Result of FASTA (omim) for
pF1KB9985
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9985, 572 aa
1>>>pF1KB9985 572 - 572 aa - 572 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.0732+/-0.000356; mu= 2.8904+/- 0.022
mean_var=209.8834+/-42.713, 0's: 0 Z-trim(121.0): 13 B-trim: 60 in 1/59
Lambda= 0.088529
statistics sampled from 36899 (36912) to 36899 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.731), E-opt: 0.2 (0.433), width: 16
Scan time: 11.540
The best scores are: opt bits E(85289)
NP_001005340 (OMIM: 604368) transmembrane glycopro ( 572) 3941 516.0 1.3e-145
XP_005249635 (OMIM: 604368) PREDICTED: transmembra ( 531) 3597 472.0 2.1e-132
XP_016867166 (OMIM: 604368) PREDICTED: transmembra ( 559) 2412 320.7 7.9e-87
XP_016867165 (OMIM: 604368) PREDICTED: transmembra ( 600) 2412 320.7 8.4e-87
XP_016867167 (OMIM: 604368) PREDICTED: transmembra ( 519) 2401 319.3 2e-86
NP_002501 (OMIM: 604368) transmembrane glycoprotei ( 560) 2401 319.3 2.1e-86
NP_001186982 (OMIM: 155550) melanocyte protein PME ( 575) 451 70.2 2e-11
NP_001307051 (OMIM: 155550) melanocyte protein PME ( 619) 451 70.3 2.1e-11
NP_001307050 (OMIM: 155550) melanocyte protein PME ( 626) 451 70.3 2.2e-11
NP_008859 (OMIM: 155550) melanocyte protein PMEL i ( 661) 451 70.3 2.3e-11
XP_006719632 (OMIM: 155550) PREDICTED: melanocyte ( 661) 451 70.3 2.3e-11
NP_001186983 (OMIM: 155550) melanocyte protein PME ( 668) 451 70.3 2.3e-11
XP_011536987 (OMIM: 155550) PREDICTED: melanocyte ( 668) 451 70.3 2.3e-11
>>NP_001005340 (OMIM: 604368) transmembrane glycoprotein (572 aa)
initn: 3941 init1: 3941 opt: 3941 Z-score: 2735.1 bits: 516.0 E(85289): 1.3e-145
Smith-Waterman score: 3941; 100.0% identity (100.0% similar) in 572 aa overlap (1-572:1-572)
10 20 30 40 50 60
pF1KB9 MECLYYFLGFLLLAARLPLDAAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MECLYYFLGFLLLAARLPLDAAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 VWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 RNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 GQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 TMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 HTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSLATTLKSYDSNTPGPAGDNPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSLATTLKSYDSNTPGPAGDNPLE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 LSRIPDENCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVTCQGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSRIPDENCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVTCQGSI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 PTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNGSGTYCVNLTLGDDTSLALTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNGSGTYCVNLTLGDDTSLALTS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 TLISVPDRDPASPLRMANSALISVGCLAIFVTVISLLVYKKHKEYNPIENSPGNVVRSKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLISVPDRDPASPLRMANSALISVGCLAIFVTVISLLVYKKHKEYNPIENSPGNVVRSKG
490 500 510 520 530 540
550 560 570
pF1KB9 LSVFLNRAKAVFFPGNQEKDPLLKNQEFKGVS
::::::::::::::::::::::::::::::::
NP_001 LSVFLNRAKAVFFPGNQEKDPLLKNQEFKGVS
550 560 570
>>XP_005249635 (OMIM: 604368) PREDICTED: transmembrane g (531 aa)
initn: 3673 init1: 3597 opt: 3597 Z-score: 2498.1 bits: 472.0 E(85289): 2.1e-132
Smith-Waterman score: 3597; 99.4% identity (99.6% similar) in 524 aa overlap (1-524:1-524)
10 20 30 40 50 60
pF1KB9 MECLYYFLGFLLLAARLPLDAAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MECLYYFLGFLLLAARLPLDAAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 VWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 RNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 GQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 TMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 HTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSLATTLKSYDSNTPGPAGDNPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSLATTLKSYDSNTPGPAGDNPLE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 LSRIPDENCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVTCQGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSRIPDENCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVTCQGSI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 PTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNGSGTYCVNLTLGDDTSLALTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNGSGTYCVNLTLGDDTSLALTS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 TLISVPDRDPASPLRMANSALISVGCLAIFVTVISLLVYKKHKEYNPIENSPGNVVRSKG
