Result of FASTA (omim) for
pF1KE0045
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0045, 661 aa
1>>>pF1KE0045 661 - 661 aa - 661 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1219+/-0.000352; mu= 21.2761+/- 0.022
mean_var=81.9034+/-16.068, 0's: 0 Z-trim(115.3): 186 B-trim: 435 in 1/55
Lambda= 0.141717
statistics sampled from 25500 (25719) to 25500 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.645), E-opt: 0.2 (0.302), width: 16
Scan time: 11.110
The best scores are: opt bits E(85289)
NP_001985 (OMIM: 134580,613235) coagulation factor ( 661) 4704 971.9 0
XP_011507585 (OMIM: 134580,613235) PREDICTED: coag ( 676) 4641 959.0 0
XP_011507586 (OMIM: 134580,613235) PREDICTED: coag ( 675) 4623 955.4 0
XP_011507588 (OMIM: 134580,613235) PREDICTED: coag ( 628) 4315 892.4 0
XP_016855599 (OMIM: 605337) PREDICTED: complement ( 519) 1034 221.5 6.3e-57
NP_110414 (OMIM: 608593,614809) complement factor ( 569) 924 199.0 4e-50
XP_011508322 (OMIM: 608593,614809) PREDICTED: comp ( 572) 924 199.0 4e-50
XP_006711192 (OMIM: 605337) PREDICTED: complement ( 570) 912 196.6 2.2e-49
NP_001188480 (OMIM: 605337) complement factor H-re ( 577) 912 196.6 2.2e-49
NP_001188479 (OMIM: 605337) complement factor H-re ( 578) 912 196.6 2.2e-49
XP_016855600 (OMIM: 605337) PREDICTED: complement ( 519) 755 164.4 9.4e-40
NP_000177 (OMIM: 126700,134370,235400,609814,61069 (1231) 757 165.2 1.3e-39
XP_016855603 (OMIM: 605337) PREDICTED: complement ( 387) 664 145.7 3e-34
NP_002104 (OMIM: 134371,235400,603075) complement ( 330) 634 139.5 1.9e-32
NP_066303 (OMIM: 235400,603075,605336) complement ( 330) 598 132.1 3.1e-30
XP_011507759 (OMIM: 134371,235400,603075) PREDICTE ( 265) 586 129.6 1.5e-29
XP_016855602 (OMIM: 605337) PREDICTED: complement ( 458) 566 125.7 3.7e-28
XP_016855601 (OMIM: 605337) PREDICTED: complement ( 468) 566 125.7 3.7e-28
NP_006675 (OMIM: 605337) complement factor H-relat ( 331) 562 124.8 5.1e-28
NP_699197 (OMIM: 611691) sushi, von Willebrand fac (3571) 548 122.9 2.1e-26
XP_011515117 (OMIM: 608399) PREDICTED: CUB and sus (2173) 509 114.7 3.7e-24
XP_016868501 (OMIM: 608399) PREDICTED: CUB and sus (3463) 509 114.9 5.1e-24
XP_016868500 (OMIM: 608399) PREDICTED: CUB and sus (3507) 509 114.9 5.2e-24
NP_443132 (OMIM: 608399) CUB and sushi domain-cont (3538) 509 114.9 5.2e-24
XP_016868499 (OMIM: 608399) PREDICTED: CUB and sus (3577) 509 114.9 5.3e-24
XP_011515118 (OMIM: 608399) PREDICTED: CUB and sus (3603) 509 114.9 5.3e-24
XP_016868498 (OMIM: 608399) PREDICTED: CUB and sus (3637) 509 114.9 5.3e-24
NP_937757 (OMIM: 608399) CUB and sushi domain-cont (3667) 509 114.9 5.4e-24
XP_016868497 (OMIM: 608399) PREDICTED: CUB and sus (3681) 509 114.9 5.4e-24
NP_937756 (OMIM: 608399) CUB and sushi domain-cont (3707) 509 114.9 5.4e-24
NP_443128 (OMIM: 608398) CUB and sushi domain-cont (3487) 505 114.1 9.1e-24
XP_016855683 (OMIM: 608398) PREDICTED: CUB and sus (3566) 505 114.1 9.3e-24
XP_016855676 (OMIM: 608398) PREDICTED: CUB and sus (3606) 505 114.1 9.3e-24
NP_001268885 (OMIM: 608398) CUB and sushi domain-c (3631) 505 114.1 9.4e-24
XP_016855679 (OMIM: 608398) PREDICTED: CUB and sus (3362) 499 112.8 2.1e-23
XP_016855678 (OMIM: 608398) PREDICTED: CUB and sus (3506) 499 112.8 2.1e-23
XP_016855677 (OMIM: 608398) PREDICTED: CUB and sus (3567) 499 112.8 2.2e-23
XP_016855675 (OMIM: 608398) PREDICTED: CUB and sus (3607) 499 112.8 2.2e-23
XP_016855674 (OMIM: 608398) PREDICTED: CUB and sus (3607) 499 112.8 2.2e-23
NP_001160096 (OMIM: 235400,603075,605336) compleme ( 269) 481 108.1 4.3e-23
NP_000706 (OMIM: 120830) C4b-binding protein alpha ( 597) 462 104.6 1.1e-21
