FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9873, 499 aa 1>>>pF1KB9873 499 - 499 aa - 499 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3660+/-0.000974; mu= 17.6414+/- 0.059 mean_var=76.6577+/-15.961, 0's: 0 Z-trim(105.1): 142 B-trim: 28 in 1/49 Lambda= 0.146486 statistics sampled from 8094 (8252) to 8094 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.624), E-opt: 0.2 (0.253), width: 16 Scan time: 3.110 The best scores are: opt bits E(32554) CCDS827.1 KCNA2 gene_id:3737|Hs108|chr1 ( 499) 3297 706.7 1.4e-203 CCDS8535.1 KCNA1 gene_id:3736|Hs108|chr12 ( 495) 2596 558.6 5.7e-159 CCDS828.2 KCNA3 gene_id:3738|Hs108|chr1 ( 575) 2392 515.5 6.1e-146 CCDS41629.1 KCNA4 gene_id:3739|Hs108|chr11 ( 653) 2188 472.4 6.4e-133 CCDS55625.1 KCNA2 gene_id:3737|Hs108|chr1 ( 356) 2014 435.5 4.6e-122 CCDS826.1 KCNA10 gene_id:3744|Hs108|chr1 ( 511) 1940 420.0 3.1e-117 CCDS12755.1 KCNA7 gene_id:3743|Hs108|chr19 ( 456) 1884 408.1 1.1e-113 CCDS8534.1 KCNA6 gene_id:3742|Hs108|chr12 ( 529) 1236 271.2 2e-72 CCDS8536.1 KCNA5 gene_id:3741|Hs108|chr12 ( 613) 932 207.0 4.9e-53 CCDS13418.1 KCNB1 gene_id:3745|Hs108|chr20 ( 858) 824 184.3 4.7e-46 CCDS6209.1 KCNB2 gene_id:9312|Hs108|chr8 ( 911) 808 180.9 5.1e-45 CCDS6279.1 KCNS2 gene_id:3788|Hs108|chr8 ( 477) 662 149.9 6e-36 CCDS1692.1 KCNS3 gene_id:3790|Hs108|chr2 ( 491) 656 148.6 1.5e-35 CCDS44547.1 KCNC1 gene_id:3746|Hs108|chr11 ( 585) 650 147.4 4.1e-35 CCDS1676.1 KCNF1 gene_id:3754|Hs108|chr2 ( 494) 642 145.6 1.2e-34 CCDS7827.1 KCNC1 gene_id:3746|Hs108|chr11 ( 511) 631 143.3 5.9e-34 CCDS9006.1 KCNC2 gene_id:3747|Hs108|chr12 ( 558) 623 141.7 2.1e-33 CCDS58255.1 KCNC2 gene_id:3747|Hs108|chr12 ( 583) 623 141.7 2.1e-33 CCDS9005.1 KCNC2 gene_id:3747|Hs108|chr12 ( 613) 623 141.7 2.2e-33 CCDS58257.1 KCNC2 gene_id:3747|Hs108|chr12 ( 618) 623 141.7 2.2e-33 CCDS58256.1 KCNC2 gene_id:3747|Hs108|chr12 ( 629) 623 141.7 2.3e-33 CCDS13342.1 KCNS1 gene_id:3787|Hs108|chr20 ( 526) 622 141.4 2.3e-33 CCDS9007.1 KCNC2 gene_id:3747|Hs108|chr12 ( 638) 623 141.7 2.3e-33 CCDS6314.1 KCNV1 gene_id:27012|Hs108|chr8 ( 500) 621 141.2 2.5e-33 CCDS44193.1 KCNC4 gene_id:3749|Hs108|chr1 ( 626) 619 140.9 4e-33 CCDS821.1 KCNC4 gene_id:3749|Hs108|chr1 ( 635) 619 140.9 4.1e-33 CCDS13436.1 KCNG1 gene_id:3755|Hs108|chr20 ( 513) 611 139.1 1.1e-32 CCDS12793.1 KCNC3 gene_id:3748|Hs108|chr19 ( 757) 610 139.0 1.8e-32 CCDS10945.1 KCNG4 gene_id:93107|Hs108|chr16 ( 519) 604 137.6 3.1e-32 CCDS12019.1 KCNG2 gene_id:26251|Hs108|chr18 ( 466) 578 132.1 1.3e-30 CCDS42674.1 KCNG3 gene_id:170850|Hs108|chr2 ( 425) 551 126.4 6.3e-29 CCDS5776.1 KCND2 gene_id:3751|Hs108|chr7 ( 630) 537 123.5 6.7e-28 CCDS1809.1 KCNG3 gene_id:170850|Hs108|chr2 ( 436) 534 122.8 7.8e-28 CCDS14314.1 KCND1 gene_id:3750|Hs108|chrX ( 647) 533 122.7 1.2e-27 CCDS6447.1 KCNV2 gene_id:169522|Hs108|chr9 ( 545) 523 120.5 4.6e-27 CCDS844.1 KCND3 gene_id:3752|Hs108|chr1 ( 636) 519 119.7 9.4e-27 CCDS843.1 KCND3 gene_id:3752|Hs108|chr1 ( 655) 519 119.7 9.6e-27 CCDS7736.1 KCNQ1 gene_id:3784|Hs108|chr11 ( 676) 322 78.1 3.4e-14 CCDS13521.1 KCNQ2 gene_id:3785|Hs108|chr20 ( 393) 299 73.1 6.4e-13 CCDS46629.1 KCNQ2 gene_id:3785|Hs108|chr20 ( 841) 299 73.3 1.2e-12 CCDS13518.1 KCNQ2 gene_id:3785|Hs108|chr20 ( 844) 299 73.3 1.2e-12 CCDS13519.1 KCNQ2 gene_id:3785|Hs108|chr20 ( 854) 299 73.3 1.2e-12 CCDS13520.1 KCNQ2 gene_id:3785|Hs108|chr20 ( 872) 299 73.3 1.2e-12 CCDS456.1 KCNQ4 gene_id:9132|Hs108|chr1 ( 695) 288 70.9 5e-12 CCDS55035.1 KCNQ5 gene_id:56479|Hs108|chr6 ( 822) 277 68.7 2.9e-11 CCDS55037.1 KCNQ5 gene_id:56479|Hs108|chr6 ( 923) 277 68.7 3.1e-11 CCDS4976.1 KCNQ5 gene_id:56479|Hs108|chr6 ( 932) 277 68.7 3.2e-11 CCDS55034.1 KCNQ5 gene_id:56479|Hs108|chr6 ( 951) 277 68.7 3.2e-11 >>CCDS827.1 KCNA2 gene_id:3737|Hs108|chr1 (499 aa) initn: 3297 init1: 3297 opt: 3297 Z-score: 3768.1 bits: 706.7 E(32554): 1.4e-203 Smith-Waterman score: 3297; 100.0% identity (100.0% similar) in 499 aa overlap (1-499:1-499) 10 20 30 40 50 60 pF1KB9 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA 430 440 450 460 470 480 490 pF1KB9 NCTLANTNYVNITKMLTDV ::::::::::::::::::: CCDS82 NCTLANTNYVNITKMLTDV 490 >>CCDS8535.1 KCNA1 gene_id:3736|Hs108|chr12 (495 aa) initn: 2528 init1: 1034 opt: 2596 Z-score: 2967.5 bits: 558.6 E(32554): 5.7e-159 Smith-Waterman score: 2596; 80.3% identity (90.9% similar) in 503 aa overlap (1-499:1-495) 10 20 30 40 50 pF1KB9 MTVATGDPADEAAALPGHPQD-TYDPEADH---ECCERVVINISGLRFETQLKTLAQFPE ::: .:. .:::.: :::::: .: .::: ::::::::::::::::::::::::::. CCDS85 MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 TLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFY ::::.::::::::::::::::::::::::::::::::::::::::::::::.:::::.:: CCDS85 TLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 ELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILIS :::::::: ::::::.::::::::::.:.::::::::::::::::::.:::::::::::: CCDS85 ELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILIS 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 IVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFE :: ::::::: ..:. .:. : : : .:.:. :. :. ::::::::::::::::::: CCDS85 IVIFCLETLPELKDD-KDFTG---TVHRIDNTTVIYN-SNIFTDPFFIVETLCIIWFSFE 190 200 210 220 230 240 250 260 270 280 290 pF1KB9 FLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVI ..:::::::::. :: ::::.::::::::::::::::.::. : :.:.:: :::::::: CCDS85 LVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQ-EGNQKGEQATSLAILRVI 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 RLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERES :::::::::::::::::::::::::::::::::::::::::::::::::::::::.: :: CCDS85 RLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAES 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB9 QFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF .: ::::::::::::::::::::: :.::::::::::::::::::::::::::::::::: CCDS85 HFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB9 YHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREEN :::::::::::: :.:.: :.. :. ::.. ::.::.:::.::::.: .::: .:. : CCDS85 YHRETEGEEQAQLLHVSS-PNLASDSDLSR-RSSSTMSKSEYMEIEEDMNNSIAHYRQVN 420 430 440 450 460 470 480 490 pF1KB9 LKTANCTLANTNYVNITKMLTDV ..::::: :: : :: .:.:::: CCDS85 IRTANCTTANQNCVNKSKLLTDV 480 490 >>CCDS828.2 KCNA3 gene_id:3738|Hs108|chr1 (575 aa) initn: 2293 init1: 984 opt: 2392 Z-score: 2733.6 bits: 515.5 E(32554): 6.1e-146 Smith-Waterman score: 2392; 74.7% identity (85.6% similar) in 514 aa overlap (3-499:66-575) 10 20 pF1KB9 MTVATGDPADEAAALPGHPQDTYDP------- :: : : .. : : :.: CCDS82 VNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPA 40 50 60 70 80 90 30 40 50 60 70 80 pF1KB9 EADHECC-ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPS ....:: ::::::::::::::::::: :::::::::::.:::::::::::::::::::: CCDS82 AGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPS 100 110 120 130 140 150 90 100 110 120 130 140 pF1KB9 FDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENE :::::::::::::.:::::::.::::::::::.::::::: ::::::...:::::::. . CCDS82 FDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRD 160 170 180 190 200 210 150 160 170 180 190 200 pF1KB9 FQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-DMHGSGVTFH ::::::::::::::::::: ::::::.::::::: ::::::: ::::.. : .:. CCDS82 FQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFE 220 230 240 250 260 270 210 220 230 240 250 260 pF1KB9 TYSNSTIGYQQ-STSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVA . .::: : . ..::.::::.::::::::::::.::::::::::: : ::::.::::: CCDS82 AAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVA 280 290 300 310 320 330 270 280 290 300 310 320 pF1KB9 IIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLK ::::::::::::::. . ::::::::::::::::::::::::::::::::::::::: CCDS82 IIPYFITLGTELAERQGN---GQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLK 340 350 360 370 380 390 330 340 350 360 370 380 pF1KB9 ASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVP ::::::::::::::::::::::::::::::. : : :::::::::::.::::::::: : CCDS82 ASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHP 400 410 420 430 440 450 390 400 410 420 430 440 pF1KB9 TTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSP .:::::::::::::::::::::::::::::::::::::::::::.::..: :: .. :: CCDS82 VTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSA 460 470 480 490 500 510 450 460 470 480 490 pF1KB9 D-LKKSRSASTISKSDYMEIQEG-VNNS---NEDFREENLKTANCTLANT--NYVNITKM . :.:.:: ::.:::.:: :.:: .:.: . :. : .::.:: :. . ::: :. CCDS82 EELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGN-STATCTTNNNPNSCVNIKKI 520 530 540 550 560 570 pF1KB9 LTDV .::: CCDS82 FTDV >>CCDS41629.1 KCNA4 gene_id:3739|Hs108|chr11 (653 aa) initn: 1877 init1: 872 opt: 2188 Z-score: 2499.8 bits: 472.4 E(32554): 6.4e-133 Smith-Waterman score: 2200; 71.7% identity (85.3% similar) in 477 aa overlap (7-468:146-621) 10 20 30 pF1KB9 MTVATGDPADEAAALPGHPQDT----YDPEADHECC : .:: . ::: :. .:: CCDS41 KILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCC 120 130 140 150 160 170 40 50 60 70 80 90 pF1KB9 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY ::::::.::::::::.::::::::::::::.:: .::::::::::::::::::::::::: CCDS41 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY 180 190 200 210 220 230 100 110 120 130 140 150 pF1KB9 QSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-RPLPENEFQRQVWL ::::::.::::::.:::.::..::.:::::. ::::::...::: : ::::::..:.:: CCDS41 QSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWL 240 250 260 270 280 290 160 170 180 190 200 pF1KB9 LFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-----DMHGSGVTFHTYS ::::::::.::: ::::::.::::::: ::::::: :::. . . : : .. : CCDS41 LFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTS 300 310 320 330 340 350 210 220 230 240 250 260 pF1KB9 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPY . . : :.::::::::.::.::::::.:: :::::.: :: :::::::::.:.:: CCDS41 APHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPY 360 370 380 390 400 410 270 280 290 300 310 320 pF1KB9 FITLGTELAEKPEDAQ-QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM ::::::.::.. .. : :::::.::::.:::::::::::::::::::::::.::.::: CCDS41 FITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASM 420 430 440 450 460 470 330 340 350 360 370 380 pF1KB9 RELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTI :::::::::::::::::::::::::::: ..: :::::::::::.::::::::: : :. CCDS41 RELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITV 480 490 500 510 520 530 390 400 410 420 430 440 pF1KB9 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQ-VTSCPKIPSSPDL :::::::::::::::::::::::::::::::::::::.:::.: : ..::: .::. : CCDS41 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNL-L 540 550 560 570 580 590 450 460 470 480 490 pF1KB9 KKSRSASTIS---KSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV :: ::... : ::.:.:..:::..: CCDS41 KKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV 600 610 620 630 640 650 >>CCDS55625.1 KCNA2 gene_id:3737|Hs108|chr1 (356 aa) initn: 2005 init1: 2005 opt: 2014 Z-score: 2304.8 bits: 435.5 E(32554): 4.6e-122 Smith-Waterman score: 2014; 94.7% identity (97.2% similar) in 320 aa overlap (1-320:1-318) 10 20 30 40 50 60 pF1KB9 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: : CCDS55 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS : .. .. ..: : :. . CCDS55 --RPLQSQKSKRGRQHLNTSHDCTLGINLVAGMTVQWTRASGPDDRQTPAVTTLHRMY 310 320 330 340 350 >>CCDS826.1 KCNA10 gene_id:3744|Hs108|chr1 (511 aa) initn: 1943 init1: 835 opt: 1940 Z-score: 2218.1 bits: 420.0 E(32554): 3.1e-117 Smith-Waterman score: 1940; 66.7% identity (83.1% similar) in 450 aa overlap (15-456:66-509) 10 20 30 40 pF1KB9 MTVATGDPADEAAALPGHPQDTYDPE--ADHECCERVVINISGL ::: : :: . .: .::.:::.:: CCDS82 SPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGL 40 50 60 70 80 90 50 60 70 80 90 100 pF1KB9 RFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPV ::::::.::.::::::::: .:::..:: .::::::::::::::.:::::::::..:::. CCDS82 RFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPA 100 110 120 130 140 150 110 120 130 140 150 160 pF1KB9 NVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPA :::.:::..:: ::::: :::..::::::.::. : :: :...:: ::::::::::. : CCDS82 NVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAA 160 170 180 190 200 210 170 180 190 200 210 220 pF1KB9 RIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPF : .:.:::.:..:::. ::::::: ::.. : :. : . ..: ::::: CCDS82 RAVAVVSVLVVVISITIFCLETLPEFREDRE----LKVVRDPNLNMSKTVLSQTMFTDPF 220 230 240 250 260 270 230 240 250 260 270 280 pF1KB9 FIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQ :.::. ::.::.::...:: .::::. :: ::::::::..::::: :: :::... : . CCDS82 FMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPS- 280 290 300 310 320 330 290 300 310 320 330 340 pF1KB9 QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF .:: :::::::.::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 -AQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF 340 350 360 370 380 350 360 370 380 390 400 pF1KB9 SSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTI ::::::::.:: ::.: ::::.::::::.::::::::: ::: ::::::.:::::::::: CCDS82 SSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTI 390 400 410 420 430 440 410 420 430 440 450 pF1KB9 ALPVPVIVSNFNYFYHRETEGEEQA------QYLQVTSCPKIPSSPDLKKSRSASTISKS ::::::::::::::::::::.::. . . . .. :. .:.:. .. . :: CCDS82 ALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKS 450 460 470 480 490 500 460 470 480 490 pF1KB9 DYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV CCDS82 RK 510 >>CCDS12755.1 KCNA7 gene_id:3743|Hs108|chr19 (456 aa) initn: 1928 init1: 839 opt: 1884 Z-score: 2154.8 bits: 408.1 E(32554): 1.1e-113 Smith-Waterman score: 1884; 68.0% identity (83.8% similar) in 419 aa overlap (31-439:11-423) 10 20 30 40 50 60 pF1KB9 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG ::::.:.:..::::::. .::..::.:::: CCDS12 MEPRCPPPCGCCERLVLNVAGLRFETRARTLGRFPDTLLG 10 20 30 40 70 80 90 100 110 120 pF1KB9 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE :: .: :..: : ::::::.::::::.:::::::::::::..::::.: ::. :: :: CCDS12 DPARRGRFYDDARREYFFDRHRPSFDAVLYYYQSGGRLRRPAHVPLDVFLEEVAFYGLGA 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB9 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF :. .::::: :::::. : ::.:::::.:::: ::..:.:::.:::.::: : CCDS12 AALARLREDEGCPVPPERPLPRRAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVF 110 120 130 140 150 160 190 200 210 220 230 pF1KB9 CLETLPIFRDENEDMHGSGVT-------FHTYSNSTI---GYQQSTSFTDPFFIVETLCI :::::: ::: : :.:.. : . :.. : :.::::.:::::: CCDS12 CLETLPDFRD---DRDGTGLAAAAAAGPFPAPLNGSSQMPGNPPRLPFNDPFFVVETLCI 170 180 190 200 210 240 250 260 270 280 290 pF1KB9 IWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSL :::::.:::...::::: :: :.::.::.:::.:::..::::::.. ::::::: CCDS12 CWFSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQ---RGVGQQAMSL 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB9 AILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE :::::::::::::::::::::::::::::::.:::::::::::::::::.:::::::::: CCDS12 AILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAE 280 290 300 310 320 330 360 370 380 390 400 410 pF1KB9 ADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIV .:. .:.: :::..::::::.:::::::::.:.:.:::::::::::::::::.::::::: CCDS12 VDRVDSHFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIV 340 350 360 370 380 390 420 430 440 450 460 470 pF1KB9 SNFNYFYHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNE :::.::::::::::: ... .: : : CCDS12 SNFSYFYHRETEGEEAGMFSHVDMQPCGPLEGKANGGLVDGEVPELPPPLWAPPGKHLVT 400 410 420 430 440 450 >>CCDS8534.1 KCNA6 gene_id:3742|Hs108|chr12 (529 aa) initn: 1794 init1: 891 opt: 1236 Z-score: 1413.8 bits: 271.2 E(32554): 2e-72 Smith-Waterman score: 2087; 69.5% identity (80.6% similar) in 489 aa overlap (17-460:20-503) 10 20 30 40 50 pF1KB9 MTVATGDPADEAAALPGHPQDTYD-PEADHE--CC--ERVVINISGLRFETQLKTLA :. ::. : ::: :: ::.:::::::::::::.::. CCDS85 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 QFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEE ::.:::::: .:.:.::::::::::::::::::::::::::::::::::::::::: :: CCDS85 LFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEE 70 80 90 100 110 120 120 130 140 150 160 pF1KB9 IRFYELGEEAMEMFREDEGYIKE---EERPLPENEFQRQVWLLFEYPESSGPARIIAIVS ::::.::.::. :::::: . : .:.::: . ::::::::::::::::::: ::::: CCDS85 IRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVS 130 140 150 160 170 180 170 180 190 200 pF1KB9 VMVILISIVSFCLETLPIFR----------------------DENEDMHGSGVTFHTYSN :.::::::: ::::::: :: .:.:: : . : . CCDS85 VLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITP 190 200 210 220 230 240 210 220 230 240 250 pF1KB9 STIGYQQSTS--------FTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIID . .: :.: ::::::.::::::.::.::.:::: ::::: .:: ::::::: CCDS85 GEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIID 250 260 270 280 290 300 260 270 280 290 300 310 pF1KB9 IVAIIPYFITLGTELAEKPED-------AQQGQQAMSLAILRVIRLVRVFRIFKLSRHSK .:::.::::::::::... :. .:.::::::::::::::::::::::::::::: CCDS85 LVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSK 310 320 330 340 350 360 320 330 340 350 360 370 pF1KB9 GLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSM ::::::.::.::::::::::::::::::::::::::::::. .: :::::::::::::.: CCDS85 GLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTM 370 380 390 400 410 420 380 390 400 410 420 430 pF1KB9 TTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQV :::::::: : :.::::::::::::::::::::::::::::::::::::: :::.:: .: CCDS85 TTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHV 430 440 450 460 470 480 440 450 460 470 480 490 pF1KB9 TSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNI : : . :. :::. . .. ..: :. : CCDS85 T-CGQ-PA-PDLRATDNG--LGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV 490 500 510 520 >>CCDS8536.1 KCNA5 gene_id:3741|Hs108|chr12 (613 aa) initn: 2085 init1: 932 opt: 932 Z-score: 1065.7 bits: 207.0 E(32554): 4.9e-53 Smith-Waterman score: 2072; 77.3% identity (87.5% similar) in 415 aa overlap (33-427:120-533) 10 20 30 40 50 60 pF1KB9 VATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLGDP .:: :::::::::::: ::::::.:::::: CCDS85 RPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDP 90 100 110 120 130 140 70 80 90 100 110 120 pF1KB9 KKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEA ::.::::::::::::::::::::.::::::::::::::::: ::.:..:::::.::.:: CCDS85 AKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEA 150 160 170 180 190 200 130 140 150 160 170 180 pF1KB9 MEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCL :: ::::::.:::::.:::.:::::::::.:::::::: :: ::::::.::::::..::: CCDS85 MERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCL 210 220 230 240 250 260 190 200 210 