FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9873, 499 aa 1>>>pF1KB9873 499 - 499 aa - 499 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1922+/-0.000452; mu= 18.8969+/- 0.028 mean_var=96.8164+/-19.960, 0's: 0 Z-trim(112.0): 259 B-trim: 363 in 2/50 Lambda= 0.130347 statistics sampled from 20300 (20716) to 20300 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.604), E-opt: 0.2 (0.243), width: 16 Scan time: 9.360 The best scores are: opt bits E(85289) NP_004965 (OMIM: 176262,616366) potassium voltage- ( 499) 3297 631.2 2.1e-180 XP_011539701 (OMIM: 176262,616366) PREDICTED: pota ( 499) 3297 631.2 2.1e-180 XP_011539700 (OMIM: 176262,616366) PREDICTED: pota ( 499) 3297 631.2 2.1e-180 XP_011539698 (OMIM: 176262,616366) PREDICTED: pota ( 499) 3297 631.2 2.1e-180 XP_011539699 (OMIM: 176262,616366) PREDICTED: pota ( 499) 3297 631.2 2.1e-180 XP_016856702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 3297 631.2 2.1e-180 XP_011539702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 3297 631.2 2.1e-180 NP_000208 (OMIM: 160120,176260) potassium voltage- ( 495) 2596 499.4 1e-140 NP_002223 (OMIM: 176263) potassium voltage-gated c ( 575) 2392 461.1 3.9e-129 NP_002224 (OMIM: 176266) potassium voltage-gated c ( 653) 2188 422.8 1.5e-117 NP_001191198 (OMIM: 176262,616366) potassium volta ( 356) 2014 389.8 7.1e-108 NP_005540 (OMIM: 602420) potassium voltage-gated c ( 511) 1940 376.0 1.4e-103 NP_114092 (OMIM: 176268) potassium voltage-gated c ( 456) 1884 365.4 1.9e-100 XP_016874759 (OMIM: 176257) PREDICTED: potassium v ( 529) 1236 243.6 1e-63 XP_016874761 (OMIM: 176257) PREDICTED: potassium v ( 529) 1236 243.6 1e-63 XP_011519257 (OMIM: 176257) PREDICTED: potassium v ( 529) 1236 243.6 1e-63 XP_005253743 (OMIM: 176257) PREDICTED: potassium v ( 529) 1236 243.6 1e-63 NP_002226 (OMIM: 176257) potassium voltage-gated c ( 529) 1236 243.6 1e-63 XP_016874760 (OMIM: 176257) PREDICTED: potassium v ( 529) 1236 243.6 1e-63 NP_002225 (OMIM: 176267,612240) potassium voltage- ( 613) 932 186.5 1.8e-46 XP_011527101 (OMIM: 600397,616056) PREDICTED: pota ( 858) 824 166.4 3e-40 XP_006723847 (OMIM: 600397,616056) PREDICTED: pota ( 858) 824 166.4 3e-40 NP_004966 (OMIM: 600397,616056) potassium voltage- ( 858) 824 166.4 3e-40 NP_004761 (OMIM: 607738) potassium voltage-gated c ( 911) 808 163.4 2.5e-39 XP_016869471 (OMIM: 607738) PREDICTED: potassium v ( 666) 667 136.7 1.9e-31 XP_016869470 (OMIM: 607738) PREDICTED: potassium v ( 666) 667 136.7 1.9e-31 NP_065748 (OMIM: 602906) potassium voltage-gated c ( 477) 662 135.6 3e-31 XP_016859548 (OMIM: 603888) PREDICTED: potassium v ( 491) 656 134.5 6.6e-31 XP_011531127 (OMIM: 603888) PREDICTED: potassium v ( 491) 656 134.5 6.6e-31 NP_001269357 (OMIM: 603888) potassium voltage-gate ( 491) 656 134.5 6.6e-31 NP_002243 (OMIM: 603888) potassium voltage-gated c ( 491) 656 134.5 6.6e-31 NP_001106212 (OMIM: 176258,616187) potassium volta ( 585) 650 133.5 1.6e-30 NP_002227 (OMIM: 603787) potassium voltage-gated c ( 494) 642 131.9 4.1e-30 NP_004967 (OMIM: 176258,616187) potassium voltage- ( 511) 631 129.9 1.8e-29 XP_011518382 (OMIM: 176258,616187) PREDICTED: pota ( 535) 631 129.9 1.8e-29 NP_715624 (OMIM: 176256) potassium voltage-gated c ( 558) 623 128.4 5.3e-29 XP_005268912 (OMIM: 176256) PREDICTED: potassium v ( 574) 623 128.4 5.4e-29 NP_001247428 (OMIM: 176256) potassium voltage-gate ( 583) 623 128.4 5.5e-29 XP_016874771 (OMIM: 176256) PREDICTED: potassium v ( 612) 623 128.4 5.7e-29 XP_006719446 (OMIM: 176256) PREDICTED: potassium v ( 612) 623 128.4 5.7e-29 XP_006719448 (OMIM: 176256) PREDICTED: potassium v ( 612) 623 128.4 5.7e-29 XP_006719447 (OMIM: 176256) PREDICTED: potassium v ( 612) 623 128.4 5.7e-29 NP_631874 (OMIM: 176256) potassium voltage-gated c ( 613) 623 128.4 5.7e-29 XP_006719445 (OMIM: 176256) PREDICTED: potassium v ( 613) 623 128.4 5.7e-29 NP_001247426 (OMIM: 176256) potassium voltage-gate ( 618) 623 128.4 5.7e-29 NP_001247427 (OMIM: 176256) potassium voltage-gate ( 629) 623 128.4 5.8e-29 NP_001309728 (OMIM: 602905) potassium voltage-gate ( 526) 622 128.2 5.8e-29 NP_002242 (OMIM: 602905) potassium voltage-gated c ( 526) 622 128.2 5.8e-29 NP_631875 (OMIM: 176256) potassium voltage-gated c ( 638) 623 128.5 5.8e-29 XP_016883335 (OMIM: 602905) PREDICTED: potassium v ( 527) 622 128.2 5.8e-29 >>NP_004965 (OMIM: 176262,616366) potassium voltage-gate (499 aa) initn: 3297 init1: 3297 opt: 3297 Z-score: 3359.8 bits: 631.2 E(85289): 2.1e-180 Smith-Waterman score: 3297; 100.0% identity (100.0% similar) in 499 aa overlap (1-499:1-499) 10 20 30 40 50 60 pF1KB9 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA 430 440 450 460 470 480 490 pF1KB9 NCTLANTNYVNITKMLTDV ::::::::::::::::::: NP_004 NCTLANTNYVNITKMLTDV 490 >>XP_011539701 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 3297 init1: 3297 opt: 3297 Z-score: 3359.8 bits: 631.2 E(85289): 2.1e-180 Smith-Waterman score: 3297; 100.0% identity (100.0% similar) in 499 aa overlap (1-499:1-499) 10 20 30 40 50 60 pF1KB9 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA 430 440 450 460 470 480 490 pF1KB9 NCTLANTNYVNITKMLTDV ::::::::::::::::::: XP_011 NCTLANTNYVNITKMLTDV 490 >>XP_011539700 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 3297 init1: 3297 opt: 3297 Z-score: 3359.8 bits: 631.2 E(85289): 2.1e-180 Smith-Waterman score: 3297; 100.0% identity (100.0% similar) in 499 aa overlap (1-499:1-499) 10 20 30 40 50 60 pF1KB9 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA 430 440 450 460 470 480 490 pF1KB9 NCTLANTNYVNITKMLTDV ::::::::::::::::::: XP_011 NCTLANTNYVNITKMLTDV 490 >>XP_011539698 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 3297 init1: 3297 opt: 3297 Z-score: 3359.8 bits: 631.2 E(85289): 2.1e-180 Smith-Waterman score: 3297; 100.0% identity (100.0% similar) in 499 aa overlap (1-499:1-499) 10 20 30 40 50 60 pF1KB9 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA 430 440 450 460 470 480 490 pF1KB9 NCTLANTNYVNITKMLTDV ::::::::::::::::::: XP_011 NCTLANTNYVNITKMLTDV 490 >>XP_011539699 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 3297 init1: 3297 opt: 3297 Z-score: 3359.8 bits: 631.2 E(85289): 2.1e-180 Smith-Waterman score: 3297; 100.0% identity (100.0% similar) in 499 aa overlap (1-499:1-499) 10 20 30 40 50 60 pF1KB9 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA 430 440 450 460 470 480 490 pF1KB9 NCTLANTNYVNITKMLTDV ::::::::::::::::::: XP_011 NCTLANTNYVNITKMLTDV 490 >>XP_016856702 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 3297 init1: 3297 opt: 3297 Z-score: 3359.8 bits: 631.2 E(85289): 2.1e-180 Smith-Waterman score: 3297; 100.0% identity (100.0% similar) in 499 aa overlap (1-499:1-499) 10 20 30 40 50 60 pF1KB9 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA 430 440 450 460 470 480 490 pF1KB9 NCTLANTNYVNITKMLTDV ::::::::::::::::::: XP_016 NCTLANTNYVNITKMLTDV 490 >>XP_011539702 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 3297 init1: 3297 opt: 3297 Z-score: 3359.8 bits: 631.2 E(85289): 2.1e-180 Smith-Waterman score: 3297; 100.0% identity (100.0% similar) in 499 aa overlap (1-499:1-499) 10 20 30 40 50 60 pF1KB9 