FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9893, 1292 aa 1>>>pF1KB9893 1292 - 1292 aa - 1292 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.6110+/-0.000672; mu= -18.6716+/- 0.041 mean_var=818.7316+/-181.754, 0's: 0 Z-trim(115.6): 986 B-trim: 1451 in 1/55 Lambda= 0.044823 statistics sampled from 24866 (26116) to 24866 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.636), E-opt: 0.2 (0.306), width: 16 Scan time: 12.870 The best scores are: opt bits E(85289) NP_001036064 (OMIM: 600543,615515) receptor tyrosi (1292) 9030 602.0 8.3e-171 XP_016859070 (OMIM: 600543,615515) PREDICTED: rece (1318) 7797 522.3 8.4e-147 NP_005226 (OMIM: 600543,615515) receptor tyrosine- (1308) 7348 493.3 4.6e-138 XP_016859067 (OMIM: 600543,615515) PREDICTED: rece (1334) 6115 413.6 4.7e-114 XP_005246433 (OMIM: 600543,615515) PREDICTED: rece (1298) 6060 410.0 5.4e-113 XP_016859069 (OMIM: 600543,615515) PREDICTED: rece (1324) 4827 330.3 5.5e-89 XP_016859068 (OMIM: 600543,615515) PREDICTED: rece (1333) 4636 317.9 2.9e-85 XP_005246434 (OMIM: 600543,615515) PREDICTED: rece (1282) 4503 309.3 1.1e-82 XP_006712427 (OMIM: 600543,615515) PREDICTED: rece (1323) 4503 309.3 1.1e-82 NP_004439 (OMIM: 137800,164870,211980,613659) rece (1255) 3921 271.7 2.3e-71 NP_001276865 (OMIM: 137800,164870,211980,613659) r (1240) 3917 271.4 2.8e-71 NP_001005862 (OMIM: 137800,164870,211980,613659) r (1225) 3885 269.3 1.1e-70 NP_001276866 (OMIM: 137800,164870,211980,613659) r (1055) 3802 263.9 4.3e-69 NP_001973 (OMIM: 190151,607598) receptor tyrosine- (1342) 3589 250.2 7e-65 XP_016859066 (OMIM: 600543,615515) PREDICTED: rece (1349) 3270 229.6 1.1e-58 NP_005219 (OMIM: 131550,211980,616069) epidermal g (1210) 3188 224.2 4.2e-57 XP_016859071 (OMIM: 600543,615515) PREDICTED: rece (1116) 3087 217.7 3.7e-55 NP_958439 (OMIM: 131550,211980,616069) epidermal g ( 628) 2194 159.6 6.3e-38 NP_958441 (OMIM: 131550,211980,616069) epidermal g ( 705) 2194 159.6 6.8e-38 NP_001276867 (OMIM: 137800,164870,211980,613659) r ( 603) 1655 124.7 1.9e-27 NP_958440 (OMIM: 131550,211980,616069) epidermal g ( 405) 1353 105.0 1.1e-21 XP_016869175 (OMIM: 600758) PREDICTED: focal adhes ( 942) 749 66.4 1.1e-09 XP_016869174 (OMIM: 600758) PREDICTED: focal adhes ( 948) 749 66.4 1.1e-09 XP_016869171 (OMIM: 600758) PREDICTED: focal adhes ( 976) 749 66.4 1.1e-09 XP_016869167 (OMIM: 600758) PREDICTED: focal adhes (1016) 749 66.4 1.1e-09 XP_016869148 (OMIM: 600758) PREDICTED: focal adhes (1031) 749 66.4 1.2e-09 XP_016869165 (OMIM: 600758) PREDICTED: focal adhes (1034) 749 66.4 1.2e-09 NP_722560 (OMIM: 600758) focal adhesion kinase 1 i (1052) 749 66.4 1.2e-09 XP_016869162 (OMIM: 600758) PREDICTED: focal adhes (1052) 749 66.4 1.2e-09 XP_016869160 (OMIM: 600758) PREDICTED: focal adhes (1055) 749 66.4 1.2e-09 XP_016869161 (OMIM: 600758) PREDICTED: focal adhes (1055) 749 66.4 1.2e-09 XP_016869159 (OMIM: 600758) PREDICTED: focal adhes (1058) 749 66.4 1.2e-09 XP_016869155 (OMIM: 600758) PREDICTED: focal adhes (1060) 749 66.4 1.2e-09 XP_016869153 (OMIM: 600758) PREDICTED: focal adhes (1061) 749 66.4 1.2e-09 XP_016869154 (OMIM: 600758) PREDICTED: focal adhes (1061) 749 66.4 1.2e-09 NP_001186578 (OMIM: 600758) focal adhesion kinase (1065) 749 66.4 1.2e-09 NP_005598 (OMIM: 600758) focal adhesion kinase 1 i (1074) 749 66.4 1.2e-09 XP_016869147 (OMIM: 600758) PREDICTED: focal adhes (1089) 749 66.5 1.2e-09 XP_016869146 (OMIM: 600758) PREDICTED: focal adhes (1099) 749 66.5 1.2e-09 XP_016869179 (OMIM: 600758) PREDICTED: focal adhes ( 913) 742 65.9 1.5e-09 XP_016869177 (OMIM: 600758) PREDICTED: focal adhes ( 919) 742 65.9 1.5e-09 XP_016869178 (OMIM: 600758) PREDICTED: focal adhes ( 919) 742 65.9 1.5e-09 XP_016869176 (OMIM: 600758) PREDICTED: focal adhes ( 934) 742 65.9 1.5e-09 XP_016869173 (OMIM: 600758) PREDICTED: focal adhes ( 949) 742 65.9 1.5e-09 XP_016869172 (OMIM: 600758) PREDICTED: focal adhes ( 955) 742 65.9 1.5e-09 NP_001303271 (OMIM: 600758) focal adhesion kinase ( 955) 742 65.9 1.5e-09 XP_016869170 (OMIM: 600758) PREDICTED: focal adhes ( 980) 742 65.9 1.5e-09 XP_006716673 (OMIM: 600758) PREDICTED: focal adhes ( 983) 742 65.9 1.5e-09 XP_006716672 (OMIM: 600758) PREDICTED: focal adhes ( 983) 742 65.9 1.5e-09 XP_005251070 (OMIM: 600758) PREDICTED: focal adhes ( 