FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9887, 753 aa 1>>>pF1KB9887 753 - 753 aa - 753 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.8917+/-0.000958; mu= 6.8356+/- 0.058 mean_var=255.5413+/-50.435, 0's: 0 Z-trim(113.9): 17 B-trim: 0 in 0/54 Lambda= 0.080231 statistics sampled from 14521 (14531) to 14521 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.76), E-opt: 0.2 (0.446), width: 16 Scan time: 4.200 The best scores are: opt bits E(32554) CCDS11932.1 TCEB3B gene_id:51224|Hs108|chr18 ( 753) 5154 610.1 4.1e-174 CCDS239.2 TCEB3 gene_id:6924|Hs108|chr1 ( 798) 1551 193.1 1.5e-48 CCDS11931.1 TCEB3C gene_id:162699|Hs108|chr18 ( 546) 1472 183.8 6.5e-46 CCDS59316.1 TCEB3CL2 gene_id:100506888|Hs108|chr18 ( 546) 1420 177.7 4.2e-44 >>CCDS11932.1 TCEB3B gene_id:51224|Hs108|chr18 (753 aa) initn: 5154 init1: 5154 opt: 5154 Z-score: 3239.3 bits: 610.1 E(32554): 4.1e-174 Smith-Waterman score: 5154; 100.0% identity (100.0% similar) in 753 aa overlap (1-753:1-753) 10 20 30 40 50 60 pF1KB9 MAAGSTTLHAVEKLQVRLATKTEPKKLEKYLQKLSALPMTADILAETGIRKTVKRLRKHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 MAAGSTTLHAVEKLQVRLATKTEPKKLEKYLQKLSALPMTADILAETGIRKTVKRLRKHQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 HVGDFARDLAARWKKLVLVDRNTRPGPQDPEESASRQRFGEALQDQEKAWGFPENATAPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 HVGDFARDLAARWKKLVLVDRNTRPGPQDPEESASRQRFGEALQDQEKAWGFPENATAPR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 SPSHSPEHRRTARRTPPGQQRPHPRSHSREPRAERKCPRIAPADSGRYRASPTRTAPLRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 SPSHSPEHRRTARRTPPGQQRPHPRSHSREPRAERKCPRIAPADSGRYRASPTRTAPLRM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 PEGPEPAAPGKQPGRGHTHAAQGGPLLCPGCQGQPQGKAVVSHSKGHKSSRQEKRPLCAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 PEGPEPAAPGKQPGRGHTHAAQGGPLLCPGCQGQPQGKAVVSHSKGHKSSRQEKRPLCAQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 GDWHSPTLIREKSCGACLREETPRMPSWASARDRQPSDFKTDKEGGQAGSGQRVPALEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 GDWHSPTLIREKSCGACLREETPRMPSWASARDRQPSDFKTDKEGGQAGSGQRVPALEEA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 PDSHQKRPQHSHSNKKRPSLDGRDPGNGTHGLSPEEKEQLSNDRETQEGKPPTAHLDRTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 PDSHQKRPQHSHSNKKRPSLDGRDPGNGTHGLSPEEKEQLSNDRETQEGKPPTAHLDRTS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 VSSLSEVEEVDMAEEFEQPTLSCEKYLTYDQLRKQKKKTGKSATTALGDKQRKANESKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 VSSLSEVEEVDMAEEFEQPTLSCEKYLTYDQLRKQKKKTGKSATTALGDKQRKANESKGT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 RESWDSAKKLPPVQESQSERLQAAGADSAGPKTVPSHVFSELWDLSEAWMQANYDPLSDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 