FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0069, 738 aa 1>>>pF1KE0069 738 - 738 aa - 738 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0018+/-0.000357; mu= 22.1006+/- 0.022 mean_var=67.4768+/-13.422, 0's: 0 Z-trim(113.0): 29 B-trim: 0 in 0/53 Lambda= 0.156134 statistics sampled from 22177 (22203) to 22177 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.62), E-opt: 0.2 (0.26), width: 16 Scan time: 10.170 The best scores are: opt bits E(85289) NP_005920 (OMIM: 155750) melanotransferrin isoform ( 738) 5067 1150.8 0 XP_011511153 (OMIM: 155750) PREDICTED: melanotrans ( 670) 4444 1010.4 0 XP_011511152 (OMIM: 155750) PREDICTED: melanotrans ( 765) 4443 1010.2 0 XP_006713706 (OMIM: 155750) PREDICTED: melanotrans ( 764) 4426 1006.4 0 NP_201573 (OMIM: 155750) melanotransferrin isoform ( 302) 1614 372.7 1.2e-102 NP_001186078 (OMIM: 150210) lactotransferrin isofo ( 666) 899 211.9 6.9e-54 NP_001308051 (OMIM: 150210) lactotransferrin isofo ( 697) 899 211.9 7.2e-54 NP_002334 (OMIM: 150210) lactotransferrin isoform ( 710) 899 211.9 7.3e-54 NP_001308050 (OMIM: 150210) lactotransferrin isofo ( 708) 836 197.7 1.4e-49 XP_016862579 (OMIM: 190000,209300) PREDICTED: sero ( 698) 606 145.9 5.3e-34 XP_016862578 (OMIM: 190000,209300) PREDICTED: sero ( 698) 606 145.9 5.3e-34 NP_001054 (OMIM: 190000,209300) serotransferrin pr ( 698) 605 145.7 6.2e-34 >>NP_005920 (OMIM: 155750) melanotransferrin isoform 1 p (738 aa) initn: 5067 init1: 5067 opt: 5067 Z-score: 6161.8 bits: 1150.8 E(85289): 0 Smith-Waterman score: 5067; 100.0% identity (100.0% similar) in 738 aa overlap (1-738:1-738) 10 20 30 40 50 60 pF1KE0 MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 DHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 IDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 IDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 YSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 LPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLIFRLLNEGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLIFRLLNEGQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 RLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLCDPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLCDPN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 RLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 SGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAVVRRDSSHAFTLDELRGKRSCHAGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAVVRRDSSHAFTLDELRGKRSCHAGF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 GSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPSSLCALCVGDEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPSSLCALCVGDEQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 GRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAELRSEDYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAELRSEDYE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE0 LLCPNGARAEVSQFAACNLAQIPPHAVMVRPDTNIFTVYGLLDKAQDLFGDDHNKNGFKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LLCPNGARAEVSQFAACNLAQIPPHAVMVRPDTNIFTVYGLLDKAQDLFGDDHNKNGFKM 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE0 FDSSNYHGQDLLFKDATVRAVPVGEKTTYRGWLGLDYVAALEGMSSQQCSGAAAPAPGAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FDSSNYHGQDLLFKDATVRAVPVGEKTTYRGWLGLDYVAALEGMSSQQCSGAAAPAPGAP 670 680 690 700 710 720 730 pF1KE0 LLPLLLPALAARLLPPAL :::::::::::::::::: NP_005 LLPLLLPALAARLLPPAL 730 >>XP_011511153 (OMIM: 155750) PREDICTED: melanotransferr (670 aa) initn: 5079 init1: 4444 opt: 4444 Z-score: 5404.0 bits: 1010.4 E(85289): 0 Smith-Waterman score: 4444; 99.8% identity (100.0% similar) in 647 aa overlap (1-647:1-647) 10 20 30 40 50 60 pF1KE0 MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 DHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 IDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 YSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 LPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLIFRLLNEGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLIFRLLNEGQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 RLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLCDPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLCDPN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 RLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 SGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAVVRRDSSHAFTLDELRGKRSCHAGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAVVRRDSSHAFTLDELRGKRSCHAGF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 GSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPSSLCALCVGDEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPSSLCALCVGDEQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 GRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAELRSEDYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAELRSEDYE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE0 LLCPNGARAEVSQFAACNLAQIPPHAVMVRPDTNIFTVYGLLDKAQDLFGDDHNKNGFKM ::::::::::::::::::::::::::::::::::::::::::::::. XP_011 LLCPNGARAEVSQFAACNLAQIPPHAVMVRPDTNIFTVYGLLDKAQNPSIPGVLYSGSLG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE0 FDSSNYHGQDLLFKDATVRAVPVGEKTTYRGWLGLDYVAALEGMSSQQCSGAAAPAPGAP XP_011 FPRGLLSPLK 670 >>XP_011511152 (OMIM: 155750) PREDICTED: melanotransferr (765 aa) initn: 4721 init1: 4443 opt: 4443 Z-score: 5401.9 bits: 1010.2 E(85289): 0 Smith-Waterman score: 5003; 96.5% identity (96.5% similar) in 765 aa overlap (1-738:1-765) 10 20 30 40 50 60 pF1KE0 MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 DHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 IDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 YSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 LPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLIFRLLNEGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLIFRLLNEGQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 RLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLCDPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLCDPN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 RLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 SGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAVVRRDSSHAFTLDELRGKRSCHAGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAVVRRDSSHAFTLDELRGKRSCHAGF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 GSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPSSLCALCVGDEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPSSLCALCVGDEQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 GRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAELRSEDYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAELRSEDYE 550 560 570 580 590 600 610 620 630 640 pF1KE0 LLCPNGARAEVSQFAACNLAQIPPHAVMVRPDTNIFTVYGLLDKAQ-------------- :::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLCPNGARAEVSQFAACNLAQIPPHAVMVRPDTNIFTVYGLLDKAQQFAASGTGRVTLPE 