Result of FASTA (omim) for
pF1KE0071
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0071, 723 aa
1>>>pF1KE0071 723 - 723 aa - 723 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.7872+/-0.000473; mu= 14.2617+/- 0.029
mean_var=221.3777+/-45.351, 0's: 0 Z-trim(117.9): 656 B-trim: 617 in 1/53
Lambda= 0.086200
statistics sampled from 29643 (30413) to 29643 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.71), E-opt: 0.2 (0.357), width: 16
Scan time: 10.710
The best scores are: opt bits E(85289)
NP_005609 (OMIM: 606582) delta-like protein 1 prec ( 723) 5389 684.2 5e-196
XP_005266991 (OMIM: 606582) PREDICTED: delta-like ( 524) 3710 475.2 2.9e-133
NP_061947 (OMIM: 605185,616589) delta-like protein ( 685) 2172 284.1 1.3e-75
NP_000205 (OMIM: 118450,187500,601920) protein jag (1218) 1771 234.5 1.9e-60
NP_660142 (OMIM: 602570) protein jagged-2 isoform (1200) 1756 232.7 6.8e-60
NP_002217 (OMIM: 602570) protein jagged-2 isoform (1238) 1706 226.5 5.1e-58
XP_016883196 (OMIM: 118450,187500,601920) PREDICTE (1059) 1439 193.2 4.6e-48
XP_011517019 (OMIM: 109730,190198,616028) PREDICTE (2314) 1001 139.2 1.8e-31
NP_060087 (OMIM: 109730,190198,616028) neurogenic (2555) 1001 139.2 1.9e-31
NP_001186930 (OMIM: 102500,600275,610205) neurogen (1235) 950 132.4 1e-29
XP_011539822 (OMIM: 102500,600275,610205) PREDICTE (2432) 950 132.9 1.5e-29
XP_016856862 (OMIM: 102500,600275,610205) PREDICTE (2432) 950 132.9 1.5e-29
XP_005270958 (OMIM: 102500,600275,610205) PREDICTE (2432) 950 132.9 1.5e-29
XP_016856861 (OMIM: 102500,600275,610205) PREDICTE (2455) 950 132.9 1.5e-29
XP_011539821 (OMIM: 102500,600275,610205) PREDICTE (2467) 950 132.9 1.5e-29
NP_077719 (OMIM: 102500,600275,610205) neurogenic (2471) 950 132.9 1.5e-29
NP_982353 (OMIM: 277300,602768) delta-like protein ( 587) 896 125.3 7e-28
NP_058637 (OMIM: 277300,602768) delta-like protein ( 618) 896 125.3 7.2e-28
NP_004548 (OMIM: 164951) neurogenic locus notch ho (2003) 892 125.5 2e-27
NP_620711 (OMIM: 607299) delta and Notch-like epid ( 737) 872 122.4 6.3e-27
XP_005259981 (OMIM: 125310,130720,600276,615293) P (2269) 858 121.4 4.1e-26
NP_000426 (OMIM: 125310,130720,600276,615293) neur (2321) 858 121.4 4.1e-26
NP_003827 (OMIM: 176290) protein delta homolog 1 i ( 383) 832 117.1 1.4e-25
NP_003052 (OMIM: 603742) slit homolog 1 protein pr (1534) 809 115.0 2.2e-24
NP_001304101 (OMIM: 176290) protein delta homolog ( 310) 796 112.5 2.7e-24
NP_001136272 (OMIM: 602772,612424) protein eyes sh (3144) 804 114.9 5.2e-24
NP_001278938 (OMIM: 602772,612424) protein eyes sh (3165) 804 114.9 5.2e-24
NP_001244895 (OMIM: 172870,600105,604210,613835) p ( 870) 742 106.4 5.1e-22
XP_011507669 (OMIM: 172870,600105,604210,613835) P (1297) 742 106.6 6.5e-22
XP_011507667 (OMIM: 172870,600105,604210,613835) P (1349) 742 106.6 6.6e-22
NP_001244894 (OMIM: 172870,600105,604210,613835) p (1382) 742 106.6 6.7e-22
NP_957705 (OMIM: 172870,600105,604210,613835) prot (1406) 742 106.7 6.8e-22
XP_016856341 (OMIM: 172870,600105,604210,613835) P (1451) 742 106.7 6.9e-22
XP_011512212 (OMIM: 603746) PREDICTED: slit homolo (1159) 740 106.3 7.2e-22
XP_016864334 (OMIM: 603746) PREDICTED: slit homolo (1495) 740 106.4 8.3e-22
XP_011512211 (OMIM: 603746) PREDICTED: slit homolo (1499) 740 106.4 8.3e-22
XP_006714049 (OMIM: 603746) PREDICTED: slit homolo (1509) 740 106.5 8.4e-22
NP_001276065 (OMIM: 603746) slit homolog 2 protein (1521) 740 106.5 8.4e-22
NP_001276064 (OMIM: 603746) slit homolog 2 protein (1525) 740 106.5 8.4e-22
NP_004778 (OMIM: 603746) slit homolog 2 protein is (1529) 740 106.5 8.4e-22
XP_005248268 (OMIM: 603746) PREDICTED: slit homolo (1533) 740 106.5 8.5e-22
XP_011516858 (OMIM: 219730,609720,616220) PREDICTE (1276) 698 101.1 2.8e-20
NP_775960 (OMIM: 219730,609720,616220) protein cru (1285) 698 101.1 2.8e-20