RESWDSAKKLPPVQESQSERLQAAGADSAGPKTVPSHVFSELWDLSEAWMQANYDPLSDS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 DSMTSQAKPEALSSPKFREEAAFPGRRVNAKMPVYSGSRPACQLQVPTLRQQCAQVLRNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 DSMTSQAKPEALSSPKFREEAAFPGRRVNAKMPVYSGSRPACQLQVPTLRQQCAQVLRNN 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 PDALSDVGEVPYWVLEPVLEGWRPDQLYRRKKDNHALVRETDELRRNHCFQDFKEEKPQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 PDALSDVGEVPYWVLEPVLEGWRPDQLYRRKKDNHALVRETDELRRNHCFQDFKEEKPQE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 NKTWREQYLRLPDAPEQRLRVMTTNIRSARGNNPNGREAKMICFKSVAKTPYDTSRRQEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 NKTWREQYLRLPDAPEQRLRVMTTNIRSARGNNPNGREAKMICFKSVAKTPYDTSRRQEK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB9 SAGDADPENGEIKPASKPAGSSHTPSSQSSSGGGRDSSSSILRWLPEKRANPCLSSSNEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 SAGDADPENGEIKPASKPAGSSHTPSSQSSSGGGRDSSSSILRWLPEKRANPCLSSSNEH 670 680 690 700 710 720 730 740 750 pF1KB9 AAPAAKTRKQAAKKVAPLMAKAIRDYKRRFSRR ::::::::::::::::::::::::::::::::: CCDS11 AAPAAKTRKQAAKKVAPLMAKAIRDYKRRFSRR 730 740 750 >>CCDS239.2 TCEB3 gene_id:6924|Hs108|chr1 (798 aa) initn: 1853 init1: 674 opt: 1551 Z-score: 985.1 bits: 193.1 E(32554): 1.5e-48 Smith-Waterman score: 2087; 47.7% identity (71.2% similar) in 791 aa overlap (1-753:27-798) 10 20 30 pF1KB9 MAAGSTTLHAVEKLQVRLATKTEPKKLEKYLQKL ::: :. :..:::::.:::.. .:::: :::.:: CCDS23 MHGGRSCGPRTRREPSSGEEAAPVTAMAAESA-LQVVEKLQARLAANPDPKKLLKYLKKL 10 20 30 40 50 40 50 60 70 80 90 pF1KB9 SALPMTADILAETGIRKTVKRLRKHQHVGDFARDLAARWKKLVLVDRNTRPGPQDPEESA :.::.:.:::::::. :::. ::::.:::.:::::.:.::::: :.::..: :: :.: CCDS23 STLPITVDILAETGVGKTVNSLRKHEHVGSFARDLVAQWKKLVPVERNAEPDEQDFEKSN 60 70 80 90 100 110 100 110 120 130 140 150 pF1KB9 SRQRFGEALQDQEKAWG-FPENATAPRSPSHSPEHRRTARRTPPGQQRPHPRSHSREPRA ::.: .::: .:. : . :. : : :.::.::. .: .::: ::..: : CCDS23 SRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPHKVSHGHERRD 120 130 140 150 160 170 160 170 180 190 pF1KB9 ERK-CPRIAP--------ADSGRYRASPTRTAPLRM--------PEGPEPAAPGKQPGRG ::: : :..: .: :. .. :. :.: .: : :: . ..::.: CCDS23 ERKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKG 180 190 200 210 220 230 200 210 220 230 240 250 pF1KB9 HTHAAQGGPLLCPGCQ---GQPQGKAVVSHSKGHKSSRQEKRPLCAQGDWHSPTLIREKS :..: : : . . :.:.::.:::..: ::::...:::. :..: .. .. :::: CCDS23 HSNAFQD--RLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAKSDEKASVVSREKS 240 250 260 270 280 290 260 270 280 290 300 310 pF1KB9 CGACLREETPRMPSWASARDRQPSDFKTDKEGGQAGSGQR---VPALEEAPDSHQKRPQH : .::. : :: .::.. ::. . :: . ::. . .: : : :.: :.:.: CCDS23 HKALSKEENRRPPSGDNAREKPPSS-GVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKH 