FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9914, 533 aa 1>>>pF1KB9914 533 - 533 aa - 533 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8647+/-0.0011; mu= 15.8990+/- 0.066 mean_var=81.6460+/-15.953, 0's: 0 Z-trim(104.1): 73 B-trim: 40 in 1/49 Lambda= 0.141941 statistics sampled from 7676 (7751) to 7676 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.609), E-opt: 0.2 (0.238), width: 16 Scan time: 2.730 The best scores are: opt bits E(32554) CCDS33568.1 PDE9A gene_id:5152|Hs108|chr21 ( 533) 3589 745.2 4.4e-215 CCDS33567.1 PDE9A gene_id:5152|Hs108|chr21 ( 540) 3355 697.3 1.2e-200 CCDS42943.1 PDE9A gene_id:5152|Hs108|chr21 ( 492) 3279 681.7 5.4e-196 CCDS42941.1 PDE9A gene_id:5152|Hs108|chr21 ( 507) 3119 648.9 4e-186 CCDS42946.1 PDE9A gene_id:5152|Hs108|chr21 ( 466) 3112 647.5 1e-185 CCDS42945.1 PDE9A gene_id:5152|Hs108|chr21 ( 526) 3024 629.5 3e-180 CCDS42942.1 PDE9A gene_id:5152|Hs108|chr21 ( 552) 3024 629.5 3.1e-180 CCDS33569.1 PDE9A gene_id:5152|Hs108|chr21 ( 567) 3024 629.5 3.2e-180 CCDS13690.1 PDE9A gene_id:5152|Hs108|chr21 ( 593) 3024 629.5 3.3e-180 CCDS33570.1 PDE9A gene_id:5152|Hs108|chr21 ( 491) 2929 610.0 2e-174 CCDS42947.1 PDE9A gene_id:5152|Hs108|chr21 ( 433) 2926 609.4 2.8e-174 CCDS42944.1 PDE9A gene_id:5152|Hs108|chr21 ( 459) 2924 609.0 3.9e-174 CCDS33571.1 PDE9A gene_id:5152|Hs108|chr21 ( 465) 2918 607.7 9.2e-174 CCDS72802.1 PDE4B gene_id:5142|Hs108|chr1 ( 503) 605 134.1 3.7e-31 CCDS12238.1 PDE4A gene_id:5141|Hs108|chr19 ( 647) 606 134.4 4e-31 CCDS30743.1 PDE4B gene_id:5142|Hs108|chr1 ( 564) 605 134.1 4.1e-31 CCDS45963.1 PDE4A gene_id:5141|Hs108|chr19 ( 825) 606 134.4 4.9e-31 CCDS30742.1 PDE4B gene_id:5142|Hs108|chr1 ( 721) 605 134.2 5e-31 CCDS45962.1 PDE4A gene_id:5141|Hs108|chr19 ( 860) 606 134.4 5.1e-31 CCDS58649.1 PDE4A gene_id:5141|Hs108|chr19 ( 864) 606 134.4 5.1e-31 CCDS632.1 PDE4B gene_id:5142|Hs108|chr1 ( 736) 605 134.2 5.1e-31 CCDS45961.1 PDE4A gene_id:5141|Hs108|chr19 ( 886) 606 134.4 5.2e-31 CCDS56370.1 PDE4D gene_id:5144|Hs108|chr5 ( 507) 593 131.6 2.1e-30 CCDS56369.1 PDE4D gene_id:5144|Hs108|chr5 ( 518) 593 131.6 2.1e-30 CCDS54858.1 PDE4D gene_id:5144|Hs108|chr5 ( 673) 593 131.7 2.6e-30 CCDS56371.1 PDE4D gene_id:5144|Hs108|chr5 ( 679) 593 131.7 2.6e-30 CCDS56372.1 PDE4D gene_id:5144|Hs108|chr5 ( 687) 593 131.7 2.7e-30 CCDS56373.1 PDE4D gene_id:5144|Hs108|chr5 ( 745) 593 131.7 2.8e-30 CCDS54859.1 PDE4D gene_id:5144|Hs108|chr5 ( 748) 593 131.7 2.9e-30 CCDS47213.1 PDE4D gene_id:5144|Hs108|chr5 ( 809) 593 131.8 3.1e-30 CCDS46016.1 PDE4C gene_id:5143|Hs108|chr19 ( 606) 571 127.2 5.4e-29 CCDS42523.1 PDE4C gene_id:5143|Hs108|chr19 ( 680) 571 127.2 6e-29 CCDS12373.1 PDE4C gene_id:5143|Hs108|chr19 ( 712) 571 127.2 6.2e-29 CCDS34901.1 PDE7A gene_id:5150|Hs108|chr8 ( 456) 544 121.6 2e-27 CCDS56538.1 PDE7A gene_id:5150|Hs108|chr8 ( 482) 544 121.6 2.1e-27 CCDS42786.1 PDE11A gene_id:50940|Hs108|chr2 ( 489) 534 119.6 8.7e-27 CCDS46459.1 PDE11A gene_id:50940|Hs108|chr2 ( 575) 534 119.6 1e-26 CCDS42785.1 PDE11A gene_id:50940|Hs108|chr2 ( 683) 534 119.6 1.1e-26 CCDS33334.1 PDE11A gene_id:50940|Hs108|chr2 ( 933) 534 119.7 1.5e-26 CCDS73345.1 PDE2A gene_id:5138|Hs108|chr11 ( 920) 526 118.1 4.6e-26 CCDS53678.1 PDE2A gene_id:5138|Hs108|chr11 ( 932) 526 118.1 4.6e-26 CCDS44670.1 PDE2A gene_id:5138|Hs108|chr11 ( 934) 526 118.1 4.6e-26 CCDS8216.1 PDE2A gene_id:5138|Hs108|chr11 ( 941) 526 118.1 4.7e-26 CCDS5175.1 PDE7B gene_id:27115|Hs108|chr6 ( 450) 519 116.5 6.8e-26 CCDS74612.1 PDE1A gene_id:5136|Hs108|chr2 ( 501) 504 113.4 6.3e-25 CCDS58741.1 PDE1A gene_id:5136|Hs108|chr2 ( 519) 504 113.4 6.5e-25 CCDS33344.1 PDE1A gene_id:5136|Hs108|chr2 ( 535) 504 113.4 6.6e-25 CCDS2285.1 PDE1A gene_id:5136|Hs108|chr2 ( 545) 504 113.4 6.7e-25 CCDS73477.1 PDE1B gene_id:5153|Hs108|chr12 ( 495) 503 113.2 7.2e-25 CCDS53800.1 PDE1B gene_id:5153|Hs108|chr12 ( 516) 503 113.2 7.4e-25 >>CCDS33568.1 PDE9A gene_id:5152|Hs108|chr21 (533 aa) initn: 3589 init1: 3589 opt: 3589 Z-score: 3974.8 bits: 745.2 E(32554): 4.4e-215 Smith-Waterman score: 3589; 100.0% identity (100.0% similar) in 533 aa overlap (1-533:1-533) 10 20 30 40 50 60 pF1KB9 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 VSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 VSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML 430 440 450 460 470 480 490 500 510 520 530 pF1KB9 QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA ::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 490 500 510 520 530 >>CCDS33567.1 PDE9A gene_id:5152|Hs108|chr21 (540 aa) initn: 3381 init1: 2918 opt: 3355 Z-score: 3715.8 bits: 697.3 E(32554): 1.2e-200 Smith-Waterman score: 3355; 93.5% identity (96.3% similar) in 541 aa overlap (1-533:1-540) 10 20 30 40 50 60 pF1KB9 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 VSIDPTMPANSERTPYKVRPVAIKQL---SEREELI---QSVLAQV-AEQFS-RAFKINE :::::::::::::. . .....: .: .:: ... ..: . ::::::: CCDS33 VSIDPTMPANSERNEL-ILYTSLRNLLFLPSKESWASHQHSVQSETCGHQATLRAFKINE 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 LKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 LKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 KLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 KLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINP 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB9 VTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 VTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICH 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 DLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 DLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQI 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB9 RQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 RQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEV 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB9 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 AEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLF 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB9 PMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 PMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDC 480 490 500 510 520 530 pF1KB9 A : CCDS33 A 540 >>CCDS42943.1 PDE9A gene_id:5152|Hs108|chr21 (492 aa) initn: 3279 init1: 3279 opt: 3279 Z-score: 3632.3 bits: 681.7 E(32554): 5.4e-196 Smith-Waterman score: 3279; 100.0% identity (100.0% similar) in 487 aa overlap (47-533:6-492) 20 30 40 50 60 70 pF1KB9 IDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPY :::::::::::::::::::::::::::::: CCDS42 MDAFRRNTTISLLTTDDAMVSIDPTMPANSERTPY 10 20 30 80 90 100 110 120 130 pF1KB9 KVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 KVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVV 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB9 EIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 EIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEAL 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB9 RKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 RKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRH 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB9 CFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 CFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYN 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB9 DISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 DISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFK 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB9 EKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 EKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGL 340 350 360 370 380 390 440 450 460 470 480 490 pF1KB9 PVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 PVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRI 400 410 420 430 440 450 500 510 520 530 pF1KB9 DDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA ::::::::::::::::::::::::::::::::::::: CCDS42 DDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 460 470 480 490 >>CCDS42941.1 PDE9A gene_id:5152|Hs108|chr21 (507 aa) initn: 3119 init1: 3119 opt: 3119 Z-score: 3455.0 bits: 648.9 E(32554): 4e-186 Smith-Waterman score: 3367; 95.1% identity (95.1% similar) in 533 aa overlap (1-533:1-507) 10 20 30 40 50 60 pF1KB9 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM ::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPR------------- 10 20 30 40 70 80 90 100 110 120 pF1KB9 VSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANH ::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 -------------TPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANH 50 60 70 80 90 130 140 150 160 170 180 pF1KB9 LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB9 PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB9 CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB9 NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB9 LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB9 LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML 400 410 420 430 440 450 490 500 510 520 530 pF1KB9 QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA ::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 460 470 480 490 500 >>CCDS42946.1 PDE9A gene_id:5152|Hs108|chr21 (466 aa) initn: 3112 init1: 3112 opt: 3112 Z-score: 3447.8 bits: 647.5 E(32554): 1e-185 Smith-Waterman score: 3112; 100.0% identity (100.0% similar) in 460 aa overlap (74-533:7-466) 50 60 70 80 90 100 pF1KB9 GLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQ :::::::::::::::::::::::::::::: CCDS42 MDAFRSTPYKVRPVAIKQLSEREELIQSVLAQVAEQ 10 20 30 110 120 130 140 150 160 pF1KB9 FSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 FSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPC 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB9 KYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 KYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLG 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB9 LVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDIL 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB9 ILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 ILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSN 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB9 IPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 IPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDI 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB9 SNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 SNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIP 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB9 MFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 MFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSR 400 410 420 430 440 450 530 pF1KB9 DVKNSEGDCA :::::::::: CCDS42 DVKNSEGDCA 460 >>CCDS42945.1 PDE9A gene_id:5152|Hs108|chr21 (526 aa) initn: 3098 init1: 3023 opt: 3024 Z-score: 3349.6 bits: 629.5 E(32554): 3e-180 Smith-Waterman score: 3024; 94.3% identity (96.0% similar) in 477 aa overlap (57-533:57-526) 30 40 50 60 70 80 pF1KB9 SKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQL ....: : : . . .. : CCDS42 RTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPP------ 30 40 50 60 70 80 90 100 110 120 130 140 pF1KB9 SEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 -EREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIK 90 100 110 120 130 150 160 170 180 190 200 pF1KB9 KMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 KMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLW 140 150 160 170 180 190 210 220 230 240 250 260 pF1KB9 EPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 EPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYS 200 210 220 230 240 250 270 280 290 300 310 320 pF1KB9 MVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 MVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHC 260 270 280 290 300 310 330 340 350 360 370 380 pF1KB9 AVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 AVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSN 320 330 340 350 360 370 390 400 410 420 430 440 pF1KB9 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDK 380 390 400 410 420 430 450 460 470 480 490 500 pF1KB9 VTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 VTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKK 440 450 460 470 480 490 510 520 530 pF1KB9 TDSLTSGATEKSRERSRDVKNSEGDCA ::::::::::::::::::::::::::: CCDS42 TDSLTSGATEKSRERSRDVKNSEGDCA 500 510 520 >>CCDS42942.1 PDE9A gene_id:5152|Hs108|chr21 (552 aa) initn: 3265 init1: 3023 opt: 3024 Z-score: 3349.3 bits: 629.5 E(32554): 3.1e-180 Smith-Waterman score: 3149; 89.0% identity (89.0% similar) in 547 aa overlap (47-533:6-552) 20 30 40 50 60 70 pF1KB9 IDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPY :::::::::::::::::::::::::::::: CCDS42 MDAFRRNTTISLLTTDDAMVSIDPTMPANSERTPY 10 20 30 80 pF1KB9 KVRPVAIKQLS------------------------------------------------- ::::::::::: CCDS42 KVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQ 40 50 60 70 80 90 90 100 110 120 130 pF1KB9 -----------EREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVV ::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 GCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVV 100 110 120 130 140 150 140 150 160 170 180 190 pF1KB9 EIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 EIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEAL 160 170 180 190 200 210 200 210 220 230 240 250 pF1KB9 RKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 RKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRH 220 230 240 250 260 270 260 270 280 290 300 310 pF1KB9 CFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 CFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYN 280 290 300 310 320 330 320 330 340 350 360 370 pF1KB9 DISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 DISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFK 340 350 360 370 380 390 380 390 400 410 420 430 pF1KB9 EKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 EKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGL 400 410 420 430 440 450 440 450 460 470 480 490 pF1KB9 PVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 PVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRI 460 470 480 490 500 510 500 510 520 530 pF1KB9 DDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA ::::::::::::::::::::::::::::::::::::: CCDS42 DDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 520 530 540 550 >>CCDS33569.1 PDE9A gene_id:5152|Hs108|chr21 (567 aa) initn: 3326 init1: 3023 opt: 3024 Z-score: 3349.1 bits: 629.5 E(32554): 3.2e-180 Smith-Waterman score: 3249; 88.3% identity (90.6% similar) in 565 aa overlap (3-533:3-567) 10 20 30 40 50 pF1KB9 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRN------TTISLL :::::::::::::::::::::::::::::::::::::::::::::. ..:. : CCDS33 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRTPYKVRPVAIKQL 10 20 30 40 50 60 60 70 80 pF1KB9 TT-------------------DDAMVSID-PTMPANSERTPYKVRPVAIKQL-------- .. : .:... : . : . :: . CCDS33 SAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIP 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB9 SEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 PEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIK 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB9 KMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 KMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLW 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB9 EPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 EPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYS 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB9 MVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 MVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHC 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB9 AVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 AVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSN 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB9 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 EEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDK 430 440 450 460 470 480 450 460 470 480 490 500 pF1KB9 VTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 VTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKK 490 500 510 520 530 540 510 520 530 pF1KB9 TDSLTSGATEKSRERSRDVKNSEGDCA ::::::::::::::::::::::::::: CCDS33 TDSLTSGATEKSRERSRDVKNSEGDCA 550 560 >>CCDS13690.1 PDE9A gene_id:5152|Hs108|chr21 (593 aa) initn: 3575 init1: 3023 opt: 3024 Z-score: 3348.8 bits: 629.5 E(32554): 3.3e-180 Smith-Waterman score: 3279; 89.4% identity (89.4% similar) in 565 aa overlap (29-533:29-593) 10 20 30 40 50 60 pF1KB9 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM :::::::::::::::::::::::::::::::: CCDS13 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM 10 20 30 40 50 60 70 80 pF1KB9 VSIDPTMPANSERTPYKVRPVAIKQLS--------------------------------- ::::::::::::::::::::::::::: CCDS13 VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE 70 80 90 100 110 120 90 100 110 120 pF1KB9 ---------------------------EREELIQSVLAQVAEQFSRAFKINELKAEVANH ::::::::::::::::::::::::::::::::: CCDS13 GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH 130 140 150 160 170 180 130 140 150 160 170 180 pF1KB9 LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV 190 200 210 220 230 240 190 200 210 220 230 240 pF1KB9 PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF 250 260 270 280 290 300 250 260 270 280 290 300 pF1KB9 CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN 310 320 330 340 350 360 310 320 330 340 350 360 pF1KB9 NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI 370 380 390 400 410 420 370 380 390 400 410 420 pF1KB9 LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL 430 440 450 460 470 480 430 440 450 460 470 480 pF1KB9 LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML 490 500 510 520 530 540 490 500 510 520 530 pF1KB9 QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA ::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 550 560 570 580 590 >>CCDS33570.1 PDE9A gene_id:5152|Hs108|chr21 (491 aa) initn: 3055 init1: 2918 opt: 2929 Z-score: 3244.9 bits: 610.0 E(32554): 2e-174 Smith-Waterman score: 2986; 86.3% identity (88.4% similar) in 534 aa overlap (1-533:1-491) 10 20 30 40 50 60 pF1KB9 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM ::::::::::::::::::::::: : CCDS33 MGSGSSSYRPKAIYLDIDGRIQK--------EHD-------------------------- 10 20 70 80 90 100 110 pF1KB9 VSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFS-RAFKINELKAEVAN .::. .: :: ... : . .:: ..: . :::::::::::::: CCDS33 -----HLPADHRRRHGLHRPHHAREF--RTHSVQS--ETCGHQATLRAFKINELKAEVAN 30 40 50 60 70 120 130 140 150 160 170 pF1KB9 HLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 HLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRD 80 90 100 110 120 130 180 190 200 210 220 230 pF1KB9 VPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 VPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWL 140 150 160 170 180 190 240 250 260 270 280 290 pF1KB9 FCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 FCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGY 200 210 220 230 240 250 300 310 320 330 340 350 pF1KB9 NNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 NNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITL 260 270 280 290 300 310 360 370 380 390 400 410 pF1KB9 ILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 ILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDC 320 330 340 350 360 370 420 430 440 450 460 470 pF1KB9 LLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 LLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIM 380 390 400 410 420 430 480 490 500 510 520 530 pF1KB9 LQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA :::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 LQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 440 450 460 470 480 490 533 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 14:49:28 2016 done: Sat Nov 5 14:49:29 2016 Total Scan time: 2.730 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]