FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9885, 653 aa 1>>>pF1KB9885 653 - 653 aa - 653 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5820+/-0.000451; mu= 15.2856+/- 0.028 mean_var=164.3745+/-34.027, 0's: 0 Z-trim(115.8): 213 B-trim: 1436 in 1/53 Lambda= 0.100036 statistics sampled from 26259 (26493) to 26259 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.659), E-opt: 0.2 (0.311), width: 16 Scan time: 11.660 The best scores are: opt bits E(85289) NP_036342 (OMIM: 254110,602290,615988) E3 ubiquiti ( 653) 4380 645.0 2.5e-184 XP_005251870 (OMIM: 254110,602290,615988) PREDICTE ( 653) 4380 645.0 2.5e-184 NP_001093149 (OMIM: 254110,602290,615988) E3 ubiqu ( 653) 4380 645.0 2.5e-184 XP_011516700 (OMIM: 254110,602290,615988) PREDICTE ( 653) 4380 645.0 2.5e-184 XP_016869975 (OMIM: 254110,602290,615988) PREDICTE ( 653) 4380 645.0 2.5e-184 NP_940988 (OMIM: 254780,608072) E3 ubiquitin-prote ( 395) 257 49.7 2.4e-05 NP_060543 (OMIM: 613184) E3 ubiquitin-protein liga ( 485) 258 49.9 2.5e-05 NP_003132 (OMIM: 109092) E3 ubiquitin-protein liga ( 475) 256 49.6 3e-05 NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 256 49.7 3.2e-05 NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 255 49.5 3.4e-05 NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 237 46.9 0.0002 NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 237 46.9 0.00021 XP_011512568 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 261) 232 45.9 0.00022 NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 235 46.7 0.00026 NP_569074 (OMIM: 605684) tripartite motif-containi ( 270) 230 45.6 0.00028 XP_011512567 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 421) 232 46.1 0.00031 XP_011512566 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 424) 232 46.1 0.00031 NP_008959 (OMIM: 609316) E3 ubiquitin-protein liga ( 425) 232 46.1 0.00031 NP_439893 (OMIM: 605701) tripartite motif-containi ( 395) 230 45.8 0.00036 NP_006769 (OMIM: 605701) tripartite motif-containi ( 481) 230 45.9 0.00041 NP_067629 (OMIM: 605684) tripartite motif-containi ( 488) 230 45.9 0.00041 NP_001003827 (OMIM: 605684) tripartite motif-conta ( 488) 230 45.9 0.00041 NP_741983 (OMIM: 617007) tripartite motif-containi ( 493) 219 44.3 0.0012 XP_005273509 (OMIM: 617007) PREDICTED: tripartite ( 298) 215 43.5 0.0013 XP_005266707 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 207 42.2 0.0023 XP_016881102 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 207 42.2 0.0023 NP_775828 (OMIM: 616512) E3 ubiquitin-protein liga ( 203) 207 42.2 0.0023 XP_005266709 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 207 42.2 0.0023 XP_011524181 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 207 42.2 0.0023 XP_011524180 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 207 42.2 0.0023 XP_016881101 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 207 42.2 0.0023 XP_005253240 (OMIM: 608487) PREDICTED: tripartite ( 493) 212 43.3 0.0025 NP_149023 (OMIM: 608487) tripartite motif-containi ( 493) 212 43.3 0.0025 XP_006718421 (OMIM: 608487) PREDICTED: tripartite ( 265) 207 42.3 0.0027 XP_016873952 (OMIM: 608487) PREDICTED: tripartite ( 265) 207 42.3 0.0027 XP_011518729 (OMIM: 608487) PREDICTED: tripartite ( 271) 207 42.3 0.0028 XP_016873951 (OMIM: 608487) PREDICTED: tripartite ( 300) 207 42.3 0.003 XP_016873950 (OMIM: 608487) PREDICTED: tripartite ( 310) 207 42.4 0.003 XP_011518728 (OMIM: 608487) PREDICTED: tripartite ( 310) 207 42.4 0.003 XP_016873949 (OMIM: 608487) PREDICTED: tripartite ( 314) 207 42.4 0.0031 NP_001307918 (OMIM: 253250,605073) E3 ubiquitin-pr ( 925) 214 43.9 0.0031 NP_001307917 (OMIM: 253250,605073) E3 ubiquitin-pr ( 925) 214 43.9 0.0031 NP_149084 (OMIM: 608487) tripartite motif-containi ( 326) 207 42.4 0.0031 XP_005253241 (OMIM: 608487) PREDICTED: tripartite ( 326) 207 