983) 742 65.9 1.5e-09 >>NP_001036064 (OMIM: 600543,615515) receptor tyrosine-p (1292 aa) initn: 9030 init1: 9030 opt: 9030 Z-score: 3187.5 bits: 602.0 E(85289): 8.3e-171 Smith-Waterman score: 9030; 100.0% identity (100.0% similar) in 1292 aa overlap (1-1292:1-1292) 10 20 30 40 50 60 pF1KB9 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB9 LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB9 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB9 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB9 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB9 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB9 ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB9 EYLVPQAFNIPPPIYTSRARIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYLVPQAFNIPPPIYTSRARIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQG 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB9 ATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRD 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KB9 KPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTL 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KB9 GKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRP 1210 1220 1230 1240 1250 1260 1270 1280 1290 pF1KB9 IVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV :::::::::::::::::::::::::::::::: NP_001 IVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV 1270 1280 1290 >>XP_016859070 (OMIM: 600543,615515) PREDICTED: receptor (1318 aa) initn: 9016 init1: 7797 opt: 7797 Z-score: 2756.5 bits: 522.3 E(85289): 8.4e-147 Smith-Waterman score: 8968; 98.0% identity (98.0% similar) in 1318 aa overlap (1-1292:1-1318) 10 20 30 40 50 60 pF1KB9 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 130 140 150 160 170 180 190 200 210 pF1KB9 NGSSGC--------------------------GRCHKSCTGRCWGPTENHCQTLTRTVCA :::::: :::::::::::::::::::::::::::: XP_016 NGSSGCLAHQDTEKNNPQLLQSLQPFSLITPGGRCHKSCTGRCWGPTENHCQTLTRTVCA 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB9 EQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQ 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB9 LEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKAC 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB9 DGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRT 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB9 VREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEIS 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB9 AGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWG 490 500 510 520 530 540 520 530 540 550 560 570 pF1KB9 PGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGP 550 560 570 580 590 600 580 590 600 610 620 630 pF1KB9 DNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCI 610 620 630 640 650 660 640 650 660 670 680 690 pF1KB9 YYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETEL 670 680 690 700 710 720 700 710 720 730 740 750 pF1KB9 VEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILN 730 740 750 760 770 780 760 770 780 790 800 810 pF1KB9 ETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDN 790 800 810 820 830 840 820 830 840 850 860 870 pF1KB9 IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKE 850 860 870 880 890 900 880 890 900 910 920 930 pF1KB9 YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLE 910 920 930 940 950 960 940 950 960 970 980 990 pF1KB9 KGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMK 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KB9 LPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRNQFVYRDGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRNQFVYRDGG 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KB9 FAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSA 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KB9 DPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHN 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KB9 ASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPR 1210 1220 1230 1240 1250 1260 1240 1250 1260 1270 1280 1290 pF1KB9 STLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV 1270 1280 1290 1300 1310 >>NP_005226 (OMIM: 600543,615515) receptor tyrosine-prot (1308 aa) initn: 7328 init1: 7328 opt: 7348 Z-score: 2599.6 bits: 493.3 E(85289): 4.6e-138 Smith-Waterman score: 