FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0032, 607 aa 1>>>pF1KE0032 607 - 607 aa - 607 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8294+/-0.000312; mu= 18.1248+/- 0.020 mean_var=93.6973+/-19.072, 0's: 0 Z-trim(118.0): 108 B-trim: 0 in 0/52 Lambda= 0.132498 statistics sampled from 30454 (30565) to 30454 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.71), E-opt: 0.2 (0.358), width: 16 Scan time: 11.840 The best scores are: opt bits E(85289) NP_932327 (OMIM: 605278) cocaine esterase isoform ( 607) 4132 800.1 0 NP_003860 (OMIM: 605278) cocaine esterase isoform ( 623) 3534 685.7 1.2e-196 XP_016879307 (OMIM: 605278) PREDICTED: cocaine est ( 450) 3041 591.4 2.2e-168 XP_011521723 (OMIM: 605278) PREDICTED: cocaine est ( 466) 2443 477.1 5.8e-134 NP_001172106 (OMIM: 605279) carboxylesterase 3 iso ( 568) 1385 274.9 5.1e-73 NP_079198 (OMIM: 605279) carboxylesterase 3 isofor ( 571) 1385 274.9 5.1e-73 XP_011521277 (OMIM: 605279) PREDICTED: carboxylest ( 547) 1368 271.7 4.7e-72 XP_011521278 (OMIM: 605279) PREDICTED: carboxylest ( 402) 1146 229.1 2.2e-59 NP_001257 (OMIM: 114835) liver carboxylesterase 1 ( 566) 1049 210.7 1.1e-53 NP_001020365 (OMIM: 114835) liver carboxylesterase ( 567) 1049 210.7 1.1e-53 XP_005255831 (OMIM: 114835) PREDICTED: liver carbo ( 567) 1049 210.7 1.1e-53 NP_001020366 (OMIM: 114835) liver carboxylesterase ( 568) 1049 210.7 1.1e-53 XP_016885526 (OMIM: 400028) PREDICTED: neuroligin- ( 816) 743 152.3 5.9e-36 XP_016885527 (OMIM: 400028) PREDICTED: neuroligin- ( 816) 743 152.3 5.9e-36 XP_016885524 (OMIM: 400028) PREDICTED: neuroligin- ( 816) 743 152.3 5.9e-36 XP_016885523 (OMIM: 400028) PREDICTED: neuroligin- ( 816) 743 152.3 5.9e-36 NP_055708 (OMIM: 400028) neuroligin-4, Y-linked is ( 816) 743 152.3 5.9e-36 XP_016885525 (OMIM: 400028) PREDICTED: neuroligin- ( 816) 743 152.3 5.9e-36 NP_001269075 (OMIM: 300427,300495,300497) neurolig ( 816) 735 150.8 1.7e-35 NP_001269074 (OMIM: 300427,300495,300497) neurolig ( 816) 735 150.8 1.7e-35 NP_065793 (OMIM: 300427,300495,300497) neuroligin- ( 816) 735 150.8 1.7e-35 XP_016885180 (OMIM: 300427,300495,300497) PREDICTE ( 816) 735 150.8 1.7e-35 NP_851849 (OMIM: 300427,300495,300497) neuroligin- ( 816) 735 150.8 1.7e-35 XP_016885181 (OMIM: 300427,300495,300497) PREDICTE ( 816) 735 150.8 1.7e-35 XP_016885182 (OMIM: 300427,300495,300497) PREDICTE ( 816) 735 150.8 1.7e-35 XP_005256801 (OMIM: 606479) PREDICTED: neuroligin- ( 818) 730 149.8 3.3e-35 XP_016867709 (OMIM: 100740,112100) PREDICTED: acet ( 692) 727 149.2 4.3e-35 XP_011514528 (OMIM: 100740,112100) PREDICTED: acet ( 695) 727 149.2 4.4e-35 XP_016867708 (OMIM: 100740,112100) PREDICTED: acet ( 780) 726 149.1 5.4e-35 XP_011514527 (OMIM: 100740,112100) PREDICTED: acet ( 783) 726 149.1 5.4e-35 NP_001269378 (OMIM: 100740,112100) acetylcholinest ( 526) 723 148.4 6e-35 NP_001289551 (OMIM: 100740,112100) acetylcholinest ( 614) 722 148.2 7.7e-35 NP_000656 (OMIM: 100740,112100) acetylcholinestera ( 614) 722 148.2 7.7e-35 NP_001289550 (OMIM: 100740,112100) acetylcholinest ( 617) 722 148.2 7.7e-35 XP_011514531 (OMIM: 100740,112100) PREDICTED: acet ( 617) 722 148.2 7.7e-35 NP_056646 (OMIM: 100740,112100) acetylcholinestera ( 617) 722 148.2 7.7e-35 XP_011514530 (OMIM: 100740,112100) PREDICTED: acet ( 617) 722 148.2 7.7e-35 XP_006716058 (OMIM: 100740,112100) PREDICTED: acet ( 617) 722 148.2 7.7e-35 XP_016861391 (OMIM: 600568) PREDICTED: neuroligin- ( 814) 716 147.2 2.1e-34 XP_016861393 (OMIM: 600568) PREDICTED: neuroligin- ( 814) 716 147.2 2.1e-34 XP_005247293 (OMIM: 600568) PREDICTED: neuroligin- ( 814) 716 147.2 