FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9919, 304 aa 1>>>pF1KB9919 304 - 304 aa - 304 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7525+/-0.000312; mu= 19.7422+/- 0.019 mean_var=77.9482+/-15.928, 0's: 0 Z-trim(117.7): 309 B-trim: 1606 in 1/53 Lambda= 0.145268 statistics sampled from 29574 (29896) to 29574 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.722), E-opt: 0.2 (0.351), width: 16 Scan time: 7.510 The best scores are: opt bits E(85289) NP_031369 (OMIM: 613578) trypsin-3 isoform 1 prepr ( 304) 2146 458.8 6.2e-129 NP_001184027 (OMIM: 613578) trypsin-3 isoform 4 pr ( 240) 1630 350.5 1.9e-96 NP_002762 (OMIM: 613578) trypsin-3 isoform 2 prepr ( 247) 1623 349.1 5.4e-96 NP_001184026 (OMIM: 613578) trypsin-3 isoform 3 pr ( 261) 1622 348.9 6.4e-96 XP_011516267 (OMIM: 613578) PREDICTED: trypsin-3 i ( 333) 1619 348.4 1.2e-95 NP_002761 (OMIM: 167800,601564) trypsin-2 isoform ( 247) 1462 315.3 7.7e-86 NP_002760 (OMIM: 167800,276000,614044) trypsin-1 p ( 247) 1433 309.2 5.2e-84 XP_011514713 (OMIM: 167800,276000,614044) PREDICTE ( 472) 1433 309.5 8.1e-84 NP_001290343 (OMIM: 167800,601564) trypsin-2 isofo ( 261) 1134 246.6 3.9e-65 NP_071329 (OMIM: 606135) kallikrein-14 preproprote ( 267) 744 164.9 1.6e-40 NP_001298111 (OMIM: 606135) kallikrein-14 prepropr ( 267) 744 164.9 1.6e-40 NP_001129504 (OMIM: 604434) kallikrein-11 isoform ( 250) 723 160.4 3.3e-39 NP_006844 (OMIM: 604434) kallikrein-11 isoform 1 p ( 250) 723 160.4 3.3e-39 NP_659196 (OMIM: 604434) kallikrein-11 isoform 2 [ ( 282) 723 160.5 3.5e-39 NP_001070959 (OMIM: 605643) kallikrein-5 prepropro ( 293) 711 158.0 2.1e-38 XP_011525005 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 711 158.0 2.1e-38 XP_011525004 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 711 158.0 2.1e-38 NP_001070960 (OMIM: 605643) kallikrein-5 prepropro ( 293) 711 158.0 2.1e-38 NP_036559 (OMIM: 605643) kallikrein-5 preproprotei ( 293) 711 158.0 2.1e-38 NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 pr ( 260) 699 155.4 1.1e-37 NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 pr ( 305) 699 155.5 1.2e-37 NP_056411 (OMIM: 605505) kallikrein-13 precursor [ ( 277) 696 154.8 1.8e-37 NP_001012982 (OMIM: 602652) kallikrein-6 isoform A ( 244) 681 151.6 1.4e-36 NP_002765 (OMIM: 602652) kallikrein-6 isoform A pr ( 244) 681 151.6 1.4e-36 NP_036447 (OMIM: 605504) kallikrein-9 precursor [H ( 250) 672 149.8 5.4e-36 NP_665901 (OMIM: 605539) kallikrein-12 isoform 2 p ( 248) 663 147.9 2e-35 NP_644806 (OMIM: 604438) kallikrein-7 isoform 1 pr ( 253) 659 147.0 3.6e-35 NP_005037 (OMIM: 604438) kallikrein-7 isoform 1 pr ( 253) 659 147.0 3.6e-35 NP_062544 (OMIM: 605539) kallikrein-12 isoform 1 p ( 254) 625 139.9 5e-33 XP_005259119 (OMIM: 602673) PREDICTED: kallikrein- ( 276) 615 137.9 2.3e-32 XP_006723350 (OMIM: 602673) PREDICTED: kallikrein- ( 276) 615 137.9 2.3e-32 XP_006723352 (OMIM: 602673) PREDICTED: kallikrein- ( 276) 615 137.9 2.3e-32 NP_002767 (OMIM: 602673) kallikrein-10 preproprote ( 276) 615 137.9 2.3e-32 XP_016882482 (OMIM: 602673) PREDICTED: kallikrein- ( 276) 615 137.9 2.3e-32 NP_665895 (OMIM: 602673) kallikrein-10 preproprote ( 276) 615 137.9 2.3e-32 NP_001070968 (OMIM: 602673) kallikrein-10 prepropr ( 276) 615 137.9 2.3e-32 XP_005259118 (OMIM: 