XP_011516859 (OMIM: 219730,609720,616220) PREDICTE (1220) 688 99.9 6.5e-20
XP_011516860 (OMIM: 219730,609720,616220) PREDICTE (1220) 688 99.9 6.5e-20
NP_699197 (OMIM: 611691) sushi, von Willebrand fac (3571) 691 100.9 9.5e-20
XP_016859266 (OMIM: 616634) PREDICTED: sushi, nido (1382) 621 91.6 2.3e-17
NP_001258875 (OMIM: 603745) slit homolog 3 protein (1530) 620 91.5 2.6e-17
XP_016865268 (OMIM: 603745) PREDICTED: slit homolo (1460) 614 90.8 4.3e-17
NP_003053 (OMIM: 603745) slit homolog 3 protein is (1523) 614 90.8 4.4e-17
>>NP_005609 (OMIM: 606582) delta-like protein 1 precurso (723 aa)
initn: 5389 init1: 5389 opt: 5389 Z-score: 3640.4 bits: 684.2 E(85289): 5e-196
Smith-Waterman score: 5389; 100.0% identity (100.0% similar) in 723 aa overlap (1-723:1-723)
10 20 30 40 50 60
pF1KE0 MGSRCALALAVLSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACRTFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MGSRCALALAVLSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACRTFF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFTWPGTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFTWPGTF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 SLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 EHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 GECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 GATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 KICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 VDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 PVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 GPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 DISVSIIGATQIKNTNKKADFHGDHSADKNGFKARYPAVDYNLVQDLKGDDTAVRDAHSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DISVSIIGATQIKNTNKKADFHGDHSADKNGFKARYPAVDYNLVQDLKGDDTAVRDAHSK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 RDTKCQPQGSSGEEKGTPTTLRGGEASERKRPDSGCSTSKDTKYQSVYVISEEKDECVIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RDTKCQPQGSSGEEKGTPTTLRGGEASERKRPDSGCSTSKDTKYQSVYVISEEKDECVIA
670 680 690 700 710 720
pF1KE0 TEV
:::
NP_005 TEV
>>XP_005266991 (OMIM: 606582) PREDICTED: delta-like prot (524 aa)
initn: 4048 init1: 3710 opt: 3710 Z-score: 2513.4 bits: 475.2 E(85289): 2.9e-133
Smith-Waterman score: 3710; 99.6% identity (99.6% similar) in 486 aa overlap (1-486:1-486)
10 20 30 40 50 60
pF1KE0 MGSRCALALAVLSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACRTFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGSRCALALAVLSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCACRTFF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFTWPGTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIRFPFGFTWPGTF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 SLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 EHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 GECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 GATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 KICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 VDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 PVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQG
::: :
XP_005 PVSSGEASERKRPDSGCSTSKDTKYQSVYVISEEKDECVIATEV
490 500 510 520
>>NP_061947 (OMIM: 605185,616589) delta-like protein 4 p (685 aa)
initn: 1696 init1: 1291 opt: 2172 Z-score: 1478.5 bits: 284.1 E(85289): 1.3e-75
Smith-Waterman score: 2496; 49.7% identity (70.5% similar) in 739 aa overlap (3-723:5-685)
10 20 30 40 50
pF1KE0 MGSRCALALAVLSALLCQVWS-----SGVFELKLQEFVNKKGLLGNRNCCRGGAGPPP
:: : . :.: :: .:. ::::.:.::::.:..:.:.. :. :
NP_061 MAAASRSASGWALL--LLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPG-----
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 CACRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPD---GGGADSAFSNPIRF
:::::::::::.:: ::: :::.:.. :::::..::.. : ::: ::...
