Result of FASTA (omim) for
pF1KE0065
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0065, 1030 aa
1>>>pF1KE0065 1030 - 1030 aa - 1030 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.5058+/-0.000562; mu= -11.7370+/- 0.034
mean_var=648.2071+/-144.681, 0's: 0 Z-trim(118.6): 1557 B-trim: 758 in 1/61
Lambda= 0.050375
statistics sampled from 29538 (31645) to 29538 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.708), E-opt: 0.2 (0.371), width: 16
Scan time: 16.390
The best scores are: opt bits E(85289)
NP_001032420 (OMIM: 300203,300672) cyclin-dependen (1030) 6907 518.8 6e-146
NP_003150 (OMIM: 300203,300672) cyclin-dependent k (1030) 6907 518.8 6e-146
NP_001310218 (OMIM: 300203,300672) cyclin-dependen ( 960) 6002 453.0 3.6e-126
XP_016864300 (OMIM: 603442) PREDICTED: cyclin-depe ( 479) 1009 89.7 4e-17
NP_003939 (OMIM: 603442) cyclin-dependent kinase-l ( 493) 1009 89.8 4.1e-17
XP_016864299 (OMIM: 603442) PREDICTED: cyclin-depe ( 493) 1009 89.8 4.1e-17
XP_006714469 (OMIM: 603442) PREDICTED: cyclin-depe ( 530) 1009 89.8 4.3e-17
NP_001317653 (OMIM: 603442) cyclin-dependent kinas ( 570) 1009 89.8 4.5e-17
XP_016864298 (OMIM: 603442) PREDICTED: cyclin-depe ( 570) 1009 89.8 4.5e-17
NP_004187 (OMIM: 603441) cyclin-dependent kinase-l ( 358) 976 87.2 1.8e-16
XP_005268214 (OMIM: 603441) PREDICTED: cyclin-depe ( 358) 976 87.2 1.8e-16
XP_016877218 (OMIM: 603441) PREDICTED: cyclin-depe ( 358) 976 87.2 1.8e-16
NP_001269165 (OMIM: 603441) cyclin-dependent kinas ( 276) 891 80.9 1.1e-14
XP_016877221 (OMIM: 603441) PREDICTED: cyclin-depe ( 279) 891 80.9 1.1e-14
XP_016877219 (OMIM: 603441) PREDICTED: cyclin-depe ( 301) 891 80.9 1.2e-14
XP_016877220 (OMIM: 603441) PREDICTED: cyclin-depe ( 301) 891 80.9 1.2e-14
XP_005268216 (OMIM: 603441) PREDICTED: cyclin-depe ( 301) 891 80.9 1.2e-14
NP_057592 (OMIM: 608459) cyclin-dependent kinase-l ( 455) 876 80.1 3.2e-14
NP_001107047 (OMIM: 608459) cyclin-dependent kinas ( 592) 876 80.2 3.8e-14
XP_016865024 (OMIM: 608459) PREDICTED: cyclin-depe ( 592) 876 80.2 3.8e-14
XP_016865021 (OMIM: 608459) PREDICTED: cyclin-depe ( 607) 876 80.2 3.8e-14
XP_016865016 (OMIM: 608459) PREDICTED: cyclin-depe ( 622) 812 75.6 9.7e-13
XP_011535578 (OMIM: 603441) PREDICTED: cyclin-depe ( 308) 763 71.6 7.4e-12
NP_004926 (OMIM: 123831,616342) cyclin-dependent-l ( 292) 734 69.5 3.1e-11
NP_001249 (OMIM: 123828) cyclin-dependent kinase 3 ( 305) 707 67.6 1.2e-10
NP_001034892 (OMIM: 610076) cyclin-dependent kinas ( 346) 707 67.6 1.3e-10
XP_005270360 (OMIM: 116940) PREDICTED: cyclin-depe ( 297) 702 67.2 1.6e-10
NP_001777 (OMIM: 116940) cyclin-dependent kinase 1 ( 297) 702 67.2 1.6e-10
NP_001307847 (OMIM: 116940) cyclin-dependent kinas ( 297) 702 67.2 1.6e-10
NP_277022 (OMIM: 176873) cyclin-dependent kinase 1 ( 526) 699 67.3 2.6e-10
NP_277025 (OMIM: 176873) cyclin-dependent kinase 1 ( 565) 699 67.3 2.7e-10
XP_011540798 (OMIM: 176873) PREDICTED: cyclin-depe ( 578) 699 67.3 2.8e-10
NP_277071 (OMIM: 116951) cyclin-dependent kinase 1 ( 770) 702 67.7 2.8e-10
NP_001300911 (OMIM: 116951) cyclin-dependent kinas ( 779) 702 67.7 2.9e-10
NP_076916 (OMIM: 116951) cyclin-dependent kinase 1 ( 780) 702 67.7 2.9e-10
NP_001300825 (OMIM: 116951) cyclin-dependent kinas ( 783) 702 67.7 2.9e-10
NP_277024 (OMIM: 176873) cyclin-dependent kinase 1 ( 748) 699 67.5 3.2e-10