XP_005273309 (OMIM: 120830) PREDICTED: C4b-binding ( 597) 462 104.6 1.1e-21
XP_005273308 (OMIM: 120830) PREDICTED: C4b-binding ( 597) 462 104.6 1.1e-21
XP_011507761 (OMIM: 600889) PREDICTED: complement ( 250) 448 101.4 4.3e-21
NP_005657 (OMIM: 600889) complement factor H-relat ( 270) 448 101.4 4.6e-21
XP_016856598 (OMIM: 600889) PREDICTED: complement ( 211) 433 98.2 3.2e-20
NP_000441 (OMIM: 131210,145500) E-selectin precurs ( 610) 407 93.3 2.8e-18
XP_005245170 (OMIM: 600889) PREDICTED: complement ( 205) 401 91.7 2.9e-18
NP_783641 (OMIM: 605886) complement component rece ( 569) 403 92.5 4.6e-18
NP_000564 (OMIM: 120620,607486,611162) complement (2039) 408 94.0 5.8e-18
>>NP_001985 (OMIM: 134580,613235) coagulation factor XII (661 aa)
initn: 4704 init1: 4704 opt: 4704 Z-score: 5196.8 bits: 971.9 E(85289): 0
Smith-Waterman score: 4704; 100.0% identity (100.0% similar) in 661 aa overlap (1-661:1-661)
10 20 30 40 50 60
pF1KE0 MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 AGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYEC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 ATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 CHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 ECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 TYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 VEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 LIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 DTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDF
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 DNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSTLSYQEPLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSTLSYQEPLR
610 620 630 640 650 660
pF1KE0 T
:
NP_001 T
>>XP_011507585 (OMIM: 134580,613235) PREDICTED: coagulat (676 aa)
initn: 4641 init1: 4641 opt: 4641 Z-score: 5127.1 bits: 959.0 E(85289): 0
Smith-Waterman score: 4641; 100.0% identity (100.0% similar) in 651 aa overlap (1-651:1-651)
10 20 30 40 50 60
pF1KE0 MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 AGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYEC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 ATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 CHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 ECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 TYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 VEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 LIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 DTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDF
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 DNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSTLSYQEPLR
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSKQTTGSGNQ
610 620 630 640 650 660
pF1KE0 T
XP_011 FNRPSELSEVKATFAI
670
>>XP_011507586 (OMIM: 134580,613235) PREDICTED: coagulat (675 aa)
initn: 2819 init1: 2340 opt: 4623 Z-score: 5107.2 bits: 955.4 E(85289): 0
Smith-Waterman score: 4623; 99.8% identity (99.8% similar) in 651 aa overlap (1-651:1-650)
10 20 30 40 50 60
pF1KE0 MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 AGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCAS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYEC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 ATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 CHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 ECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKV
:::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
XP_011 ECELNFEIHGSAEIRCEDGKWTEPPKCI-GQEKVACEEPPFIENGAANLHSKIYYNGDKV
310 320 330 340 350
