FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9949, 532 aa 1>>>pF1KB9949 532 - 532 aa - 532 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.2926+/-0.000827; mu= -20.8233+/- 0.048 mean_var=922.1821+/-212.914, 0's: 0 Z-trim(112.2): 118 B-trim: 0 in 0/50 Lambda= 0.042234 statistics sampled from 21023 (21097) to 21023 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.602), E-opt: 0.2 (0.247), width: 16 Scan time: 6.660 The best scores are: opt bits E(85289) XP_011538405 (OMIM: 174900,601299,610069) PREDICTE ( 532) 3626 238.1 5.2e-62 NP_004320 (OMIM: 174900,601299,610069) bone morpho ( 532) 3626 238.1 5.2e-62 XP_011538406 (OMIM: 174900,601299,610069) PREDICTE ( 532) 3626 238.1 5.2e-62 NP_001243722 (OMIM: 112600,603248,609441,616849) b ( 532) 2538 171.8 4.7e-42 NP_001243721 (OMIM: 112600,603248,609441,616849) b ( 502) 2520 170.7 9.7e-42 NP_001194 (OMIM: 112600,603248,609441,616849) bone ( 502) 2520 170.7 9.7e-42 XP_016864047 (OMIM: 112600,603248,609441,616849) P ( 502) 2520 170.7 9.7e-42 XP_016864049 (OMIM: 112600,603248,609441,616849) P ( 502) 2520 170.7 9.7e-42 XP_016864050 (OMIM: 112600,603248,609441,616849) P ( 502) 2520 170.7 9.7e-42 XP_016864048 (OMIM: 112600,603248,609441,616849) P ( 502) 2520 170.7 9.7e-42 XP_011530503 (OMIM: 112600,603248,609441,616849) P ( 502) 2520 170.7 9.7e-42 NP_001243723 (OMIM: 112600,603248,609441,616849) b ( 502) 2520 170.7 9.7e-42 NP_001293139 (OMIM: 132800,190181) TGF-beta recept ( 507) 1665 118.6 4.7e-26 NP_004603 (OMIM: 132800,190181) TGF-beta receptor ( 503) 1655 117.9 7.1e-26 XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 1602 114.6 6.2e-25 XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 1602 114.6 6.2e-25 XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF- ( 434) 1592 114.0 9.4e-25 NP_660302 (OMIM: 608981) activin receptor type-1C ( 493) 1585 113.7 1.4e-24 XP_005246996 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1580 113.4 1.7e-24 XP_011510408 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1580 113.4 1.7e-24 XP_011510410 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1580 113.4 1.7e-24 XP_006712888 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1580 113.4 1.7e-24 XP_011510409 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1580 113.4 1.7e-24 NP_001096 (OMIM: 102576,135100) activin receptor t ( 509) 1580 113.4 1.7e-24 XP_005246997 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1580 113.4 1.7e-24 NP_001104537 (OMIM: 102576,135100) activin recepto ( 509) 1580 113.4 1.7e-24 NP_004293 (OMIM: 601300) activin receptor type-1B ( 505) 1564 112.4 3.3e-24 NP_064732 (OMIM: 601300) activin receptor type-1B ( 453) 1523 109.8 1.8e-23 NP_001104501 (OMIM: 608981) activin receptor type- ( 443) 1522 109.8 1.8e-23 NP_001070869 (OMIM: 600376,601284) serine/threonin ( 503) 1454 105.7 3.5e-22 NP_000011 (OMIM: 600376,601284) serine/threonine-p ( 503) 1454 105.7 3.5e-22 XP_005269292 (OMIM: 600376,601284) PREDICTED: seri ( 503) 1454 105.7 3.5e-22 XP_011517252 (OMIM: 132800,190181) PREDICTED: TGF- ( 357) 1444 104.9 4.4e-22 NP_001124388 (OMIM: 132800,190181) TGF-beta recept ( 426) 1444 105.0 4.8e-22 NP_001104502 (OMIM: 608981) activin receptor type- ( 413) 1370 100.5 1.1e-20 XP_011537310 (OMIM: 600376,601284) PREDICTED: seri ( 413) 1227 91.7 4.5e-18 XP_016875688 (OMIM: 601300) PREDICTED: activin rec ( 494) 1024 79.5 2.6e-14 XP_016875689 (OMIM: 601300) PREDICTED: activin rec ( 494) 1024 79.5 2.6e-14 NP_064733 (OMIM: 601300) activin receptor type-1B ( 546) 1024 79.6 2.8e-14 XP_016875690 (OMIM: 601300) PREDICTED: activin rec ( 381) 1012 78.6 3.8e-14 NP_001104503 (OMIM: 608981) activin receptor type- ( 336) 993 77.4 7.9e-14 NP_001265509 (OMIM: 102581) activin receptor type- ( 405) 789 65.0 4.8e-10 NP_001265508 (OMIM: 102581) activin receptor type- ( 513) 789 65.2 5.5e-10 NP_001607 (OMIM: 102581) activin receptor type-2A ( 513) 789 65.2 5.5e-10 XP_016863005 (OMIM: 602730,613751) PREDICTED: acti ( 511) 717 60.8 1.2e-08 NP_001097 (OMIM: 602730,613751) activin receptor t ( 512) 717 60.8 1.2e-08 XP_016863004 (OMIM: 602730,613751) PREDICTED: acti ( 518) 717 60.8 1.2e-08 XP_016863003 (OMIM: 602730,613751) PREDICTED: acti ( 526) 717 60.8 1.2e-08 XP_005265640 (OMIM: 602730,613751) PREDICTED: acti ( 533) 717 60.8 1.2e-08 XP_016862595 (OMIM: 133239,190182,610168,614331) P ( 532) 715 60.7 1.3e-08 >>XP_011538405 (OMIM: 174900,601299,610069) PREDICTED: b (532 aa) initn: 3626 init1: 3626 opt: 3626 Z-score: 1234.3 bits: 238.1 E(85289): 5.2e-62 Smith-Waterman score: 3626; 100.0% identity (100.0% similar) in 532 aa overlap (1-532:1-532) 10 20 30 40 50 60 pF1KB9 MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 TIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 KSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 RDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 HFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLR 430 440 450 460 470 480 490 500 510 520 530 pF1KB9 PIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI 490 500 510 520 530 >>NP_004320 (OMIM: 174900,601299,610069) bone morphogene (532 aa) initn: 3626 init1: 3626 opt: 3626 Z-score: 1234.3 bits: 238.1 E(85289): 5.2e-62 Smith-Waterman score: 3626; 100.0% identity (100.0% similar) in 532 aa overlap (1-532:1-532) 10 20 30 40 50 60 pF1KB9 MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 CYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 TIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 KSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 RDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 HFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLR 430 440 450 460 470 480 490 500 510 520 530 pF1KB9 PIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI 490 500 510 520 530 >>XP_011538406 (OMIM: 174900,601299,610069) PREDICTED: b (532 aa) initn: 3626 init1: 3626 opt: 3626 Z-score: 1234.3 bits: 238.1 E(85289): 5.2e-62 Smith-Waterman score: 3626; 100.0% identity (100.0% similar) in 532 aa overlap (1-532:1-532) 10 20 30 40 50 60 pF1KB9 MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 CYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 TIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 KSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 RDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 HFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLR 430 440 450 460 470 480 490 500 510 520 530 pF1KB9 PIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI 490 500 510 520 530 >>NP_001243722 (OMIM: 112600,603248,609441,616849) bone (532 aa) initn: 2406 init1: 2040 opt: 2538 Z-score: 876.0 bits: 171.8 E(85289): 4.7e-42 Smith-Waterman score: 2538; 70.1% identity (85.9% similar) in 531 aa overlap (3-532:10-532) 10 20 30 40 50 pF1KB9 MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPE ::.:.. .: : . .:.. ::.:: .. : . :: :.: . :: NP_001 MGWLEELNWQLHIFLLIL---LSMHTRAN--FLDNMLLRSAGKLNVGTKK-EDGESTAPT 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 DTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDS :.: : :::.:..:: : :.:.::..:::::.: ...:::. :::::::.:. NP_001 PRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 PKAQLRRTIECC-RTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSS : . ::.:::: . : ::. :.:::::. : :: :. .::::..:: . .... NP_001 PIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSL-LLVLII 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 CFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAK ::: .: : .: ::. :::::..:: ::::.:::.::::::::::::::::::::: NP_001 LFCYFRY-KRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB9 QIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFI :::::.:.:::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFI 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 AADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGT :::::::::::::::::::::::::::.:: .:::....::::::.. :::::::::..: NP_001 AADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFST 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB9 QGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEV :::::::::::::::::.::::.:::::::::::: :::::::.: :::::::::: ::: NP_001 QGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEV 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB9 LDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMRE ::::::.:::: :::::.::::::.::.::::..:::::::::::...:::::::::::: NP_001 LDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMRE 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB9 VVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI .::.:.::: :::.:::::: . :::.:::::::::::::::.::::::: ::::.:. NP_001 IVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL 480 490 500 510 520 530 >>NP_001243721 (OMIM: 112600,603248,609441,616849) bone (502 aa) initn: 2406 init1: 2040 opt: 2520 Z-score: 870.4 