NP_061 --CRTFFRVCLKHFQAVVSP-GPCTFGTVSTPVLGTNSFAVRDDSSGGG-----RNPLQL
60 70 80 90 100
120 130 140 150 160
pF1KE0 PFGFTWPGTFSLIIEALHTDSPDDLATEN--PERLISRLATQRHLTVGEEWSQDLHSSGR
::.::::::::::::: :. . ::: : :. :::..: : :.::..: : ..:
NP_061 PFNFTWPGTFSLIIEAWHAPG-DDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTL
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE0 TDLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLP
: :.:::: .:...:::..:: .:. :.: :::..: :. : ::: : :: .::::
NP_061 TRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLS
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE0 GCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQD
:: ::.:.:.::.:: :: ::::: :.::: . :: ::::. ::::.:.::::::::.::
NP_061 GCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQD
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE0 LNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLEN
:::::::.::::::::.:.:: ::::.:::::::. ::: ..::: .::.::::: : :.
NP_061 LNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQED
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE0 SYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGG-YSCRCPVGYSGFNCEKKID
.: : ::::.:: :: :...:::.:::::: : . .:. :.:.:: ...: :::::.:
NP_061 GYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVD
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE0 YCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSC
:.:.::.::..:.. : . .:::. ::.: .:. .:.::: .:::.::::.: : . :
NP_061 RCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMC
410 420 430 440 450 460
470 480 490 500 510 520
pF1KE0 TCPPGYTGRNCSA--PVSRCEHAPCHNGATCHE--RGHRYVCECARGYGGPNCQFLLPEL
::: :..:: : . .. : .:: : :::. .::.: :. : :.: . :
NP_061 TCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVG-L
470 480 490 500 510 520
530 540 550 560 570 580
pF1KE0 PPGPAVVDLTEKLEGQGGPFPWVAVCAGVIL-VLMLLLGCAAVVVCVRLRLQKHRPPADP
::. :::::: :: : ::..::: .::.: .:::.. : :
NP_061 PPS----------------FPWVAVSLGVGLAVLLVLLGMVAVAV-RQLRLRR---PDD-
530 540 550 560
590 600 610 620 630 640
pF1KE0 CRGETETMNNLANCQREKDISVSIIGATQIKNTNKKADFHGDHSADK-NGFKARYPAVDY
: :.::::.. :.. ..: :.:.::::.: ... : . :: : : . ..::
NP_061 --GSREAMNNLSDFQKD-----NLIPAAQLKNTNQKKELEVDCGLDKSNCGKQQNHTLDY
570 580 590 600 610
650 660 670 680 690 700
pF1KE0 NLVQDLKGDDTAV-RDAHSKRDTKCQPQGSSGEEKGTPTTLRGGEASERKRPDSGCSTSK
::. : : . :: . : ::. .: :.. : : : .. :: .
NP_061 NLAPGPLGRGTMPGKFPHSDK--------SLGEK--APLRLHS-EKPE-CRISAICSP-R
620 630 640 650 660
710 720
pF1KE0 DTKYQSVYVISEEKDECVIATEV
:. :::: .::::..::::::::
NP_061 DSMYQSVCLISEERNECVIATEV
670 680
>>NP_000205 (OMIM: 118450,187500,601920) protein jagged- (1218 aa)
initn: 2203 init1: 962 opt: 1771 Z-score: 1206.3 bits: 234.5 E(85289): 1.9e-60
Smith-Waterman score: 1784; 41.3% identity (64.8% similar) in 576 aa overlap (2-531:11-576)
10 20 30 40 50
pF1KE0 MGSRCALALAVLSALLCQV-WSSGVFELKLQEFVNKKGLLGNRNCCRGGAG
: .: ::.: :: .: .:: :::.. . : .: : : ::: :::
NP_000 MRSPRTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCC-GGAR
10 20 30 40 50
60 70 80 90 100
pF1KE0 PP---PCA---CRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADSAF
: :. : :.:.::::.::. :. ::..::. :::.: ..:.: . : :
NP_000 NPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGND---
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE0 SNPIRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLH
: : .::.:.:: ...:..:: :: .: : .:. .: . . . .. ...:. .
