FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9981, 561 aa 1>>>pF1KB9981 561 - 561 aa - 561 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 14.4495+/-0.000427; mu= -22.3175+/- 0.027 mean_var=613.2024+/-127.483, 0's: 0 Z-trim(125.6): 93 B-trim: 63 in 1/59 Lambda= 0.051793 statistics sampled from 49635 (49743) to 49635 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.83), E-opt: 0.2 (0.583), width: 16 Scan time: 13.320 The best scores are: opt bits E(85289) NP_005855 (OMIM: 609906) embryonal Fyn-associated ( 561) 3901 306.2 1.8e-82 NP_115835 (OMIM: 609906) embryonal Fyn-associated ( 468) 3218 255.1 3.6e-67 XP_005267313 (OMIM: 609906) PREDICTED: embryonal F ( 531) 2778 222.3 3.1e-57 NP_001264103 (OMIM: 609906) embryonal Fyn-associat ( 392) 2090 170.7 7.5e-42 NP_001164192 (OMIM: 602941) breast cancer anti-est ( 660) 465 49.5 3.9e-05 NP_001164191 (OMIM: 602941) breast cancer anti-est ( 722) 465 49.5 4.2e-05 XP_016879388 (OMIM: 602941) PREDICTED: breast canc ( 823) 465 49.6 4.6e-05 XP_011521777 (OMIM: 602941) PREDICTED: breast canc ( 841) 465 49.6 4.7e-05 XP_005256317 (OMIM: 602941) PREDICTED: breast canc ( 841) 465 49.6 4.7e-05 NP_001164190 (OMIM: 602941) breast cancer anti-est ( 868) 465 49.6 4.8e-05 XP_005256316 (OMIM: 602941) PREDICTED: breast canc ( 870) 465 49.6 4.8e-05 NP_001164189 (OMIM: 602941) breast cancer anti-est ( 870) 465 49.6 4.8e-05 NP_055382 (OMIM: 602941) breast cancer anti-estrog ( 870) 465 49.6 4.8e-05 NP_001164187 (OMIM: 602941) breast cancer anti-est ( 888) 465 49.6 4.9e-05 NP_001164188 (OMIM: 602941) breast cancer anti-est ( 888) 465 49.6 4.9e-05 NP_001164186 (OMIM: 602941) breast cancer anti-est ( 888) 465 49.6 4.9e-05 XP_005256315 (OMIM: 602941) PREDICTED: breast canc ( 896) 465 49.6 4.9e-05 NP_001164185 (OMIM: 602941) breast cancer anti-est ( 916) 465 49.6 5e-05 XP_016879386 (OMIM: 602941) PREDICTED: breast canc ( 916) 465 49.6 5e-05 XP_016879387 (OMIM: 602941) PREDICTED: breast canc ( 886) 437 47.5 0.00021 NP_001257962 (OMIM: 602265) enhancer of filamentat ( 685) 383 43.4 0.0028 NP_006394 (OMIM: 602265) enhancer of filamentation ( 834) 383 43.5 0.0033 NP_001135865 (OMIM: 602265) enhancer of filamentat ( 834) 383 43.5 0.0033 >>NP_005855 (OMIM: 609906) embryonal Fyn-associated subs (561 aa) initn: 3901 init1: 3901 opt: 3901 Z-score: 1601.6 bits: 306.2 E(85289): 1.8e-82 Smith-Waterman score: 3901; 100.0% identity (100.0% similar) in 561 aa overlap (1-561:1-561) 10 20 30 40 50 60 pF1KB9 MAIATSTQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MAIATSTQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 NRVKLLPAGPAPKPSLSPASPAQPGSPYPAPDHSNEDQEVYVVPPPARPCPTSGPPAGPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NRVKLLPAGPAPKPSLSPASPAQPGSPYPAPDHSNEDQEVYVVPPPARPCPTSGPPAGPC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PPSPDLIYKIPRASGTQLAAPRDALEVYDVPPTALRVPSSGPYDCPASFSHPLTRVAPQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PPSPDLIYKIPRASGTQLAAPRDALEVYDVPPTALRVPSSGPYDCPASFSHPLTRVAPQP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 PGEDDAPYDVPLTPKPPAELEPDLEWEGGREPGPPIYAAPSNLKRASALLNLYEAPEELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PGEDDAPYDVPLTPKPPAELEPDLEWEGGREPGPPIYAAPSNLKRASALLNLYEAPEELL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 ADGEGGGTDEGIYDVPLLGPEAPPSPEPPGALASHDQDTLAQLLARSPPPPHRPRLPSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ADGEGGGTDEGIYDVPLLGPEAPPSPEPPGALASHDQDTLAQLLARSPPPPHRPRLPSAE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 SLSRRPLPALPVPEAPSPSPVPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SLSRRPLPALPVPEAPSPSPVPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGRE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 