XP_011540797 (OMIM: 176873) PREDICTED: cyclin-depe ( 760) 699 67.5 3.3e-10
XP_016858417 (OMIM: 176873) PREDICTED: cyclin-depe ( 761) 699 67.5 3.3e-10
XP_011540796 (OMIM: 176873) PREDICTED: cyclin-depe ( 770) 699 67.5 3.3e-10
XP_016858416 (OMIM: 176873) PREDICTED: cyclin-depe ( 770) 699 67.5 3.3e-10
NP_001278274 (OMIM: 176873) cyclin-dependent kinas ( 772) 699 67.5 3.3e-10
XP_016858415 (OMIM: 176873) PREDICTED: cyclin-depe ( 781) 699 67.5 3.3e-10
NP_277021 (OMIM: 176873) cyclin-dependent kinase 1 ( 782) 699 67.5 3.3e-10
XP_006711128 (OMIM: 176873) PREDICTED: cyclin-depe ( 785) 699 67.5 3.3e-10
XP_016858414 (OMIM: 176873) PREDICTED: cyclin-depe ( 791) 699 67.5 3.4e-10
XP_011540795 (OMIM: 176873) PREDICTED: cyclin-depe ( 794) 699 67.5 3.4e-10
NP_001778 (OMIM: 176873) cyclin-dependent kinase 1 ( 795) 699 67.5 3.4e-10
XP_011540792 (OMIM: 176873) PREDICTED: cyclin-depe ( 804) 699 67.5 3.4e-10
XP_011540793 (OMIM: 176873) PREDICTED: cyclin-depe ( 804) 699 67.5 3.4e-10
>>NP_001032420 (OMIM: 300203,300672) cyclin-dependent ki (1030 aa)
initn: 6907 init1: 6907 opt: 6907 Z-score: 2741.2 bits: 518.8 E(85289): 6e-146
Smith-Waterman score: 6907; 100.0% identity (100.0% similar) in 1030 aa overlap (1-1030:1-1030)
10 20 30 40 50 60
pF1KE0 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE0 KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE0 LQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE0 PAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLT
970 980 990 1000 1010 1020
1030
pF1KE0 YHENAALTGK
::::::::::
NP_001 YHENAALTGK
1030
>>NP_003150 (OMIM: 300203,300672) cyclin-dependent kinas (1030 aa)
initn: 6907 init1: 6907 opt: 6907 Z-score: 2741.2 bits: 518.8 E(85289): 6e-146
Smith-Waterman score: 6907; 100.0% identity (100.0% similar) in 1030 aa overlap (1-1030:1-1030)
10 20 30 40 50 60
pF1KE0 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE0 KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE0 LQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE0 PAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLT
970 980 990 1000 1010 1020
1030
pF1KE0 YHENAALTGK
::::::::::
NP_003 YHENAALTGK
1030
>>NP_001310218 (OMIM: 300203,300672) cyclin-dependent ki (960 aa)
initn: 6002 init1: 6002 opt: 6002 Z-score: 2386.0 bits: 453.0 E(85289): 3.6e-126
Smith-Waterman score: 6002; 100.0% identity (100.0% similar) in 904 aa overlap (1-904:1-904)
10 20 30 40 50 60
pF1KE0 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE0 KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE0 LQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISS
::::
NP_001 LQLPGQMDPGWHVSSVTRSATEGPSYSEQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL
910 920 930 940 950 960
>>XP_016864300 (OMIM: 603442) PREDICTED: cyclin-dependen (479 aa)
initn: 824 init1: 824 opt: 1009 Z-score: 428.3 bits: 89.7 E(85289): 4e-17
Smith-Waterman score: 1044; 39.1% identity (71.9% similar) in 437 aa overlap (10-432:1-433)
10 20 30 40 50 60
pF1KE0 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE
:.:.: ::.::::.::.:.:::.:.: .::::::: .:.... ::. ..::
XP_016 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMRE
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI
.:.:. :..::.:.: :. ... . :::::.:....:. :: .:::. . :..:..:.:
XP_016 IKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQII
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP
..: .::...:.::::::::.:.:.. :.:::::::::.:. ... ::.::::::::.:
XP_016 NGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEV-YTDYVATRWYRAP
120 130 140 150 160 170
190 200 210 220 230
pF1KE0 ELLLG-APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFY
:::.: . :::.::.:..::.. :. :.:::::.:.::::. :. :: : ....::
XP_016 ELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFN
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 SNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQT
.:: : :.:.: ... . ::::: :. :..:: :. :..:: : . . :.: ::
XP_016 KNPVFAGVRLPEIKEREPLERRY-PKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQM
240 250 260 270 280
300 310 320 330 340 350
pF1KE0 QRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEG
. . .: .. . ... .::...: :. . . : .. ..: : ::
XP_016 DGFAERFSQELQLKVQKDARNVSLSKKSQNRKKE--KEKDDSLVEERKTLVVQDTNADPK
290 300 310 320 330 340
360 370 380 390 400
pF1KE0 LPANESF------LNGNLA-----GASLSPLH-TKTYQASSQPGSTSKDLTNNNIPHLLS
. . : ..:. : ... : :: ..: . . :... :: .: .. : .
XP_016 IKDYKLFKIKGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRN
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE0 PKEAKSKTEFDFN-IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSR
:. : ... . :. . : ::.
XP_016 PSVAIPPLTHNLSAVAPSINSGMGTETIPIQGYRVDEKTKKCSIPFVKPNRHSPSGIYNI
410 420 430 440 450 460
>>NP_003939 (OMIM: 603442) cyclin-dependent kinase-like (493 aa)
initn: 824 init1: 824 opt: 1009 Z-score: 428.2 bits: 89.8 E(85289): 4.1e-17
Smith-Waterman score: 1044; 39.1% identity (71.9% similar) in 437 aa overlap (10-432:1-433)
10 20 30 40 50 60
pF1KE0 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE
:.:.: ::.::::.::.:.:::.:.: .::::::: .:.... ::. ..::
NP_003 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMRE
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI
.:.:. :..::.:.: :. ... . :::::.:....:. :: .:::. . :..:..:.:
NP_003 IKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQII
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP
..: .::...:.::::::::.:.:.. :.:::::::::.:. ... ::.::::::::.:
NP_003 NGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEV-YTDYVATRWYRAP
120 130 140 150 160 170
190 200 210 220 230
pF1KE0 ELLLG-APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFY
:::.: . :::.::.:..::.. :. :.:::::.:.::::. :. :: : ....::
NP_003 ELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFN
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 SNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQT
.:: : :.:.: ... . ::::: :. :..:: :. :..:: : . . :.: ::
NP_003 KNPVFAGVRLPEIKEREPLERRY-PKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQM
240 250 260 270 280
300 310 320 330 340 350
pF1KE0 QRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEG
. . .: .. . ... .::...: :. . . : .. ..: : ::
NP_003 DGFAERFSQELQLKVQKDARNVSLSKKSQNRKKE--KEKDDSLVEERKTLVVQDTNADPK
290 300 310 320 330 340
360 370 380 390 400
pF1KE0 LPANESF------LNGNLA-----GASLSPLH-TKTYQASSQPGSTSKDLTNNNIPHLLS
. . : ..:. : ... : :: ..: . . :... :: .: .. : .
NP_003 IKDYKLFKIKGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRN
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE0 PKEAKSKTEFDFN-IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSR
:. : ... . :. . : ::.