2.1e-34 XP_016861392 (OMIM: 600568) PREDICTED: neuroligin- ( 814) 716 147.2 2.1e-34 NP_001160132 (OMIM: 300336,300425,300494) neurolig ( 808) 700 144.1 1.7e-33 NP_000046 (OMIM: 177400) cholinesterase precursor ( 602) 695 143.0 2.7e-33 XP_016862456 (OMIM: 177400) PREDICTED: cholinester ( 643) 695 143.1 2.8e-33 XP_005274621 (OMIM: 300427,300495,300497) PREDICTE ( 836) 665 137.4 1.9e-31 XP_005274623 (OMIM: 300427,300495,300497) PREDICTE ( 836) 665 137.4 1.9e-31 XP_011543850 (OMIM: 300427,300495,300497) PREDICTE ( 836) 665 137.4 1.9e-31 XP_016885179 (OMIM: 300427,300495,300497) PREDICTE ( 836) 665 137.4 1.9e-31 XP_006724567 (OMIM: 300427,300495,300497) PREDICTE ( 836) 665 137.4 1.9e-31 >>NP_932327 (OMIM: 605278) cocaine esterase isoform 2 [H (607 aa) initn: 4132 init1: 4132 opt: 4132 Z-score: 4269.4 bits: 800.1 E(85289): 0 Smith-Waterman score: 4132; 100.0% identity (100.0% similar) in 607 aa overlap (1-607:1-607) 10 20 30 40 50 60 pF1KE0 MTAQSRSPTTPTFPGPSQRTPLTPCPVQTPRLGKALIHCWTDPGQPLGEQQRVRRQRTET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_932 MTAQSRSPTTPTFPGPSQRTPLTPCPVQTPRLGKALIHCWTDPGQPLGEQQRVRRQRTET 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SEPTMRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_932 SEPTMRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 TFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_932 TFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 DSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_932 DSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 YRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_932 YRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 LVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_932 LVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 KEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_932 KEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 YDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_932 YDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 VIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHVKFTEEEEQLSRKMMKYWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_932 VIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHVKFTEEEEQLSRKMMKYWA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 NFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_932 NFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEP 550 560 570 580 590 600 pF1KE0 EERHTEL ::::::: NP_932 EERHTEL >>NP_003860 (OMIM: 605278) cocaine esterase isoform 1 [H (623 aa) initn: 3534 init1: 3534 opt: 3534 Z-score: 3651.5 bits: 685.7 E(85289): 1.2e-196 Smith-Waterman score: 4089; 97.3% identity (97.4% similar) in 623 aa overlap (1-607:1-623) 10 20 30 40 50 60 pF1KE0 MTAQSRSPTTPTFPGPSQRTPLTPCPVQTPRLGKALIHCWTDPGQPLGEQQRVRRQRTET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MTAQSRSPTTPTFPGPSQRTPLTPCPVQTPRLGKALIHCWTDPGQPLGEQQRVRRQRTET 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SEPTMRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SEPTMRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 TFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 DSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 YRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 LVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 KEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 YDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMF 430 440 450 460 470 480 490 500 510 520 pF1KE0 VIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADH----------------VKF ::::::::::::::::::::::::::::::::::::::::: .:: NP_003 VIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKF 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE0 TEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQ 550 560 570 580 590 600 590 600 pF1KE0 FWKKALPQKIQELEEPEERHTEL ::::::::::::::::::::::: NP_003 FWKKALPQKIQELEEPEERHTEL 610 620 >>XP_016879307 (OMIM: 605278) PREDICTED: cocaine esteras (450 aa) initn: 3041 init1: 3041 opt: 3041 Z-score: 3144.1 bits: 591.4 E(85289): 2.2e-168 Smith-Waterman score: 3041; 100.0% identity (100.0% similar) in 450 aa overlap (158-607:1-450) 130 140 150 160 170 180 pF1KE0 AKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDC :::::::::::::::::::::::::::::: XP_016 MCLQDLTAVESEFLSQFNMTFPSDSMSEDC 10 20 30 190 200 210 220 230 240 pF1KE0 LYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLG 40 50 60 70 80 90 250 260 270 280 290 300 pF1KE0 FFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPIS 100 110 120 130 140 150 310 320 330 340 350 360 pF1KE0 QGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAI 160 170 180 190 200 210 370 380 390 400 410 420 pF1KE0 NKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEM 220 230 240 250 260 270 430 440 450 460 470 480 pF1KE0 DREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQV 280 290 300 310 320 330 490 500 510 520 530 540 pF1KE0 AHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHVKFTEEEEQLSRKMMKYWANFARNGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHVKFTEEEEQLSRKMMKYWANFARNGN 340 350 360 370 380 390 550 560 570 580 590 600 pF1KE0 PNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL 400 410 420 430 440 450 >>XP_011521723 (OMIM: 605278) PREDICTED: cocaine esteras (466 aa) initn: 2443 init1: 2443 opt: 2443 Z-score: 2526.1 bits: 477.1 E(85289): 5.8e-134 Smith-Waterman score: 2998; 96.4% identity (96.6% similar) in 466 aa overlap (158-607:1-466) 130 140 150 160 170 180 pF1KE0 AKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDC :::::::::::::::::::::::::::::: XP_011 MCLQDLTAVESEFLSQFNMTFPSDSMSEDC 10 20 30 190 200 210 220 230 240 pF1KE0 LYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLG 40 50 60 70 80 90 250 260 270 280 290 300 pF1KE0 FFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPIS 100 110 120 130 140 150 310 320 330 340 350 360 pF1KE0 QGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAI 160 170 180 190 200 210 370 380 390 400 410 420 pF1KE0 NKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEM 220 230 240 250 260 270 430 440 450 460 470 480 pF1KE0 DREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQV 280 290 300 310 320 330 490 500 510 520 530 pF1KE0 AHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADH----------------VKFTEEEEQL :::::::::::::::::::::::::::::::::: .::::::::: XP_011 AHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQL 340 350 360 370 380 390 540 550 560 570 580 590 pF1KE0 SRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALP 400 410 420 430 440 450 600 pF1KE0 QKIQELEEPEERHTEL :::::::::::::::: XP_011 QKIQELEEPEERHTEL 460 >>NP_001172106 (OMIM: 605279) carboxylesterase 3 isoform (568 aa) initn: 1462 init1: 707 opt: 1385 Z-score: 1431.9 bits: 274.9 E(85289): 5.1e-73 Smith-Waterman score: 1616; 46.3% identity (70.7% similar) in 553 aa overlap (74-602:12-560) 50 60 70 80 90 100 pF1KE0 GQPLGEQQRVRRQRTETSEPTMRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTG : .:.: :: . . : . :.: : : NP_001 MERAVRVESGVLVGVVCLLLACPATATGPEVAQPEVDTTLG 10 20 30 40 110 120 130 140 150 160 pF1KE0 QVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDL .: : : :::.. :..:::::::.::::: ::. :.: . : ::::..: : :::::. NP_001 RVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDV 50 60 70 80 90 100 170 180 190 200 210 220 pF1KE0 TAVESEFLSQFNMTFPSD--SMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMAS ...: :.: .. .. :.::::: :..:.::. ::. :::::.:::::. : :. NP_001 ESMNS---SRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAAT 110 120 130 140 150 230 240 250 260 270 280 pF1KE0 LYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGG :::: ::: .:::: .::::::::::::::.:: :: :.:: ::::::::.::: ::: NP_001 SYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGG 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE0 NPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANL . . ::.:: ::::. .:.::.::.. :::: :: .::: ::.: : .. .:: NP_001 DLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANT 220 230 240 250 260 270 350 360 370 380 390 pF1KE0 SACDQVDSEALVGCLRGKSKEEILAINKPFK--MIPGVVDGVFLPRHPQELLASADFQPV ::.. . .: ::. : :: :...: .: . : .:::. .:. :.::: :. : NP_001 LACSSSSPAEMVQCLQQKEGEE-LVLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSV 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE0 PSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIG : ..::::.::.::::. . ::...:.:: : .:: : .:: . . .::.: NP_001 PFLMGVNNHEFSWLIPRGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMMPTVIDEYLG 340 350 360 370 380 390 460 470 480 490 500 510 pF1KE0 DNGDPQTLQAQFQEMMADSMFVIPALQVAHF-QCSRAPVYFYEFQHQPSWLKNIRPPHMK .:.: :. :::.:.: .. .:... ... . : .::.::::::.:: . .:.: .: NP_001 SNSDAQAKCQAFQEFMGDVFINVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVK 400 410 420 430 440 450 520 530 540 550 pF1KE0 ADH-------------------VKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLF ::: .. ::::.::: :: :..:::.:.::...:: :: : NP_001 ADHGAEGAFVFGGPFLMDESSRLEATEEEKQLSLTMMAQWTHFARTGDPNSKALPPWPQF 460 470 480 490 500 510 560 570 580 590 600 pF1KE0 DQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL .: ::::..: : .:. .. .:::...::.:::. .. .. NP_001 NQAEQYLEINPVPRAGQKFREAWMQFWSETLPSKIQQWHQKQKNRKAQEDL 520 530 540 550 560 >>NP_079198 (OMIM: 605279) carboxylesterase 3 isoform 1 (571 aa) initn: 1462 init1: 707 opt: 1385 Z-score: 1431.9 bits: 274.9 E(85289): 5.1e-73 Smith-Waterman score: 1609; 46.2% identity (70.3% similar) in 556 aa overlap (74-602:12-563) 50 60 70 80 90 100 pF1KE0 GQPLGEQQRVRRQRTETSEPTMRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTG : .:.: :: . . : . :.: : : NP_079 MERAVRVESGVLVGVVCLLLACPATATGPEVAQPEVDTTLG 10 20 30 40 110 120 130 140 150 160 pF1KE0 QVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDL .: : : :::.. :..:::::::.::::: ::. :.: . : ::::..: : :::::. NP_079 RVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDV 50 60 70 80 90 100 170 180 190 200 210 220 pF1KE0 TAVESEFLSQFNMTFPSD--SMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMAS ...: :.: .. .. :.::::: :..:.::. ::. :::::.:::::. : :. NP_079 ESMNS---SRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAAT 110 120 130 140 150 230 240 250 260 270 280 pF1KE0 LYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGG :::: ::: .:::: .::::::::::::::.:: :: :.:: ::::::::.::: ::: NP_079 SYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGG 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE0 NPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANL . . ::.:: ::::. .:.::.::.. :::: :: .::: ::.: : .. .:: NP_079 DLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANT 220 230 240 250 260 270 350 360 370 380 390 pF1KE0 SACDQVDSEALVGCLRGKSKEEILAINKPFK--MIPGVVDGVFLPRHPQELLASADFQPV ::.. . .: ::. : :: :...: .: . : .:::. .:. :.::: :. : NP_079 LACSSSSPAEMVQCLQQKEGEE-LVLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSV 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE0 PSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIG : ..::::.::.::::. . ::...:.:: : .:: : .:: . . .::.: NP_079 PFLMGVNNHEFSWLIPRGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMMPTVIDEYLG 340 350 360 370 380 390 460 470 480 490 500 510 pF1KE0 DNGDPQTLQAQFQEMMADSMFVIPALQVAHF-QCSRAPVYFYEFQHQPSWLKNIRPPHMK .:.: :. :::.:.: .. .:... ... . : .::.::::::.:: . .:.: .: NP_079 SNSDAQAKCQAFQEFMGDVFINVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVK 400 410 420 430 440 450 520 530 540 550 pF1KE0 ADH-------------------VKF---TEEEEQLSRKMMKYWANFARNGNPNGEGLPHW ::: . : ::::.::: :: :..:::.:.::...:: : NP_079 ADHGAEGAFVFGGPFLMDESSRLAFPEATEEEKQLSLTMMAQWTHFARTGDPNSKALPPW 460 470 480 490 500 510 560 570 580 590 600 pF1KE0 PLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL : :.: ::::..: : .:. .. .:::...::.:::. .. .. NP_079 PQFNQAEQYLEINPVPRAGQKFREAWMQFWSETLPSKIQQWHQKQKNRKAQEDL 520 530 540 550 560 570 >>XP_011521277 (OMIM: 605279) PREDICTED: carboxylesteras (547 aa) initn: 1462 init1: 707 opt: 1368 Z-score: 1414.6 bits: 271.7 E(85289): 4.7e-72 Smith-Waterman score: 1592; 47.0% identity (70.4% similar) in 540 aa overlap (90-602:4-539) 60 70 80 90 100 110 pF1KE0 TSEPTMRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGV : . :.: : :.: : : :::.. : XP_011 MLCGPEVAQPEVDTTLGRVRGRQVGVKGTDRLV 10 20 30 120 130 140 150 160 170 pF1KE0 QTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFP ..:::::::.::::: ::. :.: . : ::::..: : ::::: ::: :.: .. XP_011 NVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQD---VESMNSSRFVLNGK 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE0 SD--SMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVV .. :.::::: :..:.::. ::. :::::.:::::. : :. :::: ::: .:::: XP_011 QQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAATSYDGSALAAYGDVVVV 100 110 120 130 140 150 240 250 260 270 280 290 pF1KE0 IIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTS .::::::::::::::.:: :: :.:: ::::::::.::: :::. . ::.:: ::::. XP_011 TVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSI 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE0 VSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLR .:.::.::.. :::: :: .::: ::.: : .. .:: ::.. . .: ::. XP_011 ISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSSPAEMVQCLQ 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE0 GKSKEEILAINKPFK--MIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIP : :: :...: .: . : .:::. .:. :.::: :. :: ..::::.::.:::: XP_011 QKEGEE-LVLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLIP 280 290 300 310 320 420 430 440 450 460 470 pF1KE0 KVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMM . . ::...:.:: : .:: : .:: . . .::.:.:.: :. :::.: XP_011 RGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMMPTVIDEYLGSNSDAQAKCQAFQEFM 330 340 350 360 370 380 480 490 500 510 520 pF1KE0 ADSMFVIPALQVAHF-QCSRAPVYFYEFQHQPSWLKNIRPPHMKADH------------- .: .. .:... ... . : .::.::::::.:: . .:.: .:::: XP_011 GDVFINVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFL 390 400 410 420 430 440 530 540 550 560 570 pF1KE0 ------VKF---TEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQP . : ::::.::: :: :..:::.:.::...:: :: :.: ::::..: : XP_011 MDESSRLAFPEATEEEKQLSLTMMAQWTHFARTGDPNSKALPPWPQFNQAEQYLEINPVP 450 460 470 480 490 500 580 590 600 pF1KE0 AVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL .:. .. .:::...::.:::. .. .. XP_011 RAGQKFREAWMQFWSETLPSKIQQWHQKQKNRKAQEDL 510 520 530 540 >>XP_011521278 (OMIM: 605279) PREDICTED: carboxylesteras (402 