:::::::::::::::::::::::::::::::::::::::: .:
XP_005 TLISVPDRDPASPLRMANSALISVGCLAIFVTVISLLVYKLFSENTRNTTQ
490 500 510 520 530
550 560 570
pF1KB9 LSVFLNRAKAVFFPGNQEKDPLLKNQEFKGVS
>>XP_016867166 (OMIM: 604368) PREDICTED: transmembrane g (559 aa)
initn: 3836 init1: 2412 opt: 2412 Z-score: 1679.8 bits: 320.7 E(85289): 7.9e-87
Smith-Waterman score: 3531; 94.4% identity (94.6% similar) in 552 aa overlap (1-524:1-552)
10 20 30 40 50 60
pF1KB9 MECLYYFLGFLLLAARLPLDAAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MECLYYFLGFLLLAARLPLDAAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 VWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 RNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 GQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 TMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVN
250 260 270 280 290 300
310 320 330
pF1KB9 HTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSL---------------------
:::::::::::::::::::::::::::::::::::::::
XP_016 HTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSLGTWMKLETIILSKLSQGQKTK
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB9 -------ATTLKSYDSNTPGPAGDNPLELSRIPDENCQINRYGHFQATITIVEGILEVNI
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRMFSFTATTLKSYDSNTPGPAGDNPLELSRIPDENCQINRYGHFQATITIVEGILEVNI
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB9 IQMTDVLMPVPWPESSLIDFVVTCQGSIPTEVCTIISDPTCEITQNTVCSPVDVDEMCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQMTDVLMPVPWPESSLIDFVVTCQGSIPTEVCTIISDPTCEITQNTVCSPVDVDEMCLL
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB9 TVRRTFNGSGTYCVNLTLGDDTSLALTSTLISVPDRDPASPLRMANSALISVGCLAIFVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVRRTFNGSGTYCVNLTLGDDTSLALTSTLISVPDRDPASPLRMANSALISVGCLAIFVT
490 500 510 520 530 540
520 530 540 550 560 570
pF1KB9 VISLLVYKKHKEYNPIENSPGNVVRSKGLSVFLNRAKAVFFPGNQEKDPLLKNQEFKGVS
:::::::: .:
XP_016 VISLLVYKLFSENTRNTTQ
550
>>XP_016867165 (OMIM: 604368) PREDICTED: transmembrane g (600 aa)
initn: 4180 init1: 2412 opt: 2412 Z-score: 1679.4 bits: 320.7 E(85289): 8.4e-87
Smith-Waterman score: 3875; 95.3% identity (95.3% similar) in 600 aa overlap (1-572:1-600)
10 20 30 40 50 60
pF1KB9 MECLYYFLGFLLLAARLPLDAAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MECLYYFLGFLLLAARLPLDAAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 VWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 RNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 GQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 TMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVN
250 260 270 280 290 300
310 320 330
pF1KB9 HTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSL---------------------
:::::::::::::::::::::::::::::::::::::::
XP_016 HTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSLGTWMKLETIILSKLSQGQKTK
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB9 -------ATTLKSYDSNTPGPAGDNPLELSRIPDENCQINRYGHFQATITIVEGILEVNI
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRMFSFTATTLKSYDSNTPGPAGDNPLELSRIPDENCQINRYGHFQATITIVEGILEVNI
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB9 IQMTDVLMPVPWPESSLIDFVVTCQGSIPTEVCTIISDPTCEITQNTVCSPVDVDEMCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQMTDVLMPVPWPESSLIDFVVTCQGSIPTEVCTIISDPTCEITQNTVCSPVDVDEMCLL
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB9 TVRRTFNGSGTYCVNLTLGDDTSLALTSTLISVPDRDPASPLRMANSALISVGCLAIFVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVRRTFNGSGTYCVNLTLGDDTSLALTSTLISVPDRDPASPLRMANSALISVGCLAIFVT