MEDDPAGHHNEYEGIPMAEEYDYVHLKGMDKAQGSRPPDQACTGDPELPERGMPAPQEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MEDDPAGHHNEYEGIPMAEEYDYVHLKGMDKAQGSRPPDQACTGDPELPERGMPAPQEAL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 SPGEPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SPGEPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 AHRLVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AHRLVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQ 490 500 510 520 530 540 550 560 pF1KB9 CVTELAGQALQFTTLLTSLAP ::::::::::::::::::::: NP_005 CVTELAGQALQFTTLLTSLAP 550 560 >>NP_115835 (OMIM: 609906) embryonal Fyn-associated subs (468 aa) initn: 3218 init1: 3218 opt: 3218 Z-score: 1326.9 bits: 255.1 E(85289): 3.6e-67 Smith-Waterman score: 3218; 100.0% identity (100.0% similar) in 462 aa overlap (100-561:7-468) 70 80 90 100 110 120 pF1KB9 PAPKPSLSPASPAQPGSPYPAPDHSNEDQEVYVVPPPARPCPTSGPPAGPCPPSPDLIYK :::::::::::::::::::::::::::::: NP_115 MAIATSVYVVPPPARPCPTSGPPAGPCPPSPDLIYK 10 20 30 130 140 150 160 170 180 pF1KB9 IPRASGTQLAAPRDALEVYDVPPTALRVPSSGPYDCPASFSHPLTRVAPQPPGEDDAPYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 IPRASGTQLAAPRDALEVYDVPPTALRVPSSGPYDCPASFSHPLTRVAPQPPGEDDAPYD 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB9 VPLTPKPPAELEPDLEWEGGREPGPPIYAAPSNLKRASALLNLYEAPEELLADGEGGGTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 VPLTPKPPAELEPDLEWEGGREPGPPIYAAPSNLKRASALLNLYEAPEELLADGEGGGTD 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB9 EGIYDVPLLGPEAPPSPEPPGALASHDQDTLAQLLARSPPPPHRPRLPSAESLSRRPLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 EGIYDVPLLGPEAPPSPEPPGALASHDQDTLAQLLARSPPPPHRPRLPSAESLSRRPLPA 160 170 180 190 200 210 310 320 330 340 350 360 pF1KB9 LPVPEAPSPSPVPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREMEDDPAGHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 LPVPEAPSPSPVPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREMEDDPAGHH 220 230 240 250 260 270 370 380 390 400 410 420 pF1KB9 NEYEGIPMAEEYDYVHLKGMDKAQGSRPPDQACTGDPELPERGMPAPQEALSPGEPLVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 NEYEGIPMAEEYDYVHLKGMDKAQGSRPPDQACTGDPELPERGMPAPQEALSPGEPLVVS 280 290 300 310 320 330 430 440 450 460 470 480 pF1KB9 TGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVAAHRLVFVGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 TGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVAAHRLVFVGD 340 350 360 370 380 390 490 500 510 520 530 540 pF1KB9 TLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQCVTELAGQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 TLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQCVTELAGQA 400 410 420 430 440 450 550 560 pF1KB9 LQFTTLLTSLAP :::::::::::: NP_115 LQFTTLLTSLAP 460 >>XP_005267313 (OMIM: 609906) PREDICTED: embryonal Fyn-a (531 aa) initn: 2769 init1: 2769 opt: 2778 Z-score: 1148.4 bits: 222.3 E(85289): 3.1e-57 Smith-Waterman score: 3605; 94.7% identity (94.7% similar) in 561 aa overlap (1-561:1-531) 10 20 30 40 50 60 pF1KB9 MAIATSTQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAIATSTQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 NRVKLLPAGPAPKPSLSPASPAQPGSPYPAPDHSNEDQEVYVVPPPARPCPTSGPPAGPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NRVKLLPAGPAPKPSLSPASPAQPGSPYPAPDHSNEDQEVYVVPPPARPCPTSGPPAGPC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PPSPDLIYKIPRASGTQLAAPRDALEVYDVPPTALRVPSSGPYDCPASFSHPLTRVAPQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPSPDLIYKIPRASGTQLAAPRDALEVYDVPPTALRVPSSGPYDCPASFSHPLTRVAPQP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 