83.5% similar) in 236 aa overlap (1-232:1-236) 10 20 30 40 50 60 pF1KB9 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG :::::::: .::....::::.::::::::::::.::::.:::. :::::.:: :.: ::: NP_859 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLK-RES :.:::::.::::::::.:.:::::::::.:.:.::..: :::.::.: :: :. . : : NP_859 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 PSPKEPPQDNPSS---RDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELK : . : .. .. ::. . :.:: ::: .:...: .:::::.::::.::. : NP_859 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 PLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTS :. : : :::. :.:..::::::..::.:::::: ::::.. :.:::::::..: NP_859 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 RLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAAD NP_859 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ 250 260 270 280 290 300 >>NP_005257 (OMIM: 108770,121013,612474,614049) gap junc (358 aa) initn: 1032 init1: 627 opt: 1023 Z-score: 681.8 bits: 135.0 E(85289): 3.1e-31 Smith-Waterman score: 1023; 61.0% identity (83.5% similar) in 236 aa overlap (1-232:1-236) 10 20 30 40 50 60 pF1KB9 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG :::::::: .::....::::.::::::::::::.::::.:::. :::::.:: :.: ::: NP_005 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLK-RES :.:::::.::::::::.:.:::::::::.:.:.::..: :::.::.: :: :. . : : NP_005 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 PSPKEPPQDNPSS---RDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELK : . : .. .. ::. . :.:: ::: .:...: .:::::.::::.::. : NP_005 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 PLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTS :. : : :::. :.:..::::::..::.:::::: ::::.. :.:::::::..: NP_005 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 RLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAAD NP_005 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ 250 260 270 280 290 300 >>XP_005270807 (OMIM: 121012) PREDICTED: gap junction al (333 aa) initn: 1070 init1: 603 opt: 989 Z-score: 660.2 bits: 130.9 E(85289): 4.9e-30 Smith-Waterman score: 1018; 46.6% identity (66.6% similar) in 371 aa overlap (1-359:1-328) 10 20 30 40 50 60 pF1KB9 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG ::::.:: .::...::::::.::.:::::::::::.:: :.:.::::::::: ::: ::: XP_005 MGDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPG 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEE-EQLKRES : :::::.::::::::.:.::..:::::::.:::::... : ::. ...: : . : .. XP_005 CTNVCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREERLRQKEGELRALPAKD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 PSPKEP-----PQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFE :. .. : : . ::.:. :::. ::: ... :...:.::. ::. :::. XP_005 PQVERALAAVERQMAKISVAEDGRLRIRGALMGTYVASVLCKSVLEAGFLYGQWRLYGWT 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 LKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGV ..:.. :.: ::: ::::.::::::::::::::.:. ::.::.::. :: . :..:. XP_005 MEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHLLCRCLSRGM 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 TSRLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPA .: : :: :: :: : . . : : :.::. :..:: XP_005 RARQGQDA---------PPTQGTSSDPYTDQVFF--YL-----PVGQG-----PSSPP-- 250 260 270 300 310 320 330 340 pF1KB9 ADFKMLALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQ-----PPALKAYPAASTP ::: : .:::::: ..:.. :: . : . XP_005 -----------------CPTYNG---LSSSEQNWANLTTEERLASSRPPLFLDPPPQNGQ 280 290 300 310 350 360 370 380 390 400 pF1KB9 AAPS-PVGSSSPPLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQPP :: : .:.: XP_005 KPPSRPSSSASKKQYV 320 330 435 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 19:52:18 2016 done: Fri Nov 4 19:52:20 2016 Total Scan time: 11.160 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]