490 500 510 520 530 540
520 530 540 550 560 570
pF1KB9 VISLLVYKKHKEYNPIENSPGNVVRSKGLSVFLNRAKAVFFPGNQEKDPLLKNQEFKGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VISLLVYKKHKEYNPIENSPGNVVRSKGLSVFLNRAKAVFFPGNQEKDPLLKNQEFKGVS
550 560 570 580 590 600
>>XP_016867167 (OMIM: 604368) PREDICTED: transmembrane g (519 aa)
initn: 3509 init1: 2401 opt: 2401 Z-score: 1672.7 bits: 319.3 E(85289): 2e-86
Smith-Waterman score: 3489; 97.1% identity (97.3% similar) in 524 aa overlap (1-524:1-512)
10 20 30 40 50 60
pF1KB9 MECLYYFLGFLLLAARLPLDAAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MECLYYFLGFLLLAARLPLDAAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 VWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 RNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 GQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 TMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 HTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSLATTLKSYDSNTPGPAGDNPLE
::::::::::::::::::::::::::::::::::::::: :::::::::
XP_016 HTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSL------------GPAGDNPLE
310 320 330 340
370 380 390 400 410 420
pF1KB9 LSRIPDENCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVTCQGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSRIPDENCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVTCQGSI
350 360 370 380 390 400
430 440 450 460 470 480
pF1KB9 PTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNGSGTYCVNLTLGDDTSLALTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNGSGTYCVNLTLGDDTSLALTS
410 420 430 440 450 460
490 500 510 520 530 540
pF1KB9 TLISVPDRDPASPLRMANSALISVGCLAIFVTVISLLVYKKHKEYNPIENSPGNVVRSKG
:::::::::::::::::::::::::::::::::::::::: .:
XP_016 TLISVPDRDPASPLRMANSALISVGCLAIFVTVISLLVYKLFSENTRNTTQ
470 480 490 500 510
550 560 570
pF1KB9 LSVFLNRAKAVFFPGNQEKDPLLKNQEFKGVS
>>NP_002501 (OMIM: 604368) transmembrane glycoprotein NM (560 aa)
initn: 3853 init1: 2401 opt: 2401 Z-score: 1672.2 bits: 319.3 E(85289): 2.1e-86
Smith-Waterman score: 3833; 97.9% identity (97.9% similar) in 572 aa overlap (1-572:1-560)
10 20 30 40 50 60
pF1KB9 MECLYYFLGFLLLAARLPLDAAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MECLYYFLGFLLLAARLPLDAAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 VWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 RNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 GQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 TMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 HTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSLATTLKSYDSNTPGPAGDNPLE
::::::::::::::::::::::::::::::::::::::: :::::::::
NP_002 HTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSL------------GPAGDNPLE
310 320 330 340
370 380 390 400 410 420
pF1KB9 LSRIPDENCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVTCQGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LSRIPDENCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVTCQGSI
350 360 370 380 390 400
430 440 450 460 470 480
pF1KB9 PTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNGSGTYCVNLTLGDDTSLALTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNGSGTYCVNLTLGDDTSLALTS
410 420 430 440 450 460
490 500 510 520 530 540
pF1KB9 TLISVPDRDPASPLRMANSALISVGCLAIFVTVISLLVYKKHKEYNPIENSPGNVVRSKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TLISVPDRDPASPLRMANSALISVGCLAIFVTVISLLVYKKHKEYNPIENSPGNVVRSKG
470 480 490 500 510 520
550 560 570
pF1KB9 LSVFLNRAKAVFFPGNQEKDPLLKNQEFKGVS
::::::::::::::::::::::::::::::::
NP_002 LSVFLNRAKAVFFPGNQEKDPLLKNQEFKGVS
530 540 550 560
>>NP_001186982 (OMIM: 155550) melanocyte protein PMEL is (575 aa)
initn: 529 init1: 286 opt: 451 Z-score: 326.0 bits: 70.2 E(85289): 2e-11
Smith-Waterman score: 513; 27.4% identity (50.8% similar) in 457 aa overlap (155-480:45-495)
130 140 150 160 170 180
pF1KB9 GLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTLGQYF
.:::: : : .. .:.::..: :::.