370 380 390 400 410 420
pF1KE0 TYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSS
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE0 VEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGD
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE0 LIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTV
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE0 DTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDF
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE0 DNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSTLSYQEPLR
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSKQTTGSGNQ
600 610 620 630 640 650
pF1KE0 T
XP_011 FNRPSELSEVKATFAI
660 670
>>XP_011507588 (OMIM: 134580,613235) PREDICTED: coagulat (628 aa)
initn: 4315 init1: 4315 opt: 4315 Z-score: 4767.3 bits: 892.4 E(85289): 0
Smith-Waterman score: 4315; 100.0% identity (100.0% similar) in 603 aa overlap (49-651:1-603)
20 30 40 50 60 70
pF1KE0 YAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTT
::::::::::::::::::::::::::::::
XP_011 MSIDKKLSFFCLAGYTTESGRQEEQTTCTT
10 20 30
80 90 100 110 120 130
pF1KE0 EGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSD
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE0 GWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECL
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE0 TYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNF
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE0 GWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCED
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE0 GKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE0 NRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISR
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE0 CEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPL
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE0 SELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHF
460 470 480 490 500 510
560 570 580 590 600 610
pF1KE0 LEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEFICRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEFICRG
520 530 540 550 560 570
620 630 640 650 660
pF1KE0 DTYPAELYITGSILRMQCDRGQLKYPRCIPRQSTLSYQEPLRT
:::::::::::::::::::::::::::::::::
XP_011 DTYPAELYITGSILRMQCDRGQLKYPRCIPRQSKQTTGSGNQFNRPSELSEVKATFAI
580 590 600 610 620
>>XP_016855599 (OMIM: 605337) PREDICTED: complement fact (519 aa)
initn: 986 init1: 334 opt: 1034 Z-score: 1143.0 bits: 221.5 E(85289): 6.3e-57
Smith-Waterman score: 1034; 33.0% identity (57.0% similar) in 530 aa overlap (6-515:5-518)
10 20 30 40 50 60
pF1KE0 MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCL
.. :. : .: : ::: ::....: . :: ... .::: . .. :..:
XP_016 MLLLINVILTLWVSCANGQEVKPCDFPEIQHGGL--YYKSLRRLYFPAAAGQSYSYYCD
10 20 30 40 50
70 80 90 100 110
pF1KE0 AGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPD--LSNGYISDVKLLYKIQENMRYGC
...: :: . :: .:::: :.. :.: : . ::.::. . .: ..:. .:.:
XP_016 QNFVTPSGSYWDYIHCTQDGWSPTVPCLRTCSKSDVEIENGFISESSSIYILNEETQYNC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE0 ASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQY
:: :. :.. . ::..:::.:: : : : : . :. ... ::..: ..:
XP_016 KPGYATAEGNSSGSITCLQNGWSTQPICIK---FCDMPVFENSRAKSNGMWFKLHDTLDY
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE0 ECATGYYTAGGKKTEEVECLTYGWSLTPKC--TKLKCSSLRLIENGYFHPVKQ-TYEEGD
:: :: .. :. :. . : ::: : : .. .:. : :: : .: .
XP_016 ECYDGYESSYGNTTDSIVCGEDGWSHLPTCYNSSENCGPPPPISNGDTTSFPQKVYLPWS
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 VVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRH-
:.. :. : :.:: . : : : : : : . . : : . .... ..: .