602673) PREDICTED: kallikrein- ( 276) 615 137.9 2.3e-32 NP_004908 (OMIM: 204700,603767) kallikrein-4 isofo ( 254) 611 137.0 3.8e-32 NP_001897 (OMIM: 118890) chymotrypsinogen B isofor ( 263) 606 135.9 8.1e-32 XP_011526282 (OMIM: 610477) PREDICTED: transmembra ( 690) 608 136.8 1.2e-31 XP_011526284 (OMIM: 610477) PREDICTED: transmembra ( 562) 607 136.5 1.2e-31 NP_892018 (OMIM: 610477) transmembrane protease se (1059) 608 137.0 1.6e-31 XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 608 137.0 1.6e-31 XP_011524674 (OMIM: 604434) PREDICTED: kallikrein- ( 275) 596 133.9 3.6e-31 XP_011524672 (OMIM: 604434) PREDICTED: kallikrein- ( 275) 596 133.9 3.6e-31 NP_001161077 (OMIM: 604434) kallikrein-11 isoform ( 275) 596 133.9 3.6e-31 XP_011524675 (OMIM: 604434) PREDICTED: kallikrein- ( 275) 596 133.9 3.6e-31 XP_011524673 (OMIM: 604434) PREDICTED: kallikrein- ( 275) 596 133.9 3.6e-31 XP_011524671 (OMIM: 604434) PREDICTED: kallikrein- ( 307) 596 133.9 3.9e-31 XP_005262454 (OMIM: 122700,300746,300807,306900) P ( 418) 580 130.7 4.9e-30 >>NP_031369 (OMIM: 613578) trypsin-3 isoform 1 prepropro (304 aa) initn: 2146 init1: 2146 opt: 2146 Z-score: 2435.7 bits: 458.8 E(85289): 6.2e-129 Smith-Waterman score: 2146; 100.0% identity (100.0% similar) in 304 aa overlap (1-304:1-304) 10 20 30 40 50 60 pF1KB9 MCGPDDRCPARWPGPGRAVKCGKGLAAARPGRVERGGAQRGGAGLELHPLLGGRTWRAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_031 MCGPDDRCPARWPGPGRAVKCGKGLAAARPGRVERGGAQRGGAGLELHPLLGGRTWRAAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DADGCEALGTVAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_031 DADGCEALGTVAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 CYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_031 CYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 STISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_031 STISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 FCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWKNRPGVYTKVYNYVDWIKDTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_031 FCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWKNRPGVYTKVYNYVDWIKDTI 250 260 270 280 290 300 pF1KB9 AANS :::: NP_031 AANS >>NP_001184027 (OMIM: 613578) trypsin-3 isoform 4 prepro (240 aa) initn: 1630 init1: 1630 opt: 1630 Z-score: 1852.5 bits: 350.5 E(85289): 1.9e-96 Smith-Waterman score: 1630; 99.6% identity (99.6% similar) in 236 aa overlap (69-304:5-240) 40 50 60 70 80 90 pF1KB9 QRGGAGLELHPLLGGRTWRAARDADGCEALGTVAVPFDDDDKIVGGYTCEENSLPYQVSL : :::::::::::::::::::::::::::: NP_001 MGPAGEVAVPFDDDDKIVGGYTCEENSLPYQVSL 10 20 30 100 110 120 130 140 150 pF1KB9 NSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNR 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB9 DTLDNDIMLIKLSSPAVINARVSTISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTLDNDIMLIKLSSPAVINARVSTISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCL 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB9 DAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCA 160 170 180 190 200 210 280 290 300 pF1KB9 WKNRPGVYTKVYNYVDWIKDTIAANS :::::::::::::::::::::::::: NP_001 WKNRPGVYTKVYNYVDWIKDTIAANS 220 230 240 >>NP_002762 (OMIM: 613578) trypsin-3 isoform 2 prepropro (247 aa) initn: 1623 init1: 1623 opt: 1623 Z-score: 1844.5 bits: 349.1 