610 620 630 640 650 660 650 660 670 680 690 pF1KE0 -------------DLFGDDHNKNGFKMFDSSNYHGQDLLFKDATVRAVPVGEKTTYRGWL ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSEEQVVCLRCFQDLFGDDHNKNGFKMFDSSNYHGQDLLFKDATVRAVPVGEKTTYRGWL 670 680 690 700 710 720 700 710 720 730 pF1KE0 GLDYVAALEGMSSQQCSGAAAPAPGAPLLPLLLPALAARLLPPAL ::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLDYVAALEGMSSQQCSGAAAPAPGAPLLPLLLPALAARLLPPAL 730 740 750 760 >>XP_006713706 (OMIM: 155750) PREDICTED: melanotransferr (764 aa) initn: 4424 init1: 3481 opt: 4426 Z-score: 5381.2 bits: 1006.4 E(85289): 0 Smith-Waterman score: 4986; 96.3% identity (96.3% similar) in 765 aa overlap (1-738:1-764) 10 20 30 40 50 60 pF1KE0 MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 DHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 IDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 YSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 LPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLIFRLLNEGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLIFRLLNEGQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 RLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLCDPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLCDPN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 RLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 SGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAVVRRDSSHAFTLDELRGKRSCHAGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAVVRRDSSHAFTLDELRGKRSCHAGF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 GSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPSSLCALCVGDEQ :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: XP_006 GSPAGWDVPVGALIQRGFIRPKDCDVLT-VSEFFNASCVPVNNPKNYPSSLCALCVGDEQ 490 500 510 520 530 550 560 570 580 590 600 pF1KE0 GRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAELRSEDYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAELRSEDYE 540 550 560 570 580 590 610 620 630 640 pF1KE0 LLCPNGARAEVSQFAACNLAQIPPHAVMVRPDTNIFTVYGLLDKAQ-------------- :::::::::::::::::::::::::::::::::::::::::::::: XP_006 LLCPNGARAEVSQFAACNLAQIPPHAVMVRPDTNIFTVYGLLDKAQQFAASGTGRVTLPE 600 610 620 630 640 650 650 660 670 680 690 pF1KE0 -------------DLFGDDHNKNGFKMFDSSNYHGQDLLFKDATVRAVPVGEKTTYRGWL ::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PSEEQVVCLRCFQDLFGDDHNKNGFKMFDSSNYHGQDLLFKDATVRAVPVGEKTTYRGWL 660 670 680 690 700 710 700 710 720 730 pF1KE0 GLDYVAALEGMSSQQCSGAAAPAPGAPLLPLLLPALAARLLPPAL ::::::::::::::::::::::::::::::::::::::::::::: XP_006 GLDYVAALEGMSSQQCSGAAAPAPGAPLLPLLLPALAARLLPPAL 720 730 740 750 760 >>NP_201573 (OMIM: 155750) melanotransferrin isoform 2 p (302 aa) initn: 1639 init1: 1612 opt: 1614 Z-score: 1963.7 bits: 372.7 E(85289): 1.2e-102 Smith-Waterman score: 1614; 94.2% identity (95.7% similar) in 258 aa overlap (1-257:1-256) 10 20 30 40 50 60 pF1KE0 MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_201 MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 DHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_201 DHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 IDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_201 IDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 YSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKT ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: . NP_201 YSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDES- 190 200 210 220 230 250 260 270 280 290 