FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0014, 487 aa 1>>>pF1KE0014 487 - 487 aa - 487 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9303+/-0.00129; mu= 19.7812+/- 0.077 mean_var=62.4075+/-12.976, 0's: 0 Z-trim(99.6): 36 B-trim: 269 in 1/46 Lambda= 0.162351 statistics sampled from 5760 (5782) to 5760 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.52), E-opt: 0.2 (0.178), width: 16 Scan time: 2.900 The best scores are: opt bits E(32554) CCDS8572.1 LPCAT3 gene_id:10162|Hs108|chr12 ( 487) 3270 775.3 0 CCDS1660.1 MBOAT2 gene_id:129642|Hs108|chr2 ( 520) 249 67.7 3.3e-11 CCDS34346.1 MBOAT1 gene_id:154141|Hs108|chr6 ( 495) 244 66.6 7.2e-11 >>CCDS8572.1 LPCAT3 gene_id:10162|Hs108|chr12 (487 aa) initn: 3270 init1: 3270 opt: 3270 Z-score: 4139.1 bits: 775.3 E(32554): 0 Smith-Waterman score: 3270; 100.0% identity (100.0% similar) in 487 aa overlap (1-487:1-487) 10 20 30 40 50 60 pF1KE0 MASSAEGDEGTVVALAGVLQSGFQELSLNKLATSLGASEQALRLIISIFLGYPFALFYRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 MASSAEGDEGTVVALAGVLQSGFQELSLNKLATSLGASEQALRLIISIFLGYPFALFYRH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 YLFYKETYLIHLFHTFTGLSIAYFNFGNQLYHSLLCIVLQFLILRLMGRTITAVLTTFCF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 YLFYKETYLIHLFHTFTGLSIAYFNFGNQLYHSLLCIVLQFLILRLMGRTITAVLTTFCF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 QMAYLLAGYYYTATGNYDIKWTMPHCVLTLKLIGLAVDYFDGGKDQNSLSSEQQKYAIRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 QMAYLLAGYYYTATGNYDIKWTMPHCVLTLKLIGLAVDYFDGGKDQNSLSSEQQKYAIRG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 VPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVQGELIDIPGKIPNSIIPALKRLSLGLFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 VPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVQGELIDIPGKIPNSIIPALKRLSLGLFY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 LVGYTLLSPHITEDYLLTEDYDNHPFWFRCMYMLIWGKFVLYKYVTCWLVTEGVCILTGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 LVGYTLLSPHITEDYLLTEDYDNHPFWFRCMYMLIWGKFVLYKYVTCWLVTEGVCILTGL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 GFNGFEEKGKAKWDACANMKVWLFETNPRFTGTIASFNINTNAWVARYIFKRLKFLGNKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 GFNGFEEKGKAKWDACANMKVWLFETNPRFTGTIASFNINTNAWVARYIFKRLKFLGNKE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 LSQGLSLLFLALWHGLHSGYLVCFQMEFLIVIVERQAARLIQESPTLSKLAAITVLQPFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 LSQGLSLLFLALWHGLHSGYLVCFQMEFLIVIVERQAARLIQESPTLSKLAAITVLQPFY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 YLVQQTIHWLFMGYSMTAFCLFTWDKWLKVYKSIYFLGHIFFLSLLFILPYIHKAMVPRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS85 YLVQQTIHWLFMGYSMTAFCLFTWDKWLKVYKSIYFLGHIFFLSLLFILPYIHKAMVPRK 430 440 450 460 470 480 pF1KE0 EKLKKME ::::::: CCDS85 EKLKKME >>CCDS1660.1 MBOAT2 gene_id:129642|Hs108|chr2 (520 aa) initn: 320 init1: 177 opt: 249 Z-score: 314.6 bits: 67.7 E(32554): 3.3e-11 Smith-Waterman score: 498; 24.7% identity (55.0% similar) in 469 aa overlap (28-470:12-464) 10 20 30 40 50 60 pF1KE0 MASSAEGDEGTVVALAGVLQSGFQELSLNKLATSLGASEQALRLIISIFLGYPFALFYRH :. :.... . . ... ... :...: CCDS16 MATTSTTGSTLLQPLSNAVQLPIDQVNFVVCQLFALLAAIWFRT 10 20 30 40 70 80 90 100 110 pF1KE0 YLFYKET--YLIHLFHTFTGLSIAYFNFGNQLYHSLLCIVLQFLILRLMGRTITAVLTTF :: ..: .. :. :. :: .: : :: : :. ... :. ..: . . .. CCDS16 YLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIG---VENMHNY 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE0 CFQMA--YL----LAGYYYTATGNYDIKWTMPHCVLTLKLIGLAVDYFDGG--KDQNSLS :: .: :: .. : :.:. .. : ..: :. .:: . :: ::.. :. CCDS16 CFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEE-LT 110 120 130 140 150 160 180 190 200 210 220 