NP_001 IGALLAVGATKGSQVWGGQPVYPQETDDACIFPDGGPCPSGSWSQKRSFVYVWKTWGQYW
20 30 40 50 60 70
190 200 210 220 230 240
pF1KB9 QKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHG-RAYVPIAQVKDVYVVTDQIPVFVTMF
: :: .:..:. . :: . ::::::.:.: :.:::.:. ......:::.: :..
NP_001 QVLGGPVSGLSIGTGRAMLGTHTMEVTVYHRRGSRSYVPLAHSSSAFTITDQVPFSVSVS
80 90 100 110 120 130
250 260 270 280 290 300
pF1KB9 QKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVNHTY
: ..... ::.. :. : . .:::: .: . ..: :.:::..: ..: .:.:::
NP_001 QLRALDGGNKHFLRNQPLTFALQLHDPSGYLAEADLSYTWDFGDSSGTLISRALVVTHTY
140 150 160 170 180 190
310 320
pF1KB9 VLNGTFSLNLTVKAAAP----GPCPPP-------P-------------------------
. : . .....:: : : : : :
NP_001 LEPGPVTAQVVLQAAIPLTSCGSSPVPGTTDGHRPTAEAPNTTAGQVPTTEVVGTTPGQA
200 210 220 230 240 250
330 340 350
pF1KB9 PPPRPSK------PTPSLATT----LKSYDS---------------------NTPGPAGD
: .:: :: . .: . . .: .:: .:
NP_001 PTAEPSGTTSVQVPTTEVISTAPVQMPTAESTGMTPEKVPVSEVMGTTLAEMSTPEATGM
260 270 280 290 300 310
360
pF1KB9 NPLELSRI------------------------------PDE-------------------
.: :.: . ::
NP_001 TPAEVSIVVLSGTTAAQVTTTEWVETTARELPIPEPEGPDASSIMSTESITGSLGPLLDG
320 330 340 350 360 370
370 380 390 400 410
pF1KB9 -------------NCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVV
.: . ::: :..:. ::.:: . ...:. :: :.. ....:
NP_001 TATLRLVKRQVPLDCVLYRYGSFSVTLDIVQGI------ESAEILQAVPSGEGDAFELTV
380 390 400 410 420
420 430 440 450 460 470
pF1KB9 TCQGSIPTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNG-SGTYCVNLTLGDD
.:::..: :.: ::.: :. . .:.:: . : :.... ..: :::::.:..:.:
NP_001 SCQGGLPKEACMEISSPGCQPPAQRLCQPVLPSPACQLVLHQILKGGSGTYCLNVSLADT
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB9 TSLALTSTLISVPDRDPASPLRMANSALISVGCLAIFVTVISLLVYKKHKEYNPIENSPG
.:::..:
NP_001 NSLAVVSTQLIMPGQEAGLGQVPLIVGILLVLMAVVLASLIYRRRLMKQDFSVPQLPHSS
490 500 510 520 530 540
>>NP_001307051 (OMIM: 155550) melanocyte protein PMEL is (619 aa)
initn: 843 init1: 281 opt: 451 Z-score: 325.6 bits: 70.3 E(85289): 2.1e-11
Smith-Waterman score: 754; 27.8% identity (56.8% similar) in 558 aa overlap (54-521:44-576)
30 40 50 60 70 80
pF1KB9 RFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYPVWKRGDMRWKNSWKGGRVQAVLT
::..::: : . . . :.::.:. ..