NP_003 PSVAIPPLTHNLSAVAPSINSGMGTETIPIQGYRVDEKTKKCSIPFVKPNRHSPSGIYNI
410 420 430 440 450 460
>>XP_016864299 (OMIM: 603442) PREDICTED: cyclin-dependen (493 aa)
initn: 824 init1: 824 opt: 1009 Z-score: 428.2 bits: 89.8 E(85289): 4.1e-17
Smith-Waterman score: 1044; 39.1% identity (71.9% similar) in 437 aa overlap (10-432:1-433)
10 20 30 40 50 60
pF1KE0 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE
:.:.: ::.::::.::.:.:::.:.: .::::::: .:.... ::. ..::
XP_016 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMRE
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI
.:.:. :..::.:.: :. ... . :::::.:....:. :: .:::. . :..:..:.:
XP_016 IKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQII
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP
..: .::...:.::::::::.:.:.. :.:::::::::.:. ... ::.::::::::.:
XP_016 NGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEV-YTDYVATRWYRAP
120 130 140 150 160 170
190 200 210 220 230
pF1KE0 ELLLG-APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFY
:::.: . :::.::.:..::.. :. :.:::::.:.::::. :. :: : ....::
XP_016 ELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFN
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 SNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQT
.:: : :.:.: ... . ::::: :. :..:: :. :..:: : . . :.: ::
XP_016 KNPVFAGVRLPEIKEREPLERRY-PKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQM
240 250 260 270 280
300 310 320 330 340 350
pF1KE0 QRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEG
. . .: .. . ... .::...: :. . . : .. ..: : ::
XP_016 DGFAERFSQELQLKVQKDARNVSLSKKSQNRKKE--KEKDDSLVEERKTLVVQDTNADPK
290 300 310 320 330 340
360 370 380 390 400
pF1KE0 LPANESF------LNGNLA-----GASLSPLH-TKTYQASSQPGSTSKDLTNNNIPHLLS
. . : ..:. : ... : :: ..: . . :... :: .: .. : .
XP_016 IKDYKLFKIKGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRN
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE0 PKEAKSKTEFDFN-IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSR
:. : ... . :. . : ::.
XP_016 PSVAIPPLTHNLSAVAPSINSGMGTETIPIQGYRVDEKTKKCSIPFVKPNRHSPSGIYNI
410 420 430 440 450 460
>>XP_006714469 (OMIM: 603442) PREDICTED: cyclin-dependen (530 aa)
initn: 853 init1: 824 opt: 1009 Z-score: 427.8 bits: 89.8 E(85289): 4.3e-17
Smith-Waterman score: 1048; 36.7% identity (69.3% similar) in 502 aa overlap (10-496:1-491)
10 20 30 40 50 60
pF1KE0 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE
:.:.: ::.::::.::.:.:::.:.: .::::::: .:.... ::. ..::
XP_006 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMRE
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI
.:.:. :..::.:.: :. ... . :::::.:....:. :: .:::. . :..:..:.:
XP_006 IKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQII
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP
..: .::...:.::::::::.:.:.. :.:::::::::.:. ... ::.::::::::.:
XP_006 NGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEV-YTDYVATRWYRAP
120 130 140 150 160 170
190 200 210 220 230
pF1KE0 ELLLG-APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFY
:::.: . :::.::.:..::.. :. :.:::::.:.::::. :. :: : ....::
XP_006 ELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFN
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 SNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQT
.:: : :.:.: ... . ::::: :. :..:: :. :..:: : . . :.: ::
XP_006 KNPVFAGVRLPEIKEREPLERRY-PKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQM
240 250 260 270 280
300 310 320 330 340 350
pF1KE0 QRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEG
. . .: .. . ... .::...: :. . . : .. ..: : ::
XP_006 DGFAERFSQELQLKVQKDARNVSLSKKSQNRKKE--KEKDDSLVEERKTLVVQDTNADPK
290 300 310 320 330 340
360 370 380 390 400
pF1KE0 LPANESF------LNGNLA-----GASLSPLH-TKTYQASSQPGSTSKDLTNNNIPHLLS
. . : ..:. : ... : :: ..: . . :... :: .: .. : .
XP_006 IKDYKLFKIKGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRN
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE0 PKEAKSKTEFDFN-IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSR
:. : ... . :. . : ::. . :. . .... . ..::...