aa) initn: 707 init1: 707 opt: 1146 Z-score: 1187.1 bits: 229.1 E(85289): 2.2e-59 Smith-Waterman score: 1146; 49.1% identity (70.9% similar) in 381 aa overlap (74-449:12-385) 50 60 70 80 90 100 pF1KE0 GQPLGEQQRVRRQRTETSEPTMRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTG : .:.: :: . . : . :.: : : XP_011 MERAVRVESGVLVGVVCLLLACPATATGPEVAQPEVDTTLG 10 20 30 40 110 120 130 140 150 160 pF1KE0 QVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDL .: : : :::.. :..:::::::.::::: ::. :.: . : ::::..: : ::::: XP_011 RVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQD- 50 60 70 80 90 100 170 180 190 200 210 220 pF1KE0 TAVESEFLSQFNMTFPSD--SMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMAS ::: :.: .. .. :.::::: :..:.::. ::. :::::.:::::. : :. XP_011 --VESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAAT 110 120 130 140 150 230 240 250 260 270 280 pF1KE0 LYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGG :::: ::: .:::: .::::::::::::::.:: :: :.:: ::::::::.::: ::: XP_011 SYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGG 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE0 NPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANL . . ::.:: ::::. .:.::.::.. :::: :: .::: ::.: : .. .:: XP_011 DLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANT 220 230 240 250 260 270 350 360 370 380 390 pF1KE0 SACDQVDSEALVGCLRGKSKEEILAINKPFK--MIPGVVDGVFLPRHPQELLASADFQPV ::.. . .: ::. : :: :...: .: . : .:::. .:. :.::: :. : XP_011 LACSSSSPAEMVQCLQQKEGEE-LVLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSV 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE0 PSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKM-LTLLMLPPTFGDLLREEYI : ..::::.::.::::. . : ..... .. .: . :. ::.: XP_011 PFLMGVNNHEFSWLIPRSL---DPSSRLQCSSAIMTLYCLNLSGPSNPPSFLSSSGLRAG 340 350 360 370 380 390 460 470 480 490 500 510 pF1KE0 GDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMK XP_011 VSWIQWSR 400 >>NP_001257 (OMIM: 114835) liver carboxylesterase 1 isof (566 aa) initn: 1561 init1: 686 opt: 1049 Z-score: 1084.8 bits: 210.7 E(85289): 1.1e-53 Smith-Waterman score: 1577; 46.0% identity (69.9% similar) in 552 aa overlap (90-607:18-566) 60 70 80 90 100 110 pF1KE0 TSEPTMRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGV :. :. :. : :.:::..: ..: : NP_001 MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPV 10 20 30 40 120 130 140 150 160 170 pF1KE0 QTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVE--SEFLSQFNMT ::::::::::::::::.::.: : :: :...:..: :: :: : . ::.... . . NP_001 AIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKEN 50 60 70 80 90 100 180 190 200 210 220 230 pF1KE0 FPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVV .: ..:::::::.::::: . . ::::::::::.:. : :: ::: ::: :::::: NP_001 IPL-KLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVV 110 120 130 140 150 160 240 250 260 270 280 290 pF1KE0 IIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTS ::::::. :::::::.:. ::::.:::::::::::.::: ::::: :::::::::: : NP_001 TIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGES 170 180 190 200 210 220 300 310 320 330 340 350 pF1KE0 VSSLVVSPISQGLFHGAIMESGVALLPGLIASSADV--ISTVVANLSACDQVDSEALVGC :: ::.::....::: :: :::::: :. ...:: .. .: ..: . : ..: : NP_001 VSVLVLSPLAKNLFHRAISESGVALTSVLV-KKGDVKPLAEQIAITAGCKTTTSAVMVHC 230 240 250 260 270 280 360 370 380 390 400 pF1KE0 LRGKSKEEILAINKPFK---------------MIPGVVDGVFLPRHPQELLASADFQPVP :: :..::.: . .: .. :.::..: . :.:: : .:. :: NP_001 LRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVP 290 300 310 320 330 340 410 420 430 440 450 460 pF1KE0 SIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGD .::.:..::::::: .: .. ..:...... : : :. . . :.:.: NP_001 YMVGINKQEFGWLIPMLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGG 350 360 370 380 390 400 470 480 490 500 510 pF1KE0 NGDPQTLQAQFQEMMADSMFVIPALQVA-HFQCSRAPVYFYEFQHQPSWLKNIRPPHMKA . : . : ...:: :: .:.. :: . . . ::.:.::::..::. ....: . . NP_001 TDDTVKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIG 410 420 430 440 450 460 520 530 540 550 560 pF1KE0 DH---------VKF-----TEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQY :: . : .::: .::. .::.::::::::::::::::::: ..:.: : NP_001 DHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGY 470 480 490 500 510 520 570 580 590 600 pF1KE0 LQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL ::.. . ... :: ... :: . . .: : . :. .: :: NP_001 LQIGANTQAAQKLKDKEVAFWTNLFAKKAVE-KPPQTEHIEL 530 540 550 560 >>NP_001020365 (OMIM: 114835) liver carboxylesterase 1 i (567 aa) initn: 1513 init1: 686 opt: 1049 Z-score: 1084.8 bits: 210.7 E(85289): 1.1e-53 Smith-Waterman score: 1569; 45.9% identity (70.0% similar) in 553 aa overlap (90-607:18-567) 60 70 80 90 100 110 pF1KE0 TSEPTMRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGV :. :. :. : :.:::..: ..: : NP_001 MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPV 10 20 30 40 120 130 140 150 160 170 pF1KE0 QTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVE--SEFLSQFNMT ::::::::::::::::.::.: : :: :...:..: :: :: : . ::.... . . NP_001 AIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKEN 50 60 70 80 90 100 180 190 200 210 220 230 pF1KE0 FPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVV .: ..:::::::.::::: . . ::::::::::.:. : :: ::: ::: :::::: NP_001 IPL-KLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVV 110 120 130 140 150 160 240 250 260 270 280 290 pF1KE0 IIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTS ::::::. :::::::.:. ::::.:::::::::::.::: ::::: :::::::::: : NP_001 TIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGES 170 180 190 200 210 220 300 310 320 330 340 350 pF1KE0 VSSLVVSPISQGLFHGAIMESGVALLPGLIASSADV--ISTVVANLSACDQVDSEALVGC :: ::.::....::: :: :::::: :. ...:: .. .: ..: . : ..: : NP_001 VSVLVLSPLAKNLFHRAISESGVALTSVLV-KKGDVKPLAEQIAITAGCKTTTSAVMVHC 230 240 250 260 270 280 360 370 380 390 400 pF1KE0 LRGKSKEEILAINKPFK---------------MIPGVVDGVFLPRHPQELLASADFQPVP :: :..::.: . .: .. :.::..: . :.:: : .:. :: NP_001 LRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVP 290 300 310 320 330 340 410 420 430 440 450 pF1KE0 SIVGVNNNEFGWLIP-KVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIG .::.:..::::::: ..: .. ..:...... : : :. . . :.:.: NP_001 YMVGINKQEFGWLIPMQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLG 350 360 370 380 390 400 460 470 480 490 500 510 pF1KE0 DNGDPQTLQAQFQEMMADSMFVIPALQVA-HFQCSRAPVYFYEFQHQPSWLKNIRPPHMK . : . : ...:: :: .:.. :: . . . ::.:.::::..::. ....: . NP_001 GTDDTVKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVI 410 420 430 440 450 460 520 530 540 550 560 pF1KE0 ADH---------VKF-----TEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQ .:: . : .::: .::. .::.::::::::::::::::::: ..:.: NP_001 GDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEG 470 480 490 500 510 520 570 580 590 600 pF1KE0 YLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL :::.. . ... :: ... :: . . .: : . :. .: :: NP_001 YLQIGANTQAAQKLKDKEVAFWTNLFAKKAVE-KPPQTEHIEL 530 540 550 560 607 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 07:24:12 2016 done: Fri Nov 4 07:24:13 2016 Total Scan time: 11.840 Total Display time: 0.150 Function used was FASTA [36.3.4 Apr, 2011]