NP_001 VIGALLAVGATKVPRNQDWLGVSRQLRTKAWNRQLYPEWT--EAQRLDCWRGGQVSLKVS
20 30 40 50 60 70
90 100 110 120 130 140
pF1KB9 SDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNCRNEAGLSADPYVYNWTAWSEDSD
.:.:.:.:.: .:.. : :: :: .:.... .: . .... . .. ...:
NP_001 NDGPTLIGANASFSIALNFPGSQKVLPDGQVIWVNN----TIINGSQVWGGQPVYPQETD
80 90 100 110 120
150 160 170 180 190 200
pF1KB9 GENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTLGQYFQKLGRCSVRVSVNTANVTL
.:::: : : .. .:.::..: :::.: :: .:..:. . :
NP_001 DAC--------IFPDGGPCPSGSWSQKRSFVYVWKTWGQYWQVLGGPVSGLSIGTGRAML
130 140 150 160 170
210 220 230 240 250 260
pF1KB9 GPQLMEVTVYRRHG-RAYVPIAQVKDVYVVTDQIPVFVTMFQKNDRNSSDETFLKDLPIM
: . ::::::.:.: :.:::.:. ......:::.: :.. : ..... ::.. :.
NP_001 GTHTMEVTVYHRRGSRSYVPLAHSSSAFTITDQVPFSVSVSQLRALDGGNKHFLRNQPLT
180 190 200 210 220 230
270 280 290 300 310 320
pF1KB9 FDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVNHTYVLNGTFSLNLTVKAAAP-G
: . .:::: .: . ..: :.:::..: ..: .:.:::. : . .....:: :
NP_001 FALQLHDPSGYLAEADLSYTWDFGDSSGTLISRALVVTHTYLEPGPVTAQVVLQAAIPLT
240 250 260 270 280 290
330 340 350
pF1KB9 PCPPPPPPP-----RPSKPTP-SLATTLKSYD--SNTPG------PAGDN----------
: : : ::. .: . : . . . ..::: :.: .
NP_001 SCGSSPVPGTTDGHRPTAEAPNTTAGQVPTTEVVGTTPGQAPTAEPSGTTSVQVPTTEVI
300 310 320 330 340 350
360
pF1KB9 ---PLELSR----------------------IPDE-------------------------
:... ::.
NP_001 STAPVQMPTAESTAAQVTTTEWVETTARELPIPEPEGPDASSIMSTESITGSLGPLLDGT
360 370 380 390 400 410
370 380 390 400 410
pF1KB9 ------------NCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVT
.: . ::: :..:. ::.:: . ...:. :: :.. ....:.
NP_001 ATLRLVKRQVPLDCVLYRYGSFSVTLDIVQGI------ESAEILQAVPSGEGDAFELTVS
420 430 440 450 460 470
420 430 440 450 460 470
pF1KB9 CQGSIPTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNG-SGTYCVNLTLGDDT
:::..: :.: ::.: :. . .:.:: . : :.... ..: :::::.:..:.: .
NP_001 CQGGLPKEACMEISSPGCQPPAQRLCQPVLPSPACQLVLHQILKGGSGTYCLNVSLADTN
480 490 500 510 520 530
480 490 500 510 520 530
pF1KB9 SLALTSTLISVPDRDPASPLRMANSALISVGCLAIFVTVI-SLLVYKKHKEYNPIENSPG
:::..:: . .: .. . ... :: :: : ....:. . :.:..
NP_001 SLAVVSTQLIMPGQEAG----LGQVPLI-VGILLVLMAVVLASLIYRRRLMKQDFSVPQL
540 550 560 570 580
540 550 560 570
pF1KB9 NVVRSKGLSVFLNRAKAVFFPGNQEKDPLLKNQEFKGVS
NP_001 PHSSSHWLRLPRIFCSCPIGENSPLLSGQQV
590 600 610
>>NP_001307050 (OMIM: 155550) melanocyte protein PMEL is (626 aa)
initn: 841 init1: 281 opt: 451 Z-score: 325.5 bits: 70.3 E(85289): 2.2e-11
Smith-Waterman score: 739; 27.9% identity (56.2% similar) in 560 aa overlap (54-519:44-581)
30 40 50 60 70 80
pF1KB9 RFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYPVWKRGDMRWKNSWKGGRVQAVLT
::..::: : . . . :.::.:. ..
