FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9980, 708 aa 1>>>pF1KB9980 708 - 708 aa - 708 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1216+/-0.00123; mu= 12.8931+/- 0.073 mean_var=144.8660+/-28.800, 0's: 0 Z-trim(105.7): 28 B-trim: 0 in 0/52 Lambda= 0.106559 statistics sampled from 8545 (8550) to 8545 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.609), E-opt: 0.2 (0.263), width: 16 Scan time: 3.850 The best scores are: opt bits E(32554) CCDS8299.1 MRE11 gene_id:4361|Hs108|chr11 ( 708) 4644 726.5 3.4e-209 CCDS81617.1 MRE11 gene_id:4361|Hs108|chr11 ( 707) 4627 723.8 2e-208 CCDS8298.1 MRE11 gene_id:4361|Hs108|chr11 ( 680) 3950 619.8 4.3e-177 >>CCDS8299.1 MRE11 gene_id:4361|Hs108|chr11 (708 aa) initn: 4644 init1: 4644 opt: 4644 Z-score: 3869.3 bits: 726.5 E(32554): 3.4e-209 Smith-Waterman score: 4644; 100.0% identity (100.0% similar) in 708 aa overlap (1-708:1-708) 10 20 30 40 50 60 pF1KB9 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS 610 620 630 640 650 660 670 680 690 700 pF1KB9 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR :::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR 670 680 690 700 >>CCDS81617.1 MRE11 gene_id:4361|Hs108|chr11 (707 aa) initn: 4625 init1: 3930 opt: 4627 Z-score: 3855.2 bits: 723.8 E(32554): 2e-208 Smith-Waterman score: 4627; 99.9% identity (99.9% similar) in 708 aa overlap (1-708:1-707) 10 20 30 40 50 60 pF1KB9 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLE :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: CCDS81 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGR-DTGLE 550 560 570 580 590 610 620 630 640 650 660 pF1KB9 TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS 600 610 620 630 640 650 670 680 690 700 pF1KB9 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR :::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR 660 670 680 690 700 >>CCDS8298.1 MRE11 gene_id:4361|Hs108|chr11 (680 aa) initn: 3976 init1: 3935 opt: 3950 Z-score: 3292.9 bits: 619.8 E(32554): 4.3e-177 Smith-Waterman score: 4415; 96.0% identity (96.0% similar) in 708 aa overlap (1-708:1-680) 10 20 30 40 50 60 pF1KB9 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLE ::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRA----- 550 560 570 580 590 610 620 630 640 650 660 pF1KB9 TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS ::::::::::::::::::::::::::::::::::::: CCDS82 -----------------------FKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS 600 610 620 630 670 680 690 700 pF1KB9 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR :::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR 640 650 660 670 680 708 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 18:55:48 2016 done: Sat Nov 5 18:55:49 2016 Total Scan time: 3.850 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]