pF1KE0 SEQQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVQGELIDIP-----GK--- : :. :.: .::::: ... . ..:.:: :.. :. ...:. : :: CCDS16 SSQRDLAVRRMPSLLEYLSYNCNFMGILAGPLCSYKDYITFIEGRSYHITQSGENGKEET 170 180 190 200 210 220 230 240 250 260 270 pF1KE0 -------IPNSIIPALKRLSLGLFYLVGYTLLSPHITEDYLLTEDYDNHPFW-FRCMYML ::. . . : : :: : :. . . .: . : .. : . .:. CCDS16 QYERTEPSPNTAV-VQKLLVCGLSLLFHLTICTT-LPVEYNIDEHFQATASWPTKIIYLY 230 240 250 260 270 280 290 300 310 320 330 pF1KE0 IWGKFVLYKYVTCWLVTEGVCILTGLGFNGFEEKGKAKWDACANMKVWLFETNPRFTGTI : . :: : ..... .:.:: :..:.: :.:: .:... .: . : . CCDS16 ISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFKMFL 280 290 300 310 320 330 340 350 360 370 380 390 pF1KE0 ASFNINTNAWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLVCFQMEFLIVIVE ..::.: :. : ..: .: . . .... :.:::.. :: . :: .. CCDS16 DNWNIQTALWLKRVCYERTSFSPTIQ-----TFILSAIWHGVYPGYY----LTFLTGVLM 340 350 360 370 380 400 410 420 430 440 450 pF1KE0 RQAARLIQESPTLSKLAAITVLQPFYYLVQQTIHWLFMGYSMTAFCLFTWDKWLKVYKSI ::: .... . . :. :: .. . . ..:... : :.. : :.: CCDS16 TLAARAMRNN-FRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSW 390 400 410 420 430 440 460 470 480 pF1KE0 YFLGHIFFLSLLFILPYIHKAMVPRKEKLKKME :. ::. . .:..:: CCDS16 YYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKKFDEGENSLGQNSFSTTNNVCNQN 450 460 470 480 490 500 >>CCDS34346.1 MBOAT1 gene_id:154141|Hs108|chr6 (495 aa) initn: 329 init1: 154 opt: 244 Z-score: 308.6 bits: 66.6 E(32554): 7.2e-11 Smith-Waterman score: 460; 23.6% identity (54.8% similar) in 478 aa overlap (28-482:20-484) 10 20 30 40 50 60 pF1KE0 MASSAEGDEGTVVALAGVLQSGFQELSLNKLATSLGASEQALRLIISIFLGYPFALFYRH :. :. :: . . ... ... :...: CCDS34 MAAEPQPSSLSYRTTGSTYLHPLSELLGIPLDQVNFVVCQLVALFAAFWFRI 10 20 30 40 50 70 80 90 100 110 pF1KE0 YLFYKETY--LIHLFHTFTGLSIAYFNFGNQLYHSLLCIVLQFLILRLMGRTITAVLT-T :: : . : :. :. .. : :: : .. ... . :. . ... . . CCDS34 YLRPGTTSSDVRHAVATIFGIYFVIFCFGWYSVHLFVLVLMCYAIM--VTASVSNIHRYS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 FCFQMAYL----LAGYYYTATGNYDIKWTMPHCVLTLKLIGLAVDYFDG-GKDQNSLSSE : :.:: .. : : .. : ..: :. :: . :: :. ..::.: CCDS34 FFVAMGYLTICHISRIYIFHYGILTTDFSGPLMIVTQKITTLAFQVHDGLGRRAEDLSAE 120 130 140 150 160 170 180 190 200 210 220 pF1KE0 QQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVQGE-----LIDIPGKI---- :.. ::. ::.:: .. . . ..:: ... :. ...:. :... : CCDS34 QHRLAIKVKPSFLEYLSYLLNFMSVIAGPCNNFKDYIAFIEGKHIHMKLLEVNWKRKGFH 180 190 200 210 220 230 230 240 250 260 270 pF1KE0 ----PNSIIPALKRLSLGLFYLVGYTLLSPHITEDYLLTEDYDNHPFWF--RCMYMLIWG :. ....:.. : :. . :. . :. .:. : : : :. . CCDS34 SLPEPSPTGAVIHKLGITLVSLLLFLTLTKTFPVTCLV-DDWFVHKASFPARLCYLYVVM 240 250 260 270 280 280 290 300 310 320 330 pF1KE0 KFVLYKYVTCWLVTEGVCILTGLGFNGFEEKGKAKWDACANMKVWLFETNPRFTGTIASF . :: : ....: .:.::.: ...:. :: .:...: .:: : . .. CCDS34 QASKPKYYFAWTLADAVNNAAGFGFSGVDKNGNFCWDLLSNLNIWKIETATSFKMYLENW 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE0 NINTNAWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLVCFQMEFLIVIVERQA ::.: .:. ..:. . . :.... :::::.. :: : .:.... : : CCDS34 NIQTATWLKCVCYQRVPWYPTV-----LTFILSALWHGVYPGYYFTFLTGILVTLAAR-A 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE0 ARLIQESPTLSKLAAITVLQPFYYLVQQTIHWLFMGYSMTAFCLFTWDKWLKVYKSIYFL .: . ::. : .: . . : : : ..:... : ... . ...:::.:: CCDS34 VRNNYRHYFLSSRALKAVYDAGTWAVTQ----LAVSYTVAPFVMLAVEPTISLYKSMYFY 410 420 430 440 450 460 470 480 pF1KE0 GHIFFLSLLFILPYIHKAMVPRKEKLKKME ::. : ....::. .: . :. . CCDS34 LHIISLLIILFLPMKPQAHTQRRPQTLNSINKRKTD 460 470 480 490 487 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 08:23:09 2016 done: Fri Nov 4 08:23:10 2016 Total Scan time: 2.900 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]