220 pF1KB9 ETLPIFRDENEDM----------------HGSGVTFHTYSNSTIGYQQSTSFTDPFFIVE :::: :::: : . .:::: . :. :.. ...::::::: CCDS85 ETLPEFRDERELLRHPPAPHQPPAPAPGANGSGV-MAPPSGPTVAPLLPRTLADPFFIVE 270 280 290 300 310 320 230 240 250 260 270 280 pF1KB9 TLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDA----Q : :.:::.::.::::::::::::: :::::::.:::.::::::::::::. . : CCDS85 TTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQ 330 340 350 360 370 380 290 300 310 320 330 340 pF1KB9 QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILF .:::::::::::::::::::::::::::::::::::.::.:::::::::::::::::::: CCDS85 NGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILF 390 400 410 420 430 440 350 360 370 380 390 400 pF1KB9 SSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTI ::::::::::.. ..: :::::::::::.::::::::: : :.::::::::::::::::: CCDS85 SSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTI 450 460 470 480 490 500 410 420 430 440 450 460 pF1KB9 ALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQ :::::::::::::::::::. :: : CCDS85 ALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGG 510 520 530 540 550 560 >>CCDS13418.1 KCNB1 gene_id:3745|Hs108|chr20 (858 aa) initn: 872 init1: 520 opt: 824 Z-score: 940.3 bits: 184.3 E(32554): 4.7e-46 Smith-Waterman score: 934; 35.7% identity (65.1% similar) in 501 aa overlap (13-481:14-486) 10 20 30 40 50 pF1KB9 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLL ..:: .:.. .: : .:: .:..:: :. .:: ..:.: : CCDS13 MPAGMTKHGSRSTSSLPPEPMEIVRSKA---CSRRVRLNVGGLAHEVLWRTLDRLPRTRL 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 GDPK------KRMRYFDPLR---NEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFS : . . .. : :::::::. .: .:: .:..: ::. .. :: CCDS13 GKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTG-RLHMMEEMCALSFS 60 70 80 90 100 110 120 130 140 150 pF1KB9 EEI----------------RFYELGEEAMEMFREDEGYIKEEERPLPEN----EFQRQVW .:. :... :. : .... ..:.: .: : ....: CCDS13 QELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLW 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB9 LLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTI :.: :.:: :.:.::.:.: :..: ... :.::: ... .: CCDS13 DLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDE----------------- 180 190 200 210 220 230 240 250 260 pF1KB9 GYQQSTSFTDPFFI-VETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFIT . :::. .: . ::..:: ::..:.:.::.. :.: :: . .: ::..::.::..: CCDS13 -FGQSTD--NPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVT 220 230 240 250 260 270 270 280 290 300 310 320 pF1KB9 LGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELG . :.:. ... : :.. .....:..:..::.::.::: ::: :: ::. :. ::: CCDS13 I--FLTESNKSVLQFQNVRR--VVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELG 280 290 300 310 320 330 330 340 350 360 370 380 pF1KB9 LLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKI :::.:: .:...::: :.::: :: ...: ::: .::::...::::::::. : :. ::: CCDS13 LLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKI 340 350 360 370 380 390 390 400 410 420 430 440 pF1KB9 VGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSP-DLK-KS ::.:: :::::.::::.:.::.::. ::... . :. . .. : .: ... :. CCDS13 VGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKD 400 410 420 430 440 450 450 460 470 480 490 pF1KB9 RSASTISKSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV : .: : . ..: : ...: ..: . : CCDS13 AFARSIEMMDIVVEKNGENMGKKDKVQDNHLSPNKWKWTKRTLSETSSSKSFETKEQGSP 460 470 480 490 500 510 CCDS13 EKARSSSSPQHLNVQQLEDMYNKMAKTQSQPILNTKESAAQSKPKEELEMESIPSPVAPL 520 530 540 550 560 570 499 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 19:55:56 2016 done: Fri Nov 4 19:55:57 2016 Total Scan time: 3.110 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]