42.4 0.0031 XP_016880155 (OMIM: 253250,605073) PREDICTED: E3 u ( 947) 214 43.9 0.0032 XP_016880156 (OMIM: 253250,605073) PREDICTED: E3 u ( 947) 214 43.9 0.0032 XP_011523138 (OMIM: 253250,605073) PREDICTED: E3 u ( 950) 214 43.9 0.0032 XP_016880153 (OMIM: 253250,605073) PREDICTED: E3 u ( 956) 214 43.9 0.0032 NP_056109 (OMIM: 253250,605073) E3 ubiquitin-prote ( 964) 214 43.9 0.0032 NP_001005207 (OMIM: 253250,605073) E3 ubiquitin-pr ( 964) 214 43.9 0.0032 >>NP_036342 (OMIM: 254110,602290,615988) E3 ubiquitin-pr (653 aa) initn: 4380 init1: 4380 opt: 4380 Z-score: 3430.2 bits: 645.0 E(85289): 2.5e-184 Smith-Waterman score: 4380; 100.0% identity (100.0% similar) in 653 aa overlap (1-653:1-653) 10 20 30 40 50 60 pF1KB9 MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRSCGRRLPRQFCRSCGLVLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 CPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRSCGRRLPRQFCRSCGLVLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGELQRRKAALEGVSKDLQAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 EPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGELQRRKAALEGVSKDLQAR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 YKAVLQEYGHEERRVQDELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 YKAVLQEYGHEERRVQDELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 YFLAKIKQADVALLEETADEEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 YFLAKIKQADVALLEETADEEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 VNVEDSWAMEATASAASTSVTFREMDMSPEEVVASPRASPAKQRGPEAASNIQQCLFLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VNVEDSWAMEATASAASTSVTFREMDMSPEEVVASPRASPAKQRGPEAASNIQQCLFLKK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 MGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGIDSFVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGIDSFVLS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 FLGADLPNLTPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCVACHRSQLSKPWGITALPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 FLGADLPNLTPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCVACHRSQLSKPWGITALPS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 GQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNLENR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 GQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNLENR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 QNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 QNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEIL 550 560 570 580 590 600 610 620 630 640 650 pF1KB9 HFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCIKIYSYHLRRYSTP ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 HFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCIKIYSYHLRRYSTP 610 620 630 640 650 >>XP_005251870 (OMIM: 254110,602290,615988) PREDICTED: E (653 aa) initn: 4380 init1: 4380 opt: 4380 Z-score: 3430.2 bits: 645.0 E(85289): 2.5e-184 Smith-Waterman score: 4380; 100.0% identity (100.0% similar) in 653 aa overlap (1-653:1-653) 10 20 30 40 50 60 pF1KB9 MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRSCGRRLPRQFCRSCGLVLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRSCGRRLPRQFCRSCGLVLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGELQRRKAALEGVSKDLQAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGELQRRKAALEGVSKDLQAR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 YKAVLQEYGHEERRVQDELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YKAVLQEYGHEERRVQDELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 YFLAKIKQADVALLEETADEEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YFLAKIKQADVALLEETADEEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 VNVEDSWAMEATASAASTSVTFREMDMSPEEVVASPRASPAKQRGPEAASNIQQCLFLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VNVEDSWAMEATASAASTSVTFREMDMSPEEVVASPRASPAKQRGPEAASNIQQCLFLKK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 MGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGIDSFVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGIDSFVLS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 FLGADLPNLTPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCVACHRSQLSKPWGITALPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FLGADLPNLTPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCVACHRSQLSKPWGITALPS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 GQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNLENR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNLENR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 QNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEIL 550 560 570 580 590 600 610 620 630 640 650 pF1KB9 HFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCIKIYSYHLRRYSTP ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCIKIYSYHLRRYSTP 610 620 630 640 650 >>NP_001093149 (OMIM: 254110,602290,615988) E3 ubiquitin (653 aa) initn: 4380 init1: 4380 opt: 4380 Z-score: 3430.2 bits: 645.0 E(85289): 2.5e-184 Smith-Waterman score: 4380; 100.0% identity (100.0% similar) in 653 aa overlap (1-653:1-653) 10 20 30 40 50 60 pF1KB9 MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRSCGRRLPRQFCRSCGLVLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRSCGRRLPRQFCRSCGLVLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGELQRRKAALEGVSKDLQAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGELQRRKAALEGVSKDLQAR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 YKAVLQEYGHEERRVQDELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YKAVLQEYGHEERRVQDELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 YFLAKIKQADVALLEETADEEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YFLAKIKQADVALLEETADEEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 VNVEDSWAMEATASAASTSVTFREMDMSPEEVVASPRASPAKQRGPEAASNIQQCLFLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNVEDSWAMEATASAASTSVTFREMDMSPEEVVASPRASPAKQRGPEAASNIQQCLFLKK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 MGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGIDSFVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGIDSFVLS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 FLGADLPNLTPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCVACHRSQLSKPWGITALPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLGADLPNLTPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCVACHRSQLSKPWGITALPS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 GQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNLENR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNLENR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 QNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEIL 550 560 570 580 590 600 610 620 630 640 650 pF1KB9 HFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCIKIYSYHLRRYSTP ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCIKIYSYHLRRYSTP 610 620 630 640 650 >>XP_011516700 (OMIM: 254110,602290,615988) PREDICTED: E (653 aa) initn: 4380 init1: 4380 opt: 4380 Z-score: 3430.2 bits: 645.0 E(85289): 2.5e-184 Smith-Waterman score: 4380; 100.0% identity (100.0% similar) in 653 aa overlap (1-653:1-653) 10 20 30 40 50 60 pF1KB9 MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRSCGRRLPRQFCRSCGLVLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRSCGRRLPRQFCRSCGLVLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGELQRRKAALEGVSKDLQAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGELQRRKAALEGVSKDLQAR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 YKAVLQEYGHEERRVQDELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YKAVLQEYGHEERRVQDELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 YFLAKIKQADVALLEETADEEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YFLAKIKQADVALLEETADEEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 