8988; 98.8% identity (98.8% similar) in 1308 aa overlap (1-1292:1-1308) 10 20 30 40 50 60 pF1KB9 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB9 LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB9 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB9 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB9 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB9 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB9 ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 970 980 990 1000 1010 1020 1030 1040 1050 1060 pF1KB9 EYLVPQAFNIPPPIYTSRARIDSNR----------------NQFVYRDGGFAAEQGVSVP ::::::::::::::::::::::::: ::::::::::::::::::: NP_005 EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVP 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 1120 pF1KB9 YRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERS 1090 1100 1110 1120 1130 1140 1130 1140 1150 1160 1170 1180 pF1KB9 PRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED 1150 1160 1170 1180 1190 1200 1190 1200 1210 1220 1230 1240 pF1KB9 EYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ 1210 1220 1230 1240 1250 1260 1250 1260 1270 1280 1290 pF1KB9 EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV :::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV 1270 1280 1290 1300 >>XP_016859067 (OMIM: 600543,615515) PREDICTED: receptor (1334 aa) initn: 7314 init1: 6095 opt: 6115 Z-score: 2168.6 bits: 413.6 E(85289): 4.7e-114 Smith-Waterman score: 8926; 96.9% identity (96.9% similar) in 1334 aa overlap (1-1292:1-1334) 10 20 30 40 50 60 pF1KB9 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 130 140 150 160 170 180 190 200 210 pF1KB9 NGSSGC--------------------------GRCHKSCTGRCWGPTENHCQTLTRTVCA :::::: :::::::::::::::::::::::::::: XP_016 NGSSGCLAHQDTEKNNPQLLQSLQPFSLITPGGRCHKSCTGRCWGPTENHCQTLTRTVCA 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB9 EQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQ 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB9 LEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKAC 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB9 DGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRT 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB9 VREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEIS 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB9 AGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWG 490 500 510 520 530 540 520 530 540 550 560 570 pF1KB9 PGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGP 550 560 570 580 590 600 580 590 600 610 620 630 pF1KB9 DNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCI 610 620 630 640 650 660 640 650 660 670 680 690 pF1KB9 YYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETEL 670 680 690 700 710 720 700 710 720 730 740 750 pF1KB9 VEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILN 730 740 750 760 770 780 760 770 780 790 800 810 pF1KB9 ETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDN 790 800 810 820 830 840 820 830 840 850 860 870 pF1KB9 IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKE 850 860 870 880 890 900 880 890 900 910 920 930 pF1KB9 YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLE 910 920 930 940 950 960 940 950 960 970 980 990 pF1KB9 KGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMK 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 pF1KB9 LPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNR--------- ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPP 1030 1040 1050 1060 1070 1080 1050 1060 1070 1080 1090 pF1KB9 -------NQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKP ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKP 1090 1100 1110 1120 1130 1140 1100 1110 1120 1130 1140 1150 pF1KB9 VAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSR 1150 1160 1170 1180 1190 1200 1160 1170 1180 1190 1200 1210 pF1KB9 RKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAK 1210 1220 1230 1240 1250 1260 1220 1230 1240 1250 1260 1270 pF1KB9 KAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGT 1270 1280 1290 1300 1310 1320 1280 1290 pF1KB9 VLPPPPYRHRNTVV :::::::::::::: XP_016 VLPPPPYRHRNTVV 1330 >>XP_005246433 (OMIM: 600543,615515) PREDICTED: receptor (1298 aa) initn: 7161 init1: 4503 opt: 6060 Z-score: 2149.5 