FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9882, 613 aa 1>>>pF1KB9882 613 - 613 aa - 613 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.6007+/-0.000353; mu= 6.4177+/- 0.022 mean_var=245.2196+/-49.099, 0's: 0 Z-trim(123.0): 124 B-trim: 441 in 1/57 Lambda= 0.081902 statistics sampled from 41961 (42087) to 41961 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.781), E-opt: 0.2 (0.493), width: 16 Scan time: 11.780 The best scores are: opt bits E(85289) NP_002225 (OMIM: 176267,612240) potassium voltage- ( 613) 4157 504.3 5e-142 XP_016874760 (OMIM: 176257) PREDICTED: potassium v ( 529) 1247 160.4 1.5e-38 XP_016874761 (OMIM: 176257) PREDICTED: potassium v ( 529) 1247 160.4 1.5e-38 XP_016874759 (OMIM: 176257) PREDICTED: potassium v ( 529) 1247 160.4 1.5e-38 NP_002226 (OMIM: 176257) potassium voltage-gated c ( 529) 1247 160.4 1.5e-38 XP_011519257 (OMIM: 176257) PREDICTED: potassium v ( 529) 1247 160.4 1.5e-38 XP_005253743 (OMIM: 176257) PREDICTED: potassium v ( 529) 1247 160.4 1.5e-38 NP_002224 (OMIM: 176266) potassium voltage-gated c ( 653) 1216 156.8 2.1e-37 NP_114092 (OMIM: 176268) potassium voltage-gated c ( 456) 1118 145.1 5.1e-34 NP_002223 (OMIM: 176263) potassium voltage-gated c ( 575) 990 130.0 2.1e-29 NP_001191198 (OMIM: 176262,616366) potassium volta ( 356) 932 123.0 1.8e-27 XP_011539698 (OMIM: 176262,616366) PREDICTED: pota ( 499) 932 123.1 2.2e-27 XP_011539701 (OMIM: 176262,616366) PREDICTED: pota ( 499) 932 123.1 2.2e-27 XP_016856702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 932 123.1 2.2e-27 XP_011539700 (OMIM: 176262,616366) PREDICTED: pota ( 499) 932 123.1 2.2e-27 XP_011539702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 932 123.1 2.2e-27 NP_004965 (OMIM: 176262,616366) potassium voltage- ( 499) 932 123.1 2.2e-27 XP_011539699 (OMIM: 176262,616366) PREDICTED: pota ( 499) 932 123.1 2.2e-27 NP_000208 (OMIM: 160120,176260) potassium voltage- ( 495) 928 122.7 3.1e-27 NP_005540 (OMIM: 602420) potassium voltage-gated c ( 511) 838 112.0 5e-24 NP_004761 (OMIM: 607738) potassium voltage-gated c ( 911) 694 95.3 1e-18 XP_006723847 (OMIM: 600397,616056) PREDICTED: pota ( 858) 682 93.8 2.6e-18 NP_004966 (OMIM: 600397,616056) potassium voltage- ( 858) 682 93.8 2.6e-18 XP_011527101 (OMIM: 600397,616056) PREDICTED: pota ( 858) 682 93.8 2.6e-18 XP_016869471 (OMIM: 607738) PREDICTED: potassium v ( 666) 639 88.6 7.3e-17 XP_016869470 (OMIM: 607738) PREDICTED: potassium v ( 666) 639 88.6 7.3e-17 NP_001309728 (OMIM: 602905) potassium voltage-gate ( 526) 618 86.0 3.4e-16 NP_002242 (OMIM: 602905) potassium voltage-gated c ( 526) 618 86.0 3.4e-16 XP_016883335 (OMIM: 602905) PREDICTED: potassium v ( 527) 618 86.0 3.4e-16 XP_011527107 (OMIM: 603788) PREDICTED: potassium v ( 513) 615 85.7 4.3e-16 XP_011527102 (OMIM: 603788) PREDICTED: potassium v ( 513) 615 85.7 4.3e-16 XP_011527103 (OMIM: 603788) PREDICTED: potassium v ( 513) 615 85.7 4.3e-16 XP_006723848 (OMIM: 603788) PREDICTED: potassium v ( 513) 615 85.7 4.3e-16 XP_011527105 (OMIM: 603788) PREDICTED: potassium v ( 513) 615 85.7 4.3e-16 XP_011527106 (OMIM: 603788) PREDICTED: potassium v ( 513) 615 85.7 4.3e-16 NP_002228 (OMIM: 603788) potassium voltage-gated c ( 513) 615 85.7 4.3e-16 XP_011527108 (OMIM: 603788) PREDICTED: potassium v ( 513) 615 85.7 4.3e-16 XP_011527104 (OMIM: 603788) PREDICTED: potassium v ( 513) 615 85.7 4.3e-16 XP_011531127 (OMIM: 603888) PREDICTED: potassium v ( 491) 605 84.5 9.5e-16 NP_002243 (OMIM: 603888) potassium voltage-gated c ( 491) 605 84.5 9.5e-16 NP_001269357 (OMIM: 603888) potassium voltage-gate ( 491) 605 84.5 9.5e-16 XP_016859548 (OMIM: 603888) PREDICTED: potassium v ( 491) 605 84.5 9.5e-16 NP_002227 (OMIM: 603787) potassium voltage-gated c ( 494) 568 80.1 2e-14 NP_055194 (OMIM: 608164) potassium voltage-gated c ( 500) 567 80.0 2.2e-14 NP_758857 (OMIM: 607603) potassium voltage-gated c ( 519) 562 79.4 3.3e-14 XP_016881194 (OMIM: 605696) PREDICTED: potassium v ( 466) 542 77.0 1.6e-13 NP_036415 (OMIM: 605696) potassium voltage-gated c ( 466) 542 77.0 1.6e-13 XP_011524220 (OMIM: 605696) PREDICTED: potassium v ( 466) 542 77.0 1.6e-13 XP_011524222 (OMIM: 605696) PREDICTED: potassium v ( 466) 542 77.0 1.6e-13 NP_758847 (OMIM: 606767) potassium voltage-gated c ( 425) 541 76.9 1.6e-13 >>NP_002225 (OMIM: 176267,612240) potassium voltage-gate (613 aa) initn: 4157 