bits: 170.7 E(85289): 9.7e-42 Smith-Waterman score: 2520; 73.3% identity (88.2% similar) in 491 aa overlap (43-532:14-502) 20 30 40 50 60 70 pF1KB9 AYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAI :.:.: . :: :.: : :::.:.. NP_001 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSV 10 20 30 40 80 90 100 110 120 130 pF1KB9 NNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECC-RTNLCN :: : :.:.::..:::::.: ...:::. :::::::.:.: . ::.:::: . : :: NP_001 NNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECN 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB9 QYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNR . :.:::::. : :: :. .::::..:: . .... ::: .: : .: ::. NP_001 KDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLII-LFCYFRY-KRQETRPRYSI 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB9 DLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMG :::::..:: ::::.:::.::::::::::::::::::::::::::.:.::::::::::: NP_001 GLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMG 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB9 KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDY 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB9 HENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIK ::::::::.:: .:::....::::::.. :::::::::..::::::::::::::::::.: NP_001 HENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVK 290 300 310 320 330 340 380 390 400 410 420 430 pF1KB9 KNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIY :::.:::::::::::: :::::::.: :::::::::: :::::::::.:::: :::::.: NP_001 KNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMY 350 360 370 380 390 400 440 450 460 470 480 490 pF1KB9 SFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDE :::::.::.::::..:::::::::::...::::::::::::.::.:.::: :::.::: NP_001 SFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDE 410 420 430 440 450 460 500 510 520 530 pF1KB9 CLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI ::: . :::.:::::::::::::::.::::::: ::::.:. NP_001 CLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL 470 480 490 500 >>NP_001194 (OMIM: 112600,603248,609441,616849) bone mor (502 aa) initn: 2406 init1: 2040 opt: 2520 Z-score: 870.4 bits: 170.7 E(85289): 9.7e-42 Smith-Waterman score: 2520; 73.3% identity (88.2% similar) in 491 aa overlap (43-532:14-502) 20 30 40 50 60 70 pF1KB9 AYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAI :.:.: . :: :.: : :::.:.. NP_001 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSV 10 20 30 40 80 90 100 110 120 130 pF1KB9 NNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECC-RTNLCN :: : :.:.::..:::::.: ...:::. :::::::.:.: . ::.:::: . : :: NP_001 NNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECN 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB9 QYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNR . :.:::::. : :: :. .::::..:: . .... ::: .: : .: ::. NP_001 KDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLII-LFCYFRY-KRQETRPRYSI 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB9 DLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMG :::::..:: ::::.:::.::::::::::::::::::::::::::.:.::::::::::: NP_001 GLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMG 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB9 KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDY 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB9 HENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIK ::::::::.:: .:::....::::::.. :::::::::..::::::::::::::::::.: NP_001 HENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVK 290 300 310 320 330 340 380 390 400 410 420 430 pF1KB9 KNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIY :::.:::::::::::: :::::::.: :::::::::: :::::::::.:::: :::::.: NP_001 KNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMY 350 360 370 380 390 400 440 450 460 470 480 490 pF1KB9 SFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDE :::::.::.::::..:::::::::::...::::::::::::.::.:.::: :::.::: NP_001 SFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDE 410 420 430 440 450 460 500 510 520 530 pF1KB9 CLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI ::: . :::.:::::::::::::::.::::::: ::::.:. NP_001 CLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL 470 480 490 500 >>XP_016864047 (OMIM: 112600,603248,609441,616849) PREDI (502 aa) initn: 2406 init1: 2040 opt: 2520 Z-score: 870.4 bits: 170.7 E(85289): 