FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9980, 708 aa 1>>>pF1KB9980 708 - 708 aa - 708 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2430+/-0.000533; mu= 12.0205+/- 0.033 mean_var=162.1644+/-31.973, 0's: 0 Z-trim(112.7): 13 B-trim: 0 in 0/52 Lambda= 0.100716 statistics sampled from 21686 (21696) to 21686 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.604), E-opt: 0.2 (0.254), width: 16 Scan time: 11.800 The best scores are: opt bits E(85289) XP_016873261 (OMIM: 600814,604391) PREDICTED: doub ( 708) 4644 687.9 3.6e-197 NP_005582 (OMIM: 600814,604391) double-strand brea ( 708) 4644 687.9 3.6e-197 XP_011541139 (OMIM: 600814,604391) PREDICTED: doub ( 708) 4644 687.9 3.6e-197 NP_001317276 (OMIM: 600814,604391) double-strand b ( 707) 4627 685.4 2e-196 XP_006718905 (OMIM: 600814,604391) PREDICTED: doub ( 707) 4627 685.4 2e-196 NP_005581 (OMIM: 600814,604391) double-strand brea ( 680) 3950 587.0 8e-167 XP_005274065 (OMIM: 600814,604391) PREDICTED: doub ( 552) 3584 533.8 7e-151 >>XP_016873261 (OMIM: 600814,604391) PREDICTED: double-s (708 aa) initn: 4644 init1: 4644 opt: 4644 Z-score: 3660.7 bits: 687.9 E(85289): 3.6e-197 Smith-Waterman score: 4644; 100.0% identity (100.0% similar) in 708 aa overlap (1-708:1-708) 10 20 30 40 50 60 pF1KB9 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS 610 620 630 640 650 660 670 680 690 700 pF1KB9 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR 670 680 690 700 >>NP_005582 (OMIM: 600814,604391) double-strand break re (708 aa) initn: 4644 init1: 4644 opt: 4644 Z-score: 3660.7 bits: 687.9 E(85289): 3.6e-197 Smith-Waterman score: 4644; 100.0% identity (100.0% similar) in 708 aa overlap (1-708:1-708) 10 20 30 40 50 60 pF1KB9 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS 610 620 630 640 650 660 670 680 690 700 pF1KB9 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR :::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR 670 680 690 700 >>XP_011541139 (OMIM: 600814,604391) PREDICTED: double-s (708 aa) initn: 4644 init1: 4644 opt: 4644 Z-score: 3660.7 bits: 687.9 E(85289): 3.6e-197 Smith-Waterman score: 4644; 100.0% identity (100.0% similar) in 708 aa overlap (1-708:1-708) 10 20 30 40 50 60 pF1KB9 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS 610 620 630 640 650 660 670 680 690 700 pF1KB9 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR 670 680 690 700 >>NP_001317276 (OMIM: 600814,604391) double-strand break (707 aa) initn: 4625 init1: 3930 opt: 4627 Z-score: 3647.4 bits: 685.4 E(85289): 2e-196 Smith-Waterman score: 4627; 99.9% identity (99.9% similar) in 708 aa overlap (1-708:1-707) 10 20 30 40 50 60 pF1KB9 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLE :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: NP_001 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGR-DTGLE 550 560 570 580 590 610 620 630 640 650 660 pF1KB9 TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS 600 610 620 630 640 650 670 680 690 700 pF1KB9 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR 660 670 680 690 700 >>XP_006718905 (OMIM: 600814,604391) PREDICTED: double-s (707 aa) initn: 4625 init1: 3930 opt: 4627 Z-score: 3647.4 bits: 685.4 E(85289): 2e-196 Smith-Waterman score: 4627; 99.9% identity (99.9% similar) in 708 aa overlap (1-708:1-707) 10 20 30 40 50 60 pF1KB9 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLE :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: XP_006 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGR-DTGLE 550 560 570 580 590 610 620 630 640 650 660 pF1KB9 TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS 600 610 620 630 640 650 670 680 690 700 pF1KB9 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR :::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR 660 670 680 690 700 >>NP_005581 (OMIM: 600814,604391) double-strand break re (680 aa) initn: 3976 init1: 3935 opt: 3950 Z-score: 3116.0 bits: 587.0 E(85289): 8e-167 Smith-Waterman score: 4415; 96.0% identity (96.0% similar) in 708 aa overlap (1-708:1-680) 10 20 30 40 50 60 pF1KB9 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLE ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRA----- 550 560 570 580 590 610 620 630 640 650 660 pF1KB9 TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS ::::::::::::::::::::::::::::::::::::: NP_005 -----------------------FKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS 600 610 620 630 670 680 690 700 pF1KB9 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR :::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR 640 650 660 670 680 >>XP_005274065 (OMIM: 600814,604391) PREDICTED: double-s (552 aa) initn: 3584 init1: 3584 opt: 3584 Z-score: 2829.8 bits: 533.8 E(85289): 7e-151 Smith-Waterman score: 3584; 100.0% identity (100.0% similar) in 552 aa overlap (157-708:1-552) 130 140 150 160 170 180 pF1KB9 GNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPD :::::::::::::::::::::::::::::: XP_005 MSVEKIDISPVLLQKGSTKIALYGLGSIPD 10 20 30 190 200 210 220 230 240 pF1KB9 ERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHE 40 50 60 70 80 90 250 260 270 280 290 300 pF1KB9 HECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQ 100 110 120 130 140 150 310 320 330 340 350 360 pF1KB9 FFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEKPLVRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEKPLVRLR 160 170 180 190 200 210 370 380 390 400 410 420 pF1KB9 VDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEGTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEGTT 220 230 240 250 260 270 430 440 450 460 470 480 pF1KB9 LRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLK 280 290 300 310 320 330 490 500 510 520 530 540 pF1KB9 ERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAFSADDLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAFSADDLM 340 350 360 370 380 390 550 560 570 580 590 600 pF1KB9 SIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLETSTRSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLETSTRSR 400 410 420 430 440 450 610 620 630 640 650 660 pF1KB9 NSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTDQRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTDQRW 460 470 480 490 500 510 670 680 690 700 pF1KB9 SSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR :::::::::::::::::::::::::::::::::::::::::: XP_005 SSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR 520 530 540 550 708 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 18:55:49 2016 done: Sat Nov 5 18:55:51 2016 Total Scan time: 11.800 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]