NP_000 RNRIVLPFSFAWPRSYTLLVEAW--DSSND--TVQPDSIIEKASHSGMINPSRQWQTLKQ
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE0 SSGRTDLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEP
..: . ..:. : .::..::: ::. ::::::: :::..: . :.:.: :: :: :..
NP_000 NTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRA
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE0 ICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLF
:: ::. .:: : ::.:.:. :::: :::.:: .:::.:: :..:::: :. .::: .
NP_000 ICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQL
240 250 260 270 280 290
290 300 310
pF1KE0 CNQDLNYCTHHKPCKNGATCTNTGQGSYTCSC----------------------------
:..::::: :.:: ::.::.::: .: :::
NP_000 CDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCK
300 310 320 330 340 350
320 330 340 350 360
pF1KE0 ----------RPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELS
::.:: :: .::.:.:. :..::.: :: :...:.::: . :: :.:.
NP_000 ETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLD
360 370 380 390 400 410
370 380 390 400 410 420
pF1KE0 AMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDA
: : :: :. :.. ..: : : :. : ::. .:. : .. :.: :.: :: ..
NP_000 ANECEAKPCVNAKSCKNLI-ASYYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNG
420 430 440 450 460 470
430 440 450 460 470 480
pF1KE0 YLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCE
: : : :..: ::. ..:.:::.:: ::: :.. .: :.: :: :..: :. .. ::
NP_000 YRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCE
480 490 500 510 520 530
490 500 510 520 530 540
pF1KE0 HAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPA-VVDLTEKLEGQGGPFPW
::.::: :..:. : :.: . : : ::. : . : :.:
NP_000 PNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEG
540 550 560 570 580 590
550 560 570 580 590 600
pF1KE0 VAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREKDISVS
NP_000 VRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNS
600 610 620 630 640 650
>--
initn: 927 init1: 641 opt: 862 Z-score: 595.4 bits: 121.5 E(85289): 2e-26
Smith-Waterman score: 862; 37.2% identity (62.4% similar) in 298 aa overlap (245-531:578-872)
220 230 240 250 260 270
pF1KE0 GWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPG---CL-HGTCQQ
: :. . : .:: . : :: :..
NP_000 FCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKS
550 560 570 580 590 600
280 290 300 310 320
pF1KE0 P----WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCE
. :.:..:. : .:....: : . .::.::.:: . : .:: : : :. :: ::
NP_000 QSGGKFTCDCNKGFTGTYCHENINDC-ESNPCRNGGTCID-GVNSYKCICSDGWEGAYCE
610 620 630 640 650 660
330 340 350 360 370 380
pF1KE0 LGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPD
.:..:. .::.:::.: :: :.. : : :. :: :. : .. : ::: : : :
NP_000 TNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGD
670 680 690 700 710 720
390 400 410 420 430 440
pF1KE0 GGYSCRCPVGYSGFNCE-KKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVD
. ..: :: :. : .:. . . : .:: ::. :: :... : :. :. : : .:..
NP_000 A-FKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTN
730 740 750 760 770 780
450 460 470 480 490 500
pF1KE0 DCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVC
::. :: :.::: :: : . : : ::..: .: ...:. .:: :::: .. . : :
NP_000 DCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRC
790 800 810 820 830 840
510 520 530 540 550 560
pF1KE0 ECARGYGGPNCQFLL--PELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCA
: :..: .:: . : . : .. :
NP_000 VCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLL
850 860 870 880 890 900
>>NP_660142 (OMIM: 602570) protein jagged-2 isoform b pr (1200 aa)
initn: 1892 init1: 1002 opt: 1756 Z-score: 1196.3 bits: 232.7 E(85289): 6.8e-60
Smith-Waterman score: 1796; 43.9% identity (64.7% similar) in 556 aa overlap (9-542:13-560)
10 20 30 40 50
pF1KE0 MGSRCALALAVLSALLCQVWSS-GVFELKLQEFVNKKGLLGNRNCCRGGAGPP---
: .: :: :. : :::.:. . : .: : . :: : .