XP_006 PSVAIPPLTHNLSAVAPSINSGMGTETIPI-----QGYRVDEKTKKCSIPFVKPNRHSPS
410 420 430 440 450 460
470 480 490 500 510 520
pF1KE0 HSY-IDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLN
: :.. .:. : :: .:. ::.:.
XP_006 GIYNINVTTLVTRN-SRLTKKESK-ILSESRIPSLAAIDLHTPSITLHQVSGPPLSDDSG
470 480 490 500 510 520
530 540 550 560 570 580
pF1KE0 SPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSL
XP_006 ADLPQMEHQH
530
>>NP_001317653 (OMIM: 603442) cyclin-dependent kinase-li (570 aa)
initn: 824 init1: 824 opt: 1009 Z-score: 427.5 bits: 89.8 E(85289): 4.5e-17
Smith-Waterman score: 1053; 34.4% identity (66.8% similar) in 561 aa overlap (10-546:1-552)
10 20 30 40 50 60
pF1KE0 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE
:.:.: ::.::::.::.:.:::.:.: .::::::: .:.... ::. ..::
NP_001 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMRE
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI
.:.:. :..::.:.: :. ... . :::::.:....:. :: .:::. . :..:..:.:
NP_001 IKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQII
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP
..: .::...:.::::::::.:.:.. :.:::::::::.:. ... ::.::::::::.:
NP_001 NGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEV-YTDYVATRWYRAP
120 130 140 150 160 170
190 200 210 220 230
pF1KE0 ELLLG-APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFY
:::.: . :::.::.:..::.. :. :.:::::.:.::::. :. :: : ....::
NP_001 ELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFN
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 SNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQT
.:: : :.:.: ... . ::::: :. :..:: :. :..:: : . . :.: ::
NP_001 KNPVFAGVRLPEIKEREPLERRY-PKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQM
240 250 260 270 280
300 310 320 330 340 350
pF1KE0 QRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEG
. . .: .. . ... .::...: :. . . : .. ..: : ::
NP_001 DGFAERFSQELQLKVQKDARNVSLSKKSQNRKKE--KEKDDSLVEERKTLVVQDTNADPK
290 300 310 320 330 340
360 370 380 390 400
pF1KE0 LPANESF------LNGNLA-----GASLSPLH-TKTYQASSQPGSTSKDLTNNNIPHLLS
. . : ..:. : ... : :: ..: . . :... :: .: .. : .
NP_001 IKDYKLFKIKGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRN
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE0 PKEAKSKTEFDFN-IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSR
:. : ... . :. . : ::. . .. ... ... . ..::...
NP_001 PSVAIPPLTHNLSAVAPSINSGMGTETIPIQGYRVDEK-----TKKCSIPFVKPNRHSPS
410 420 430 440 450 460
470 480 490 500 510
pF1KE0 HSY---IDTIPQSSRSPSYRTKAKSHGALSDSK----SVSNLSEARAQ--IAEPSTSRYF
: . :. .: .. . .: . . . .: . . ..: : :: ::. :
NP_001 GIYNINVTTLVSSEKNLFWASKKRREYSRTDVRLPELNYNHLPELRALGGIARNSRLTKK
470 480 490 500 510 520
520 530 540 550 560 570
pF1KE0 PSSCLDLNS-PTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEH
:. :. . :. . :. . :: . ::
NP_001 ESKILSESRIPSLAAIDLHTPSITLHQVSGPPLSDDSGADLPQMEHQH
530 540 550 560 570
>>XP_016864298 (OMIM: 603442) PREDICTED: cyclin-dependen (570 aa)
initn: 824 init1: 824 opt: 1009 Z-score: 427.5 bits: 89.8 E(85289): 4.5e-17
Smith-Waterman score: 1053; 34.4% identity (66.8% similar) in 561 aa overlap (10-546:1-552)
10 20 30 40 50 60
pF1KE0 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE
:.:.: ::.::::.::.:.:::.:.: .::::::: .:.... ::. ..::
XP_016 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMRE
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI
.:.:. :..::.:.: :. ... . :::::.:....:. :: .:::. . :..:..:.:
XP_016 IKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQII
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP
..: .::...:.::::::::.:.:.. :.:::::::::.:. ... ::.::::::::.:
XP_016 NGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEV-YTDYVATRWYRAP
120 130 140 150 160 170
190 200 210 220 230
pF1KE0 ELLLG-APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFY
:::.: . :::.::.:..::.. :. :.:::::.:.::::. :. :: : ....::
XP_016 ELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFN
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 SNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQT
.:: : :.:.: ... . ::::: :. :..:: :. :..:: : . . :.: ::
XP_016 KNPVFAGVRLPEIKEREPLERRY-PKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQM
240 250 260 270 280
300 310 320 330 340 350
pF1KE0 QRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEG
. . .: .. . ... .::...: :. . . : .. ..: : ::
XP_016 DGFAERFSQELQLKVQKDARNVSLSKKSQNRKKE--KEKDDSLVEERKTLVVQDTNADPK
290 300 310 320 330 340
360 370 380 390 400
pF1KE0 LPANESF------LNGNLA-----GASLSPLH-TKTYQASSQPGSTSKDLTNNNIPHLLS
. . : ..:. : ... : :: ..: . . :... :: .: .. : .