300 310 320 330 340 350 320 330 340 350 360 pF1KB9 -----SHSNKKRPSLDGRDPGNGTHGLSPEEKEQLSNDRETQEGKPPTAHLDRTSVSSLS .. .:.. .::. : :.:. : :. ::. ::. .: ::: : .::: :..:: CCDS23 RDPEKAKLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKT-NLDRKSLGSLP 360 370 380 390 400 410 370 380 390 400 410 420 pF1KB9 EVEEVDMAEEFEQPTLSCEKYLTYDQLRKQKKKTGKSATTALGDKQRKANESKGTRESWD .:::.:: .::::::.: :.::.::: ::.::: :...:::::: : :.::.: .. : CCDS23 KVEETDMEDEFEQPTMSFESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKSTGKNLD 420 430 440 450 460 470 430 440 450 460 470 480 pF1KB9 SAKKLPPVQESQSERLQAAGADSAGPKTVPSHVFSELWDLSEAWMQANYDPLSDSDSMTS :..::: :....::. :::: : . ::. :. : :: .:::: :: . . ..: CCDS23 SVQKLPKVNKTKSEK--PAGADLAKLRKVPD-VLPVLPDLPLPAIQANYRPLPSLELISS 480 490 500 510 520 530 490 500 510 520 530 540 pF1KB9 -QAKPEALSSPKFREEAAFPGRRVNAKMPVYSGSRPACQLQVPTLRQQCAQVLRNNPDAL : : .:.:::. .:::.: :::.:.:: :::::. : .. ::.::: .::.:: :.. CCDS23 FQPKRKAFSSPQEEEEAGFTGRRMNSKMQVYSGSKCAYLPKMMTLHQQCIRVLKNNIDSI 540 550 560 570 580 590 550 560 570 580 590 600 pF1KB9 SDVGEVPYWVLEPVLEGWRPDQLYRRKKDNHALVRETDELRRNHCFQDFKEEKPQENKTW .:: ::: ::::::: :::::: .. ::.:..:::.: . :: .:::::.:.: ..: CCDS23 FEVGGVPYSVLEPVLERCTPDQLYRIEEYNHVLIEETDQLWKVHCHRDFKEERPEEYESW 600 610 620 630 640 650 610 620 630 640 650 660 pF1KB9 REQYLRLPDAPEQRLRVMTTNIRSARGNNPNGREAKMICFKSVAKTPYDTSRRQEK--SA ::.:::: :: ::::::.: ::. :..:.:.::.::: .:::: : :. ::::: .. CCDS23 REMYLRLQDAREQRLRVLTKNIQFAHANKPKGRQAKMAFVNSVAKPPRDVRRRQEKFGTG 660 670 680 690 700 710 670 680 690 700 710 720 pF1KB9 GDADPENGEIKPASKPAGSSHTPSSQSSSGGGRDSSSSILRWLPEKRANPCLSSSNEHAA : : ::. .:::: : ::::. .:. : . . ::. : :.:. : : CCDS23 GAAVPEKIKIKPAPYPMGSSHASASSISFNPS-----------PEEPAYDGPSTSSAHLA 720 730 740 750 760 730 740 750 pF1KB9 PAAKT------RKQAAKKVAPLMAKAIRDYKRRFSRR :.... :: ..::.::.:::.:. .: ::::: CCDS23 PVVSSTVSYDPRKPTVKKIAPMMAKTIKAFKNRFSRR 770 780 790 >>CCDS11931.1 TCEB3C gene_id:162699|Hs108|chr18 (546 aa) initn: 3033 init1: 1425 opt: 1472 Z-score: 937.8 bits: 183.8 E(32554): 6.5e-46 Smith-Waterman score: 2630; 61.2% identity (67.1% similar) in 753 aa overlap (1-753:1-546) 10 20 30 40 50 60 pF1KB9 MAAGSTTLHAVEKLQVRLATKTEPKKLEKYLQKLSALPMTADILAETGIRKTVKRLRKHQ ::::::::.:: :::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 MAAGSTTLRAVGKLQVRLATKTEPKKLEKYLQKLSALPMTADILAETGIRKTVKRLRKHQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 HVGDFARDLAARWKKLVLVDRNTRPGPQDPEESASRQRFGEALQDQEKAWGFPENATAPR ::::::::::::::::::::::: : ::::::::::::::::::..:::::::::::::: CCDS11 HVGDFARDLAARWKKLVLVDRNTGPDPQDPEESASRQRFGEALQEREKAWGFPENATAPR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 SPSHSPEHRRTARRTPPGQQRPHPRSHSREPRAERKCPRIAPADSGRYRASPTRTAPLRM :::::::::::::::::::::::::: ::::::::: ::.:::::: .: ::::::: : CCDS11 SPSHSPEHRRTARRTPPGQQRPHPRSPSREPRAERKRPRMAPADSGPHRDPPTRTAPLPM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 PEGPEPAAPGKQPGRGHTHAAQGGPLLCPGCQGQPQGKAVVSHSKGHKSSRQEKRPLCAQ :::::::.::.::::::.::::::::: ::::::::.:: :::::::::: CCDS11 PEGPEPAVPGEQPGRGHAHAAQGGPLLGQGCQGQPQGEAVGSHSKGHKSSR--------- 190 200 210 220 230 250 260 270 280 290 300 pF1KB9 GDWHSPTLIREKSCGACLREETPRMPSWASARDRQPSDFKTDKEGGQAGSGQRVPALEEA :: CCDS11 --------------GA-------------------------------------------- 310 320 330 340 350 360 pF1KB9 PDSHQKRPQHSHSNKKRPSLDGRDPGNGTHGLSPEEKEQLSNDRETQEGKPPTAHLDRTS CCDS11 ------------------------------------------------------------ 370 380 390 400 410 420 pF1KB9 VSSLSEVEEVDMAEEFEQPTLSCEKYLTYDQLRKQKKKTGKSATTALGDKQRKANESKGT CCDS11 ------------------------------------------------------------ 430 440 450 460 470 480 pF1KB9 RESWDSAKKLPPVQESQSERLQAAGADSAGPKTVPSHVFSELWDLSEAWMQANYDPLSDS ::.: :::::::::::::::::::::::::::::::::: :::::::::: :: CCDS11 -----SAQKSPPVQESQSERLQAAGADSAGPKTVPSHVFSELWDPSEAWMQANYDLLSAF 240 250 260 270 280 490 500 510 520 530 540 pF1KB9 DSMTSQAKPEALSSPKFREEAAFPGRRVNAKMPVYSGSRPACQLQVPTLRQQCAQVLRNN ..:::::.:::::.: ..::::::::::::::::::::::::::::::::::: .: ::: CCDS11 EAMTSQANPEALSAPALQEEAAFPGRRVNAKMPVYSGSRPACQLQVPTLRQQCLRVPRNN 290 300 310 320 330 340 550 560 570 580 590 600 pF1KB9 PDALSDVGEVPYWVLEPVLEGWRPDQLYRRKKDNHALVRETDELRRNHCFQDFKEEKPQE ::::.:: ::: ::::::::: :::::: .::: ::.:::::: : ::.:::::::::: CCDS11 PDALGDVEGVPYSVLEPVLEGWTPDQLYRTEKDNAALARETDELWRIHCLQDFKEEKPQE 350 360 370 380 390 400 610 620 630 640 650 660 pF1KB9 NKTWREQYLRLPDAPEQRLRVMTTNIRSARGNNPNGREAKMICFKSVAKTPYDTSRRQEK ...::: :::: :: ::::::.::.::::: :.:.::..:::::.::::::::.:::::: CCDS11 HESWRELYLRLRDAREQRLRVVTTKIRSARENKPSGRQTKMICFNSVAKTPYDASRRQEK 410 420 430 440 450 460 670 680 690 700 710 720 pF1KB9 SAGDADPENGEIKPASKPAGSSHTPSSQSSSGGGRDSSSSILRWLPEKRANPCLSSSNEH ::: ::: :::..:: ::::::..::. ... :: :... :::.: CCDS11 SAGAADPGNGEMEPAPKPAGSSQAPSGLGDGDGGSVSGGG---------------SSNRH 470 480 490 500 510 730 740 750 pF1KB9 AAPAAKTRKQAAKKVAPLMAKAIRDYKRRFSRR :::: :::::::::::::::::::::: ::::: CCDS11 AAPADKTRKQAAKKVAPLMAKAIRDYKGRFSRR 520 530 540 >>CCDS59316.1 TCEB3CL2 gene_id:100506888|Hs108|chr18 (546 aa) initn: 3007 init1: 1420 opt: 1420 Z-score: 905.3 bits: 177.7 E(32554): 4.2e-44 Smith-Waterman score: 2604; 60.8% identity (66.8% similar) in 753 aa overlap (1-753:1-546) 10 20 30 40 50 60 pF1KB9 MAAGSTTLHAVEKLQVRLATKTEPKKLEKYLQKLSALPMTADILAETGIRKTVKRLRKHQ ::::::::.:: :::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 MAAGSTTLRAVGKLQVRLATKTEPKKLEKYLQKLSALPMTADILAETGIRKTVKRLRKHQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 