NP_660 MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG
10 20 30 40 50 60
60 70 80 90 100
pF1KE0 PCA---CRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGA-DSAFS---
:. : :. :::::.:::.:.: ::.:: ..::::: .:: :: .:.: : : .
NP_660 GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR
70 80 90 100 110 120
110 120 130 140 150
pF1KE0 -----NP--IRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEE
.: . .:: :.:: .:.::.:: :. .: : : :: :.. .. ..
NP_660 AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDND---TTPNEELLIERVSHAGMINPEDR
130 140 150 160 170
160 170 180 190 200 210
pF1KE0 WSQDLHSSGRT-DLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWK
: ..:: ::.. :. . : :::.::. :. :::::.: :::.:: . :.:.: ::
NP_660 W-KSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWM
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE0 GPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQ
: : : .: ::. :: : ::::.: :::::.::::. ::::.::.: .::::::.
NP_660 GKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCE
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE0 EGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPC
.::::.:..::::: :.:: ::.:: :. .: :.: ::.: .:: . : .::
NP_660 TNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPC
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE0 KNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGY
::::: .. ... : :: :. : : :. ::..:: :: : :. :: . : :: .
NP_660 ANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG-FECICPEQW
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE0 SGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGT
: .:. .. : .. :..:. : :: ..: : : ::.::::. . :.:::::: .::
NP_660 VGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGL
420 430 440 450 460 470
460 470 480 490 500 510
pF1KE0 CRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQ
:.: .. : : :: :..: : . :. :: .::.::: :.. : : : .:: ::.
NP_660 CEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCS
480 490 500 510 520 530
520 530 540 550 560 570
pF1KE0 FLLPELP-PGPA--VVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQ
.:. : :: : :.: . : : :
NP_660 --VPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTG
540 550 560 570 580 590
>--
initn: 645 init1: 645 opt: 842 Z-score: 582.0 bits: 119.0 E(85289): 1.1e-25
Smith-Waterman score: 842; 37.4% identity (58.5% similar) in 294 aa overlap (265-549:571-851)
240 250 260 270 280 290
pF1KE0 GFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTC-QQP---WQCNCQEGWGGLFCNQDLN
:: : .:: ..: :. :. : .:.....
NP_660 PGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENID
550 560 570 580 590 600
300 310 320 330 340 350
pF1KE0 YCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSY
: .::.::.:: . .. : : :. : :. . ..: :.::.. : : :: :..
NP_660 DCLG-QPCRNGGTCIDE-VDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDF
610 620 630 640 650
360 370 380 390 400
pF1KE0 SCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCE-KKIDYC
:.: :. :: :. . : : ::: : :: : . : :: :..: .: : . :
NP_660 YCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDT-FRCACPPGWKGSTCAVAKNSSC
660 670 680 690 700 710
410 420 430 440 450 460
pF1KE0 SSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTC
.:: ::. :: : .. : :. :. :: : :..:: :: ::: : :::: : : :
NP_660 LPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCEC
720 730 740 750 760 770
470 480 490 500 510 520
pF1KE0 PPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAV
::..: .: ...:. .:: :::: .. . : : : : .:: :: :
NP_660 APGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ----------EV
780 790 800 810 820
530 540 550 560 570 580
pF1KE0 VDLTEKLEGQGGPFP----WVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRG
. . .. ..: ::: :: :
NP_660 IGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCP
830 840 850 860 870 880
>>NP_002217 (OMIM: 602570) protein jagged-2 isoform a pr (1238 aa)
initn: 1524 init1: 1002 opt: 1706 Z-score: 1162.6 bits: 226.5 E(85289): 5.1e-58
Smith-Waterman score: 1746; 42.8% identity (65.1% similar) in 538 aa overlap (9-527:13-544)
10 20 30 40 50
pF1KE0 MGSRCALALAVLSALLCQVWSS-GVFELKLQEFVNKKGLLGNRNCCRGGAGPP---
: .: :: :. : :::.:. . : .: : . :: : .
NP_002 MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG
10 20 30 40 50 60
60 70 80 90 100
pF1KE0 PCA---CRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGA-DSAFS---
:. : :. :::::.:::.:.: ::.:: ..::::: .:: :: .:.: : : .