PGEDDAPYDVPLTPKPPAELEPDLEWEGGREPGPPIYAAPSNLKRASALLNLYEAPEELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PGEDDAPYDVPLTPKPPAELEPDLEWEGGREPGPPIYAAPSNLKRASALLNLYEAPEELL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 ADGEGGGTDEGIYDVPLLGPEAPPSPEPPGALASHDQDTLAQLLARSPPPPHRPRLPSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ADGEGGGTDEGIYDVPLLGPEAPPSPEPPGALASHDQDTLAQLLARSPPPPHRPRLPSAE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 SLSRRPLPALPVPEAPSPSPVPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLSRRPLPALPVPEAPSPSPVPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGRE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 MEDDPAGHHNEYEGIPMAEEYDYVHLKGMDKAQGSRPPDQACTGDPELPERGMPAPQEAL ::::::::::::::::::::::::::: ::: XP_005 MEDDPAGHHNEYEGIPMAEEYDYVHLK------------------------------EAL 370 380 390 430 440 450 460 470 480 pF1KB9 SPGEPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SPGEPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVA 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB9 AHRLVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AHRLVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQ 460 470 480 490 500 510 550 560 pF1KB9 CVTELAGQALQFTTLLTSLAP ::::::::::::::::::::: XP_005 CVTELAGQALQFTTLLTSLAP 520 530 >>NP_001264103 (OMIM: 609906) embryonal Fyn-associated s (392 aa) initn: 2115 init1: 2056 opt: 2090 Z-score: 872.4 bits: 170.7 E(85289): 7.5e-42 Smith-Waterman score: 2526; 83.5% identity (83.5% similar) in 462 aa overlap (100-561:7-392) 70 80 90 100 110 120 pF1KB9 PAPKPSLSPASPAQPGSPYPAPDHSNEDQEVYVVPPPARPCPTSGPPAGPCPPSPDLIYK :::::::::::::::::::::::::::::: NP_001 MAIATSVYVVPPPARPCPTSGPPAGPCPPSPDLIYK 10 20 30 130 140 150 160 170 180 pF1KB9 IPRASGTQLAAPRDALEVYDVPPTALRVPSSGPYDCPASFSHPLTRVAPQPPGEDDAPYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IPRASGTQLAAPRDALEVYDVPPTALRVPSSGPYDCPASFSHPLTRVAPQPPGEDDAP-- 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB9 VPLTPKPPAELEPDLEWEGGREPGPPIYAAPSNLKRASALLNLYEAPEELLADGEGGGTD NP_001 ------------------------------------------------------------ 250 260 270 280 290 300 pF1KB9 EGIYDVPLLGPEAPPSPEPPGALASHDQDTLAQLLARSPPPPHRPRLPSAESLSRRPLPA :::::::::::::::::::::::::::::::::::::::::::::: NP_001 --------------PSPEPPGALASHDQDTLAQLLARSPPPPHRPRLPSAESLSRRPLPA 100 110 120 130 140 310 320 330 340 350 360 pF1KB9 LPVPEAPSPSPVPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREMEDDPAGHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPVPEAPSPSPVPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREMEDDPAGHH 150 160 170 180 190 200 370 380 390 400 410 420 pF1KB9 NEYEGIPMAEEYDYVHLKGMDKAQGSRPPDQACTGDPELPERGMPAPQEALSPGEPLVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEYEGIPMAEEYDYVHLKGMDKAQGSRPPDQACTGDPELPERGMPAPQEALSPGEPLVVS 210 220 230 240 250 260 430 440 450 460 470 480 pF1KB9 TGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVAAHRLVFVGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVAAHRLVFVGD 270 280 290 300 310 320 490 500 510 520 530 540 pF1KB9 TLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQCVTELAGQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQCVTELAGQA 330 340 350 360 370 380 550 560 pF1KB9 LQFTTLLTSLAP :::::::::::: NP_001 LQFTTLLTSLAP 390 >>NP_001164192 (OMIM: 602941) breast cancer anti-estroge (660 aa) initn: 529 init1: 390 opt: 465 Z-score: 213.1 bits: 49.5 E(85289): 3.9e-05 Smith-Waterman score: 551; 30.5% identity (51.8% similar) in 587 aa overlap (58-560:98-658) 30 40 50 60 70 80 pF1KB9 RGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGPAPK-------PSLSPAS :: . : .: :: . :... :. NP_001 NGRDPLLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAK 70 80 90 100 110 120 90 100 110 120 130 pF1KB9 PAQPG-SPY----PAPDHSNEDQEVYVVPPPARPCPTSGPPAGPCPPSPDLIYKIPRASG : .:. .: : :: : ..:: ::::: : . :: : :.: .: .:: NP_001 PFDPARTPLVLAAPPPD-SPPAEDVYDVPPPA-PDLYDVPP-GLRRPGPGTLYDVPRERV 130 140 150 160 170 180 140 150 160 170 180 pF1KB9 TQ-LAAPRDALE--VYDVPPTALR-VPSSGPYDCPASF-----SHPLTRVAPQPPGEDDA .: ... :: ::: : : .:. : .: :. . . ::.. NP_001 LPPEVADGGVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGRE-- 190 200 210 220 230 240 190 200 210 220 230 pF1KB9 PYDVPLTPKPPAELEP----------DLEWEGG-----REPGPPIYAAPSNLKRASALLN : .. .. . :.:. :: .: : :. : ..:. : : .. NP_001 PLELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQ 250 260 270 280 290 300 240 250 260 270 pF1KB9 LYEAPEELLADGEGG-GTDEGIYDVPL---LGPEAPPSPEPPGALASHDQ---------- : .::: .... :. : : :. . . .:..: : NP_001 --SAVHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSG 310 320 330 340 350 360 280 290 300 310 320 pF1KB9 ---DTLAQLLARSPPPPHRPR-LPS-----AESLSRRPLPALPVPEAPSPSPVPSPAPGR . : .:.: : :. . : : : : :: . : ::. . . :.:. . NP_001 ATLEDLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGG-TLHPNPTD-K 370 380 390 400 410 330 340 350 360 370 380 pF1KB9 KGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREMEDDPAGHHNEYEGIPMAEEYDYVHLKG .:::.:::: :: .:.: :.... :: : :.::::::.: NP_001 TSSIQSRPLPSPPKFTS----------------QDSPDGQYENSEGGWM-EDYDYVHLQG 420 430 440 450 460 390 400 410 420 pF1KB9 ---MDKAQGSRPPDQACT--GDPELP-------ER-----GMP--------APQEALSPG ..:.: . : : .: :: . : .: . :.:: NP_001 KEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLAPG 470 480 490 500 510 520 430 440 450 460 470 480 pF1KB9 EPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVAAHR . .. .: ::: :: ::... ..: :: :..... .::::..:: ::: :...::. NP_001 RTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHK 530 540 550 560 570 580 490 500 510 520 530 540 pF1KB9 LVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQCVT :::.::::.: : .: .:.:: .. : . ::. : ..:.::: ::: : :.::. : NP_001 LVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERVK 590 600 610 620 630 640 550 560 pF1KB9 ELAGQALQFTTLLTSLAP ::. .. :: .: .:: NP_001 ELGHSTQQFRRVLGQLAAA 650 660 >>NP_001164191 (OMIM: 602941) breast cancer anti-estroge (722 aa) initn: 668 init1: 390 opt: 465 Z-score: 212.6 bits: 49.5 E(85289): 4.2e-05 Smith-Waterman score: 551; 30.5% identity (51.8% similar) in 587 aa overlap (58-560:160-720) 30 40 50 60 70 80 pF1KB9 RGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGPAPK-------PSLSPAS :: . : .: :: . :... :. NP_001 NGRDPLLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAK 130 140 150 160 170 180 90 100 110 120 130 pF1KB9 PAQPG-SPY----PAPDHSNEDQEVYVVPPPARPCPTSGPPAGPCPPSPDLIYKIPRASG : .:. .: : :: : ..:: ::::: : . :: : :.: .: .:: NP_001 PFDPARTPLVLAAPPPD-SPPAEDVYDVPPPA-PDLYDVPP-GLRRPGPGTLYDVPRERV 190 200 210 220 230 240 140 150 160 170 180 pF1KB9 TQ-LAAPRDALE--VYDVPPTALR-VPSSGPYDCPASF-----SHPLTRVAPQPPGEDDA .: ... :: ::: : : .:. : .: :. . . ::.. NP_001 LPPEVADGGVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGRE-- 250 260 270 280 290 300 190 200 210 220 230 pF1KB9 PYDVPLTPKPPAELEP----------DLEWEGG-----REPGPPIYAAPSNLKRASALLN : .. .. . :.:. :: .: : :. : ..:. : : .. NP_001 PLELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQ 310 320 330 340 350 360 240 250 260 270 pF1KB9 LYEAPEELLADGEGG-GTDEGIYDVPL---LGPEAPPSPEPPGALASHDQ---------- : .::: .... :. : : :. . . .:..: : NP_001 --SAVHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSG 370 380 390 400 410 420 280 290 300 310 320 pF1KB9 ---DTLAQLLARSPPPPHRPR-LPS-----AESLSRRPLPALPVPEAPSPSPVPSPAPGR . : .:.: : :. . : : : : :: . : ::. . . :.:. . NP_001 ATLEDLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGG-TLHPNPTD-K 430 440 450 460 470 480 330 340 350 360 370 380 pF1KB9 KGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREMEDDPAGHHNEYEGIPMAEEYDYVHLKG .:::.:::: :: .:.: :.... :: : :.::::::.: NP_001 TSSIQSRPLPSPPKFTS----------------QDSPDGQYENSEGGWM-EDYDYVHLQG 490 500 510 520 390 400 410 420 pF1KB9 ---MDKAQGSRPPDQACT--GDPELP-------ER-----GMP--------APQEALSPG ..:.: . : : .: :: . : .: . :.:: NP_001 KEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLAPG 530 540 550 560 570 580 430 440 450 460 470 480 pF1KB9 EPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVAAHR . .. .: ::: :: ::... ..: :: :..... .::::..:: ::: :...::. NP_001 RTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHK 590 600 610 620 630 640 490 500 510 520 530 540 pF1KB9 LVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQCVT :::.::::.: : .: .:.:: .. : . ::. : ..:.::: ::: : :.::. : NP_001 LVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERVK 650 660 670 680 690 700 550 560 pF1KB9 ELAGQALQFTTLLTSLAP ::. .. :: .: .:: NP_001 ELGHSTQQFRRVLGQLAAA 710 720 >>XP_016879388 (OMIM: 602941) PREDICTED: breast cancer a (823 aa) initn: 650 init1: 390 opt: 465 Z-score: 211.8 bits: 49.6 E(85289): 4.6e-05 Smith-Waterman score: 551; 30.5% identity (51.8% similar) in 587 aa overlap (58-560:261-821) 30 40 50 60 70 80 pF1KB9 RGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGPAPK-------PSLSPAS :: . : .: :: . :... :. XP_016 AGMGHDIYQVPPSMDTRSWEGTKPPAKVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAK 240 250 260 270 280 290 90 100 110 120 130 pF1KB9 PAQPG-SPY----PAPDHSNEDQEVYVVPPPARPCPTSGPPAGPCPPSPDLIYKIPRASG : .:. .: : :: : ..:: ::::: : . :: : :.: .: .:: XP_016 PFDPARTPLVLAAPPPD-SPPAEDVYDVPPPA-PDLYDVPP-GLRRPGPGTLYDVPRERV 300 310 320 330 340 140 150 160 170 180 pF1KB9 TQ-LAAPRDALE--VYDVPPTALR-VPSSGPYDCPASF-----SHPLTRVAPQPPGEDDA .: ... :: ::: : : .:. : .: :. . . ::.. XP_016 LPPEVADGGVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGRE-- 350 360 370 380 390 400 190 200 210 220 230 pF1KB9 PYDVPLTPKPPAELEP----------DLEWEGG-----REPGPPIYAAPSNLKRASALLN : .. .. . :.:. :: .: : :. : ..:. : : .. XP_016 PLELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQ 410 420 430 440 450 460 240 250 260 270 pF1KB9 LYEAPEELLADGEGG-GTDEGIYDVPL---LGPEAPPSPEPPGALASHDQ---------- : .::: .... :. : : :. . . .:..: : XP_016 --SAVHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSG 470 480 490 500 510 520 280 290 300 310 320 pF1KB9 ---DTLAQLLARSPPPPHRPR-LPS-----AESLSRRPLPALPVPEAPSPSPVPSPAPGR . : .:.: : :. . : : : : :: . : ::. . . :.:. . XP_016 ATLEDLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGG-TLHPNPTD-K 530 540 550 560 570 580 330 340 350 360 370 380 pF1KB9 KGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREMEDDPAGHHNEYEGIPMAEEYDYVHLKG .:::.:::: :: .:.: :.... :: : :.::::::.: XP_016 TSSIQSRPLPSPPKFTS----------------QDSPDGQYENSEGGWM-EDYDYVHLQG 590 600 610 620 390 400 410 420 pF1KB9 ---MDKAQGSRPPDQACT--GDPELP-------ER-----GMP--------APQEALSPG ..:.: . : : .: :: . : .: . :.:: XP_016 KEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLAPG 630 640 650 660 670 680 430 440 450 460 470 480 pF1KB9 EPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVAAHR . .. .: ::: :: ::... ..: :: :..... .::::..:: ::: :...::. XP_016 RTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHK 690 700 710 720 730 740 490 500 510 520 530 540 pF1KB9 LVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQCVT :::.::::.: : .: .:.:: .. : . ::. : ..:.::: ::: : :.::. : XP_016 LVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERVK 750 760 770 780 790 800 550 560 pF1KB9 ELAGQALQFTTLLTSLAP ::. .. :: .: .:: XP_016 ELGHSTQQFRRVLGQLAAA 810 820 >-- initn: 231 init1: 167 opt: 433 Z-score: 198.9 bits: 47.2 E(85289): 0.00024 Smith-Waterman score: 433; 39.0% identity (61.0% similar) in 218 aa overlap (9-212:53-255) 10 20 30 pF1KB9 MAIATSTQLARALYDNTAESPQELSFRRGDVLRVLQRE ::.:::::.::::.:::::.::.. ::... XP_016 GPQGTGQPCSCGHWAEGQGGPPEPAGGPNVLAKALYDNVAESPDELSFRKGDIMTVLEQD 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB9 GAGGLDGWCLCSLHGQQGIVPANRVKLL-------PAGPAPKPSLSPASPAQPGSPYPAP . ::::: ::::::.:::::.::.:.: ::::.: : .::.: ::: ::: XP_016 -TQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKKPAGPGPGPPATPAQP-QPGLHAPAP 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB9 DHSNEDQEVYVVPPPARPCPTSGPPAGPCPPSPDL-IYKIPRASGTQLAAPRDALEVYDV : : . ..: .: : : . : : . . .:..: : :. .: . .. XP_016 PAS---QYTPMLPNTYQPQPDSVYLV-PTPSKAQQGLYQVPGPS-PQFQSP----PAKQT 150 160 170 180 190 160 170 180 190 200 pF1KB9 PPTALRVPSSGPYDCPASFSHPLTRVAPQPPGEDDAPYDVPLTP---KPPAELEPDLE-- . ..: :. ::. : .: : : : . :.:: . . .. :... XP_016 STFSKQTPHH-PFPSPAT---DLYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDTR 200 210 220 230 240 210 220 230 240 250 260 pF1KB9 -WEGGREPGPPIYAAPSNLKRASALLNLYEAPEELLADGEGGGTDEGIYDVPLLGPEAPP ::: . : XP_016 SWEGTKPPAKVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAPPPD 250 260 270 280 290 300 >>XP_011521777 (OMIM: 602941) PREDICTED: breast cancer a (841 aa) initn: 693 init1: 390 opt: 465 Z-score: 211.7 bits: 49.6 E(85289): 4.7e-05 Smith-Waterman score: 551; 30.5% identity (51.8% similar) in 587 aa overlap (58-560:279-839) 30 40 50 60 70 80 pF1KB9 RGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGPAPK-------PSLSPAS :: . : .: :: . :... :. XP_011 NGRDPLLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAK 250 260 270 280 290 300 90 100 110 120 130 pF1KB9 PAQPG-SPY----PAPDHSNEDQEVYVVPPPARPCPTSGPPAGPCPPSPDLIYKIPRASG : .:. .: : :: : ..:: ::::: : . :: : :.: .: .:: XP_011 PFDPARTPLVLAAPPPD-SPPAEDVYDVPPPA-PDLYDVPP-GLRRPGPGTLYDVPRERV 310 320 330 340 350 360 140 150 160 170 180 pF1KB9 TQ-LAAPRDALE--VYDVPPTALR-VPSSGPYDCPASF-----SHPLTRVAPQPPGEDDA .: ... :: ::: : : .:. : .: :. . . ::.. XP_011 LPPEVADGGVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGRE-- 370 380 390 400 410 420 190 200 210 220 230 pF1KB9 PYDVPLTPKPPAELEP----------DLEWEGG-----REPGPPIYAAPSNLKRASALLN : .. .. . :.:. :: .: : :. : ..:. : : .. XP_011 PLELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQ 430 440 450 460 470 480 240 250 260 270 pF1KB9 LYEAPEELLADGEGG-GTDEGIYDVPL---LGPEAPPSPEPPGALASHDQ---------- : .::: .... :. : : :. . . .:..: : XP_011 --SAVHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSG 490 500 510 520 530 540 280 290 300 310 320 pF1KB9 ---DTLAQLLARSPPPPHRPR-LPS-----AESLSRRPLPALPVPEAPSPSPVPSPAPGR . : .:.: : :. . : : : : :: . : ::. . . :.:. . XP_011 ATLEDLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGG-TLHPNPTD-K 550 560 570 580 590 330 340 350 360 370 380 pF1KB9 KGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREMEDDPAGHHNEYEGIPMAEEYDYVHLKG .:::.:::: :: .:.: :.... :: : :.::::::.: XP_011 TSSIQSRPLPSPPKFTS----------------QDSPDGQYENSEGGWM-EDYDYVHLQG 600 610 620 630 640 390 400 410 420 pF1KB9 ---MDKAQGSRPPDQACT--GDPELP-------ER-----GMP--------APQEALSPG ..:.: . : : .: :: . : .: . :.:: XP_011 KEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLAPG 650 660 670 680 690 700 430 440 450 460 470 480 pF1KB9 EPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVAAHR . .. .: ::: :: ::... ..: :: :..... .::::..:: ::: :...::. XP_011 RTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHK 710 