FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0037, 740 aa 1>>>pF1KE0037 740 - 740 aa - 740 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6536+/-0.000378; mu= 19.0992+/- 0.024 mean_var=90.5745+/-18.398, 0's: 0 Z-trim(113.7): 91 B-trim: 0 in 0/54 Lambda= 0.134763 statistics sampled from 23148 (23239) to 23148 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.638), E-opt: 0.2 (0.272), width: 16 Scan time: 12.920 The best scores are: opt bits E(85289) NP_005459 (OMIM: 602640) N-acetylated-alpha-linked ( 740) 4911 965.6 0 XP_011543009 (OMIM: 602640) PREDICTED: N-acetylate ( 692) 4606 906.3 0 XP_011543008 (OMIM: 602640) PREDICTED: N-acetylate ( 737) 4497 885.1 0 XP_011543011 (OMIM: 602640) PREDICTED: N-acetylate ( 547) 3605 711.6 2.1e-204 XP_011543012 (OMIM: 602640) PREDICTED: N-acetylate ( 522) 3387 669.2 1.2e-191 XP_011543014 (OMIM: 602640) PREDICTED: N-acetylate ( 508) 3035 600.7 4.6e-171 XP_011543013 (OMIM: 602640) PREDICTED: N-acetylate ( 508) 3035 600.7 4.6e-171 XP_011543010 (OMIM: 602640) PREDICTED: N-acetylate ( 687) 3024 598.7 2.6e-170 NP_004467 (OMIM: 600934) glutamate carboxypeptidas ( 750) 1737 348.5 5.8e-95 XP_016872923 (OMIM: 600934) PREDICTED: glutamate c ( 735) 1726 346.4 2.5e-94 NP_001180400 (OMIM: 600934) glutamate carboxypepti ( 735) 1726 346.4 2.5e-94 XP_016872921 (OMIM: 600934) PREDICTED: glutamate c ( 805) 1726 346.4 2.7e-94 XP_016872926 (OMIM: 600934) PREDICTED: glutamate c ( 693) 1723 345.8 3.6e-94 XP_016872931 (OMIM: 600934) PREDICTED: glutamate c ( 693) 1723 345.8 3.6e-94 XP_016872932 (OMIM: 600934) PREDICTED: glutamate c ( 693) 1723 345.8 3.6e-94 XP_016872925 (OMIM: 600934) PREDICTED: glutamate c ( 693) 1723 345.8 3.6e-94 NP_005458 (OMIM: 611636) N-acetylated-alpha-linked ( 740) 1721 345.4 4.9e-94 XP_016872532 (OMIM: 611636) PREDICTED: N-acetylate ( 775) 1721 345.4 5.1e-94 XP_016872534 (OMIM: 611636) PREDICTED: N-acetylate ( 686) 1697 340.7 1.2e-92 XP_016872808 (OMIM: 609020) PREDICTED: putative N- ( 693) 1697 340.7 1.2e-92 NP_001014986 (OMIM: 600934) glutamate carboxypepti ( 719) 1506 303.6 1.9e-81 XP_016872924 (OMIM: 600934) PREDICTED: glutamate c ( 704) 1495 301.4 8e-81 NP_001180401 (OMIM: 600934) glutamate carboxypepti ( 704) 1495 301.4 8e-81 XP_016872922 (OMIM: 600934) PREDICTED: glutamate c ( 774) 1495 301.5 8.6e-81 XP_016872929 (OMIM: 600934) PREDICTED: glutamate c ( 662) 1492 300.8 1.1e-80 XP_016872930 (OMIM: 600934) PREDICTED: glutamate c ( 662) 1492 300.8 1.1e-80 XP_016872927 (OMIM: 600934) PREDICTED: glutamate c ( 662) 1492 300.8 1.1e-80 XP_016872928 (OMIM: 600934) PREDICTED: glutamate c ( 662) 1492 300.8 1.1e-80 XP_011518260 (OMIM: 600934) PREDICTED: glutamate c ( 543) 1181 240.3 1.6e-62 XP_016872937 (OMIM: 600934) PREDICTED: glutamate c ( 442) 1135 231.3 6.6e-60 XP_016872935 (OMIM: 600934) PREDICTED: glutamate c ( 442) 1135 231.3 6.6e-60 XP_016872936 (OMIM: 600934) PREDICTED: glutamate c ( 442) 1135 231.3 6.6e-60 XP_016872934 (OMIM: 600934) PREDICTED: glutamate c ( 442) 1135 231.3 6.6e-60 XP_016872933 (OMIM: 600934) PREDICTED: glutamate c ( 442) 1135 231.3 6.6e-60 NP_001180402 (OMIM: 600934) glutamate carboxypepti ( 442) 1135 231.3 6.6e-60 NP_710163 (OMIM: 609020) putative N-acetylated-alp ( 442) 1134 231.1 7.6e-60 NP_001287859 (OMIM: 611636) N-acetylated-alpha-lin ( 707) 1099 224.5 1.2e-57 XP_016872533 (OMIM: 611636) PREDICTED: N-acetylate ( 742) 1099 224.5 1.3e-57 XP_016872938 (OMIM: 600934) PREDICTED: glutamate c ( 411) 904 186.4 2.1e-46 XP_016872940 (OMIM: 600934) PREDICTED: glutamate c ( 411) 904 186.4 2.1e-46 XP_016872939 (OMIM: 600934) PREDICTED: glutamate c ( 411) 904 186.4 2.1e-46 XP_016872535 (OMIM: 611636) PREDICTED: N-acetylate ( 428) 698 146.3 2.4e-34 NP_001193784 (OMIM: 604250,604720) transferrin rec ( 630) 413 91.0 1.6e-17 XP_016868062 (OMIM: 604250,604720) PREDICTED: tran ( 801) 413 91.1 1.9e-17 XP_005250610 (OMIM: 604250,604720) PREDICTED: tran ( 801) 413 91.1 1.9e-17 NP_003218 (OMIM: 604250,604720) transferrin recept ( 801) 413 91.1 1.9e-17 NP_001300895 (OMIM: 190010,616740) transferrin rec ( 478) 381 84.7 9.5e-16 NP_001300894 (OMIM: 190010,616740) transferrin rec ( 679) 381 84.8 1.2e-15 NP_001121620 (OMIM: 190010,616740) transferrin rec ( 760) 381 84.9 1.3e-15 NP_003225 (OMIM: 190010,616740) transferrin recept ( 760) 381 84.9 1.3e-15 >>NP_005459 (OMIM: 602640) N-acetylated-alpha-linked aci (740 aa) initn: 4911 init1: 4911 opt: 4911 Z-score: 5161.0 bits: 965.6 E(85289): 0 Smith-Waterman score: 4911; 100.0% identity (100.0% similar) in 740 aa overlap (1-740:1-740) 10 20 30 40 50 60 pF1KE0 MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIREN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIREN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 IGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 IGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 LSIYDNWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTSARI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LSIYDNWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTSARI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 YPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSFL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE0 QAAQQDLGALLEQHSISLGPLVTAVEKFEAEAAALGQRISTLQKGSPDPLQVRMLNDQLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QAAQQDLGALLEQHSISLGPLVTAVEKFEAEAAALGQRISTLQKGSPDPLQVRMLNDQLM 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE0 LLERTFLNPRAFPEERYYSHVLWAPRTGSVVTFPGLSNACSRARDTASGSEAWAEVQRQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LLERTFLNPRAFPEERYYSHVLWAPRTGSVVTFPGLSNACSRARDTASGSEAWAEVQRQL 670 680 690 700 710 720 730 740 pF1KE0 SIVVTALEGAAATLRPVADL :::::::::::::::::::: NP_005 SIVVTALEGAAATLRPVADL 730 740 >>XP_011543009 (OMIM: 602640) PREDICTED: N-acetylated-al (692 aa) initn: 4606 init1: 4606 opt: 4606 Z-score: 4841.0 bits: 906.3 E(85289): 0 Smith-Waterman score: 4606; 100.0% identity (100.0% similar) in 692 aa overlap (49-740:1-692) 20 30 40 50 60 70 pF1KE0 LGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIRENLRELSREPHLASSPRDED :::::::::::::::::::::::::::::: XP_011 MGQLDAHRIRENLRELSREPHLASSPRDED 10 20 30 80 90 100 110 120 130 pF1KE0 LVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIVGPTGGIIHSCHRTEENVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIVGPTGGIIHSCHRTEENVT 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE0 GEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQGIKLEGTIALTRYGGVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQGIKLEGTIALTRYGGVGR 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE0 GAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLPPSGVERGSYYEYFGDPLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLPPSGVERGSYYEYFGDPLT 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE0 PYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNGTLAPATWQGALGCHYRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNGTLAPATWQGALGCHYRLG 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE0 PGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPDRYVLYGNHRDSWVHGAVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPDRYVLYGNHRDSWVHGAVD 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE0 PSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGLIGSTEFTEEFFNKLQERT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGLIGSTEFTEEFFNKLQERT 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE0 VAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGDLSIYDNWIRYFNRSSPVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGDLSIYDNWIRYFNRSSPVY 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE0 GLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTSARIYPTYHTAFDTFDYVDKFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTSARIYPTYHTAFDTFDYVDKFL 460 470 480 490 500 510 560 570 580 590 600 610 pF1KE0 DPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSFLQAAQQDLGALLEQHSISL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSFLQAAQQDLGALLEQHSISL 520 530 540 550 560 570 620 630 640 650 660 670 pF1KE0 GPLVTAVEKFEAEAAALGQRISTLQKGSPDPLQVRMLNDQLMLLERTFLNPRAFPEERYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPLVTAVEKFEAEAAALGQRISTLQKGSPDPLQVRMLNDQLMLLERTFLNPRAFPEERYY 580 590 600 610 620 630 680 690 700 710 720 730 pF1KE0 SHVLWAPRTGSVVTFPGLSNACSRARDTASGSEAWAEVQRQLSIVVTALEGAAATLRPVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHVLWAPRTGSVVTFPGLSNACSRARDTASGSEAWAEVQRQLSIVVTALEGAAATLRPVA 640 650 660 670 680 690 740 pF1KE0 DL :: XP_011 DL >>XP_011543008 (OMIM: 602640) PREDICTED: N-acetylated-al (737 aa) initn: 4510 init1: 3378 opt: 4497 Z-score: 4726.0 bits: 885.1 E(85289): 0 Smith-Waterman score: 4497; 93.7% identity (95.3% similar) in 741 aa overlap (1-740:1-737) 10 20 30 40 50 60 pF1KE0 MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIREN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIREN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 IGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGD 430 440 450 460 470 480 490 500 510 520 530 pF1KE0 LSIYDNWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAY-TYDRSKTSAR :::::::::::::::::::::: . : :: : .. : .: .. : : .: . XP_011 LSIYDNWIRYFNRSSPVYGLVPR-ARLQPGST-PPTTQPLTPLTMWTSFWTRVRRETRGI 490 500 510 520 530 540 550 560 570 580 590 pF1KE0 IYPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSF . : . . : . : ::::::::::::::::::::::::::::::::::::::: XP_011 LRPGQER-LKTEPW-PCHLAAGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSF 540 550 560 570 580 590 600 610 620 630 640 650 pF1KE0 LQAAQQDLGALLEQHSISLGPLVTAVEKFEAEAAALGQRISTLQKGSPDPLQVRMLNDQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQAAQQDLGALLEQHSISLGPLVTAVEKFEAEAAALGQRISTLQKGSPDPLQVRMLNDQL 600 610 620 630 640 650 660 670 680 690 700 710 pF1KE0 MLLERTFLNPRAFPEERYYSHVLWAPRTGSVVTFPGLSNACSRARDTASGSEAWAEVQRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLLERTFLNPRAFPEERYYSHVLWAPRTGSVVTFPGLSNACSRARDTASGSEAWAEVQRQ 660 670 680 690 700 710 720 730 740 pF1KE0 LSIVVTALEGAAATLRPVADL ::::::::::::::::::::: XP_011 LSIVVTALEGAAATLRPVADL 720 730 >>XP_011543011 (OMIM: 602640) PREDICTED: N-acetylated-al (547 aa) initn: 3605 init1: 3605 opt: 3605 Z-score: 3790.6 bits: 711.6 E(85289): 2.1e-204 Smith-Waterman score: 3605; 98.7% identity (99.8% similar) in 542 aa overlap (1-542:1-542) 10 20 30 40 50 60 pF1KE0 MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIREN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIREN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 IGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 LSIYDNWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTSARI :::::::::::::::::::::::::::::::::::::::::::::::::::::.... :. XP_011 LSIYDNWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRASAAIRL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 YPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSFL .: XP_011 WPGQRGV >>XP_011543012 (OMIM: 602640) PREDICTED: N-acetylated-al (522 aa) initn: 3382 init1: 3382 opt: 3387 Z-score: 3561.8 bits: 669.2 E(85289): 1.2e-191 Smith-Waterman score: 3387; 98.6% identity (98.8% similar) in 513 aa overlap (1-512:1-513) 10 20 30 40 50 60 pF1KE0 MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIREN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIREN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 IGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGD 430 440 450 460 470 480 490 500 510 520 530 pF1KE0 LSIYDNWIRYFNRSSPVYGLVPSLGS-LGAGSDYAPFVHFLGISSMDIAYTYDRSKTSAR :::::::::::::::::::::: : . : : : XP_011 LSIYDNWIRYFNRSSPVYGLVPRLQQPSGCGPDSGECDSPAQ 490 500 510 520 540 550 560 570 580 590 pF1KE0 IYPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSF >>XP_011543014 (OMIM: 602640) PREDICTED: N-acetylated-al (508 aa) initn: 3020 init1: 3020 opt: 3035 Z-score: 3192.1 bits: 600.7 E(85289): 4.6e-171 Smith-Waterman score: 3035; 92.6% identity (94.4% similar) in 499 aa overlap (1-496:1-497) 10 20 30 40 50 60 pF1KE0 MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIREN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIREN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL 370 380 390 400 410 420 430 440 450 460 470 pF1KE0 IGSTEFTEEFFNKLQERTVAYINVDISVFANAT--LRVQGTPPVQSVVFSATKEIRSPGP ::::::::::::::::::::::::::::: : : . .. :. .: ::: XP_011 IGSTEFTEEFFNKLQERTVAYINVDISVFDPLTRPWRPEHLRQLDPVLQPQQPGVR-PGP 430 440 450 460 470 480 490 500 510 520 530 pF1KE0 GDLSIYDNWIRYFN-RSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTS .:.. : : . :: : XP_011 -QLGFSGCWQRLCTLRSLPGHLLHGHCLYL 480 490 500 >>XP_011543013 (OMIM: 602640) PREDICTED: N-acetylated-al (508 aa) initn: 3020 init1: 3020 opt: 3035 Z-score: 3192.1 bits: 600.7 E(85289): 4.6e-171 Smith-Waterman score: 3035; 92.6% identity (94.4% similar) in 499 aa overlap (1-496:1-497) 10 20 30 40 50 60 pF1KE0 MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIREN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIREN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL 370 380 390 400 410 420 430 440 450 460 470 pF1KE0 IGSTEFTEEFFNKLQERTVAYINVDISVFANAT--LRVQGTPPVQSVVFSATKEIRSPGP ::::::::::::::::::::::::::::: : : . .. :. .: ::: XP_011 IGSTEFTEEFFNKLQERTVAYINVDISVFDPLTRPWRPEHLRQLDPVLQPQQPGVR-PGP 430 440 450 460 470 480 490 500 510 520 530 pF1KE0 GDLSIYDNWIRYFN-RSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTS .:.. : : . :: : XP_011 -QLGFSGCWQRLCTLRSLPGHLLHGHCLYL 480 490 500 >>XP_011543010 (OMIM: 602640) PREDICTED: N-acetylated-al (687 aa) initn: 4335 init1: 3020 opt: 3024 Z-score: 3178.7 bits: 598.7 E(85289): 2.6e-170 Smith-Waterman score: 4246; 90.3% identity (91.1% similar) in 740 aa overlap (1-740:1-687) 10 20 30 40 50 60 pF1KE0 MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIREN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIREN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 IGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGD ::::::::::::::::::::::::::::: :. :. : : XP_011 IGSTEFTEEFFNKLQERTVAYINVDISVF----------DPL-------TRPWR---PEH 430 440 450 460 490 500 510 520 530 540 pF1KE0 LSIYDNWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTSARI : : :: : :. .. : : .::::::: XP_011 LRQLD----------PV--LQPQQPGVRPG----P-----------------QSKTSARI 470 480 550 560 570 580 590 600 pF1KE0 YPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSFL 490 500 510 520 530 540 610 620 630 640 650 660 pF1KE0 QAAQQDLGALLEQHSISLGPLVTAVEKFEAEAAALGQRISTLQKGSPDPLQVRMLNDQLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QAAQQDLGALLEQHSISLGPLVTAVEKFEAEAAALGQRISTLQKGSPDPLQVRMLNDQLM 550 560 570 580 590 600 670 680 690 700 