NP_002 GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR
70 80 90 100 110 120
110 120 130 140 150
pF1KE0 -----NP--IRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEE
.: . .:: :.:: .:.::.:: :. .: : : :: :.. .. ..
NP_002 AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDND---TTPNEELLIERVSHAGMINPEDR
130 140 150 160 170
160 170 180 190 200 210
pF1KE0 WSQDLHSSGRT-DLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWK
: ..:: ::.. :. . : :::.::. :. :::::.: :::.:: . :.:.: ::
NP_002 W-KSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWM
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE0 GPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQ
: : : .: ::. :: : ::::.: :::::.::::. ::::.::.: .::::::.
NP_002 GKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCE
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE0 EGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPC
.::::.:..::::: :.:: ::.:: :. .: :.: ::.: .:: . : .::
NP_002 TNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPC
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE0 KNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGY
::::: .. ... : :: :. : : :. ::..:: :: : :. :: . : :: .
NP_002 ANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG-FECICPEQW
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE0 SGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGT
: .:. . : ..:: :. .: .: .: : : :..: .: ::.:: . : .:::
NP_002 VGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDC-RGQCQHGGT
420 430 440 450 460 470
460 470 480 490 500 510
pF1KE0 CRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQ
:.: :: ..:.:: :. ::.: ..: .:::.:. :.. . . :.: .:..:: :.
NP_002 CKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE
480 490 500 510 520 530
520 530 540 550 560 570
pF1KE0 FLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHR
. :.:
NP_002 VDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAG
540 550 560 570 580 590
>--
initn: 645 init1: 645 opt: 859 Z-score: 593.3 bits: 121.1 E(85289): 2.6e-26
Smith-Waterman score: 860; 35.7% identity (54.4% similar) in 373 aa overlap (183-549:552-889)
160 170 180 190 200 210
pF1KE0 LTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVC
: :: . .: :: :: .:. : :
NP_002 CHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEG-DYYCACPDD-FGGKNCSVPREP-C
530 540 550 560 570
220 230 240 250 260 270
pF1KE0 NPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRV-GWQGRYCDECIRYPGCLHGTCQQP
:: : : . :: . : :: : : .:: :. :: :.
NP_002 -PG--GA-CR---VIDGCGSDAGP-GMPGTAASGVCGPHGR----CVSQPG---GN----
580 590 600 610
280 290 300 310 320 330
pF1KE0 WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDE
..: :. :. : .:..... : .::.::.:: . .. : : :. : :. . ..
NP_002 FSCICDSGFTGTYCHENIDDCLG-QPCRNGGTCIDE-VDAFRCFCPSGWEGELCDTNPND
620 630 640 650 660 670
340 350 360 370 380 390
pF1KE0 CDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSC
: :.::.. : : :: :.. :.: :. :: :. . : : ::: : :: : . :
NP_002 CLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDT-FRC
680 690 700 710 720 730
400 410 420 430 440 450
pF1KE0 RCPVGYSGFNCE-KKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASS
:: :..: .: : . : .:: ::. :: : .. : :. :. :: : :..::
NP_002 ACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPL
740 750 760 770 780 790
460 470 480 490 500 510
pF1KE0 PCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARG
:: ::: : :::: : : : ::..: .: ...:. .:: :::: .. . : : : :
NP_002 PCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPG
800 810 820 830 840 850
520 530 540 550 560
pF1KE0 YGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFP----WVAVCAGVILVLMLLLGCAAVV
.:: :: :. . .. ..: ::: :: :
NP_002 RAGPRCQ----------EVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWC
860 870 880 890 900
570 580 590 600 610 620
pF1KE0 VCVRLRLQKHRPPADPCRGETETMNNLANCQREKDISVSIIGATQIKNTNKKADFHGDHS
NP_002 GWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHL
910 920 930 940 950 960
>>XP_016883196 (OMIM: 118450,187500,601920) PREDICTED: p (1059 aa)
initn: 2203 init1: 962 opt: 1439 Z-score: 983.8 bits: 193.2 E(85289): 4.6e-48
Smith-Waterman score: 1452; 42.4% identity (65.1% similar) in 413 aa overlap (158-531:7-417)
130 140 150 160 170 180
pF1KE0 HTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEG
.:. ...: . ..:. : .::..::: :
XP_016 MINPSRQWQTLKQNTGVAHFEYQIRVTCDDYYYGFG
10 20 30
190 200 210 220 230 240
pF1KE0 CSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRV
:. ::::::: :::..: . :.:.: :: :: :.. :: ::. .:: : ::.:.:.