pF1KE0 LPSWGQALL-SQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLIFRLLNEG :: :. :.. : : NP_201 -PSRRQTWTRSEEEEGECPAHEEARRTMRSSAGQAWKWAPVHRPQDESDKGEFGKRAKSR 240 250 260 270 280 290 >>NP_001186078 (OMIM: 150210) lactotransferrin isoform 2 (666 aa) initn: 702 init1: 461 opt: 899 Z-score: 1088.4 bits: 211.9 E(85289): 6.9e-54 Smith-Waterman score: 1582; 40.9% identity (67.4% similar) in 687 aa overlap (50-710:7-653) 20 30 40 50 60 70 pF1KE0 GMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSADHCVQLIAAQEADAITLDG : . :.. : .:.: :: ..:::.:::: NP_001 MRKVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDG 10 20 30 80 90 100 110 120 130 pF1KE0 GAIYEAG-KEHGLKPVVGEVYDQEVG--TSYYAVAVVRRSSHVTIDTLKGVKSCHTGINR : ::::: . :.::..::: : : :::::::.... .. :.:.::::::. : NP_001 GFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRR 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE0 TVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETSYSESLCRLCRGDSSGE :.:::::.: : . . ::. .:..:::::: . .. .::::: : .:: NP_001 TAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFP-NLCRLCAG--TGE 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE0 GVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKTLPSWGQALLSQDFELL . : : : :..:::::.:: .:::::::...:::.:. . .. ...::: NP_001 NKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAE--------RDEYELL 160 170 180 190 200 260 270 280 290 300 310 pF1KE0 CRDGSRADVTEWRQCHLARVPAHAVVVRADTDG--GLIFRLLNEGQRLFSHEGS-SFQMF : :..: : ....:::::::.::::.:. ..: :. :: ..:. :... : .::.: NP_001 CPDNTRKPVDKFKDCHLARVPSHAVVARS-VNGKEDAIWNLLRQAQEKFGKDKSPKFQLF 210 220 230 240 250 260 320 330 340 350 360 pF1KE0 SSEAYGQKDLLFKDST---SELVP-IATQTYEAWLGHEYLHAMKGLLCDPNRLPPY---L .: . ::::::::::. :.. : : . : :: :. :...: . ... . NP_001 GSPS-GQKDLLFKDSAIGFSRVPPRIDSGLY---LGSGYFTAIQNLRKSEEEVAARRARV 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE0 RWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTLSGEDIY ::... :..::.. . . . : ::.. . :. . ..::..:.: .: NP_001 VWCAVGEQELRKCNQWS-----GLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVY 330 340 350 360 370 430 440 450 460 470 pF1KE0 TAGKTYGLVPAAGEHYAPEDSSN-----------SYYVVAVVRRDSSHAFTLDELRGKRS :::: ::::. .:.: ..::. .: .:::::: :. ..: . ..::.: NP_001 TAGKC-GLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRR-SDTSLTWNSVKGKKS 380 390 400 410 420 430 480 490 500 510 520 530 pF1KE0 CHAGFGSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPSSLCALC ::.. :::..:.: : : . .: .:.:. ::.: ..:. :.::::: NP_001 CHTAVDRTAGWNIPMGLL----FNQTGSCKF----DEYFSQSCAPGSDPR---SNLCALC 440 450 460 470 480 540 550 560 570 580 590 pF1KE0 VGDEQGRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAELR .:::::.:::: ::.:::::: ::::::.:::::::::. .::..::.:.:.: :: .:. NP_001 IGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNEAWAKDLK 490 500 510 520 530 540 600 610 620 630 640 650 pF1KE0 SEDYELLCPNGARAEVSQFAACNLAQIPPHAVMVRPDTNIFTVYGLLDKAQDLFGDDHNK :. ::: .: : :.. .:.::. : :::. : : .. . .: . : :: . . NP_001 LADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMD-KVERLKQVLLHQQAKFGRNGSD 550 560 570 580 590 600 660 670 680 690 700 710 pF1KE0 --NGFKMFDSSNYHGQDLLFKDATVRAVPVGEKTTYRGWLGLDYVAALEGMSSQQCSGAA . : .:.: . ..:::.: : . . ::::. .:: .:::.. .. ..:: NP_001 CPDKFCLFQSET---KNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNL--KKCSTSP 610 620 630 640 650 720 730 pF1KE0 APAPGAPLLPLLLPALAARLLPPAL NP_001 LLEACEFLRK 660 >>NP_001308051 (OMIM: 150210) lactotransferrin isoform 4 (697 aa) initn: 1039 init1: 461 opt: 899 Z-score: 1088.1 bits: 211.9 E(85289): 7.2e-54 Smith-Waterman score: 1643; 40.8% identity (67.5% similar) in 714 aa overlap (23-710:12-684) 10 20 30 40 50 60 pF1KE0 MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSA :.:::.:.:: :: . .. .:.. : . :.. : NP_001 MGLCLAGRRRSVQWCAVSQPEATKCFQWQRNMRKVR-GPPVSCIKRDSP 10 20 30 40 70 80 90 100 110 pF1KE0 DHCVQLIAAQEADAITLDGGAIYEAG-KEHGLKPVVGEVYDQEVG--TSYYAVAVVRRSS .:.: :: ..:::.::::: ::::: . :.::..::: : : :::::::.... NP_001 IQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGG 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE0 HVTIDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAG .. :.:.::::::. ::.:::::.: : . . ::. .:..:::::: NP_001 SFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGAD 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE0 ETSYSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTD . .. .::::: : .::. : : : :..:::::.:: .:::::::...:::.:. . NP_001 KGQFP-NLCRLCAG--TGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLS 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE0 GKTLPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDG--GLIFRL .. ...:::: :..: : ....:::::::.::::.:. ..: :. : NP_001 DEAE--------RDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARS-VNGKEDAIWNL 230 240 250 260 270 300 310 320 330 340 350 pF1KE0 LNEGQRLFSHEGS-SFQMFSSEAYGQKDLLFKDST---SELVP-IATQTYEAWLGHEYLH : ..:. :... : .::.:.: . ::::::::::. :.. : : . : :: :. NP_001 LRQAQEKFGKDKSPKFQLFGSPS-GQKDLLFKDSAIGFSRVPPRIDSGLY---LGSGYFT 280 290 300 310 320 330 360 370 380 390 400 pF1KE0 AMKGLLCDPNRLPPY---LRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQHCM :...: . ... . ::... :..::.. . . . : ::.. . :. NP_001 AIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWS-----GLSEGSVTCSSASTTEDCI 340 350 360 370 380 410 420 430 440 450 pF1KE0 ERIQAEQVDAVTLSGEDIYTAGKTYGLVPAAGEHYAPEDSSN-----------SYYVVAV . ..::..:.: .::::: ::::. .:.: ..::. .: .::: NP_001 ALVLKGEADAMSLDGGYVYTAGKC-GLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAV 390 400 410 420 430 440 460 470 480 490 500 510 pF1KE0 VRRDSSHAFTLDELRGKRSCHAGFGSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNA ::: :. ..: . ..::.:::.. :::..:.: : : . .: .:.:. NP_001 VRR-SDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLL----FNQTGSCKF----DEYFSQ 450 460 470 480 490 520 530 540 550 560 570 pF1KE0 SCVPVNNPKNYPSSLCALCVGDEQGRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHT ::.: ..:. :.:::::.:::::.:::: ::.:::::: ::::::.:::::::::. . NP_001 SCAPGSDPR---SNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDVAFVKDV 500 510 520 530 540 550 580 590 600 610 620 630 pF1KE0 TVFDNTNGHNSEPWAAELRSEDYELLCPNGARAEVSQFAACNLAQIPPHAVMVRPDTNIF ::..::.:.:.: :: .:. :. ::: .: : :.. .:.::. : :::. : : .. NP_001 TVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMD-KVE 560 570 580 590 600 610 640 650 660 670 680 690 pF1KE0 TVYGLLDKAQDLFGDDHNK--NGFKMFDSSNYHGQDLLFKDATVRAVPVGEKTTYRGWLG . .: . : :: . . . : .:.: . ..:::.: : . . ::::. .:: NP_001 RLKQVLLHQQAKFGRNGSDCPDKFCLFQSET---KNLLFNDNTECLARLHGKTTYEKYLG 620 630 640 650 660 670 700 710 720 730 pF1KE0 LDYVAALEGMSSQQCSGAAAPAPGAPLLPLLLPALAARLLPPAL .:::.. .. ..:: NP_001 PQYVAGITNL--KKCSTSPLLEACEFLRK 680 690 >>NP_002334 (OMIM: 150210) lactotransferrin isoform 1 pr (710 aa) initn: 1039 init1: 461 opt: 899 Z-score: 1088.0 