HVGDFARDLAARWKKLVLVDRNTRPGPQDPEESASRQRFGEALQDQEKAWGFPENATAPR ::::::::::::::::::::::: : ::::::::::::::::::..:::::::::::::: CCDS59 HVGDFARDLAARWKKLVLVDRNTGPDPQDPEESASRQRFGEALQEREKAWGFPENATAPR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 SPSHSPEHRRTARRTPPGQQRPHPRSHSREPRAERKCPRIAPADSGRYRASPTRTAPLRM :::::::::::::::::::::::::: ::::::::: ::.:::::: .: ::::::: : CCDS59 SPSHSPEHRRTARRTPPGQQRPHPRSPSREPRAERKRPRMAPADSGPHRDPPTRTAPLPM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 PEGPEPAAPGKQPGRGHTHAAQGGPLLCPGCQGQPQGKAVVSHSKGHKSSRQEKRPLCAQ :::::::.::.::::::.::::::::: ::::::::.:: :::::::::: CCDS59 PEGPEPAVPGEQPGRGHAHAAQGGPLLGQGCQGQPQGEAVGSHSKGHKSSR--------- 190 200 210 220 230 250 260 270 280 290 300 pF1KB9 GDWHSPTLIREKSCGACLREETPRMPSWASARDRQPSDFKTDKEGGQAGSGQRVPALEEA :: CCDS59 --------------GA-------------------------------------------- 310 320 330 340 350 360 pF1KB9 PDSHQKRPQHSHSNKKRPSLDGRDPGNGTHGLSPEEKEQLSNDRETQEGKPPTAHLDRTS CCDS59 ------------------------------------------------------------ 370 380 390 400 410 420 pF1KB9 VSSLSEVEEVDMAEEFEQPTLSCEKYLTYDQLRKQKKKTGKSATTALGDKQRKANESKGT CCDS59 ------------------------------------------------------------ 430 440 450 460 470 480 pF1KB9 RESWDSAKKLPPVQESQSERLQAAGADSAGPKTVPSHVFSELWDLSEAWMQANYDPLSDS ::.: :::::::::::::: ::::::::::::::::::: :::::::::: :: CCDS59 -----SAQKSPPVQESQSERLQAAVADSAGPKTVPSHVFSELWDPSEAWMQANYDLLSAF 240 250 260 270 280 490 500 510 520 530 540 pF1KB9 DSMTSQAKPEALSSPKFREEAAFPGRRVNAKMPVYSGSRPACQLQVPTLRQQCAQVLRNN ..:::::.:::::.: ..::::::::::::::::::::::::::::::::::: .: ::: CCDS59 EAMTSQANPEALSAPTLQEEAAFPGRRVNAKMPVYSGSRPACQLQVPTLRQQCLRVPRNN 290 300 310 320 330 340 550 560 570 580 590 600 pF1KB9 PDALSDVGEVPYWVLEPVLEGWRPDQLYRRKKDNHALVRETDELRRNHCFQDFKEEKPQE ::::.:: ::: .:::::::: ::: :: .::: ::.:::::: : ::.:::::::::: CCDS59 PDALGDVEGVPYSALEPVLEGWTPDQPYRTEKDNAALARETDELWRIHCLQDFKEEKPQE 350 360 370 380 390 400 610 620 630 640 650 660 pF1KB9 NKTWREQYLRLPDAPEQRLRVMTTNIRSARGNNPNGREAKMICFKSVAKTPYDTSRRQEK ...::: :::: :: ::::::.::.::::: :.:.::..:::::.::::::::.:::::: CCDS59 HESWRELYLRLRDAREQRLRVVTTKIRSARENKPSGRQTKMICFNSVAKTPYDASRRQEK 410 420 430 440 450 460 670 680 690 700 710 720 pF1KB9 SAGDADPENGEIKPASKPAGSSHTPSSQSSSGGGRDSSSSILRWLPEKRANPCLSSSNEH ::: ::: :::..:: ::::::..::. ... :: :... :::.: CCDS59 SAGAADPGNGEMEPAPKPAGSSQAPSGLGDGDGGSVSGGG---------------SSNRH 470 480 490 500 510 730 740 750 pF1KB9 AAPAAKTRKQAAKKVAPLMAKAIRDYKRRFSRR :::: :::::::::::::::::::::: ::::: CCDS59 AAPADKTRKQAAKKVAPLMAKAIRDYKGRFSRR 520 530 540 753 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 09:38:47 2016 done: Sat Nov 5 09:38:48 2016 Total Scan time: 4.200 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]