bits: 410.0 E(85289): 5.4e-113 Smith-Waterman score: 8798; 97.3% identity (97.5% similar) in 1308 aa overlap (1-1292:1-1298) 10 20 30 40 50 60 pF1KB9 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG ::::::::::::::::::::::::: : . .::: :::::::::::: XP_005 NSFIFKYADPDRECHPCHPNCTQGCIGSSIEDCIGL----------MDRTPLIAAGVIGG 610 620 630 640 650 670 680 690 700 710 720 pF1KB9 LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB9 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 720 730 740 750 760 770 790 800 810 820 830 840 pF1KB9 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 780 790 800 810 820 830 850 860 870 880 890 900 pF1KB9 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 840 850 860 870 880 890 910 920 930 940 950 960 pF1KB9 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KB9 ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 960 970 980 990 1000 1010 1030 1040 1050 1060 pF1KB9 EYLVPQAFNIPPPIYTSRARIDSNR----------------NQFVYRDGGFAAEQGVSVP ::::::::::::::::::::::::: ::::::::::::::::::: XP_005 EYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVP 1020 1030 1040 1050 1060 1070 1070 1080 1090 1100 1110 1120 pF1KB9 YRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERS 1080 1090 1100 1110 1120 1130 1130 1140 1150 1160 1170 1180 pF1KB9 PRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED 1140 1150 1160 1170 1180 1190 1190 1200 1210 1220 1230 1240 pF1KB9 EYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ 1200 1210 1220 1230 1240 1250 1250 1260 1270 1280 1290 pF1KB9 EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV :::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV 1260 1270 1280 1290 >>XP_016859069 (OMIM: 600543,615515) PREDICTED: receptor (1324 aa) initn: 7147 init1: 3270 opt: 4827 Z-score: 1718.5 bits: 330.3 E(85289): 5.5e-89 Smith-Waterman score: 8736; 95.4% identity (95.6% similar) in 1334 aa overlap (1-1292:1-1324) 10 20 30 40 50 60 pF1KB9 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 130 140 150 160 170 180 190 200 210 pF1KB9 NGSSGC--------------------------GRCHKSCTGRCWGPTENHCQTLTRTVCA :::::: :::::::::::::::::::::::::::: XP_016 NGSSGCLAHQDTEKNNPQLLQSLQPFSLITPGGRCHKSCTGRCWGPTENHCQTLTRTVCA 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB9 EQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQ 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB9 LEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKAC 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB9 DGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRT 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB9 VREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEIS 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB9 AGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWG 490 500 510 520 530 540 520 530 540 550 560 570 pF1KB9 PGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGP 550 560 570 580 590 600 580 590 600 610 620 630 pF1KB9 DNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCI ::::::::::::::::::::::::::::::::::::::::::::::::::: : . .::: XP_016 DNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCIGSSIEDCI 610 620 630 640 650 660 640 650 660 670 680 690 pF1KB9 YYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETEL :::::::::::::::::::::::::::::::::::::::::::::: XP_016 GL----------MDRTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETEL 670 680 690 700 710 700 710 720 730 740 750 pF1KB9 VEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILN 720 730 740 750 760 770 760 770 780 790 800 810 pF1KB9 ETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDN 780 790 800 810 820 830 820 830 840 850 860 870 pF1KB9 IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKE 840 850 860 870 880 890 880 890 900 910 920 930 pF1KB9 YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLE 900 910 920 930 940 950 940 950 960 970 980 990 pF1KB9 KGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMK 960 970 980 990 1000 1010 1000 1010 1020 1030 1040 pF1KB9 LPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNR--------- ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPP 1020 1030 1040 1050 1060 1070 1050 1060 1070 1080 1090 pF1KB9 -------NQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKP ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKP 1080 1090 1100 1110 1120 1130 1100 1110 1120 1130 1140 1150 pF1KB9 VAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSR 1140 1150 1160 1170 1180 1190 1160 1170 1180 1190 1200 1210 pF1KB9 RKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAK 1200 1210 1220 1230 1240 1250 1220 1230 1240 1250 1260 1270 pF1KB9 KAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGT 1260 1270 1280 1290 1300 1310 1280 1290 pF1KB9 VLPPPPYRHRNTVV :::::::::::::: XP_016 VLPPPPYRHRNTVV 1320 >>XP_016859068 (OMIM: 600543,615515) PREDICTED: receptor (1333 aa) initn: 5853 init1: 4569 opt: 4636 Z-score: 1651.7 bits: 317.9 E(85289): 2.9e-85 Smith-Waterman score: 8862; 96.9% identity (96.9% similar) in 1324 aa overlap (10-1292:10-1333) 10 20 30 40 50 60 pF1KB9 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 130 140 150 160 170 180 190 200 210 pF1KB9 NGSSGC--------------------------GRCHKSCTGRCWGPTENHCQTLTRTVCA :::::: :::::::::::::::::::::::::::: XP_016 NGSSGCLAHQDTEKNNPQLLQSLQPFSLITPGGRCHKSCTGRCWGPTENHCQTLTRTVCA 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB9 EQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQ 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB9 LEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKAC 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB9 DGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRT 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB9 VREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEIS 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB9 AGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWG 490 500 510 520 530 540 520 530 540 550 560 570 pF1KB9 PGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGP 550 560 570 580 590 600 580 590 600 610 620 pF1KB9 DNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGC--------- ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCIGSSIEDCI 610 620 630 640 650 660 630 640 650 660 670 pF1KB9 ------NGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKS :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLMDRCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKS 670 680 690 700 710 720 680 690 700 710 720 730 pF1KB9 IKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVP 730 740 750 760 770 780 740 750 760 770 780 790 pF1KB9 EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLM 790 800 810 820 830 840 800 810 820 830 840 850 pF1KB9 PHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKI 850 860 870 880 890 900 860 870 880 890 900 910 pF1KB9 TDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGK 910 920 930 940 950 960 920 930 940 950 960 970 pF1KB9 PYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMAR 970 980 990 1000 1010 1020 980 990 1000 1010 1020 1030 pF1KB9 DPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRA 1030 1040 1050 1060 1070 1080 1040 1050 1060 1070 1080 1090 pF1KB9 RIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPV 1090 1100 1110 1120 1130 1140 1100 1110 1120 1130 1140 1150 pF1KB9 APHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRR 1150 1160 1170 1180 1190 1200 1160 1170 1180 1190 1200 1210 pF1KB9 KNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKK 1210 1220 1230 1240 1250 1260 1220 1230 1240 1250 1260 1270 pF1KB9 AFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTV 1270 1280 1290 1300 1310 1320 1280 1290 pF1KB9 LPPPPYRHRNTVV ::::::::::::: XP_016 LPPPPYRHRNTVV 1330 >>XP_005246434 (OMIM: 600543,615515) PREDICTED: receptor (1282 aa) initn: 8863 init1: 4503 opt: 4503 Z-score: 1605.4 bits: 309.3 E(85289): 1.1e-82 Smith-Waterman score: 8840; 98.5% identity (98.7% similar) in 1292 aa overlap (1-1292:1-1282) 10 20 30 40 50 60 pF1KB9 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG ::::::::::::::::::::::::: : . .::: :::::::::::: XP_005 NSFIFKYADPDRECHPCHPNCTQGCIGSSIEDCIGL----------MDRTPLIAAGVIGG 610 620 630 640 650 670 680 690 700 710 720 pF1KB9 LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB9 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 720 730 740 750 760 770 790 800 810 820 830 840 pF1KB9 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 780 790 800 810 820 830 850 860 870 880 890 900 pF1KB9 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ 840 850 860 