FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9969, 552 aa 1>>>pF1KB9969 552 - 552 aa - 552 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.6679+/-0.000425; mu= -1.6503+/- 0.026 mean_var=214.2834+/-46.425, 0's: 0 Z-trim(117.8): 64 B-trim: 1056 in 1/51 Lambda= 0.087615 statistics sampled from 30080 (30152) to 30080 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.703), E-opt: 0.2 (0.354), width: 16 Scan time: 11.400 The best scores are: opt bits E(85289) NP_059345 (OMIM: 605475) brain-specific angiogenes ( 552) 3626 471.4 3.3e-132 NP_001138360 (OMIM: 605475) brain-specific angioge ( 534) 3457 450.0 8.6e-126 XP_006721700 (OMIM: 605475) PREDICTED: brain-speci ( 535) 3445 448.5 2.5e-125 XP_005257000 (OMIM: 605475) PREDICTED: brain-speci ( 567) 3346 436.0 1.5e-121 NP_006331 (OMIM: 605475) brain-specific angiogenes ( 520) 3340 435.2 2.4e-121 NP_059344 (OMIM: 605475) brain-specific angiogenes ( 521) 3340 435.2 2.4e-121 XP_011522496 (OMIM: 605475) PREDICTED: brain-speci ( 568) 3334 434.5 4.3e-121 XP_005257005 (OMIM: 605475) PREDICTED: brain-speci ( 522) 3328 433.7 6.8e-121 XP_005257002 (OMIM: 605475) PREDICTED: brain-speci ( 553) 3229 421.2 4.2e-117 XP_005257001 (OMIM: 605475) PREDICTED: brain-speci ( 554) 3229 421.2 4.2e-117 XP_006721699 (OMIM: 605475) PREDICTED: brain-speci ( 554) 3217 419.7 1.2e-116 XP_011522495 (OMIM: 605475) PREDICTED: brain-speci ( 554) 3217 419.7 1.2e-116 XP_006721698 (OMIM: 605475) PREDICTED: brain-speci ( 555) 3217 419.7 1.2e-116 XP_016879506 (OMIM: 605475) PREDICTED: brain-speci ( 529) 3167 413.3 9.2e-115 XP_016879507 (OMIM: 605475) PREDICTED: brain-speci ( 457) 2953 386.3 1.1e-106 XP_011522499 (OMIM: 605475) PREDICTED: brain-speci ( 291) 1894 252.3 1.5e-66 XP_011522497 (OMIM: 605475) PREDICTED: brain-speci ( 292) 1882 250.8 4.4e-66 XP_011522498 (OMIM: 605475) PREDICTED: brain-speci ( 292) 1882 250.8 4.4e-66 XP_016879508 (OMIM: 605475) PREDICTED: brain-speci ( 292) 1882 250.8 4.4e-66 NP_061330 (OMIM: 611877) brain-specific angiogenes ( 511) 904 127.3 1.2e-28 XP_016869589 (OMIM: 608486) PREDICTED: metastasis ( 673) 239 43.3 0.0029 XP_016869588 (OMIM: 608486) PREDICTED: metastasis ( 689) 239 43.3 0.003 XP_016869587 (OMIM: 608486) PREDICTED: metastasis ( 690) 239 43.3 0.003 XP_016869583 (OMIM: 608486) PREDICTED: metastasis ( 738) 239 43.3 0.0032 XP_016869582 (OMIM: 608486) PREDICTED: metastasis ( 754) 239 43.3 0.0032 NP_055566 (OMIM: 608486) metastasis suppressor pro ( 755) 239 43.3 0.0032 XP_016869581 (OMIM: 608486) PREDICTED: metastasis ( 799) 239 43.3 0.0034 XP_016869575 (OMIM: 608486) PREDICTED: metastasis ( 863) 239 43.4 0.0036 XP_006716764 (OMIM: 608486) PREDICTED: metastasis ( 864) 239 43.4 0.0036 XP_016879368 (OMIM: 616951) PREDICTED: MTSS1-like ( 867) 238 43.2 0.004 XP_006716769 (OMIM: 608486) PREDICTED: metastasis ( 677) 235 42.8 0.0042 XP_005251175 (OMIM: 608486) PREDICTED: metastasis ( 694) 235 42.8 0.0043 XP_006716768 (OMIM: 608486) PREDICTED: metastasis ( 742) 235 42.8 0.0045 XP_006716767 (OMIM: 608486) PREDICTED: metastasis ( 758) 235 42.8 0.0046 NP_001269900 (OMIM: 608486) metastasis suppressor ( 759) 235 42.8 0.0046 XP_006716766 (OMIM: 608486) PREDICTED: metastasis ( 786) 235 42.8 0.0047 XP_005251170 (OMIM: 608486) PREDICTED: metastasis ( 803) 235 42.8 0.0048 XP_006716765 (OMIM: 608486) PREDICTED: metastasis ( 851) 235 42.8 0.0051 XP_006716763 (OMIM: 608486) PREDICTED: metastasis ( 867) 235 42.8 0.0052 XP_005251168 (OMIM: 608486) PREDICTED: metastasis ( 868) 235 42.8 0.0052 >>NP_059345 (OMIM: 605475) brain-specific angiogenesis i (552 aa) initn: 3626 init1: 3626 opt: 3626 Z-score: 2494.6 bits: 471.4 E(85289): 3.3e-132 Smith-Waterman score: 3626; 100.0% identity (100.0% similar) in 552 aa overlap (1-552:1-552) 10 20 30 40 50 60 pF1KB9 MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 ELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 ELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 KKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 KKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 DGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 DGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 VQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 VQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 GVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 GVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 LPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 LPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 TKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 TKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 