720 730 740 750 760 490 500 510 520 530 540 pF1KB9 LVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQCVT :::.::::.: : .: .:.:: .. : . ::. : ..:.::: ::: : :.::. : XP_011 LVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERVK 770 780 790 800 810 820 550 560 pF1KB9 ELAGQALQFTTLLTSLAP ::. .. :: .: .:: XP_011 ELGHSTQQFRRVLGQLAAA 830 840 >>XP_005256317 (OMIM: 602941) PREDICTED: breast cancer a (841 aa) initn: 693 init1: 390 opt: 465 Z-score: 211.7 bits: 49.6 E(85289): 4.7e-05 Smith-Waterman score: 551; 30.5% identity (51.8% similar) in 587 aa overlap (58-560:279-839) 30 40 50 60 70 80 pF1KB9 RGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGPAPK-------PSLSPAS :: . : .: :: . :... :. XP_005 NGRDPLLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAK 250 260 270 280 290 300 90 100 110 120 130 pF1KB9 PAQPG-SPY----PAPDHSNEDQEVYVVPPPARPCPTSGPPAGPCPPSPDLIYKIPRASG : .:. .: : :: : ..:: ::::: : . :: : :.: .: .:: XP_005 PFDPARTPLVLAAPPPD-SPPAEDVYDVPPPA-PDLYDVPP-GLRRPGPGTLYDVPRERV 310 320 330 340 350 360 140 150 160 170 180 pF1KB9 TQ-LAAPRDALE--VYDVPPTALR-VPSSGPYDCPASF-----SHPLTRVAPQPPGEDDA .: ... :: ::: : : .:. : .: :. . . ::.. XP_005 LPPEVADGGVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGRE-- 370 380 390 400 410 420 190 200 210 220 230 pF1KB9 PYDVPLTPKPPAELEP----------DLEWEGG-----REPGPPIYAAPSNLKRASALLN : .. .. . :.:. :: .: : :. : ..:. : : .. XP_005 PLELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQ 430 440 450 460 470 480 240 250 260 270 pF1KB9 LYEAPEELLADGEGG-GTDEGIYDVPL---LGPEAPPSPEPPGALASHDQ---------- : .::: .... :. : : :. . . .:..: : XP_005 --SAVHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSG 490 500 510 520 530 540 280 290 300 310 320 pF1KB9 ---DTLAQLLARSPPPPHRPR-LPS-----AESLSRRPLPALPVPEAPSPSPVPSPAPGR . : .:.: : :. . : : : : :: . : ::. . . :.:. . XP_005 ATLEDLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGG-TLHPNPTD-K 550 560 570 580 590 330 340 350 360 370 380 pF1KB9 KGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREMEDDPAGHHNEYEGIPMAEEYDYVHLKG .:::.:::: :: .:.: :.... :: : :.::::::.: XP_005 TSSIQSRPLPSPPKFTS----------------QDSPDGQYENSEGGWM-EDYDYVHLQG 600 610 620 630 640 390 400 410 420 pF1KB9 ---MDKAQGSRPPDQACT--GDPELP-------ER-----GMP--------APQEALSPG ..:.: . : : .: :: . : .: . :.:: XP_005 KEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLAPG 650 660 670 680 690 700 430 440 450 460 470 480 pF1KB9 EPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVAAHR . .. .: ::: :: ::... ..: :: :..... .::::..:: ::: :...::. XP_005 RTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHK 710 720 730 740 750 760 490 500 510 520 530 540 pF1KB9 LVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQCVT :::.::::.: : .: .:.:: .. : . ::. : ..:.::: ::: : :.::. : XP_005 LVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERVK 770 780 790 800 810 820 550 560 pF1KB9 ELAGQALQFTTLLTSLAP ::. .. :: .: .:: XP_005 ELGHSTQQFRRVLGQLAAA 830 840 >>NP_001164190 (OMIM: 602941) breast cancer anti-estroge (868 aa) initn: 704 init1: 390 opt: 465 Z-score: 211.5 bits: 49.6 E(85289): 4.8e-05 Smith-Waterman score: 551; 30.5% identity (51.8% similar) in 587 aa overlap (58-560:306-866) 30 40 50 60 70 80 pF1KB9 RGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGPAPK-------PSLSPAS :: . : .: :: . :... :. NP_001 NGRDPLLEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAK 280 290 300 310 320 330 90 100 110 120 130 pF1KB9 PAQPG-SPY----PAPDHSNEDQEVYVVPPPARPCPTSGPPAGPCPPSPDLIYKIPRASG : .:. .: : :: : ..:: ::::: : . :: : :.: .: .:: NP_001 PFDPARTPLVLAAPPPD-SPPAEDVYDVPPPA-PDLYDVPP-GLRRPGPGTLYDVPRERV 340 350 360 370 380 390 140 150 160 170 180 