XP_016 IKDYKLFKIKGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRN
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE0 PKEAKSKTEFDFN-IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSR
:. : ... . :. . : ::. . .. ... ... . ..::...
XP_016 PSVAIPPLTHNLSAVAPSINSGMGTETIPIQGYRVDEK-----TKKCSIPFVKPNRHSPS
410 420 430 440 450 460
470 480 490 500 510
pF1KE0 HSY---IDTIPQSSRSPSYRTKAKSHGALSDSK----SVSNLSEARAQ--IAEPSTSRYF
: . :. .: .. . .: . . . .: . . ..: : :: ::. :
XP_016 GIYNINVTTLVSSEKNLFWASKKRREYSRTDVRLPELNYNHLPELRALGGIARNSRLTKK
470 480 490 500 510 520
520 530 540 550 560 570
pF1KE0 PSSCLDLNS-PTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEH
:. :. . :. . :. . :: . ::
XP_016 ESKILSESRIPSLAAIDLHTPSITLHQVSGPPLSDDSGADLPQMEHQH
530 540 550 560 570
>>NP_004187 (OMIM: 603441) cyclin-dependent kinase-like (358 aa)
initn: 846 init1: 745 opt: 976 Z-score: 416.8 bits: 87.2 E(85289): 1.8e-16
Smith-Waterman score: 986; 43.0% identity (74.9% similar) in 358 aa overlap (9-354:1-356)
10 20 30 40 50 60
pF1KE0 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE
.:.:.: .: .:::.::::.:::...: .::::::: .::.. .:. .:::
NP_004 MMEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALRE
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI
..::. ::. :.:.: :.:::. .:.::::: ....:. :... ::: . ::: .: .
NP_004 IRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP
.:...:::.. .:::.::::.::....:.::::::::: :. : . ::.::::::::::
NP_004 QAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLT-GPSDYYTDYVATRWYRSP
120 130 140 150 160 170
190 200 210 220 230
pF1KE0 ELLLG-APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFY
:::.: . :: ::.:..::...:: .: ::.::.:..:::. :.:.:: : .....:
NP_004 ELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFS
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 SNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQT
.: : :...: . . :: .. .: . : :.:. :..::..: :: :.:: :..
NP_004 TNQYFSGVKIPDPEDMEPLELKFPNI-SYPALGLLKGCLHMDPTQRLTCEQLLHHPYFEN
240 250 260 270 280 290
300 310 320 330 340
pF1KE0 QRLLD------RSPSRSAKRKP--YH--VESSTLSNRNQAGKSTALQS-HHRSNSKDIQN
: .. .:.:.. :: .: .:.: :. : :. : . ... : ..
NP_004 IREIEDLAKEHNKPTRKTLRKSRKHHCFTETSKLQYLPQLTGSSILPALDNKKYYCDTKK
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE0 LSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSP
:. .:
NP_004 LNYRFPNI
1030 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 05:14:38 2016 done: Fri Nov 4 05:14:40 2016
Total Scan time: 16.390 Total Display time: 0.210
Function used was FASTA [36.3.4 Apr, 2011]