VNVEDSWAMEATASAASTSVTFREMDMSPEEVVASPRASPAKQRGPEAASNIQQCLFLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VNVEDSWAMEATASAASTSVTFREMDMSPEEVVASPRASPAKQRGPEAASNIQQCLFLKK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 MGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGIDSFVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGIDSFVLS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 FLGADLPNLTPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCVACHRSQLSKPWGITALPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLGADLPNLTPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCVACHRSQLSKPWGITALPS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 GQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNLENR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNLENR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 QNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEIL 550 560 570 580 590 600 610 620 630 640 650 pF1KB9 HFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCIKIYSYHLRRYSTP ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCIKIYSYHLRRYSTP 610 620 630 640 650 >>XP_016869975 (OMIM: 254110,602290,615988) PREDICTED: E (653 aa) initn: 4380 init1: 4380 opt: 4380 Z-score: 3430.2 bits: 645.0 E(85289): 2.5e-184 Smith-Waterman score: 4380; 100.0% identity (100.0% similar) in 653 aa overlap (1-653:1-653) 10 20 30 40 50 60 pF1KB9 MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRSCGRRLPRQFCRSCGLVLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCRSCGRRLPRQFCRSCGLVLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGELQRRKAALEGVSKDLQAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGELQRRKAALEGVSKDLQAR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 YKAVLQEYGHEERRVQDELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YKAVLQEYGHEERRVQDELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 YFLAKIKQADVALLEETADEEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YFLAKIKQADVALLEETADEEEPELTASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 VNVEDSWAMEATASAASTSVTFREMDMSPEEVVASPRASPAKQRGPEAASNIQQCLFLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNVEDSWAMEATASAASTSVTFREMDMSPEEVVASPRASPAKQRGPEAASNIQQCLFLKK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 MGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGIDSFVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGAKGSTPGMFNLPVSLYVTSQGEVLVADRGNYRIQVFTRKGFLKEIRRSPSGIDSFVLS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 FLGADLPNLTPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCVACHRSQLSKPWGITALPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLGADLPNLTPLSVAMNCQGLIGVTDSYDNSLKVYTLDGHCVACHRSQLSKPWGITALPS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 GQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNLENR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGLGLNLENR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 QNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEIL 550 560 570 580 590 600 610 620 630 640 650 pF1KB9 HFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCIKIYSYHLRRYSTP ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HFPKGGGYSVLIREGLTCPVGIALTPKGQLLVLDCWDHCIKIYSYHLRRYSTP 610 620 630 640 650 >>NP_940988 (OMIM: 254780,608072) E3 ubiquitin-protein l (395 aa) initn: 369 init1: 151 opt: 257 Z-score: 217.0 bits: 49.7 E(85289): 2.4e-05 Smith-Waterman score: 321; 27.2% identity (55.1% similar) in 412 aa overlap (246-643:16-390) 220 230 240 250 260 270 pF1KB9 SNSQVVEEQSYLLNIAEVQAVSRCDYFLAKIKQADVALLE-ETADEEEPELTASLPRELT ...:...::: .. :. . ::.:. NP_940 MAAEASESGPALHELMREAEISLLECKVCFEKFGHRQQRRPRNLS 10 20 30 40 280 290 300 310 320 330 pF1KB9 LQDVELLKVGHVGPLQIGQAVKKPRTVNVEDSWAMEATASAASTSVTFREMDMSPEEVVA ::: : :. .:::. .: . .: . .:: . . . :... NP_940 --------CGHVVCLACVAALAHPRTLALECPFCRRAC-RGCDTSDCLPVLHLI--ELLG 50 60 70 80 90 340 350 360 370 380 390 pF1KB9 SP-RASPAKQRGPEAASNIQQCLFLKKMGAKGSTPGMFNLPVSLYVTSQ-GEVLVADRGN : : ::: .:. .: . : . .:. :. . : :..: . . :.:.:. : NP_940 SALRQSPAAHRAAPSAPGALTCH--HTFGGWGT---LVN-PTGLALCPKTGRVVVVHDGR 100 110 120 130 140 400 410 420 430 440 450 pF1KB9 YRIQVFTRKGFLKEIRRSPSGIDSFVLSFLGADLPNLTPLSVAMNCQGLIGVTDSYDNSL :...: : . . . .: :. . :. . .... .:. . :::. : :. NP_940 RRVKIFDSGGGCAH-QFGEKG-DA------AQDIRYPVDVTITNDCH--VVVTDAGDRSI 150 160 170 180 190 460 470 480 490 500 510 pF1KB9 KVYTLDGHCVACHRSQLSKPWGITALPSGQFVVTDVEGGKLWCFTVDRGSGVVKYSCLCS ::. . :. .:.: :::. . :.. .::::.:.:.: . :: . ::.. . NP_940 KVFDFFGQIKLVIGGQFSLPWGVETTPQNGIVVTDAEAGSLHLLDVDFAEGVLRRTE--- 200 210 220 230 240 250 520 530 540 550 560 pF1KB9 AVRPKFVTCDAEGT-VYFTQGLGLNLENRQNEHHLEGGFSIGSV-----GPDGQLGRQIS : . :. .:. : . : :: : : : .. :. . . :: :.. NP_940 --RLQAHLCNPRGVAVSWLTGAIAVLE-----HPLALGTGVCSTRVKVFSSSMQLVGQVD 260 270 280 290 300 570 580 590 600 610 620 pF1KB9 HF-FSENEDFRCIAG-MCVDARGDLIVADSSRKEILHFPKGGGYSV---LIREGLTCPVG : .: . :. . : .:..::::.: :: . : . : .. .::. ::. NP_940 TFGLSLYFPSKITASAVTFDHQGNVIVADTSGPAILCLGKPEEFPVPKPMVTHGLSHPVA 310 320 330 340 350 360 630 640 650 pF1KB9 IALTPKGQLLVLDCWDHCIKIYSYHLRRYSTP ...: ...::::: .: ::.: NP_940 LTFTKENSLLVLDTASHSIKVYKVDWG 370 380 390 >>NP_060543 (OMIM: 613184) E3 ubiquitin-protein ligase T (485 aa) initn: 117 init1: 71 opt: 258 Z-score: 216.7 bits: 49.9 E(85289): 2.5e-05 Smith-Waterman score: 258; 23.9% identity (59.6% similar) in 255 aa overlap (11-248:7-250) 10 20 30 40 50 pF1KB9 MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLL---ASSIN ..:. : . ::::: .: .: : . :::..:..:: : . : : NP_060 MDPTALVEAIVEEVACPICM-TFLRE---PMSIDCGHSFCHSCLSGLWEIPGESQN 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 -GVRCPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLL--MCRSCGRRLPRQFCRS : ::.: .. .: . .:.. . : ..:: .:. :..: ..::. NP_060 WGYTCPLCRAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKL-KMFCKE 60 70 80 90 100 110 120 130 140 150 160 pF1KB9 CGLVLCEPCREA-DHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGEL------QRRK :..:: : .. .:. .: ..:....: : . .. : : .:.. . : .:.. NP_060 DVLIMCEACSQSPEHE--AHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKR 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 AALEGVSKDLQARYKAVLQEYGHEERRVQDELARSRKF---FTGSLAEVEKSNSQVVEEQ .: .. ...: .... :. . .: .. . :.. ...:: ... .... : NP_060 TATWKIQ--VETRKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETM--Q 170 180 190 200 210 220 230 240 250 260 270 280 pF1KB9 SYLLNIAEVQAVSRCDY-FLAKIKQADVALLEETADEEEPELTASLPRELTLQDVELLKV . :: .:. :. . ..:..:. NP_060 KLELNHSELIQQSQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLEL 230 240 250 260 270 280 >>NP_003132 (OMIM: 109092) E3 ubiquitin-protein ligase T (475 aa) initn: 178 init1: 70 opt: 256 Z-score: 215.2 bits: 49.6 E(85289): 3e-05 Smith-Waterman score: 270; 25.8% identity (55.2% similar) in 299 aa overlap (6-290:2-279) 10 20 30 40 50 60 pF1KB9 MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVR :: : . : . ::::.. :.: : ..:::..:..:. .. .. .: NP_003 MASAARLTMMWEEVTCPICLDPFVE----PVSIECGHSFCQECISQV--GKGGGSV 10 20 30 40 50 70 80 90 100 110 pF1KB9 CPFCSKITRITSLT---QLTDNLTVLKIIDTAGLSEAVGLLMCRSCGRRLPRQFCRSCGL :: : . . .: ::.. .. :: :. . :.. : :.:: . ::.. : NP_003 CPVCRQRFLLKNLRPNRQLANMVNNLKEISQEA-REGTQGERCAVHGERL-HLFCEKDGK 60 70 80 90 100 120 130 140 150 160 170 pF1KB9 VLCEPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGELQRRKAALEGVSKDL .:: : .. .. : .:..:::.: . ::: . .:::.:.. : . .. NP_003 ALCWVCAQS-RKHRDHAMVPLEEAAQE----YQEKL---QVALGELRRKQELAEKLEVEI 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB9 QARYKAVLQEYGHEERRVQDELARSRKFFTGSLAEVEKSNSQVVE----EQSYLLNIAEV . . .. :.. :......: :.: :. . : .: :: .:. :. NP_003 