XP_016 RVEYQCQSYYELQGSKYVTCSNGDW-SEPPRCISMKP-CEFPEIQ-HGHLYYENTRRPYF
240 250 260 270 280 290
300 310 320 330 340
pF1KE0 ----GEIVHIECELNFEI-HGSA--EIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAA
:. :. :: :: :.: . : :.. : : ::::
XP_016 PVATGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWLPTVPCLRTCSKSDIE----IENGFI
300 310 320 330 340
350 360 370 380 390 400
pF1KE0 NLHSKIYYNGDKVTYACKSGYLL---HGSNEITCNRGKWTLPPECVENNENCKHPPVVMN
. :.:: . .. : :: :: ..:. ::: .. :. : :....:.: :: . :
XP_016 SESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPICINSSEKCGPPPPISN
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE0 GAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRN
: ... .: :. : :::.:. :: :.::. : .:.:: :: :..:: .. . ::.:
XP_016 GDTTSFLLKVYVPQSRVEYQCQSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKN
410 420 430 440 450 460
470 480 490 500 510 520
pF1KE0 NIEMKWKYEGKVLH--GDLIDFVCKQGYDLSPLTPLSELSVQ--CNRGEVKYPLCTRKES
::..: : . : :: :.:.:: ::. . : :: : : .: :.:: :
XP_016 NIQLKGKSDIKYYAKTGDTIEFMCKLGYNANT----SVLSFQAVCREGIVEYPRCE
470 480 490 500 510
530 540 550 560 570 580
pF1KE0 KGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLE
>>NP_110414 (OMIM: 608593,614809) complement factor H-re (569 aa)
initn: 861 init1: 456 opt: 924 Z-score: 1020.9 bits: 199.0 E(85289): 4e-50
Smith-Waterman score: 1040; 31.5% identity (55.8% similar) in 572 aa overlap (91-646:23-568)
70 80 90 100 110
pF1KE0 AGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQ-----ENMR
: : . .:.. : . .. : .
NP_110 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFY
10 20 30 40 50
120 130 140 150 160 170
pF1KE0 YGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDK
:.: .. . . . . : .::: : : . : : . ::. .. :
NP_110 YSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLR---MCSFPFVKNGHSESSGLIHLEGDT
60 70 80 90 100
180 190 200 210 220 230
pF1KE0 VQYECATGYYTAGGKKTEEVECLTYGWSLTPKC--TKLKCSSLRLIENGYFHPVKQTYEE
:: : ::: ...:. . :. ::: : : :: .: : : .: :..:.
NP_110 VQIICNTGYSLQNNEKN--ISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKV
110 120 130 140 150 160
240 250 260 270 280 290
pF1KE0 GDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQT-HSTTY
:::..: :..: ::: .:::.::: :. :.:.:. : ::: :.... .. :
NP_110 GDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEY
170 180 190 200 210 220
300 310 320 330 340 350
pF1KE0 RHGEIVHIECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSK
:.:.:. .:. :: :.: .:.: ::.:: : :.: : :. : : .: : ..
NP_110 GHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVE-QVKT-CGYIPELEYGYVQPSVP
230 240 250 260 270 280
360 370 380 390 400
pF1KE0 IYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLPPECVENNE--NCKHPPVVMNGAVA-D
: .: .: :.. : . :.: ::: : :: : :: ... :: : .. . .
NP_110 PYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLS
290 300 310 320 330 340
410 420 430 440 450 460
pF1KE0 GILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEP----CTVNVDYMNRNN
: . .: ..:::.. . : : : .:::. : : : . : .:
NP_110 G--KEFNHNSRIRYRCSDIFRYRHS---VCINGKWNPEVDCTEKREQFCPPPPQIPNAQN
350 360 370 380 390 400
470 480 490 500 510 520
pF1KE0 IEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVK-YPLCTRKESKGMC
. .:. :. . .::..: : : .. . :. :. . : :. :: ..:
NP_110 MTTTVNYQD----GEKVAVLCKENY----LLPEAK-EIVCKDGRWQSLPRCV--ESTAYC
410 420 430 440
530 540 550 560 570 580
pF1KE0 TSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTL
:: :..: : ...: ::.: ::: . . :.:: . : . .:. :: ::.::..