E(85289): 5.4e-96 Smith-Waterman score: 1623; 100.0% identity (100.0% similar) in 234 aa overlap (71-304:14-247) 50 60 70 80 90 100 pF1KB9 GGAGLELHPLLGGRTWRAARDADGCEALGTVAVPFDDDDKIVGGYTCEENSLPYQVSLNS :::::::::::::::::::::::::::::: NP_002 MNPFLILAFVGAAVAVPFDDDDKIVGGYTCEENSLPYQVSLNS 10 20 30 40 110 120 130 140 150 160 pF1KB9 GSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDT 50 60 70 80 90 100 170 180 190 200 210 220 pF1KB9 LDNDIMLIKLSSPAVINARVSTISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LDNDIMLIKLSSPAVINARVSTISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDA 110 120 130 140 150 160 230 240 250 260 270 280 pF1KB9 PVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWK 170 180 190 200 210 220 290 300 pF1KB9 NRPGVYTKVYNYVDWIKDTIAANS :::::::::::::::::::::::: NP_002 NRPGVYTKVYNYVDWIKDTIAANS 230 240 >>NP_001184026 (OMIM: 613578) trypsin-3 isoform 3 prepro (261 aa) initn: 1622 init1: 1622 opt: 1622 Z-score: 1843.0 bits: 348.9 E(85289): 6.4e-96 Smith-Waterman score: 1622; 99.6% identity (100.0% similar) in 234 aa overlap (71-304:28-261) 50 60 70 80 90 100 pF1KB9 GGAGLELHPLLGGRTWRAARDADGCEALGTVAVPFDDDDKIVGGYTCEENSLPYQVSLNS .::::::::::::::::::::::::::::: NP_001 MHMRETSGFTLKKGRSAPLVFHPPDALIAVPFDDDDKIVGGYTCEENSLPYQVSLNS 10 20 30 40 50 110 120 130 140 150 160 pF1KB9 GSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDT 60 70 80 90 100 110 170 180 190 200 210 220 pF1KB9 LDNDIMLIKLSSPAVINARVSTISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDNDIMLIKLSSPAVINARVSTISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDA 120 130 140 150 160 170 230 240 250 260 270 280 pF1KB9 PVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWK 180 190 200 210 220 230 290 300 pF1KB9 NRPGVYTKVYNYVDWIKDTIAANS :::::::::::::::::::::::: NP_001 NRPGVYTKVYNYVDWIKDTIAANS 240 250 260 >>XP_011516267 (OMIM: 613578) PREDICTED: trypsin-3 isofo (333 aa) initn: 1684 init1: 1618 opt: 1619 Z-score: 1838.3 bits: 348.4 E(85289): 1.2e-95 Smith-Waterman score: 1641; 80.6% identity (86.3% similar) in 315 aa overlap (8-304:21-333) 10 20 30 40 pF1KB9 MCGPDDRCPARWPGPGRAVKCGKGLAAARPG----RVERG-GAQR-G : : : ::.. :.: .: :. .. : : .: XP_011 MPRTLAGTGKGGQVWKGSGGCQAWQSGAGRGAA-GRGGPGAAPASGWTHLASGAGCRRLR 10 20 30 40 50 50 60 70 80 pF1KB9 GAG--LELHPLLGGRTWRAA-----RDAD-----GCEALGTVAVPFDDDDKIVGGYTCEE ::: . .:... :. : .: . . :: ::::::::::::::::::: XP_011 GAGHSTQKNPVFNWLIWKILERERHRGSDYLPIRNQNELG-VAVPFDDDDKIVGGYTCEE 60 70 80 90 100 110 90 100 110 120 130 140 pF1KB9 NSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAK 120 130 140 150 160 170 150 160 170 180 190 200 pF1KB9 IIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTAPPAAGTECLISGWGNTLSFGA ::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::: XP_011 IIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGA 180 190 200 210 220 230 210 220 230 240 250 260 pF1KB9 DYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQG 240 250 260 270 280 290 270 280 290 300 pF1KB9 VVSWGHGCAWKNRPGVYTKVYNYVDWIKDTIAANS ::::::::::::::::::::::::::::::::::: XP_011 VVSWGHGCAWKNRPGVYTKVYNYVDWIKDTIAANS 300 310 320 330 >>NP_002761 (OMIM: 167800,601564) trypsin-2 isoform 2 pr (247 aa) initn: 1462 init1: 1462 opt: 1462 Z-score: 1662.1 bits: 315.3 E(85289): 7.7e-86 Smith-Waterman score: 1462; 