710 720 pF1KE0 LLERTFLNPRAFPEERYYSHVLWAPRTGSVVTFPGLSNACSRARDTASGSEAWAEVQRQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLERTFLNPRAFPEERYYSHVLWAPRTGSVVTFPGLSNACSRARDTASGSEAWAEVQRQL 610 620 630 640 650 660 730 740 pF1KE0 SIVVTALEGAAATLRPVADL :::::::::::::::::::: XP_011 SIVVTALEGAAATLRPVADL 670 680 >>NP_004467 (OMIM: 600934) glutamate carboxypeptidase 2 (750 aa) initn: 952 init1: 535 opt: 1737 Z-score: 1825.9 bits: 348.5 E(85289): 5.8e-95 Smith-Waterman score: 1740; 38.3% identity (70.3% similar) in 751 aa overlap (2-738:19-750) 10 20 30 40 pF1KE0 MQWTKVLGLGLGAAALLGLGIILGHFAIPK-KANSLAPQDLDL .: . .: : :.... ::...: : . .:....:. NP_004 MWNLLHETDSAVATARRPRWLCAGALVL-AGGFFLLGFLFGWFIKSSNEATNITPK---- 10 20 30 40 50 50 60 70 80 90 100 pF1KE0 EILETVMGQLDAHRIRENLRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTY . ... . .: :. :.. : .... ::::.. .. .:.. . ..:: : ::::.: . : NP_004 HNMKAFLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWK--EFGLDSVELAHY 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE0 EVLLSFPSQEQPNVVDIVGPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGL .::::.:.. .:: ..:.. :. : . : : .. :.: :..:..:.: :.: NP_004 DVLLSYPNKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGD 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE0 LVYANRGAEEDFKELQTQ-GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPAD :::.: . ::: .:. . :. : :...::: : :: :. :: :. ::..:.:::: NP_004 LVYVNYARTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPAD 180 190 200 210 220 230 230 240 250 260 270 pF1KE0 -INDGLSSPDETFPNSWYLPPSGVERGSYYEY--FGDPLTPYLPAVPSSFRVDLANVSGF . :..: .:..: :: .::.::. . :::::: :: ..: .:.. :. NP_004 YFAPGVKS----YPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGL 240 250 260 270 280 280 290 300 310 320 330 pF1KE0 PPIPTQPIGFQDARDLLCNLNGTLAP-ATWQGALGCHYRLGPGFRPDGDFPADSQVNVSV : ::..:::. ::. :: ...:. : ..:.:.: : .:::: :.: . ..:.. . NP_004 PSIPVHPIGYYDAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGF--TGNF-STQKVKMHI 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE0 YNRLELRNSSNVLGIIRGAVEPDRYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLL .. :. ::.: .::::::::::. :.:::::: :..::.::.::. :. : .::: NP_004 HSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLK 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE0 KKGTWRPRRSIVFASWGAEEFGLIGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQ :.: :::::.:.:::: ::::::.::::..:: :::: :::::.: :. .: ::::. NP_004 KEG-WRPRRTILFASWDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVD 410 420 430 440 450 460 460 470 480 490 500 510 pF1KE0 GTPPVQSVVFSATKEIRSPGPG--DLSIYDNWIRYFNRSSPVYGLVPSLGSLGAGSDYAP :: . :.: . :::..:: : :.:..: . . :: .. .: ...::.:.:. NP_004 CTPLMYSLVHNLTKELKSPDEGFEGKSLYESWTK--KSPSPEFSGMPRISKLGSGNDFEV 470 480 490 500 510 520 520 530 540 550 560 570 pF1KE0 FVHFLGISSMDIAYTYDRSKTSARIYPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSV : . :::.: :: . .. :: ::....:.. :.:: :: :. : .::.. :.. NP_004 FFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGM 530 540 550 560 570 580 580 590 600 610 620 630 pF1KE0 ILRLSDSFFLPLKVSDYSETLRSF---LQAAQQDLGALLEQHSISLGPLVTAVEKFEAEA ...:..:. ::. ::. .::.. . . .. .. .:.:. : .::..: : NP_004 VFELANSIVLPFDCRDYAVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIA 590 600 610 620 630 640 640 650 660 670 680 690 pF1KE0 AALGQRISTLQKGSPDPLQVRMLNDQLMLLERTFLNPRAFPEERYYSHVLWAPRTGSVV- . ...:.. ..:. .:. .::.:::::.:::.:..: ..:.. .: ::..:: . . NP_004 SKFSERLQDFDKS--NPIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYA 650 660 670 680 690 700 700 710 720 730 740 pF1KE0 --TFPGLSNACSRARDTASGSEAWAEVQRQLSIVVTALEGAAATLRPVADL .:::. .: .. .. :.::.::.::. ... ....:: :: :: NP_004 GESFPGIYDALFDIESKVDPSKAWGEVKRQIYVAAFTVQAAAETLSEVA 710 720 730 740 750 >>XP_016872923 (OMIM: 600934) PREDICTED: glutamate carbo (735 aa) initn: 952 init1: 535 opt: 1726 Z-score: 1814.4 bits: 346.4 E(85289): 2.5e-94 Smith-Waterman score: 1728; 38.8% identity (69.9% similar) in 745 aa overlap (9-738:9-735) 10 20 30 40 50 pF1KE0 MQWTKVLGLGLGAAALLG-LGIILGHFAIPK-KANSLAPQDLDLEILETVMGQLDAHRIR : :.: : : :. :: : . .:....:. . ... . .: :. :. XP_016 MTAGSSYPLFLAAYACTGCLAERLGWFIKSSNEATNITPK----HNMKAFLDELKAENIK 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 ENLRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVD . : .... ::::.. .. .:.. . ..:: : ::::.: . :.::::.:.. .:: .. XP_016 KFLYNFTQIPHLAGTEQNFQLAKQIQSQWK--EFGLDSVELAHYDVLLSYPNKTHPNYIS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 IVGPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQ :.. :. : . : : .. :.: :..:..:.: :.: :::.: . ::: .:. XP_016 IINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYARTEDFFKLE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 TQ-GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPAD-INDGLSSPDETFPNS . :. : :...::: : :: :. :: :. ::..:.:::: . :..: .:.. XP_016 RDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVKS----YPDG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 WYLPPSGVERGSYYEY--FGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDL : :: .::.::. . :::::: :: ..: .:.. :.: ::..:::. ::. : XP_016 WNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYYDAQKL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 LCNLNGTLAP-ATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGII : ...:. : ..:.:.: : .:::: :.: . ..:.. ... :. ::.: . XP_016 LEKMGGSAPPDSSWRGSLKVPYNVGPGFT--GNF-STQKVKMHIHSTNEVTRIYNVIGTL 300 310 320 330 340 360 370 380 390 400 410 pF1KE0 RGAVEPDRYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASW ::::::::::. :.:::::: :..::.::.::. :. : .::: :.: :::::.:.:::: XP_016 RGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEG-WRPRRTILFASW 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE0 GAEEFGLIGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEI ::::::.::::..:: :::: :::::.: :. .: ::::. :: . :.: . :::. XP_016 DAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKEL 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE0 RSPGPG--DLSIYDNWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTY .:: : :.:..: . . :: .. .: ...::.:.:. : . :::.: :: XP_016 KSPDEGFEGKSLYESWTK--KSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTK 470 480 490 500 510 520 540 550 560 570 580 590 pF1KE0 DRSKTSARIYPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFFLPLKVSD . .. :: ::....:.. :.:: :: :. : .::.. :.....:..:. ::. : XP_016 NWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRD 530 540 550 560 570 580 600 610 620 630 640 pF1KE0 YSETLRSF---LQAAQQDLGALLEQHSISLGPLVTAVEKFEAEAAALGQRISTLQKGSPD :. .::.. . . .. .. .:.:. : .::..: :. ...:.. ..:. . XP_016 YAVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKS--N 590 600 610 620 630 640 650 660 670 680 690 700 pF1KE0 PLQVRMLNDQLMLLERTFLNPRAFPEERYYSHVLWAPRTGSVV---TFPGLSNACSRARD :. .::.:::::.:::.:..: ..:.. .: ::..:: . . .:::. .: .. XP_016 PIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIES 650 660 670 680 690 700 710 720 730 740 pF1KE0 TASGSEAWAEVQRQLSIVVTALEGAAATLRPVADL .. :.::.::.::. ... ....:: :: :: XP_016 KVDPSKAWGEVKRQIYVAAFTVQAAAETLSEVA 710 720 730 740 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 06:45:20 2016 done: Fri Nov 4 06:45:22 2016 Total Scan time: 12.920 Total Display time: 0.200 Function used was FASTA [36.3.4 Apr, 2011]