bits: 211.9 E(85289): 7.3e-54 Smith-Waterman score: 1652; 40.8% identity (66.9% similar) in 731 aa overlap (6-710:12-697) 10 20 30 40 50 pF1KE0 MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLC ::: : :: : :.:::.:.:: :: . .. .:.. : . : NP_002 MKLVFLVLLFLGALGLCLAGRR----RSVQWCAVSQPEATKCFQWQRNMRKVR-GPPVSC 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 VRGTSADHCVQLIAAQEADAITLDGGAIYEAG-KEHGLKPVVGEVYDQEVG--TSYYAVA .. : .:.: :: ..:::.::::: ::::: . :.::..::: : : ::::: NP_002 IKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 VVRRSSHVTIDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGS ::.... .. :.:.::::::. ::.:::::.: : . . ::. .:..: NP_002 VVKKGGSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSAS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 CVPGAGETSYSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHST ::::: . .. .::::: : .::. : : : :..:::::.:: .:::::::...:: NP_002 CVPGADKGQFP-NLCRLCAG--TGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIREST 180 190 200 210 220 230 240 250 260 270 280 pF1KE0 VLENTDGKTLPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDG-- :.:. . .. ...:::: :..: : ....:::::::.::::.:. ..: NP_002 VFEDLSDEAE--------RDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARS-VNGKE 240 250 260 270 280 290 300 310 320 330 340 pF1KE0 GLIFRLLNEGQRLFSHEGS-SFQMFSSEAYGQKDLLFKDST---SELVP-IATQTYEAWL :. :: ..:. :... : .::.:.: . ::::::::::. :.. : : . : : NP_002 DAIWNLLRQAQEKFGKDKSPKFQLFGSPS-GQKDLLFKDSAIGFSRVPPRIDSGLY---L 290 300 310 320 330 350 360 370 380 390 400 pF1KE0 GHEYLHAMKGLLCDPNRLPPY---LRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAK : :. :...: . ... . ::... :..::.. . . . : ::. NP_002 GSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWS-----GLSEGSVTCSSAS 340 350 360 370 380 390 410 420 430 440 450 pF1KE0 SPQHCMERIQAEQVDAVTLSGEDIYTAGKTYGLVPAAGEHYAPEDSSN-----------S . . :. . ..::..:.: .::::: ::::. .:.: ..::. . NP_002 TTEDCIALVLKGEADAMSLDGGYVYTAGKC-GLVPVLAENYKSQQSSDPDPNCVDRPVEG 400 410 420 430 440 450 460 470 480 490 500 510 pF1KE0 YYVVAVVRRDSSHAFTLDELRGKRSCHAGFGSPAGWDVPVGALIQRGFIRPKDCDVLTAV : .:::::: :. ..: . ..::.:::.. :::..:.: : : . .: NP_002 YLAVAVVRR-SDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLL----FNQTGSCKF---- 460 470 480 490 500 520 530 540 550 560 570 pF1KE0 SEFFNASCVPVNNPKNYPSSLCALCVGDEQGRNKCVGNSQERYYGYRGAFRCLVENAGDV .:.:. ::.: ..:. :.:::::.:::::.:::: ::.:::::: ::::::.:::::: NP_002 DEYFSQSCAPGSDPR---SNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDV 510 520 530 540 550 560 580 590 600 610 620 630 pF1KE0 AFVRHTTVFDNTNGHNSEPWAAELRSEDYELLCPNGARAEVSQFAACNLAQIPPHAVMVR :::. .::..::.:.:.: :: .:. :. ::: .: : :.. .:.::. : :::. : NP_002 AFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSR 570 580 590 600 610 620 640 650 660 670 680 pF1KE0 PDTNIFTVYGLLDKAQDLFGDDHNK--NGFKMFDSSNYHGQDLLFKDATVRAVPVGEKTT : .. . .: . : :: . . . : .:.: . ..:::.: : . . ::: NP_002 MD-KVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSET---KNLLFNDNTECLARLHGKTT 630 640 650 660 670 690 700 710 720 730 pF1KE0 YRGWLGLDYVAALEGMSSQQCSGAAAPAPGAPLLPLLLPALAARLLPPAL :. .:: .:::.. .. ..:: NP_002 YEKYLGPQYVAGITNL--KKCSTSPLLEACEFLRK 680 690 700 710 >>NP_001308050 (OMIM: 150210) lactotransferrin isoform 3 (708 aa) initn: 1037 init1: 461 opt: 836 Z-score: 1011.4 bits: 197.7 E(85289): 1.4e-49 Smith-Waterman score: 1641; 40.9% identity (67.2% similar) in 731 aa overlap (6-710:12-695) 10 20 30 40 50 