89.7% identity (96.2% similar) in 234 aa overlap (71-304:14-247) 50 60 70 80 90 100 pF1KB9 GGAGLELHPLLGGRTWRAARDADGCEALGTVAVPFDDDDKIVGGYTCEENSLPYQVSLNS ::.:::::::::::: :::::.:::::::: NP_002 MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNS 10 20 30 40 110 120 130 140 150 160 pF1KB9 GSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDT : ::::::::::::::::.::::.:::::::::::.::::::::::::::::::::: : NP_002 GYHFCGGSLISEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRT 50 60 70 80 90 100 170 180 190 200 210 220 pF1KB9 LDNDIMLIKLSSPAVINARVSTISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDA :::::.:::::::::::.:::.::::::::::::: :::::::::: ::::::::.:::: NP_002 LDNDILLIKLSSPAVINSRVSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDA 110 120 130 140 150 160 230 240 250 260 270 280 pF1KB9 PVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWK :::.::::.:::::::::.::::::::::::::: ::::::: ::.:::.::::.::: : NP_002 PVLSQAECEASYPGKITNNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQK 170 180 190 200 210 220 290 300 pF1KB9 NRPGVYTKVYNYVDWIKDTIAANS :::::::::::::::::::::::: NP_002 NRPGVYTKVYNYVDWIKDTIAANS 230 240 >>NP_002760 (OMIM: 167800,276000,614044) trypsin-1 prepr (247 aa) initn: 1433 init1: 1433 opt: 1433 Z-score: 1629.2 bits: 309.2 E(85289): 5.2e-84 Smith-Waterman score: 1433; 87.2% identity (96.2% similar) in 234 aa overlap (71-304:14-247) 50 60 70 80 90 100 pF1KB9 GGAGLELHPLLGGRTWRAARDADGCEALGTVAVPFDDDDKIVGGYTCEENSLPYQVSLNS .:.::::::::::::.:::::.:::::::: NP_002 MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNS 10 20 30 40 110 120 130 140 150 160 pF1KB9 GSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDT : ::::::::.:::::::.::::.:::::::::::.::::::::::::::::::.:.: : NP_002 GYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKT 50 60 70 80 90 100 170 180 190 200 210 220 pF1KB9 LDNDIMLIKLSSPAVINARVSTISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDA :.:::::::::: ::::::::::::::::::.::.::::::::: : ::::::::.:::: NP_002 LNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDA 110 120 130 140 150 160 230 240 250 260 270 280 pF1KB9 PVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWK :::.::.:.::::::::..::::::::::::::: ::::::::::::::::::: ::: : NP_002 PVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQK 170 180 190 200 210 220 290 300 pF1KB9 NRPGVYTKVYNYVDWIKDTIAANS :.::::::::::: :::.:::::: NP_002 NKPGVYTKVYNYVKWIKNTIAANS 230 240 >>XP_011514713 (OMIM: 167800,276000,614044) PREDICTED: t (472 aa) initn: 1457 init1: 1433 opt: 1433 Z-score: 1625.8 bits: 309.5 E(85289): 8.1e-84 Smith-Waterman score: 1433; 87.2% identity (96.2% similar) in 234 aa overlap (71-304:239-472) 50 60 70 80 90 100 pF1KB9 GGAGLELHPLLGGRTWRAARDADGCEALGTVAVPFDDDDKIVGGYTCEENSLPYQVSLNS .:.::::::::::::.:::::.:::::::: XP_011 VRYKDESSTTSQAHSTTMNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNS 210 220 230 240 250 260 110 120 130 140 150 160 pF1KB9 GSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDT : ::::::::.:::::::.::::.:::::::::::.::::::::::::::::::.:.: : XP_011 GYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKT 270 280 290 300 310 320 170 180 190 200 210 220 pF1KB9 LDNDIMLIKLSSPAVINARVSTISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDA :.:::::::::: ::::::::::::::::::.::.::::::::: : ::::::::.:::: XP_011 LNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDA 330 340 350 360 370 380 230 240 250 260 270 280 pF1KB9 PVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWK :::.::.:.::::::::..::::::::::::::: ::::::::::::::::::: ::: : XP_011 PVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQK 390 400 410 420 430 440 290 300 pF1KB9 NRPGVYTKVYNYVDWIKDTIAANS :.::::::::::: :::.:::::: XP_011 NKPGVYTKVYNYVKWIKNTIAANS 450 460 470 >>NP_001290343 (OMIM: 167800,601564) trypsin-2 isoform 1 (261 aa) initn: 1113 init1: 1113 opt: 1134 Z-score: 1290.3 bits: 246.6 E(85289): 3.9e-65 Smith-Waterman score: 1424; 84.7% identity (90.7% similar) in 248 aa overlap (71-304:14-261) 50 60 70 80 90 100 pF1KB9 GGAGLELHPLLGGRTWRAARDADGCEALGTVAVPFDDDDKIVGGYTCEENSLPYQVSLNS ::.:::::::::::: :::::.:::::::: NP_001 MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNS 10 20 30 40 110 120 130 140 pF1KB9 GSHFCGGSLISEQWVVSAAHCYKT--------------RIQVRLGEHNIKVLEGNEQFIN : ::::::::::::::::.::::. :::::::::::.:::::::::: NP_001 GYHFCGGSLISEQWVVSAGHCYKSAINSKLSGRGCEYHRIQVRLGEHNIEVLEGNEQFIN 50 60 70 80 90 100 150 160 170 180 190 200 pF1KB9 AAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTAPPAAGTECLISGWGNTLS ::::::::::: ::::::.:::::::::::.:::.::::::::::::: :::::::::: NP_001 AAKIIRHPKYNSRTLDNDILLIKLSSPAVINSRVSAISLPTAPPAAGTESLISGWGNTLS 110 120 130 140 150 160 210 220 230 240 250 260 pF1KB9 FGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQ ::::::::.:::::::.::::.:::::::::.::::::::::::::: ::::::: ::. NP_001 SGADYPDELQCLDAPVLSQAECEASYPGKITNNMFCVGFLEGGKDSCQGDSGGPVVSNGE 170 180 190 200 210 220 270 280 290 300 pF1KB9 LQGVVSWGHGCAWKNRPGVYTKVYNYVDWIKDTIAANS :::.::::.::: ::::::::::::::::::::::::: NP_001 LQGIVSWGYGCAQKNRPGVYTKVYNYVDWIKDTIAANS 230 240 250 260 >>NP_071329 (OMIM: 606135) kallikrein-14 preproprotein [ (267 aa) initn: 747 init1: 589 opt: 744 Z-score: 848.4 bits: 164.9 E(85289): 1.6e-40 Smith-Waterman score: 744; 43.1% identity (70.0% similar) in 260 aa overlap (50-300:5-264) 20 30 40 50 60 70 pF1KB9 KCGKGLAAARPGRVERGGAQRGGAGLELHPLLGGRTWRAA-RDADGCEALGTVAVPF--- .::. :: .: . :: ..:. . NP_071 MSLRVLGSGTWPSAPKMFLLLTALQVLAIAMTQS 10 20 30 80 90 100 110 120 130 pF1KB9 -DDDDKIVGGYTCEENSLPYQVSLNSGSH---FCGGSLISEQWVVSAAHCYKTRIQVRLG .:..::.::.:: ..: :.:..: .: . .:::.:.: :::..:::: . .:: :: NP_071 QEDENKIIGGHTCTRSSQPWQAALLAGPRRRFLCGGALLSGQWVITAAHCGRPILQVALG 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB9 EHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTAPPA .::.. :...: . ... . ::.:: : :::.::..:..:: :. : : . : . NP_071 KHNLRRWEATQQVLRVVRQVTHPNYNSRTHDNDLMLLQLQQPARIGRAVRPIEVTQACAS 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB9 AGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKD :: : .::::. : : :: :.:.. . . :. .:: :: .: :.: .:::: NP_071 PGTSCRVSGWGTISSPIARYPASLQCVNINISPDEVCQKAYPRTITPGMVCAGVPQGGKD 160 170 180 190 200 210 260 270 280 290 300 pF1KB9 SCQRDSGGPVVCNGQLQGVVSWG-HGCAWKNRPGVYTKVYNYVDWIKDTIAANS ::: :::::.:: :::::.:::: . :: . :::::.. .: .::..:. NP_071 SCQGDSGGPLVCRGQLQGLVSWGMERCALPGYPGVYTNLCKYRSWIEETMRDK 220 230 240 250 260 304 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 09:36:33 2016 done: Fri Nov 4 09:36:35 2016 Total Scan time: 7.510 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]