init1: 4157 opt: 4157 Z-score: 2670.8 bits: 504.3 E(85289): 5e-142 Smith-Waterman score: 4157; 100.0% identity (100.0% similar) in 613 aa overlap (1-613:1-613) 10 20 30 40 50 60 pF1KB9 MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 RVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 SGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 EYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNII 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 DVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 VGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 TQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSL 550 560 570 580 590 600 610 pF1KB9 YALCLDTSRETDL ::::::::::::: NP_002 YALCLDTSRETDL 610 >>XP_016874760 (OMIM: 176257) PREDICTED: potassium volta (529 aa) initn: 1777 init1: 945 opt: 1247 Z-score: 813.3 bits: 160.4 E(85289): 1.5e-38 Smith-Waterman score: 2056; 70.3% identity (81.0% similar) in 468 aa overlap (86-531:12-473) 60 70 80 90 100 110 pF1KB9 AQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGD-PGLGTVEDQALGT : : : .... :: : : : XP_016 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGG------GG 10 20 30 120 130 140 150 160 170 pF1KB9 ASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDG . .:. :::::::::::: ::. ::.::::::..:.:.::::::::::::::::::. XP_016 GCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDA 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB9 ILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKE---EEKPLPRNE ::::::::::::::::: ::.: .:::::::::::. :::::: . : .::::: . XP_016 ILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQP 100 110 120 130 140 150 240 250 260 270 280 pF1KB9 FQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFR-DERE-----LLRHP :::::::.:::::::: ::.:::::::::::::. :::::::.:: : : . : XP_016 FQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVS 160 170 180 190 200 210 290 300 310 320 330 pF1KB9 PAPHQPPAPAPGANGS---------GVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFT :. . . : : :. .. ... : ..::::.::: :..::: XP_016 PVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFT 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB9 FELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELA---EQQPGGGGGGQNGQQA ::::::: ::::: .: ::::::::.::::::::::::::. ::::..:::::::::: XP_016 FELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQA 280 290 300 310 320 330 400 410 420 430 440 450 pF1KB9 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVY 340 350 360 370 380 390 460 470 480 490 500 510 pF1KB9 FAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVP :::::.. . : ::::::::::::::::::::: :.:::::::::::::::::::::::: XP_016 FAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVP 400 410 420 430 440 450 520 530 540 550 560 570 pF1KB9 VIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENA ::::::::::::::..:: XP_016 VIVSNFNYFYHRETEQEEQGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPT 460 470 480 490 500 510 >>XP_016874761 (OMIM: 176257) PREDICTED: potassium volta (529 aa) initn: 1777 init1: 945 opt: 1247 Z-score: 813.3 bits: 160.4 E(85289): 1.5e-38 Smith-Waterman score: 2056; 70.3% identity (81.0% similar) in 468 aa overlap (86-531:12-473) 60 70 80 90 100 110 pF1KB9 AQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGD-PGLGTVEDQALGT : : : .... :: : : : XP_016 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGG------GG 10 20 30 120 130 140 150 160 170 pF1KB9 ASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDG . .:. :::::::::::: ::. ::.::::::..:.:.::::::::::::::::::. XP_016 GCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDA 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB9 ILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKE---EEKPLPRNE ::::::::::::::::: ::.: .:::::::::::. :::::: . : .::::: . XP_016 ILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQP 100 110 120 130 140 150 240 250 260 270 280 pF1KB9 FQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFR-DERE-----LLRHP :::::::.:::::::: ::.:::::::::::::. :::::::.:: : : . : XP_016 FQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVS 160 170 180 190 200 210 290 300 310 320 330 pF1KB9 PAPHQPPAPAPGANGS---------GVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFT :. . . : : :. .. ... : ..::::.::: :..::: XP_016 PVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFT 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB9 FELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELA---EQQPGGGGGGQNGQQA ::::::: ::::: .: ::::::::.::::::::::::::. ::::..:::::::::: XP_016 FELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQA 280 290 300 310 320 330 400 410 420 430 440 450 pF1KB9 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVY 340 350 360 370 380 390 460 470 480 490 500 510 pF1KB9 FAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVP :::::.. . : ::::::::::::::::::::: :.:::::::::::::::::::::::: XP_016 FAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVP 400 410 420 430 440 450 520 530 540 550 560 570 pF1KB9 VIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENA ::::::::::::::..:: XP_016 VIVSNFNYFYHRETEQEEQGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPT 460 470 480 490 500 510 >>XP_016874759 (OMIM: 176257) PREDICTED: potassium volta (529 aa) initn: 1777 init1: 945 opt: 1247 Z-score: 813.3 bits: 160.4 E(85289): 1.5e-38 Smith-Waterman score: 2056; 70.3% identity (81.0% similar) in 468 aa overlap (86-531:12-473) 60 70 80 90 100 110 pF1KB9 AQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGD-PGLGTVEDQALGT : : : .... :: : : : XP_016 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGG------GG 10 20 30 120 130 140 150 160 170 pF1KB9 ASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDG . .:. :::::::::::: ::. ::.::::::..:.:.::::::::::::::::::. XP_016 GCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDA 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB9 ILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKE---EEKPLPRNE ::::::::::::::::: ::.: .:::::::::::. :::::: . : .::::: . XP_016 ILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQP 100 110 120 130 140 150 240 250 260 270 280 pF1KB9 FQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFR-DERE-----LLRHP :::::::.:::::::: ::.:::::::::::::. :::::::.:: : : . : XP_016 FQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVS 160 170 180 190 200 210 290 300 310 320 330 pF1KB9 PAPHQPPAPAPGANGS---------GVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFT :. . . : : :. .. ... : ..::::.::: :..::: XP_016 PVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFT 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB9 FELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELA---EQQPGGGGGGQNGQQA ::::::: ::::: .: ::::::::.::::::::::::::. ::::..:::::::::: XP_016 FELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQA 280 290 300 310 320 330 400 410 420 430 440 450 pF1KB9 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVY 340 350 360 370 380 390 460 470 480 490 500 510 pF1KB9 FAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVP :::::.. . : ::::::::::::::::::::: :.:::::::::::::::::::::::: XP_016 FAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVP 400 410 420 430 440 450 520 530 540 550 560 570 pF1KB9 VIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENA ::::::::::::::..:: XP_016 VIVSNFNYFYHRETEQEEQGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPT 460 470 480 490 500 510 >>NP_002226 (OMIM: 176257) potassium voltage-gated chann (529 aa) initn: 1777 init1: 945 opt: 1247 Z-score: 813.3 bits: 160.4 E(85289): 1.5e-38 Smith-Waterman score: 2056; 70.3% identity (81.0% similar) in 468 aa overlap (86-531:12-473) 60 70 80 90 100 110 pF1KB9 AQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGD-PGLGTVEDQALGT : : : .... :: : : : NP_002 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGG------GG 10 20 30 120 130 140 150 160 170 pF1KB9 ASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDG . .:. :::::::::::: ::. ::.::::::..:.:.::::::::::::::::::. NP_002 GCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDA 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB9 ILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKE---EEKPLPRNE ::::::::::::::::: ::.: .:::::::::::. :::::: . : .::::: . NP_002 ILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQP 100 110 120 130 140 150 240 250 260 270 280 pF1KB9 FQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFR-DERE-----LLRHP :::::::.:::::::: ::.:::::::::::::. :::::::.:: : : . : NP_002 FQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVS 160 170 180 190 200 210 290 300 310 320 330 pF1KB9 PAPHQPPAPAPGANGS---------GVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFT :. . . : : :. .. ... : ..::::.::: :..::: NP_002 PVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFT 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB9 FELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELA---EQQPGGGGGGQNGQQA ::::::: ::::: .: ::::::::.::::::::::::::. ::::..:::::::::: NP_002 FELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQA 280 290 300 310 320 330 400 410 420 430 440 450 pF1KB9 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVY 340 350 360 370 380 390 460 470 480 490 500 510 pF1KB9 FAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVP :::::.. . : ::::::::::::::::::::: :.:::::::::::::::::::::::: NP_002 FAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVP 400 410 420 430 440 450 520 530 540 550 560 570 pF1KB9 VIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENA ::::::::::::::..:: NP_002 VIVSNFNYFYHRETEQEEQGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPT 460 470 480 490 500 510 >>XP_011519257 (OMIM: 176257) PREDICTED: potassium volta (529 aa) initn: 1777 init1: 945 opt: 1247 Z-score: 813.3 bits: 160.4 E(85289): 1.5e-38 Smith-Waterman score: 2056; 70.3% identity (81.0% similar) in 468 aa overlap (86-531:12-473) 60 70 80 90 100 110 pF1KB9 AQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGD-PGLGTVEDQALGT : : : .... :: : : : XP_011 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGG------GG 10 20 30 120 130 140 150 160 170 pF1KB9 ASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDG . .:. :::::::::::: ::. ::.::::::..:.:.::::::::::::::::::. XP_011 GCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDA 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB9 ILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKE---EEKPLPRNE ::::::::::::::::: ::.: .:::::::::::. :::::: . : .::::: . XP_011 ILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQP 100 110 120 130 140 150 240 250 260 270 280 pF1KB9 FQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFR-DERE-----LLRHP :::::::.:::::::: ::.:::::::::::::. :::::::.:: : : . : XP_011 FQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVS 160 170 180 190 200 210 290 300 310 320 330 pF1KB9 PAPHQPPAPAPGANGS---------GVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFT :. . . : : :. .. ... : ..::::.::: :..::: XP_011 PVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFT 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB9 FELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELA---EQQPGGGGGGQNGQQA ::::::: ::::: .: ::::::::.::::::::::::::. ::::..:::::::::: XP_011 FELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQA 280 290 300 310 320 330 400 410 420 430 440 450 pF1KB9 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVY 340 350 360 370 380 390 460 470 480 490 500 510 pF1KB9 FAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVP :::::.. . : ::::::::::::::::::::: :.:::::::::::::::::::::::: XP_011 FAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVP 400 410 420 430 440 450 520 530 540 550 560 570 pF1KB9 VIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENA ::::::::::::::..:: XP_011 VIVSNFNYFYHRETEQEEQGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPT 460 470 480 490 500 510 >>XP_005253743 (OMIM: 176257) PREDICTED: potassium volta (529 aa) initn: 1777 init1: 945 opt: 1247 Z-score: 813.3 bits: 160.4 E(85289): 1.5e-38 Smith-Waterman score: 2056; 70.3% identity (81.0% similar) in 468 aa overlap (86-531:12-473) 60 70 80 90 100 110 pF1KB9 AQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGD-PGLGTVEDQALGT : : : .... :: : : : XP_005 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGG------GG 10 20 30 120 130 140 150 160 170 pF1KB9 ASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDG . .:. :::::::::::: ::. ::.::::::..:.:.::::::::::::::::::. XP_005 GCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDA 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB9 ILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKE---EEKPLPRNE ::::::::::::::::: ::.: .:::::::::::. :::::: . : .::::: . XP_005 ILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQP 100 110 120 130 140 150 240 250 260 270 280 pF1KB9 FQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFR-DERE-----LLRHP :::::::.:::::::: ::.:::::::::::::. :::::::.:: : : . : XP_005 FQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVS 160 170 180 190 200 210 290 300 