870 880 890 910 920 930 940 950 960 pF1KB9 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KB9 ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KB9 EYLVPQAFNIPPPIYTSRARIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EYLVPQAFNIPPPIYTSRARIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQG 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KB9 ATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRD 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KB9 KPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTL 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KB9 GKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRP 1200 1210 1220 1230 1240 1250 1270 1280 1290 pF1KB9 IVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV :::::::::::::::::::::::::::::::: XP_005 IVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV 1260 1270 1280 >>XP_006712427 (OMIM: 600543,615515) PREDICTED: receptor (1323 aa) initn: 6194 init1: 4503 opt: 4503 Z-score: 1605.3 bits: 309.3 E(85289): 1.1e-82 Smith-Waterman score: 8948; 97.7% identity (97.7% similar) in 1323 aa overlap (1-1292:1-1323) 10 20 30 40 50 60 pF1KB9 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA 550 560 570 580 590 600 610 620 630 640 pF1KB9 NSFIFKYADPDRECHPCHPNCTQGC---------------NGPTSHDCIYYPWTGHSTLP ::::::::::::::::::::::::: :::::::::::::::::::: XP_006 NSFIFKYADPDRECHPCHPNCTQGCIGSSIEDCIGLMDRCNGPTSHDCIYYPWTGHSTLP 610 620 630 640 650 660 650 660 670 680 690 700 pF1KB9 QHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAP 670 680 690 700 710 720 710 720 730 740 750 760 pF1KB9 NQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEF 730 740 750 760 770 780 770 780 790 800 810 820 pF1KB9 MDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCV 790 800 810 820 830 840 830 840 850 860 870 880 pF1KB9 QIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIK 850 860 870 880 890 900 890 900 910 920 930 940 pF1KB9 WMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPIC 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KB9 TIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQ 970 980 990 1000 1010 1020 1010 1020 1030 1040 pF1KB9 NLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNR----------------NQFV :::::::::::::::::::::::::::::::::::::::: :::: XP_006 NLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFV 1030 1040 1050 1060 1070 1080 1050 1060 1070 1080 1090 1100 pF1KB9 YRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSST 1090 1100 1110 1120 1130 1140 1110 1120 1130 1140 1150 1160 pF1KB9 QRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDN 1150 1160 1170 1180 1190 1200 1170 1180 1190 1200 1210 1220 pF1KB9 PEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNH 1210 1220 1230 1240 1250 1260 1230 1240 1250 1260 1270 1280 pF1KB9 SLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRN 1270 1280 1290 1300 1310 1320 1290 pF1KB9 TVV ::: XP_006 TVV >>NP_004439 (OMIM: 137800,164870,211980,613659) receptor (1255 aa) initn: 3387 init1: 1682 opt: 3921 Z-score: 1402.1 bits: 271.7 E(85289): 2.3e-71 Smith-Waterman score: 3966; 47.6% identity (71.1% similar) in 1287 aa overlap (10-1269:9-1249) 10 20 30 40 50 pF1KB9 MKPATGLWVWVSLLVAAGTVQP-SDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVV : .::.: . : . : .::.::. :: .. : . ::. :..:.:: NP_004 MELAALCRW-GLLLA--LLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 MGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAI .::::.: . : .::::....:: ::::.: :: : .::. :::.:::.:.:: ::::. NP_004 QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 FLNYRKDGNF---------GLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNP . : .: ::.:: :..:::::.::: ...: ::: ::: :.:: .. NP_004 LDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKN 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 WPSNLTLVSTNGSSGCGRCHKSCTG-RCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDC :::..:: : .: : : : :::: . . ::.::::::: : .:: :: .:: NP_004 NQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGC-ARCKGPLPTDC 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB9 CHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFC ::..::.::.::: .::.::..:: :: : .:: .:: ::. : ...::.:: : NP_004 CHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASC 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB9 VKKCPHNFV-VDSSSCVRACPSSKMEVE-ENGIKMCKPCTDICPKACDGIGTGSLMSAQT : ::.:.. .: .::. .:: ..:: :.: . :. :. : ..: :.: : ... NP_004 VTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRA 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB9 VDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSW : :.::..: .: :: :.: :: .. ::: . ..::.:.::.:..::::.: :..: NP_004 VTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAW 360 370 380 390 400 410 410 420 430 440 450 460 pF1KB9 PPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLC : .. :.:::.:: .: ::.:..: : :. ::. : ..::.:...: : :..:: NP_004 PDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLC 420 430 440 450 460 470 470 480 490 500 510 520 pF1KB9 YYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFS . ::. : :: . .: .. :: ..:..::..:..::. :::::: ::..: .: NP_004 FVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFL 480 490 500 510 520 530 530 540 550 560 570 580 pF1KB9 RGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGP ::. :.: : . .: ::. :. :. : :.:. ..: .:: :: :.:. :.:.:: : NP_004 RGQECVEECRVLQGLPREYVNARHCLPCHPECQP-QNGSVTCFGPEADQCVACAHYKDPP 540 550 560 570 580 590 590 600 610 620 630 640 pF1KB9 NCVEKCPDGLQGANSF--IFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLP :: .::.:.. :. :.:. : . :.:: :::..: .. : : NP_004 FCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGC-----------P 600 610 620 630 640 650 660 670 680 690 700 pF1KB9 QHAR-TPL--IAAGVIGGLFILVIVGLTFAVYVRRKSIK-KKRALRRFL-ETELVEPLTP . : .:: : ..:.: ....:..:..:.. ..:.. : .: ..::.: :::::::::: NP_004 AEQRASPLTSIISAVVG-ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTP 650 660 670 680 690 700 710 720 730 740 750 760 pF1KB9 SGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPK ::. :::::.::::::::..:::::::::::::::::.:.::.::::::::.: :.:.:: NP_004 SGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPK 710 720 730 740 750 760 770 780 790 800 810 820 pF1KB9 ANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLL :: :..::: .::.. :.. ::::.::. :.::::::::.::::..:.:.. .::: : NP_004 ANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDL 770 780 790 800 810 820 830 840 850 860 870 880 pF1KB9 LNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGG ::::.:::::: :::. :::::::::::::::::::::::::::::::. :: ::.:::: NP_004 LNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGG 830 840 850 860 870 880 890 900 910 920 930 940 pF1KB9 KMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLP :.:::::::: : :.:::::::::::::.:::::::.:::::::.:::::::::::::: NP_004 KVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLP 890 900 910 920 930 940 950 960 970 980 990 1000 pF1KB9 QPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPND :::::::::::.::::::::.. ::.:.::..:::::::::::..:::..: . :: : NP_004 QPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNED-LGPASPLD 950 960 970 980 990 1000 1010 1020 1030 1040 1050 pF1KB9 SKFFQNLLDEEDLEDMMDAEEYLVPQ-AFNIPPPIYTSRARIDSNRNQFVYRDGGFAAEQ : :...::...:. :..::::::::: .: : : . . . . . :.:: NP_004 STFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTL 1010 1020 1030 1040 1050 1060 1060 1070 1080 1090 1100 1110 pF1KB9 GVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVF :. : . . : :: ..:: ...:: . :. . . ... : :::: :::: NP_004 GLE-PSEEEAPRSPLAP-SEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVP 1070 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 pF1KB9 APERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGP : .: : ::..:. .:. ::.: . : ..: : : : .:. NP_004 LP-----SETD--GYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAA-RPA--GATLER 1120 1130 1140 1150 1160 1180 1190 1200 1210 1220 1230 pF1KB9 PKAEDEYVNEPLY-LNTFANTLGKAEYLKNNILSMPEKA-----KKAFDNPDYWNHSLPP ::. . : . . .:.... . ::: . . :. . :::: ::... : NP_004 PKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPE 1170 1180 1190 1200 1210 1220 1240 1250 1260 1270 1280 1290 pF1KB9 RSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV :.. :. .. : ::::::: NP_004 RGA--PPSTFKGTPT--------------AENPEYLGLDVPV 1230 1240 1250 1292 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:03:15 2016 done: Sun Nov 6 18:03:17 2016 Total Scan time: 12.870 Total Display time: 0.780 Function used was FASTA [36.3.4 Apr, 2011]