NP_110 GPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVV
450 460 470 480 490 500
590 600 610 620 630 640
pF1KE0 SFTEMEKNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYP
: .:.:::. ::: :.. . :. .:: :. .: . .:.. .: :..:...::
NP_110 SEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCK---FPHKAMISSPPFRAICQEGKFEYP
510 520 530 540 550 560
650 660
pF1KE0 RCIPRQSTLSYQEPLRT
:
NP_110 ICE
>>XP_011508322 (OMIM: 608593,614809) PREDICTED: compleme (572 aa)
initn: 861 init1: 456 opt: 924 Z-score: 1020.9 bits: 199.0 E(85289): 4e-50
Smith-Waterman score: 1040; 31.5% identity (55.8% similar) in 572 aa overlap (91-646:26-571)
70 80 90 100 110
pF1KE0 AGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQ-----ENMR
: : . .:.. : . .. : .
XP_011 MVKPLRQKRNQENVVFHRPCEAGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFY
10 20 30 40 50
120 130 140 150 160 170
pF1KE0 YGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDK
:.: .. . . . . : .::: : : . : : . ::. .. :
XP_011 YSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLR---MCSFPFVKNGHSESSGLIHLEGDT
60 70 80 90 100 110
180 190 200 210 220 230
pF1KE0 VQYECATGYYTAGGKKTEEVECLTYGWSLTPKC--TKLKCSSLRLIENGYFHPVKQTYEE
:: : ::: ...:. . :. ::: : : :: .: : : .: :..:.
XP_011 VQIICNTGYSLQNNEKN--ISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKV
120 130 140 150 160 170
240 250 260 270 280 290
pF1KE0 GDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQT-HSTTY
:::..: :..: ::: .:::.::: :. :.:.:. : ::: :.... .. :
XP_011 GDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEY
180 190 200 210 220 230
300 310 320 330 340 350
pF1KE0 RHGEIVHIECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSK
:.:.:. .:. :: :.: .:.: ::.:: : :.: : :. : : .: : ..
XP_011 GHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVE-QVKT-CGYIPELEYGYVQPSVP
240 250 260 270 280
360 370 380 390 400
pF1KE0 IYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLPPECVENNE--NCKHPPVVMNGAVA-D
: .: .: :.. : . :.: ::: : :: : :: ... :: : .. . .
XP_011 PYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLS
290 300 310 320 330 340
410 420 430 440 450 460
pF1KE0 GILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEP----CTVNVDYMNRNN
: . .: ..:::.. . : : : .:::. : : : . : .:
XP_011 G--KEFNHNSRIRYRCSDIFRYRHS---VCINGKWNPEVDCTEKREQFCPPPPQIPNAQN
350 360 370 380 390 400
470 480 490 500 510 520
pF1KE0 IEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVK-YPLCTRKESKGMC
. .:. :. . .::..: : : .. . :. :. . : :. :: ..:
XP_011 MTTTVNYQD----GEKVAVLCKENY----LLPEAK-EIVCKDGRWQSLPRCV--ESTAYC
410 420 430 440 450
530 540 550 560 570 580
pF1KE0 TSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTL
:: :..: : ...: ::.: ::: . . :.:: . : . .:. :: ::.::..