NP_001 VIGALLAVGATKVPRNQDWLGVSRQLRTKAWNRQLYPEWT--EAQRLDCWRGGQVSLKVS
20 30 40 50 60 70
90 100 110 120 130 140
pF1KB9 SDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNCRNEAGLSADPYVYNWTAWSEDSD
.:.:.:.:.: .:.. : :: :: .:.... .: . .... . .. ...:
NP_001 NDGPTLIGANASFSIALNFPGSQKVLPDGQVIWVNN----TIINGSQVWGGQPVYPQETD
80 90 100 110 120
150 160 170 180 190 200
pF1KB9 GENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTLGQYFQKLGRCSVRVSVNTANVTL
.:::: : : .. .:.::..: :::.: :: .:..:. . :
NP_001 DAC--------IFPDGGPCPSGSWSQKRSFVYVWKTWGQYWQVLGGPVSGLSIGTGRAML
130 140 150 160 170
210 220 230 240 250 260
pF1KB9 GPQLMEVTVYRRHG-RAYVPIAQVKDVYVVTDQIPVFVTMFQKNDRNSSDETFLKDLPIM
: . ::::::.:.: :.:::.:. ......:::.: :.. : ..... ::.. :.
NP_001 GTHTMEVTVYHRRGSRSYVPLAHSSSAFTITDQVPFSVSVSQLRALDGGNKHFLRNQPLT
180 190 200 210 220 230
270 280 290 300 310 320
pF1KB9 FDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVNHTYVLNGTFSLNLTVKAAAP-G
: . .:::: .: . ..: :.:::..: ..: .:.:::. : . .....:: :
NP_001 FALQLHDPSGYLAEADLSYTWDFGDSSGTLISRALVVTHTYLEPGPVTAQVVLQAAIPLT
240 250 260 270 280 290
330 340 350
pF1KB9 PCPPPPPPP-----RPSKPTP-SLATTLKSYD--SNTPG------PAGDN----------
: : : ::. .: . : . . . ..::: :.: .
NP_001 SCGSSPVPGTTDGHRPTAEAPNTTAGQVPTTEVVGTTPGQAPTAEPSGTTSVQVPTTEVI
300 310 320 330 340 350
360
pF1KB9 ---PLELSR----------------------IPDE-------------------------
:... ::.
NP_001 STAPVQMPTAESTAAQVTTTEWVETTARELPIPEPEGPDASSIMSTESITGSLGPLLDGT
360 370 380 390 400 410
370 380 390 400 410
pF1KB9 ------------NCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVT
.: . ::: :..:. ::.:: . ...:. :: :.. ....:.
NP_001 ATLRLVKRQVPLDCVLYRYGSFSVTLDIVQGI------ESAEILQAVPSGEGDAFELTVS
420 430 440 450 460 470
420 430 440 450 460 470
pF1KB9 CQGSIPTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNG-SGTYCVNLTLGDDT
:::..: :.: ::.: :. . .:.:: . : :.... ..: :::::.:..:.: .
NP_001 CQGGLPKEACMEISSPGCQPPAQRLCQPVLPSPACQLVLHQILKGGSGTYCLNVSLADTN
480 490 500 510 520 530
480 490 500 510 520
pF1KB9 SLALTSTLISVPDRDPASPLRMANSAL----ISVGCLAIFVTVI-SLLVYKKHKEYNPIE
:::..:: . .: :. : ...: . :: : ....:. . :.:
NP_001 SLAVVSTQLIMPV--PGILLTGQEAGLGQVPLIVGILLVLMAVVLASLIYRRRLMKQDFS
540 550 560 570 580 590
530 540 550 560 570
pF1KB9 NSPGNVVRSKGLSVFLNRAKAVFFPGNQEKDPLLKNQEFKGVS
NP_001 VPQLPHSSSHWLRLPRIFCSCPIGENSPLLSGQQV
600 610 620
>>NP_008859 (OMIM: 155550) melanocyte protein PMEL isofo (661 aa)
initn: 685 init1: 286 opt: 451 Z-score: 325.2 bits: 70.3 E(85289): 2.3e-11
Smith-Waterman score: 650; 26.7% identity (52.2% similar) in 558 aa overlap (54-480:44-581)
30 40 50 60 70 80
pF1KB9 RFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYPVWKRGDMRWKNSWKGGRVQAVLT
::..::: : . . . :.::.:. ..