310 320 330 pF1KB9 PAPHQPPAPAPGANGS---------GVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFT :. . . : : :. .. ... : ..::::.::: :..::: XP_005 PVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFT 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB9 FELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELA---EQQPGGGGGGQNGQQA ::::::: ::::: .: ::::::::.::::::::::::::. ::::..:::::::::: XP_005 FELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQA 280 290 300 310 320 330 400 410 420 430 440 450 pF1KB9 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVY 340 350 360 370 380 390 460 470 480 490 500 510 pF1KB9 FAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVP :::::.. . : ::::::::::::::::::::: :.:::::::::::::::::::::::: XP_005 FAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVP 400 410 420 430 440 450 520 530 540 550 560 570 pF1KB9 VIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENA ::::::::::::::..:: XP_005 VIVSNFNYFYHRETEQEEQGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPT 460 470 480 490 500 510 >>NP_002224 (OMIM: 176266) potassium voltage-gated chann (653 aa) initn: 2147 init1: 877 opt: 1216 Z-score: 792.3 bits: 156.8 E(85289): 2.1e-37 Smith-Waterman score: 2064; 57.7% identity (74.9% similar) in 610 aa overlap (13-589:41-632) 10 20 30 40 pF1KB9 MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGL : .: .. : : : . :: . . : NP_002 SGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGSGGSGGGSHHHHQSRGA 20 30 40 50 60 70 50 60 70 80 90 pF1KB9 SDGPKEPAPKG-------RGAQRDADSGVRPLPPLPD--PG---VRPLPPLPEELPRPRR . . .: :. .. : .: : :. . : : :: . . NP_002 CTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRELSEE--EEDE 80 90 100 110 120 100 110 120 130 pF1KB9 PPPEDEEEEG-------DPG-------LGTVEDQALGTASLHH----QRVHINISGLRFE :.::::: : : : .. . : .:... .:: ::.:::::: NP_002 EEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVINVSGLRFE 130 140 150 160 170 180 140 150 160 170 180 190 pF1KB9 TQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVS ::. ::::::.:::::: :: .:::::::::::::::::::.:::::::::::.::::: NP_002 TQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVP 190 200 210 220 230 240 200 210 220 230 240 250 pF1KB9 LDVFADEIRFYQLGDEAMERFREDEGFIKEEE-KPLPRNEFQRQVWLIFEYPESSGSARA .:.:..:..:::::.::. .:::::::..::: . ::.:::..:.::.:::::::. ::. NP_002 FDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARG 250 260 270 280 290 300 260 270 280 290 300 310 pF1KB9 IAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPT :::::::::::::. :::::::::::.:.:. : . :..: :.. :.: NP_002 IAIVSVLVILISIVIFCLETLPEFRDDRDLVM---------ALSAGGHG-GLLNDTSAPH 310 320 330 340 350 320 330 340 350 360 370 pF1KB9 VAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFIT . . ::::::::.:..::.::..:: :::::.: : .:::::::.:.:.::::: NP_002 LENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFIT 360 370 380 390 400 410 380 390 400 410 420 430 pF1KB9 LGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASM :::.::.:: :::.::. :::::.::::.:::::::::::::::::::::::.::.::: NP_002 LGTDLAQQQ--GGGNGQQ-QQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASM 420 430 440 450 460 470 440 450 460 470 480 490 pF1KB9 RELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITV :::::::::::::::::::::::::::. :::.:::::::::::::::::::::.:::: NP_002 RELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITV 480 490 500 510 520 530 500 510 520 530 540 550 pF1KB9 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRG ::::::::::::::::::::::::::::::::::::..:: . : :.. : : : . NP_002 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLT--QNAVSC-PYLPSN 540 550 560 570 580 590 560 570 580 590 600 pF1KB9 VQRKV-SGSRGSFCKAGGTLENADSARRGSCPLE-KCNVKAKSNVDLRRSLYALCLDTSR . .: :.. .:. . :: ...... : : ::. : NP_002 LLKKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETD 600 610 620 630 640 650 610 pF1KB9 ETDL NP_002 V >>NP_114092 (OMIM: 176268) potassium voltage-gated chann (456 aa) initn: 1886 init1: 824 opt: 1118 Z-score: 731.7 bits: 145.1 E(85289): 5.1e-34 Smith-Waterman score: 1865; 67.0% identity (83.6% similar) in 427 aa overlap (120-546:13-423) 90 100 110 120 130 140 pF1KB9 RPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDP .:. .:..::::::. ::..::.:::::: NP_114 MEPRCPPPCGCCERLVLNVAGLRFETRARTLGRFPDTLLGDP 10 20 30 40 150 160 170 180 190 200 pF1KB9 AKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEA :.: :..: : ::::::.:::::..:::::::::::::..: :::: .:. :: :: : NP_114 ARRGRFYDDARREYFFDRHRPSFDAVLYYYQSGGRLRRPAHVPLDVFLEEVAFYGLGAAA 50 60 70 80 90 100 210 220 230 240 250 260 pF1KB9 MERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCL . :.::::: :.:::: : ::.::.::.:::: .::..:.:::::::.::..::: NP_114 LARLREDEGCPVPPERPLPRRAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVFCL 110 120 130 140 150 160 270 280 290 300 310 320 pF1KB9 ETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVET ::::.:::.:. : : ::: :::. : :..: : :: . ::::.::: NP_114 ETLPDFRDDRDGTGLAAAAAAGPFPAP-LNGSSQM--PGNP---PRLP--FNDPFFVVET 170 180 190 200 210 330 340 350 360 370 380 pF1KB9 TCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQN :. ::.::::::...::::: : .:.::.:: :::.:::..::::::.:. : NP_114 LCICWFSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQR----G---V 220 230 240 250 260 390 400 410 420 430 440 pF1KB9 GQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFS :::::::::::::::::::::::::::::::::::.::.:::::::::::::::::.::: NP_114 GQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFS 270 280 290 300 310 320 450 460 470 480 490 500 pF1KB9 SAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIA :::::::.: .::.:::..:::::::::::::::: :.:::::::::::::::::::. NP_114 SAVYFAEVDRVDSHFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTIS 330 340 350 360 370 380 510 520 530 540 550 560 pF1KB9 LPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGT ::::::::::.:::::::. :: ..... . : :: NP_114 LPVPVIVSNFSYFYHRETEGEEAGMFSHVD-MQPCGPLEGKANGGLVDGEVPELPPPLWA 390 400 410 420 430 440 570 580 590 600 610 pF1KB9 LENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL NP_114 PPGKHLVTEV 450 >>NP_002223 (OMIM: 176263) potassium voltage-gated chann (575 aa) initn: 1769 init1: 930 opt: 990 Z-score: 648.7 bits: 130.0 E(85289): 2.1e-29 Smith-Waterman score: 2148; 68.5% identity (79.3% similar) in 511 aa overlap (37-531:13-495) 10 20 30 40 50 60 pF1KB9 PLENGGAMTVRGGDEARAGCGQATGGELQCPPTA-GLSDGPKEPAPKGRGAQRDADSGV- ::.: . :..:: .: ::. .. : NP_002 MDERLSLLRSPPPPSARHRAHPPQRPASSG-GAHTLVNHGYA 10 20 30 40 70 80 90 100 110 pF1KB9 -----RPLPPLPDPGVRPLPPLPE-ELPRPRRPPPE--------DEEEEGDPGLGTVEDQ : ::: : : : : : :. ::. :. : :.: NP_002 EPAAGRELPP--DMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSL-----P 50 60 70 80 90 120 130 140 150 160 170 pF1KB9 ALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRP : : . .:: :::::::::::: :: :::.:::::: .:.::::::::::::::::: NP_002 AAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRP 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB9 SFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRN :::.::::::::::.:::::: .:.:..::::::::.::::.:::::::..:::.:::: NP_002 SFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRR 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB9 EFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQ .:::::::.:::::::: ::.:::::::::::::. ::::::::::::.. .: . : NP_002 DFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKD---YPASTSQ 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB9 PPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKA : : . :: : : ...::::.::: :.:::.:::::::::::::: NP_002 DSFEAAGNSTSGSRAGAS----------SFSDPFFVVETLCIIWFSFELLVRFFACPSKA 280 290 300 310 320 360 370 380 390 400 410 pF1KB9 GFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRI :::::::.::.:::.::::::::::::.: : :::::::::::::::::::::: NP_002 TFSRNIMNLIDIVAIIPYFITLGTELAERQ--G-----NGQQAMSLAILRVIRLVRVFRI 330 340 350 360 370 420 430 440 450 460 470 pF1KB9 FKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDA ::::::::::::::.::.::::::::::::::::::::::::::::::. . ::::::: NP_002 FKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDA 380 390 400 410 420 430 480 490 500 510 520 530 pF1KB9 FWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHE ::::::::::::::::.:.:.::::::::::::::::::::::::::::::::::::. : NP_002 FWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGE 440 450 460 470 480 490 540 550 560 570 580 590 pF1KB9 EPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKA : NP_002 EQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTA 500 510 520 530 540 550 613 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 19:58:28 2016 done: Fri Nov 4 19:58:30 2016 Total Scan time: 11.780 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]