XP_011 GPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVV
460 470 480 490 500 510
590 600 610 620 630 640
pF1KE0 SFTEMEKNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYP
: .:.:::. ::: :.. . :. .:: :. .: . .:.. .: :..:...::
XP_011 SEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCK---FPHKAMISSPPFRAICQEGKFEYP
520 530 540 550 560
650 660
pF1KE0 RCIPRQSTLSYQEPLRT
:
XP_011 ICE
570
>>XP_006711192 (OMIM: 605337) PREDICTED: complement fact (570 aa)
initn: 1139 init1: 262 opt: 912 Z-score: 1007.7 bits: 196.6 E(85289): 2.2e-49
Smith-Waterman score: 925; 28.1% identity (53.0% similar) in 627 aa overlap (38-646:27-569)
10 20 30 40 50 60
pF1KE0 FIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTES
:: ... .::: . .. :..: ...: :
XP_006 MLLLINVILTLWVSCANGQEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPS
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 GRQEEQTTCTTEGWSPEPRCFKKCTKPD--LSNGYISDVKLLYKIQENMRYGCASGYKTT
: . :: .:::: :.. :.: : . ::.::. . .: ..:. .:.: :: :.
XP_006 GSYWDYIHCTQDGWSPTVPCLRTCSKSDVEIENGFISESSSIYILNEETQYNCKPGYATA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 GGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYY
:.. . ::..:::.:: : : : : . :. ... ::..: ..::: ::
XP_006 EGNSSGSITCLQNGWSTQPICIK---FCDMPVFENSRAKSNGMWFKLHDTLDYECYDGYE
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 TAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENY
.. :. :. . : ::: : :
XP_006 SSYGNTTDSIVCGEDGWSHLPTC-------------------------------------
180 190
250 260 270 280 290 300
pF1KE0 YLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELN
: : : : ::::. .. . . .: :. .:.
XP_006 ---------------YNSSENC-G-----PPPPISNGDTTSFPQKVYLPWSRVEYQCQSY
200 210 220 230
310 320 330 340 350 360
pF1KE0 FEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHS--KIYY---NGDKV
.:..:: . : .: :.:::.:: . :: : :..: .. . :. .:..
XP_006 YELQGSKYVTCSNGDWSEPPRCISMKP---CEFPE-IQHGHLYYENTRRPYFPVATGQSY
240 250 260 270 280 290
370 380 390 400 410
pF1KE0 TYACKSGYLL-HGS--NEITCNRGKWTLPPECVENNENCKHPPV-VMNGAVADGILASYA
.: : .... :: . : :.. : :. ..:.. . . :: .... . :
XP_006 SYYCDQNFVTPSGSYWDYIHCTQDGWLPTVPCL---RTCSKSDIEIENGFISESS-SIYI
300 310 320 330 340
420 430 440 450 460 470
pF1KE0 TGSSVEYRCNEYYLLRGSKIS---RCEQGKWSSPPVCLEPCTVNVDYMNRNNIE-MKWKY
.. ..:.:. : .. : : :. ::. :.:.. : . : .: . . :..:
XP_006 LNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPICIKFCDMPVFENSRAKSNGMRFK-
350 360 370 380 390 400
480 490 500 510 520 530
pF1KE0 EGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNR-GEVKYPLCTRKESKGMCTSPPLIK
:: : .:. : .::..: . . :. :.. : ..: : . : : :: :.
XP_006 ----LH-DTLDYECYDGYEISYGNTTG--SIVCGEDGWSHFPTCYNSSEK--CGPPPPIS
410 420 430 440 450
540 550 560 570 580 590
pF1KE0 HGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEK
.: : . .: : :::.: ... :.:: . : .: :. :: :..:: .. .:.:
XP_006 NGDTTSFLLKVYVPQSRVEYQCQSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNK
460 470 480 490 500 510
600 610 620 630 640
pF1KE0 NNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQ--CDRGQLKYPRCIPR
::. :: : . . :. :::.:. : :. :.: .: : .: ..::::
XP_006 NNIQLKGKSDIKYYAKTGDTIEFMCKLG-YNANT----SVLSFQAVCREGIVEYPRCE
520 530 540 550 560 570
650 660
pF1KE0 QSTLSYQEPLRT
>>NP_001188480 (OMIM: 605337) complement factor H-relate (577 aa)
initn: 1139 init1: 262 opt: 912 Z-score: 1007.6 bits: 196.6 E(85289): 2.2e-49
Smith-Waterman score: 925; 28.1% identity (53.0% similar) in 627 aa overlap (38-646:34-576)
10 20 30 40 50 60
pF1KE0 FIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTES
:: ... .::: . .. :..: ...: :
NP_001 LINVILTLWVSCANGQVKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 GRQEEQTTCTTEGWSPEPRCFKKCTKPD--LSNGYISDVKLLYKIQENMRYGCASGYKTT
: . :: .:::: :.. :.: : . ::.::. . .: ..:. .:.: :: :.