NP_008 VIGALLAVGATKVPRNQDWLGVSRQLRTKAWNRQLYPEWT--EAQRLDCWRGGQVSLKVS
20 30 40 50 60 70
90 100 110 120 130 140
pF1KB9 SDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNCRNEAGLSADPYVYNWTAWSEDSD
.:.:.:.:.: .:.. : :: :: .:.... .: . .... . .. ...:
NP_008 NDGPTLIGANASFSIALNFPGSQKVLPDGQVIWVNN----TIINGSQVWGGQPVYPQETD
80 90 100 110 120
150 160 170 180 190 200
pF1KB9 GENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTLGQYFQKLGRCSVRVSVNTANVTL
.:::: : : .. .:.::..: :::.: :: .:..:. . :
NP_008 DAC--------IFPDGGPCPSGSWSQKRSFVYVWKTWGQYWQVLGGPVSGLSIGTGRAML
130 140 150 160 170
210 220 230 240 250 260
pF1KB9 GPQLMEVTVYRRHG-RAYVPIAQVKDVYVVTDQIPVFVTMFQKNDRNSSDETFLKDLPIM
: . ::::::.:.: :.:::.:. ......:::.: :.. : ..... ::.. :.
NP_008 GTHTMEVTVYHRRGSRSYVPLAHSSSAFTITDQVPFSVSVSQLRALDGGNKHFLRNQPLT
180 190 200 210 220 230
270 280 290 300 310 320
pF1KB9 FDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVNHTYVLNGTFSLNLTVKAAAP--
: . .:::: .: . ..: :.:::..: ..: .:.:::. : . .....:: :
NP_008 FALQLHDPSGYLAEADLSYTWDFGDSSGTLISRALVVTHTYLEPGPVTAQVVLQAAIPLT
240 250 260 270 280 290
330 340
pF1KB9 --GPCPPP-------P-------------------------PPPRPSK------PTPSLA
: : : : : .:: :: .
NP_008 SCGSSPVPGTTDGHRPTAEAPNTTAGQVPTTEVVGTTPGQAPTAEPSGTTSVQVPTTEVI
300 310 320 330 340 350
350 360
pF1KB9 TT----LKSYDS---------------------NTPGPAGDNPLELSRI-----------
.: . . .: .:: .: .: :.: .
NP_008 STAPVQMPTAESTGMTPEKVPVSEVMGTTLAEMSTPEATGMTPAEVSIVVLSGTTAAQVT
360 370 380 390 400 410
370
pF1KB9 -------------------PDE--------------------------------NCQINR
:: .: . :
NP_008 TTEWVETTARELPIPEPEGPDASSIMSTESITGSLGPLLDGTATLRLVKRQVPLDCVLYR
420 430 440 450 460 470
380 390 400 410 420 430
pF1KB9 YGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVTCQGSIPTEVCTIISDPTC
:: :..:. ::.: :. ...:. :: :.. ....:.:::..: :.: ::.: :
NP_008 YGSFSVTLDIVQG------IESAEILQAVPSGEGDAFELTVSCQGGLPKEACMEISSPGC
480 490 500 510 520 530
440 450 460 470 480 490
pF1KB9 EITQNTVCSPVDVDEMCLLTVRRTFNG-SGTYCVNLTLGDDTSLALTSTLISVPDRDPAS
. . .:.:: . : :.... ..: :::::.:..:.: .:::..:
NP_008 QPPAQRLCQPVLPSPACQLVLHQILKGGSGTYCLNVSLADTNSLAVVSTQLIMPGQEAGL
540 550 560 570 580 590
500 510 520 530 540 550
pF1KB9 PLRMANSALISVGCLAIFVTVISLLVYKKHKEYNPIENSPGNVVRSKGLSVFLNRAKAVF
NP_008 GQVPLIVGILLVLMAVVLASLIYRRRLMKQDFSVPQLPHSSSHWLRLPRIFCSCPIGENS
600 610 620 630 640 650
572 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 08:02:09 2016 done: Sat Nov 5 08:02:11 2016
Total Scan time: 11.540 Total Display time: 0.130
Function used was FASTA [36.3.4 Apr, 2011]