9.7e-42 Smith-Waterman score: 2520; 73.3% identity (88.2% similar) in 491 aa overlap (43-532:14-502) 20 30 40 50 60 70 pF1KB9 AYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAI :.:.: . :: :.: : :::.:.. XP_016 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSV 10 20 30 40 80 90 100 110 120 130 pF1KB9 NNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECC-RTNLCN :: : :.:.::..:::::.: ...:::. :::::::.:.: . ::.:::: . : :: XP_016 NNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECN 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB9 QYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNR . :.:::::. : :: :. .::::..:: . .... ::: .: : .: ::. XP_016 KDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLII-LFCYFRY-KRQETRPRYSI 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB9 DLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMG :::::..:: ::::.:::.::::::::::::::::::::::::::.:.::::::::::: XP_016 GLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMG 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB9 KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDY 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB9 HENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIK ::::::::.:: .:::....::::::.. :::::::::..::::::::::::::::::.: XP_016 HENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVK 290 300 310 320 330 340 380 390 400 410 420 430 pF1KB9 KNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIY :::.:::::::::::: :::::::.: :::::::::: :::::::::.:::: :::::.: XP_016 KNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMY 350 360 370 380 390 400 440 450 460 470 480 490 pF1KB9 SFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDE :::::.::.::::..:::::::::::...::::::::::::.::.:.::: :::.::: XP_016 SFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDE 410 420 430 440 450 460 500 510 520 530 pF1KB9 CLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI ::: . :::.:::::::::::::::.::::::: ::::.:. XP_016 CLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL 470 480 490 500 >>XP_016864049 (OMIM: 112600,603248,609441,616849) PREDI (502 aa) initn: 2406 init1: 2040 opt: 2520 Z-score: 870.4 bits: 170.7 E(85289): 9.7e-42 Smith-Waterman score: 2520; 73.3% identity (88.2% similar) in 491 aa overlap (43-532:14-502) 20 30 40 50 60 70 pF1KB9 AYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAI :.:.: . :: :.: : :::.:.. XP_016 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSV 10 20 30 40 80 90 100 110 120 130 pF1KB9 NNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECC-RTNLCN :: : :.:.::..:::::.: ...:::. :::::::.:.: . ::.:::: . : :: XP_016 NNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECN 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB9 QYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNR . :.:::::. : :: :. .::::..:: . .... ::: .: : .: ::. XP_016 KDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLII-LFCYFRY-KRQETRPRYSI 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB9 DLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMG :::::..:: ::::.:::.::::::::::::::::::::::::::.:.::::::::::: XP_016 GLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMG 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB9 KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDY 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB9 HENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIK ::::::::.:: .:::....::::::.. :::::::::..::::::::::::::::::.: XP_016 HENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVK 290 300 310 320 330 340 380 390 400 410 420 430 pF1KB9 KNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIY :::.:::::::::::: :::::::.: :::::::::: :::::::::.:::: :::::.: XP_016 KNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMY 350 360 370 380 390 400 440 450 460 470 480 490 pF1KB9 SFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDE :::::.::.::::..:::::::::::...::::::::::::.::.:.::: :::.::: XP_016 SFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDE 410 420 430 440 450 460 500 510 520 530 pF1KB9 CLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI ::: . :::.:::::::::::::::.::::::: ::::.:. XP_016 CLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL 470 480 490 500 >>XP_016864050 (OMIM: 112600,603248,609441,616849) PREDI (502 aa) initn: 2406 init1: 2040 opt: 2520 Z-score: 870.4 bits: 170.7 E(85289): 9.7e-42 Smith-Waterman