NP_001 GSYWDYIHCTQDGWSPTVPCLRTCSKSDVEIENGFISESSSIYILNEETQYNCKPGYATA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYY
:.. . ::..:::.:: : : : : . :. ... ::..: ..::: ::
NP_001 EGNSSGSITCLQNGWSTQPICIK---FCDMPVFENSRAKSNGMWFKLHDTLDYECYDGYE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 TAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENY
.. :. :. . : ::: : :
NP_001 SSYGNTTDSIVCGEDGWSHLPTC-------------------------------------
190 200
250 260 270 280 290 300
pF1KE0 YLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELN
: : : : ::::. .. . . .: :. .:.
NP_001 ---------------YNSSENC-G-----PPPPISNGDTTSFPQKVYLPWSRVEYQCQSY
210 220 230 240
310 320 330 340 350 360
pF1KE0 FEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHS--KIYY---NGDKV
.:..:: . : .: :.:::.:: . :: : :..: .. . :. .:..
NP_001 YELQGSKYVTCSNGDWSEPPRCISMKP---CEFPE-IQHGHLYYENTRRPYFPVATGQSY
250 260 270 280 290
370 380 390 400 410
pF1KE0 TYACKSGYLL-HGS--NEITCNRGKWTLPPECVENNENCKHPPV-VMNGAVADGILASYA
.: : .... :: . : :.. : :. ..:.. . . :: .... . :
NP_001 SYYCDQNFVTPSGSYWDYIHCTQDGWLPTVPCL---RTCSKSDIEIENGFISESS-SIYI
300 310 320 330 340 350
420 430 440 450 460 470
pF1KE0 TGSSVEYRCNEYYLLRGSKIS---RCEQGKWSSPPVCLEPCTVNVDYMNRNNIE-MKWKY
.. ..:.:. : .. : : :. ::. :.:.. : . : .: . . :..:
NP_001 LNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPICIKFCDMPVFENSRAKSNGMRFK-
360 370 380 390 400 410
480 490 500 510 520 530
pF1KE0 EGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNR-GEVKYPLCTRKESKGMCTSPPLIK
:: : .:. : .::..: . . :. :.. : ..: : . : : :: :.
NP_001 ----LH-DTLDYECYDGYEISYGNTTG--SIVCGEDGWSHFPTCYNSSEK--CGPPPPIS
420 430 440 450 460
540 550 560 570 580 590
pF1KE0 HGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEK
.: : . .: : :::.: ... :.:: . : .: :. :: :..:: .. .:.:
NP_001 NGDTTSFLLKVYVPQSRVEYQCQSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNK
470 480 490 500 510 520
600 610 620 630 640
pF1KE0 NNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQ--CDRGQLKYPRCIPR
::. :: : . . :. :::.:. : :. :.: .: : .: ..::::
NP_001 NNIQLKGKSDIKYYAKTGDTIEFMCKLG-YNANT----SVLSFQAVCREGIVEYPRCE
530 540 550 560 570
650 660
pF1KE0 QSTLSYQEPLRT
>>NP_001188479 (OMIM: 605337) complement factor H-relate (578 aa)
initn: 1139 init1: 262 opt: 912 Z-score: 1007.6 bits: 196.6 E(85289): 2.2e-49
Smith-Waterman score: 925; 28.1% identity (53.0% similar) in 627 aa overlap (38-646:35-577)
10 20 30 40 50 60
pF1KE0 FIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTES
:: ... .::: . .. :..: ...: :
NP_001 INVILTLWVSCANGQEVKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 GRQEEQTTCTTEGWSPEPRCFKKCTKPD--LSNGYISDVKLLYKIQENMRYGCASGYKTT
: . :: .:::: :.. :.: : . ::.::. . .: ..:. .:.: :: :.