QTASGFKQRPYSVAVPAFSQGLDDYGARSMSRNPFAHVQLKPTVTNDRCDLSAQGPEGRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 QTASGFKQRPYSVAVPAFSQGLDDYGARSMSRNPFAHVQLKPTVTNDRCDLSAQGPEGRE 490 500 510 520 530 540 550 pF1KB9 HGDGSARTLAGR :::::::::::: NP_059 HGDGSARTLAGR 550 >>NP_001138360 (OMIM: 605475) brain-specific angiogenesi (534 aa) initn: 3457 init1: 3457 opt: 3457 Z-score: 2379.3 bits: 450.0 E(85289): 8.6e-126 Smith-Waterman score: 3457; 100.0% identity (100.0% similar) in 528 aa overlap (1-528:1-528) 10 20 30 40 50 60 pF1KB9 MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 ELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 KKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 DGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 VQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 GVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 LPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 TKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 QTASGFKQRPYSVAVPAFSQGLDDYGARSMSRNPFAHVQLKPTVTNDRCDLSAQGPEGRE :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QTASGFKQRPYSVAVPAFSQGLDDYGARSMSRNPFAHVQLKPTVTNDRSAPLLS 490 500 510 520 530 550 pF1KB9 HGDGSARTLAGR >>XP_006721700 (OMIM: 605475) PREDICTED: brain-specific (535 aa) initn: 2308 init1: 2308 opt: 3445 Z-score: 2371.1 bits: 448.5 E(85289): 2.5e-125 Smith-Waterman score: 3445; 99.8% identity (99.8% similar) in 529 aa overlap (1-528:1-529) 10 20 30 40 50 60 pF1KB9 MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 ELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 KKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 DGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 VQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMN 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 GVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATT-ENK :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: XP_006 GVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTAENK 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB9 TLPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TLPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESE 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB9 KTKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KTKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB9 AQTASGFKQRPYSVAVPAFSQGLDDYGARSMSRNPFAHVQLKPTVTNDRCDLSAQGPEGR ::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AQTASGFKQRPYSVAVPAFSQGLDDYGARSMSRNPFAHVQLKPTVTNDRSAPLLS 490 500 510 520 530 540 550 pF1KB9 EHGDGSARTLAGR >>XP_005257000 (OMIM: 605475) PREDICTED: brain-specific (567 aa) initn: 3459 init1: 3345 opt: 3346 Z-score: 2303.1 bits: 436.0 E(85289): 1.5e-121 Smith-Waterman score: 3374; 94.1% identity (94.1% similar) in 560 aa overlap (2-528:2-561) 10 20 pF1KB9 MSLSRSEEMHRLTENVYK---------------------------------TIMEQFNPS ::::::::::::::::: ::::::::: XP_005 MSLSRSEEMHRLTENVYKRVEEKYQRNLFPIFSPSALKPESRNFRGESWQGTIMEQFNPS 10 20 30 40 50 60 30 40 50 60 70 80 pF1KB9 LRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQ 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB9 NQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKK 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB9 SQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKN 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB9 SAAYHSKGKELLAQKLPLWQQACADPSKIPERAVQLMQQVASNGATLPSALSASKSNLVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SAAYHSKGKELLAQKLPLWQQACADPSKIPERAVQLMQQVASNGATLPSALSASKSNLVI 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB9 SDPIPGAKPLPVPPELAPFVGRMSAQESTPIMNGVTGPDGEDYSPWADRKAAQPKSLSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDPIPGAKPLPVPPELAPFVGRMSAQESTPIMNGVTGPDGEDYSPWADRKAAQPKSLSPP 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB9 QSQSKLSDSYSNTLPVRKSVTPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QSQSKLSDSYSNTLPVRKSVTPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAA 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB9 GDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMSL 430 440 450 460 470 480 450 460 470 480 490 500 pF1KB9 QQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPAQTASGFKQRPYSVAVPAFSQGLDDYGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPAQTASGFKQRPYSVAVPAFSQGLDDYGA 490 500 510 520 530 540 510 520 530 540 550 pF1KB9 RSMSRNPFAHVQLKPTVTNDRCDLSAQGPEGREHGDGSARTLAGR ::::::::::::::::::::: XP_005 RSMSRNPFAHVQLKPTVTNDRSAPLLS 550 560 >>NP_006331 (OMIM: 605475) brain-specific angiogenesis i (520 aa) initn: 3340 init1: 3340 opt: 3340 Z-score: 2299.6 bits: 435.2 E(85289): 2.4e-121 Smith-Waterman score: 3340; 100.0% identity (100.0% similar) in 511 aa overlap (1-511:1-511) 10 20 30 40 50 60 pF1KB9 MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 ELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 KKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 KKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 DGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 VQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 GVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 LPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 TKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 TKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 QTASGFKQRPYSVAVPAFSQGLDDYGARSMSRNPFAHVQLKPTVTNDRCDLSAQGPEGRE ::::::::::::::::::::::::::::::: NP_006 QTASGFKQRPYSVAVPAFSQGLDDYGARSMSSADVEVARF 490 500 510 520 550 pF1KB9 HGDGSARTLAGR >>NP_059344 (OMIM: 605475) brain-specific angiogenesis i (521 aa) initn: 3340 init1: 3340 opt: 3340 Z-score: 2299.6 bits: 435.2 E(85289): 2.4e-121 Smith-Waterman score: 3340; 100.0% identity (100.0% similar) in 511 aa overlap (1-511:1-511) 10 20 30 40 50 60 pF1KB9 MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 ELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 ELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 KKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 KKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 DGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 DGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 VQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 VQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 GVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 GVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 LPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 LPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 TKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 TKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 QTASGFKQRPYSVAVPAFSQGLDDYGARSMSRNPFAHVQLKPTVTNDRCDLSAQGPEGRE ::::::::::::::::::::::::::::::: NP_059 QTASGFKQRPYSVAVPAFSQGLDDYGARSMSSGSGTLVSTV 490 500 510 520 550 pF1KB9 HGDGSARTLAGR >>XP_011522496 (OMIM: 605475) PREDICTED: brain-specific (568 aa) initn: 2310 init1: 2196 opt: 3334 Z-score: 2294.9 bits: 434.5 E(85289): 4.3e-121 Smith-Waterman score: 3362; 93.9% identity (93.9% similar) in 561 aa overlap (2-528:2-562) 10 20 pF1KB9 MSLSRSEEMHRLTENVYK---------------------------------TIMEQFNPS ::::::::::::::::: ::::::::: XP_011 MSLSRSEEMHRLTENVYKRVEEKYQRNLFPIFSPSALKPESRNFRGESWQGTIMEQFNPS 10 20 30 40 50 60 30 40 50 60 70 80 pF1KB9 LRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQ 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB9 NQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKK 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB9 SQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKN 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB9 SAAYHSKGKELLAQKLPLWQQACADPSKIPERAVQLMQQVASNGATLPSALSASKSNLVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAAYHSKGKELLAQKLPLWQQACADPSKIPERAVQLMQQVASNGATLPSALSASKSNLVI 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB9 SDPIPGAKPLPVPPELAPFVGRMSAQESTPIMNGVTGPDGEDYSPWADRKAAQPKSLSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDPIPGAKPLPVPPELAPFVGRMSAQESTPIMNGVTGPDGEDYSPWADRKAAQPKSLSPP 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB9 QSQSKLSDSYSNTLPVRKSVTPKNSYATT-ENKTLPRSSSMAAGLERNGRMRVKAIFSHA ::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::: XP_011 QSQSKLSDSYSNTLPVRKSVTPKNSYATTAENKTLPRSSSMAAGLERNGRMRVKAIFSHA 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB9 AGDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMS 430 440 450 460 470 480 450 460 470 480 490 500 pF1KB9 LQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPAQTASGFKQRPYSVAVPAFSQGLDDYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPAQTASGFKQRPYSVAVPAFSQGLDDYG 490 500 510 520 530 540 510 520 530 540 550 pF1KB9 ARSMSRNPFAHVQLKPTVTNDRCDLSAQGPEGREHGDGSARTLAGR :::::::::::::::::::::: XP_011 ARSMSRNPFAHVQLKPTVTNDRSAPLLS 550 560 >>XP_005257005 (OMIM: 605475) PREDICTED: brain-specific (522 aa) initn: 2308 init1: 2308 opt: 3328 Z-score: 2291.4 bits: 433.7 E(85289): 6.8e-121 Smith-Waterman score: 3328; 99.8% identity (99.8% similar) in 512 aa overlap (1-511:1-512) 10 20 30 40 50 60 pF1KB9 MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 ELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 KKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 DGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 VQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMN 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 GVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATT-ENK :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: XP_005 GVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTAENK 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB9 TLPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESE 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB9 KTKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KTKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB9 AQTASGFKQRPYSVAVPAFSQGLDDYGARSMSRNPFAHVQLKPTVTNDRCDLSAQGPEGR :::::::::::::::::::::::::::::::: XP_005 AQTASGFKQRPYSVAVPAFSQGLDDYGARSMSSGSGTLVSTV 490 500 510 520 540 550 pF1KB9 EHGDGSARTLAGR >>XP_005257002 (OMIM: 605475) PREDICTED: brain-specific (553 aa) initn: 3342 init1: 3228 opt: 3229 Z-score: 2223.4 bits: 421.2 E(85289): 4.2e-117 Smith-Waterman score: 3257; 93.9% identity (93.9% similar) in 543 aa overlap (2-511:2-544) 10 20 pF1KB9 MSLSRSEEMHRLTENVYK---------------------------------TIMEQFNPS ::::::::::::::::: ::::::::: XP_005 MSLSRSEEMHRLTENVYKRVEEKYQRNLFPIFSPSALKPESRNFRGESWQGTIMEQFNPS 10 20 30 40 50 60 30 40 50 60 70 80 pF1KB9 LRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQ 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB9 NQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKK 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB9 SQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKN 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB9 SAAYHSKGKELLAQKLPLWQQACADPSKIPERAVQLMQQVASNGATLPSALSASKSNLVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SAAYHSKGKELLAQKLPLWQQACADPSKIPERAVQLMQQVASNGATLPSALSASKSNLVI 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB9 SDPIPGAKPLPVPPELAPFVGRMSAQESTPIMNGVTGPDGEDYSPWADRKAAQPKSLSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDPIPGAKPLPVPPELAPFVGRMSAQESTPIMNGVTGPDGEDYSPWADRKAAQPKSLSPP 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB9 QSQSKLSDSYSNTLPVRKSVTPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QSQSKLSDSYSNTLPVRKSVTPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAA 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB9 GDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMSL 430 440 450 460 470 480 450 460 470 480 490 500 pF1KB9 QQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPAQTASGFKQRPYSVAVPAFSQGLDDYGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPAQTASGFKQRPYSVAVPAFSQGLDDYGA 490 500 510 520 530 540 510 520 530 540 550 pF1KB9 RSMSRNPFAHVQLKPTVTNDRCDLSAQGPEGREHGDGSARTLAGR :::: XP_005 RSMSSADVEVARF 550 >>XP_005257001 (OMIM: 605475) PREDICTED: brain-specific (554 aa) initn: 3342 init1: 3228 opt: 3229 Z-score: 2223.4 bits: 421.2 E(85289): 4.2e-117 Smith-Waterman score: 3257; 93.9% identity (93.9% similar) in 543 aa overlap (2-511:2-544) 10 20 pF1KB9 MSLSRSEEMHRLTENVYK---------------------------------TIMEQFNPS ::::::::::::::::: ::::::::: XP_005 MSLSRSEEMHRLTENVYKRVEEKYQRNLFPIFSPSALKPESRNFRGESWQGTIMEQFNPS 10 20 30 40 50 60 30 40 50 60 70 80 pF1KB9 LRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQ 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB9 NQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKK 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB9 SQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKN 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB9 SAAYHSKGKELLAQKLPLWQQACADPSKIPERAVQLMQQVASNGATLPSALSASKSNLVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SAAYHSKGKELLAQKLPLWQQACADPSKIPERAVQLMQQVASNGATLPSALSASKSNLVI 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB9 SDPIPGAKPLPVPPELAPFVGRMSAQESTPIMNGVTGPDGEDYSPWADRKAAQPKSLSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDPIPGAKPLPVPPELAPFVGRMSAQESTPIMNGVTGPDGEDYSPWADRKAAQPKSLSPP 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB9 QSQSKLSDSYSNTLPVRKSVTPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QSQSKLSDSYSNTLPVRKSVTPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAA 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB9 GDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMSL 430 440 450 460 470 480 450 460 470 480 490 500 pF1KB9 QQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPAQTASGFKQRPYSVAVPAFSQGLDDYGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPAQTASGFKQRPYSVAVPAFSQGLDDYGA 490 500 510 520 530 540 510 520 530 540 550 pF1KB9 RSMSRNPFAHVQLKPTVTNDRCDLSAQGPEGREHGDGSARTLAGR :::: XP_005 RSMSSGSGTLVSTV 550 552 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 09:08:13 2016 done: Fri Nov 4 09:08:15 2016 Total Scan time: 11.400 Total Display time: 0.140 Function used was FASTA [36.3.4 Apr, 2011]