AIKRADWKKTVETQKSRIHAEFVQQKNF----LVEEEQRQLQELEKDEREQLRILGEKEA 170 180 190 200 210 240 250 260 270 280 pF1KB9 QAVSRCDYFLAKIKQAD-------VALLEETADEEEPELTASLPRELTLQDVELLKVGHV . ... . . :.. : . ::.:. : . .: ..: . . :: .: :: NP_003 KLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNL-KDLDITSPELRSVCHV 220 230 240 250 260 270 290 300 310 320 330 340 pF1KB9 GPLQIGQAVKKPRTVNVEDSWAMEATASAASTSVTFREMDMSPEEVVASPRASPAKQRGP :. NP_003 PGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQ 280 290 300 310 320 330 >>NP_001003818 (OMIM: 607564) tripartite motif-containin (516 aa) initn: 139 init1: 88 opt: 256 Z-score: 214.8 bits: 49.7 E(85289): 3.2e-05 Smith-Waterman score: 256; 24.9% identity (56.9% similar) in 269 aa overlap (3-262:27-285) 10 20 30 pF1KB9 MAAAAASHLNLDALREVLECPICMESFTEEQLRPKL :. .: . .: .:: . ::::.: .:: : NP_001 MCGSERILQAGNILEIRVGQAGARRVATMTSPVLVD-IREEVTCPICLELLTE----PLS 10 20 30 40 50 40 50 60 70 80 pF1KB9 LHCGHTICRQCLEKLLASSINGVR----CPFCSKITRITSLT---QLTDNLTVLKIIDTA . :::..:. :. :. : . :: :. . .: .:.. . :. . . NP_001 IDCGHSFCQACITPNGRESVIGQEGERSCPVCQTSYQPGNLRPNRHLANIVRRLREV-VL 60 70 80 90 100 110 90 100 110 120 130 140 pF1KB9 GLSEAVGLLMCRSCGRRLPRQFCRSCGLVLCEPC-READHQPPGHCTLPVKEAAEERRRD : .. . ..: . :..: . ::. : :.: : : .:. :: :. :.:.:.: .. NP_001 GPGKQLKAVLCADHGEKL-QLFCQEDGKVICWLCERSQEHR--GHHTFLVEEVAQEYQEK 120 130 140 150 160 170 150 160 170 180 190 200 pF1KB9 FGEKLTRLRELMGELQRRKAALEGVSKDLQARYKAVLQEYGHEERRVQDELARSRKFFTG : :.: .:.. : .. : .. . . . ... . : .... : : .. NP_001 FQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPERCRIQTEFNQLRNILDRVEQRELK 180 190 200 210 220 230 210 220 230 240 250 260 pF1KB9 SLAEVEKSNSQVVEEQSYLLNIAEVQAVSRCDYFLAKIKQAD-VALLEETADEEEPELTA .: . ::.. ...:: : . ..:.. . : . :.. . ::....: : NP_001 KLEQEEKKGLRIIEEAENDL-VHQTQSLRELISDLERRCQGSTMELLQDVSDVTERSEFW 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB9 SLPRELTLQDVELLKVGHVGPLQIGQAVKKPRTVNVEDSWAMEATASAASTSVTFREMDM NP_001 TLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSYWVDVTLNPHTANLNLVLAKNRRQ 300 310 320 330 340 350 >>NP_477514 (OMIM: 607564) tripartite motif-containing p (488 aa) initn: 139 init1: 88 opt: 255 Z-score: 214.3 bits: 49.5 E(85289): 3.4e-05 Smith-Waterman score: 255; 24.8% identity (56.6% similar) in 258 aa overlap (14-262:9-257) 10 20 30 40 50 60 pF1KB9 MAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTICRQCLEKLLASSINGVR .:: . ::::.: .:: : . :::..:. :. :. : . NP_477 MTSPVLVDIREEVTCPICLELLTE----PLSIDCGHSFCQACITPNGRESVIGQE 10 20 30 40 50 70 80 90 100 110 pF1KB9 ----CPFCSKITRITSLT---QLTDNLTVLKIIDTAGLSEAVGLLMCRSCGRRLPRQFCR :: :. . .: .:.. . :. . . : .. . ..: . :..: . ::. NP_477 GERSCPVCQTSYQPGNLRPNRHLANIVRRLREV-VLGPGKQLKAVLCADHGEKL-QLFCQ 60 70 80 90 100 120 130 140 150 160 170 pF1KB9 SCGLVLCEPC-READHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELMGELQRRKAALEG : :.: : : .:. :: :. :.:.:.: .. : :.: .:.. : .. : .. NP_477 EDGKVICWLCERSQEHR--GHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIRE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB9 VSKDLQARYKAVLQEYGHEERRVQDELARSRKFFTGSLAEVEKSNSQVVEEQSYLLNIAE . . . ... . : .... : : .. .: . ::.. ...:: : . . NP_477 KKTSWKNQMEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDL-VHQ 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB9 VQAVSRCDYFLAKIKQAD-VALLEETADEEEPELTASLPRELTLQDVELLKVGHVGPLQI .:.. . : . :.. . ::....: : NP_477 TQSLRELISDLERRCQGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRM 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB9 GQAVKKPRTVNVEDSWAMEATASAASTSVTFREMDMSPEEVVASPRASPAKQRGPEAASN NP_477 LRVCRELTDVQSYWVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDCSVLG 290 300 310 320 330 340 653 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 20:00:22 2016 done: Fri Nov 4 20:00:24 2016 Total Scan time: 11.660 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]