score: 2520; 73.3% identity (88.2% similar) in 491 aa overlap (43-532:14-502) 20 30 40 50 60 70 pF1KB9 AYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAI :.:.: . :: :.: : :::.:.. XP_016 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSV 10 20 30 40 80 90 100 110 120 130 pF1KB9 NNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECC-RTNLCN :: : :.:.::..:::::.: ...:::. :::::::.:.: . ::.:::: . : :: XP_016 NNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECN 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB9 QYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNR . :.:::::. : :: :. .::::..:: . .... ::: .: : .: ::. XP_016 KDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLII-LFCYFRY-KRQETRPRYSI 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB9 DLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMG :::::..:: ::::.:::.::::::::::::::::::::::::::.:.::::::::::: XP_016 GLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMG 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB9 KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDY 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB9 HENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIK ::::::::.:: .:::....::::::.. :::::::::..::::::::::::::::::.: XP_016 HENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVK 290 300 310 320 330 340 380 390 400 410 420 430 pF1KB9 KNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIY :::.:::::::::::: :::::::.: :::::::::: :::::::::.:::: :::::.: XP_016 KNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMY 350 360 370 380 390 400 440 450 460 470 480 490 pF1KB9 SFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDE :::::.::.::::..:::::::::::...::::::::::::.::.:.::: :::.::: XP_016 SFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDE 410 420 430 440 450 460 500 510 520 530 pF1KB9 CLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI ::: . :::.:::::::::::::::.::::::: ::::.:. XP_016 CLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL 470 480 490 500 >>XP_016864048 (OMIM: 112600,603248,609441,616849) PREDI (502 aa) initn: 2406 init1: 2040 opt: 2520 Z-score: 870.4 bits: 170.7 E(85289): 9.7e-42 Smith-Waterman score: 2520; 73.3% identity (88.2% similar) in 491 aa overlap (43-532:14-502) 20 30 40 50 60 70 pF1KB9 AYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAI :.:.: . :: :.: : :::.:.. XP_016 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSV 10 20 30 40 80 90 100 110 120 130 pF1KB9 NNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECC-RTNLCN :: : :.:.::..:::::.: ...:::. :::::::.:.: . ::.:::: . : :: XP_016 NNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECN 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB9 QYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNR . :.:::::. : :: :. .::::..:: . .... ::: .: : .: ::. XP_016 KDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLII-LFCYFRY-KRQETRPRYSI 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB9 DLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMG :::::..:: ::::.:::.::::::::::::::::::::::::::.:.::::::::::: XP_016 GLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMG 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB9 KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDY 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB9 HENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIK ::::::::.:: .:::....::::::.. :::::::::..::::::::::::::::::.: XP_016 HENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVK 290 300 310 320 330 340 380 390 400 410 420 430 pF1KB9 KNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIY :::.:::::::::::: :::::::.: :::::::::: :::::::::.:::: :::::.: XP_016 KNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMY 350 360 370 380 390 400 440 450 460 470 480 490 pF1KB9 SFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDE :::::.::.::::..:::::::::::...::::::::::::.::.:.::: :::.::: XP_016 SFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDE 410 420 430 440 450 460 500 510 520 530 pF1KB9 CLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI ::: . :::.:::::::::::::::.::::::: ::::.:. XP_016 CLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL 470 480 490 500 532 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 08:17:07 2016 done: Sat Nov 5 08:17:08 2016 Total Scan time: 6.660 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]