pF1KE0 MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLC ::: : :: : :.:::.:.:: :: . .. .:.. : . : NP_001 MKLVFLVLLFLGALGLCLAGRR----RSVQWCAVSQPEATKCFQWQRNMRKVR-GPPVSC 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 VRGTSADHCVQLIAAQEADAITLDGGAIYEAG-KEHGLKPVVGEVYDQEVG--TSYYAVA .. : .:.: :: ..:::.::::: ::::: . :.::..::: : : ::::: NP_001 IKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 VVRRSSHVTIDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGS ::.... .. :.:.::::::. ::.:::::.: : . . ::. .:..: NP_001 VVKKGGSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSAS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 CVPGAGETSYSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHST ::::: . .. .::::: : .::. : : : :..:::::.:: .:::::::...:: NP_001 CVPGADKGQFP-NLCRLCAG--TGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIREST 180 190 200 210 220 230 240 250 260 270 280 pF1KE0 VLENTDGKTLPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDG-- :.:. . .. ...:::: :..: : ....:::::::.::::.:. ..: NP_001 VFEDLSDEAE--------RDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARS-VNGKE 240 250 260 270 280 290 300 310 320 330 340 pF1KE0 GLIFRLLNEGQRLFSHEGS-SFQMFSSEAYGQKDLLFKDST---SELVP-IATQTYEAWL :. :: ..:. :... : .::.:.: . ::::::::::. :.. : : . : : NP_001 DAIWNLLRQAQEKFGKDKSPKFQLFGSPS-GQKDLLFKDSAIGFSRVPPRIDSGLY---L 290 300 310 320 330 350 360 370 380 390 400 pF1KE0 GHEYLHAMKGLLCDPNRLPPY---LRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAK : :. :...: . ... . ::... :..::.. . . . : ::. NP_001 GSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWS-----GLSEGSVTCSSAS 340 350 360 370 380 390 410 420 430 440 450 pF1KE0 SPQHCMERIQAEQVDAVTLSGEDIYTAGKTYGLVPAAGEHYAPEDSSN-----------S . . :. ...: .::..:.: .::::: ::::. .:.: ..::. . NP_001 TTEDCIA-LKGE-ADAMSLDGGYVYTAGKC-GLVPVLAENYKSQQSSDPDPNCVDRPVEG 400 410 420 430 440 450 460 470 480 490 500 510 pF1KE0 YYVVAVVRRDSSHAFTLDELRGKRSCHAGFGSPAGWDVPVGALIQRGFIRPKDCDVLTAV : .:::::: :. ..: . ..::.:::.. :::..:.: : : . .: NP_001 YLAVAVVRR-SDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLL----FNQTGSCKF---- 460 470 480 490 500 520 530 540 550 560 570 pF1KE0 SEFFNASCVPVNNPKNYPSSLCALCVGDEQGRNKCVGNSQERYYGYRGAFRCLVENAGDV .:.:. ::.: ..:. :.:::::.:::::.:::: ::.:::::: ::::::.:::::: NP_001 DEYFSQSCAPGSDPR---SNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDV 510 520 530 540 550 580 590 600 610 620 630 pF1KE0 AFVRHTTVFDNTNGHNSEPWAAELRSEDYELLCPNGARAEVSQFAACNLAQIPPHAVMVR :::. .::..::.:.:.: :: .:. :. ::: .: : :.. .:.::. : :::. : NP_001 AFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSR 560 570 580 590 600 610 640 650 660 670 680 pF1KE0 PDTNIFTVYGLLDKAQDLFGDDHNK--NGFKMFDSSNYHGQDLLFKDATVRAVPVGEKTT : .. . .: . : :: . . . : .:.: . ..:::.: : . . ::: NP_001 MD-KVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSET---KNLLFNDNTECLARLHGKTT 620 630 640 650 660 670 690 700 710 720 730 pF1KE0 YRGWLGLDYVAALEGMSSQQCSGAAAPAPGAPLLPLLLPALAARLLPPAL :. .:: .:::.. .. ..:: NP_001 YEKYLGPQYVAGITNL--KKCSTSPLLEACEFLRK 680 690 700 >>XP_016862579 (OMIM: 190000,209300) PREDICTED: serotran (698 aa) initn: 579 init1: 277 opt: 606 Z-score: 731.4 bits: 145.9 E(85289): 5.3e-34 Smith-Waterman score: 899; 39.6% identity (66.7% similar) in 414 aa overlap (310-710:301-685) 280 290 300 310 320 330 pF1KE0 AVVVRADTDGGLIFRLLNEGQRLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQT ::.::: .: ::::::::. .. . . XP_016 VARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSSP-HG-KDLLFKDSAHGFLKVPPRM 280 290 300 310 320 340 350 360 370 380 390 pF1KE0 -YEAWLGHEYLHAMKGL---LCD--PNRLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLKP . .::.::. :...: : :. ..::.:: : :: . .: XP_016 DAKMYLGYEYVTAIRNLREGTCPEAPTDECKPVKWCALSHHERLKCDEWSVN-----SVG 330 340 350 360 370 380 400 410 420 430 440 450 pF1KE0 EIQCVSAKSPQHCMERIQAEQVDAVTLSGEDIYTAGKTYGLVPAAGEHYAPEDSSNS--- .:.::::.. . :. .:. ..::..:.: .: ::: ::::. .:.: :. .. XP_016 KIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGKC-GLVPVLAENYNKSDNCEDTPE 390 400 410 420 430 440 460 470 480 490 500 pF1KE0 --YYVVAVVRRDSSHAFTLDELRGKRSCHAGFGSPAGWDVPVGALIQRGFIRPKDCDVLT :...:::....: .: :.:.::.:::.. : :::..:.: : . . . : XP_016 AGYFAIAVVKKSASD-LTWDNLKGKKSCHTAVGRTAGWNIPMGLL----YNKINHCR--- 450 460 470 480 490 510 520 530 540 550 560 pF1KE0 AVSEFFNASCVPVNNPKNYPSSLCALCVGDEQGRNKCVGNSQERYYGYRGAFRCLVENAG .:::. .:.: .. :. :::: ::.:. : : : :..: :::: ::::::::. : XP_016 -FDEFFSEGCAP-GSKKD--SSLCKLCMGS--GLNLCEPNNKEGYYGYTGAFRCLVEK-G 500 510 520 530 540 570 580 590 600 610 620 pF1KE0 DVAFVRHTTVFDNTNGHNSEPWAAELRSEDYELLCPNGARAEVSQFAACNLAQIPPHAVM :::::.: :: .::.:.: .::: .: .:::::: .:.: : ..: :.::. : :::. XP_016 DVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLARAPNHAVV 550 560 570 580 590 600 630 640 650 660 670 680 pF1KE0 VRPDTNIFTVYGLLDKAQDLFGDD--HNKNGFKMFDSSNYHGQDLLFKDATVRAVPVGEK .: : . :. .: . : :::.. ...: .: : . .::::.: :: . . .. XP_016 TRKDKEA-CVHKILRQQQHLFGSNVTDCSGNFCLFRSET---KDLLFRDDTVCLAKLHDR 610 620 630 640 650 660 690 700 710 720 730 pF1KE0 TTYRGWLGLDYVAALEGMSSQQCSGAAAPAPGAPLLPLLLPALAARLLPPAL .::. .:: .:: :. .. ..:: XP_016 NTYEKYLGEEYVKAVGNL--RKCSTSSLLEACTFRRP 670 680 690 >-- initn: 684 init1: 211 opt: 527 Z-score: 635.3 bits: 128.1 E(85289): 1.2e-28 Smith-Waterman score: 766; 42.9% identity (68.7% similar) in 319 aa overlap (1-308:1-298) 10 20 30 40 50 pF1KE0 MRGPSGALWL--LLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREA--GIQPSLLCVR :: ::: . .:.: .. :::::.:. : :: .. . .. . . ::. ::. XP_016 MRLAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 GTSADHCVQLIAAQEADAITLDGGAIYEAG-KEHGLKPVVGEVYD--QEVGTSYYAVAVV .: :.. :::.::::.:::.: .:.: ..:::::.: : .. : ::::::: XP_016 KASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 RRSSHVTIDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCV ...: .. :.: ::::::..:..:::.:.: : . : . :::...:.:::. XP_016 KKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCD--LPEPRKPLEKAVANFFSGSCA 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 PGAGETSYSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVL : : :.. . ::.:: : : : :..:. :::::.:: .::::::::::::.. XP_016 PCADGTDFPQ-LCQLCPG-------CGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIF 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 ENTDGKTLPSWGQALLSQD-FELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGG-- :: .:. ..: .:::: :..: : :...::::.::.:.::.: . :: XP_016 ENLANKA---------DRDQYELLCLDNTRKPVDEYKDCHLAQVPSHTVVAR--SMGGKE 240 250 260 270 300 310 320 330 340 pF1KE0 -LIFRLLNEGQRLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYL ::..:::..:. :... : XP_016 DLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYV 280 290 300 310 320 330 738 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 04:37:45 2016 done: Fri Nov 4 04:37:47 2016 Total Scan time: 10.170 Total Display time: 0.180 Function used was FASTA [36.3.4 Apr, 2011]