pF1KB9 TQ-LAAPRDALE--VYDVPPTALR-VPSSGPYDCPASF-----SHPLTRVAPQPPGEDDA .: ... :: ::: : : .:. : .: :. . . ::.. NP_001 LPPEVADGGVVDSGVYAVPPPAEREAPAEGKRLSASSTGSTRSSQSASSLEVAGPGRE-- 400 410 420 430 440 450 190 200 210 220 230 pF1KB9 PYDVPLTPKPPAELEP----------DLEWEGG-----REPGPPIYAAPSNLKRASALLN : .. .. . :.:. :: .: : :. : ..:. : : .. NP_001 PLELEVAVEALARLQQGVSATVAHLLDLAGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQ 460 470 480 490 500 510 240 250 260 270 pF1KB9 LYEAPEELLADGEGG-GTDEGIYDVPL---LGPEAPPSPEPPGALASHDQ---------- : .::: .... :. : : :. . . .:..: : NP_001 --SAVHELLEFARSAVGNAAHTSDRALHAKLSRQLQKMEDVHQTLVAHGQALDAGRGGSG 520 530 540 550 560 280 290 300 310 320 pF1KB9 ---DTLAQLLARSPPPPHRPR-LPS-----AESLSRRPLPALPVPEAPSPSPVPSPAPGR . : .:.: : :. . : : : : :: . : ::. . . :.:. . NP_001 ATLEDLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKATAPGPEGGG-TLHPNPTD-K 570 580 590 600 610 620 330 340 350 360 370 380 pF1KB9 KGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREMEDDPAGHHNEYEGIPMAEEYDYVHLKG .:::.:::: :: .:.: :.... :: : :.::::::.: NP_001 TSSIQSRPLPSPPKFTS----------------QDSPDGQYENSEGGWM-EDYDYVHLQG 630 640 650 660 390 400 410 420 pF1KB9 ---MDKAQGSRPPDQACT--GDPELP-------ER-----GMP--------APQEALSPG ..:.: . : : .: :: . : .: . :.:: NP_001 KEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLAPG 670 680 690 700 710 720 430 440 450 460 470 480 pF1KB9 EPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVAAHR . .. .: ::: :: ::... ..: :: :..... .::::..:: ::: :...::. NP_001 RTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVAHSKFVILSAHK 730 740 750 760 770 780 490 500 510 520 530 540 pF1KB9 LVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQCVT :::.::::.: : .: .:.:: .. : . ::. : ..:.::: ::: : :.::. : NP_001 LVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVERVK 790 800 810 820 830 840 550 560 pF1KB9 ELAGQALQFTTLLTSLAP ::. .. :: .: .:: NP_001 ELGHSTQQFRRVLGQLAAA 850 860 >-- initn: 246 init1: 167 opt: 473 Z-score: 214.7 bits: 50.2 E(85289): 3.2e-05 Smith-Waterman score: 473; 35.2% identity (57.5% similar) in 315 aa overlap (9-297:5-296) 10 20 30 40 50 60 pF1KB9 MAIATSTQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPA ::.:::::.::::.:::::.::.. ::... . ::::: ::::::.:::::. NP_001 MENVLAKALYDNVAESPDELSFRKGDIMTVLEQD-TQGLDGWWLCSLHGRQGIVPG 10 20 30 40 50 70 80 90 100 110 pF1KB9 NRVKLL-------PAGPAPKPSLSPASPAQPGSPYPAPDHSNEDQEVYVVPPPARPCPTS ::.:.: ::::.: : .::.: ::: ::: : : . ..: .: : : NP_001 NRLKILVGMYDKKPAGPGPGPPATPAQP-QPGLHAPAPPAS---QYTPMLPNTYQPQPDS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 GPPAGPCPPSPDL-IYKIPRASGTQLAAPRDALEVYDVPPTALRVPSSGPYDCPASFSHP . : : . . .:..: : :. .: . .. . ..: :. ::. NP_001 VYLV-PTPSKAQQGLYQVPGPS-PQFQSP----PAKQTSTFSKQTPHH-PFPSPAT---D 120 130 140 150 160 180 190 200 210 220 pF1KB9 LTRVAPQPPGEDDAPYDVPLTP---KPPAELEPDLE---WEGGREPGP---PIYAAPSNL : .: : : : . :.:: . . .. :... ::: . :. : .. . . NP_001 LYQVPPGPGGPAQDIYQVPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGYV 170 180 190 200 210 220 230 240 250 260 270 pF1KB9 KRASA-LLNLYEAPEELLADGEGGGTDEGIYDVP----LL----GPEAPPSPEPPGALAS .:. . :. :..::: : . ::::: :: : :. .: : .. . NP_001 YEAAQPEQDEYDIPRHLLAPGP-----QDIYDVPPVRGLLPSQYGQEVYDTP-PMAVKGP 230 240 250 260 270 280 290 300 310 320 330 pF1KB9 HDQDTLAQLLARSPPPPHRPRLPSAESLSRRPLPALPVPEAPSPSPVPSPAPGRKGSIQD . .: : : . . :: . :: NP_001 NGRDPL--LEVYDVPPSVEKGLPPSNHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAK 280 290 300 310 320 330 561 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 15:03:34 2016 done: Sat Nov 5 15:03:36 2016 Total Scan time: 13.320 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]