NP_001 GSYWDYIHCTQDGWSPTVPCLRTCSKSDVEIENGFISESSSIYILNEETQYNCKPGYATA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYY
:.. . ::..:::.:: : : : : . :. ... ::..: ..::: ::
NP_001 EGNSSGSITCLQNGWSTQPICIK---FCDMPVFENSRAKSNGMWFKLHDTLDYECYDGYE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 TAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENY
.. :. :. . : ::: : :
NP_001 SSYGNTTDSIVCGEDGWSHLPTC-------------------------------------
190 200
250 260 270 280 290 300
pF1KE0 YLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELN
: : : : ::::. .. . . .: :. .:.
NP_001 ---------------YNSSENC-G-----PPPPISNGDTTSFPQKVYLPWSRVEYQCQSY
210 220 230 240
310 320 330 340 350 360
pF1KE0 FEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHS--KIYY---NGDKV
.:..:: . : .: :.:::.:: . :: : :..: .. . :. .:..
NP_001 YELQGSKYVTCSNGDWSEPPRCISMKP---CEFPE-IQHGHLYYENTRRPYFPVATGQSY
250 260 270 280 290
370 380 390 400 410
pF1KE0 TYACKSGYLL-HGS--NEITCNRGKWTLPPECVENNENCKHPPV-VMNGAVADGILASYA
.: : .... :: . : :.. : :. ..:.. . . :: .... . :
NP_001 SYYCDQNFVTPSGSYWDYIHCTQDGWLPTVPCL---RTCSKSDIEIENGFISESS-SIYI
300 310 320 330 340 350
420 430 440 450 460 470
pF1KE0 TGSSVEYRCNEYYLLRGSKIS---RCEQGKWSSPPVCLEPCTVNVDYMNRNNIE-MKWKY
.. ..:.:. : .. : : :. ::. :.:.. : . : .: . . :..:
NP_001 LNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPICIKFCDMPVFENSRAKSNGMRFK-
360 370 380 390 400 410
480 490 500 510 520 530
pF1KE0 EGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNR-GEVKYPLCTRKESKGMCTSPPLIK
:: : .:. : .::..: . . :. :.. : ..: : . : : :: :.
NP_001 ----LH-DTLDYECYDGYEISYGNTTG--SIVCGEDGWSHFPTCYNSSEK--CGPPPPIS
420 430 440 450 460
540 550 560 570 580 590
pF1KE0 HGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEK
.: : . .: : :::.: ... :.:: . : .: :. :: :..:: .. .:.:
NP_001 NGDTTSFLLKVYVPQSRVEYQCQSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNK
470 480 490 500 510 520
600 610 620 630 640
pF1KE0 NNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQ--CDRGQLKYPRCIPR
::. :: : . . :. :::.:. : :. :.: .: : .: ..::::
NP_001 NNIQLKGKSDIKYYAKTGDTIEFMCKLG-YNANT----SVLSFQAVCREGIVEYPRCE
530 540 550 560 570
650 660
pF1KE0 QSTLSYQEPLRT
661 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 06:19:37 2016 done: Fri Nov 4 06:19:39 2016
Total Scan time: 11.110 Total Display time: 0.180
Function used was FASTA [36.3.4 Apr, 2011]