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA 430 440 450 460 470 480 490 pF1KB9 NCTLANTNYVNITKMLTDV ::::::::::::::::::: XP_011 NCTLANTNYVNITKMLTDV 490 >>NP_000208 (OMIM: 160120,176260) potassium voltage-gate (495 aa) initn: 2528 init1: 1034 opt: 2596 Z-score: 2647.4 bits: 499.4 E(85289): 1e-140 Smith-Waterman score: 2596; 80.3% identity (90.9% similar) in 503 aa overlap (1-499:1-495) 10 20 30 40 50 pF1KB9 MTVATGDPADEAAALPGHPQD-TYDPEADH---ECCERVVINISGLRFETQLKTLAQFPE ::: .:. .:::.: :::::: .: .::: ::::::::::::::::::::::::::. NP_000 MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 TLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFY ::::.::::::::::::::::::::::::::::::::::::::::::::::.:::::.:: NP_000 TLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 ELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILIS :::::::: ::::::.::::::::::.:.::::::::::::::::::.:::::::::::: NP_000 ELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILIS 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 IVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFE :: ::::::: ..:. .:. : : : .:.:. :. :. ::::::::::::::::::: NP_000 IVIFCLETLPELKDD-KDFTG---TVHRIDNTTVIYN-SNIFTDPFFIVETLCIIWFSFE 190 200 210 220 230 240 250 260 270 280 290 pF1KB9 FLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVI ..:::::::::. :: ::::.::::::::::::::::.::. : :.:.:: :::::::: NP_000 LVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQ-EGNQKGEQATSLAILRVI 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 RLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERES :::::::::::::::::::::::::::::::::::::::::::::::::::::::.: :: NP_000 RLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAES 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB9 QFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF .: ::::::::::::::::::::: :.::::::::::::::::::::::::::::::::: NP_000 HFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB9 YHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREEN :::::::::::: :.:.: :.. :. ::.. ::.::.:::.::::.: .::: .:. : NP_000 YHRETEGEEQAQLLHVSS-PNLASDSDLSR-RSSSTMSKSEYMEIEEDMNNSIAHYRQVN 420 430 440 450 460 470 480 490 pF1KB9 LKTANCTLANTNYVNITKMLTDV ..::::: :: : :: .:.:::: NP_000 IRTANCTTANQNCVNKSKLLTDV 480 490 >>NP_002223 (OMIM: 176263) potassium voltage-gated chann (575 aa) initn: 2293 init1: 984 opt: 2392 Z-score: 2439.3 bits: 461.1 E(85289): 3.9e-129 Smith-Waterman score: 2392; 74.7% identity (85.6% similar) in 514 aa overlap (3-499:66-575) 10 20 pF1KB9 MTVATGDPADEAAALPGHPQDTYDP------- :: : : .. : : :.: NP_002 VNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPA 40 50 60 70 80 90 30 40 50 60 70 80 pF1KB9 EADHECC-ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPS ....:: ::::::::::::::::::: :::::::::::.:::::::::::::::::::: NP_002 AGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPS 100 110 120 130 140 150 90 100 110 120 130 140 pF1KB9 FDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENE :::::::::::::.:::::::.::::::::::.::::::: ::::::...:::::::. . NP_002 FDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRD 160 170 180 190 200 210 150 160 170 180 190 200 pF1KB9 FQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-DMHGSGVTFH ::::::::::::::::::: ::::::.::::::: ::::::: ::::.. : .:. NP_002 FQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFE 220 230 240 250 260 270 210 220 230 240 250 260 pF1KB9 TYSNSTIGYQQ-STSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVA . .::: : . ..::.::::.::::::::::::.::::::::::: : ::::.::::: NP_002 AAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVA 280 290 300 310 320 330 270 280 290 300 310 320 pF1KB9 IIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLK ::::::::::::::. . ::::::::::::::::::::::::::::::::::::::: NP_002 IIPYFITLGTELAERQGN---GQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLK 340 350 360 370 380 390 330 340 350 360 370 380 pF1KB9 ASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVP ::::::::::::::::::::::::::::::. : : :::::::::::.::::::::: : NP_002 ASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHP 400 410 420 430 440 450 390 400 410 420 430 440 pF1KB9 TTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSP .:::::::::::::::::::::::::::::::::::::::::::.::..: :: .. :: NP_002 VTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSA 460 470 480 490 500 510 450 460 470 480 490 pF1KB9 D-LKKSRSASTISKSDYMEIQEG-VNNS---NEDFREENLKTANCTLANT--NYVNITKM . :.:.:: ::.:::.:: :.:: .:.: . :. : .::.:: :. . ::: :. NP_002 EELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGN-STATCTTNNNPNSCVNIKKI 520 530 540 550 560 570 pF1KB9 LTDV .::: NP_002 FTDV >>NP_002224 (OMIM: 176266) potassium voltage-gated chann (653 aa) initn: 1877 init1: 872 opt: 2188 Z-score: 2231.3 bits: 422.8 E(85289): 1.5e-117 Smith-Waterman score: 2200; 71.7% identity (85.3% similar) in 477 aa overlap (7-468:146-621) 10 20 30 pF1KB9 MTVATGDPADEAAALPGHPQDT----YDPEADHECC : .:: . ::: :. .:: NP_002 KILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCC 120 130 140 150 160 170 40 50 60 70 80 90 pF1KB9 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY ::::::.::::::::.::::::::::::::.:: .::::::::::::::::::::::::: NP_002 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY 180 190 200 210 220 230 100 110 120 130 140 150 pF1KB9 QSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-RPLPENEFQRQVWL ::::::.::::::.:::.::..::.:::::. ::::::...::: : ::::::..:.:: NP_002 QSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWL 240 250 260 270 280 290 160 170 180 190 200 pF1KB9 LFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-----DMHGSGVTFHTYS ::::::::.::: ::::::.::::::: ::::::: :::. . . : : .. : NP_002 LFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTS 300 310 320 330 340 350 210 220 230 240 250 260 pF1KB9 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPY . . : :.::::::::.::.::::::.:: :::::.: :: :::::::::.:.:: NP_002 APHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPY 360 370 380 390 400 410 270 280 290 300 310 320 pF1KB9 FITLGTELAEKPEDAQ-QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM ::::::.::.. .. : :::::.::::.:::::::::::::::::::::::.::.::: NP_002 FITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASM 420 430 440 450 460 470 330 340 350 360 370 380 pF1KB9 RELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTI :::::::::::::::::::::::::::: ..: :::::::::::.::::::::: : :. NP_002 RELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITV 480 490 500 510 520 530 390 400 410 420 430 440 pF1KB9 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQ-VTSCPKIPSSPDL :::::::::::::::::::::::::::::::::::::.:::.: : ..::: .::. : NP_002 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNL-L 540 550 560 570 580 590 450 460 470 480 490 pF1KB9 KKSRSASTIS---KSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV :: ::... : ::.:.:..:::..: NP_002 KKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV 600 610 620 630 640 650 499 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 19:55:57 2016 done: Fri Nov 4 19:55:58 2016 Total Scan time: 9.360 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]