XP_016 CNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQY
40 50 60 70 80 90
250 260 270 280 290 300
pF1KE0 GWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNT
:::: :::.:: .:::.:: :..:::: :. .::: .:..::::: :.:: ::.::.::
XP_016 GWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNT
100 110 120 130 140 150
310 320
pF1KE0 GQGSYTCSC--------------------------------------RPGYTGATCELGI
: .: ::: ::.:: :: .:
XP_016 GPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNI
160 170 180 190 200 210
330 340 350 360 370 380
pF1KE0 DECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGY
:.:.:. :..::.: :: :...:.::: . :: :.:.: : :: :. :.. ..:
XP_016 DDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLI-ASY
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE0 SCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCAS
: : :. : ::. .:. : .. :.: :.: :: ..: : : :..: ::. ..:.:::
XP_016 YCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECAS
280 290 300 310 320 330
450 460 470 480 490 500
pF1KE0 SPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECAR
.:: ::: :.. .: :.: :: :..: :. .. :: ::.::: :..:. : :.: .
XP_016 NPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPE
340 350 360 370 380 390
510 520 530 540 550 560
pF1KE0 GYGGPNCQFLLPELPPGPA-VVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVVVC
: : ::. : . : :.:
XP_016 DYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKF
400 410 420 430 440 450
>--
initn: 927 init1: 641 opt: 862 Z-score: 596.0 bits: 121.4 E(85289): 1.8e-26
Smith-Waterman score: 862; 37.2% identity (62.4% similar) in 298 aa overlap (245-531:419-713)
220 230 240 250 260 270
pF1KE0 GWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPG---CL-HGTCQQ
: :. . : .:: . : :: :..
XP_016 FCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKS
390 400 410 420 430 440
280 290 300 310 320
pF1KE0 P----WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCE
. :.:..:. : .:....: : . .::.::.:: . : .:: : : :. :: ::
XP_016 QSGGKFTCDCNKGFTGTYCHENINDC-ESNPCRNGGTCID-GVNSYKCICSDGWEGAYCE
450 460 470 480 490 500
330 340 350 360 370 380
pF1KE0 LGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPD
.:..:. .::.:::.: :: :.. : : :. :: :. : .. : ::: : : :
XP_016 TNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGD
510 520 530 540 550 560
390 400 410 420 430 440
pF1KE0 GGYSCRCPVGYSGFNCE-KKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVD
. ..: :: :. : .:. . . : .:: ::. :: :... : :. :. : : .:..
XP_016 A-FKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTN
570 580 590 600 610 620
450 460 470 480 490 500
pF1KE0 DCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVC
::. :: :.::: :: : . : : ::..: .: ...:. .:: :::: .. . : :
XP_016 DCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRC
630 640 650 660 670 680
510 520 530 540 550 560
pF1KE0 ECARGYGGPNCQFLL--PELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCA
: :..: .:: . : . : .. :
XP_016 VCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLL
690 700 710 720 730 740
>>XP_011517019 (OMIM: 109730,190198,616028) PREDICTED: n (2314 aa)
initn: 1396 init1: 540 opt: 1001 Z-score: 685.9 bits: 139.2 E(85289): 1.8e-31
Smith-Waterman score: 1065; 39.6% identity (61.4% similar) in 376 aa overlap (163-516:485-853)
140 150 160 170 180 190
pF1KE0 DDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSV--
.:.. : .:. .:. :: . : .:..
XP_011 GINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLN-GYKCDCDPGWSGTNCDINN
460 470 480 490 500 510
200 210 220 230 240
pF1KE0 -FCRPRDDAFGHFTCGERGEK---VCNPGWKGPYCTEPI--CLPG-CDEQHGFC--DKPG
:. . : :: . .: :..:: : : : . : .: : : : :
XP_011 NECESNPCVNGG-TCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQ-GTCIDDVAG
520 530 540 550 560 570
250 260 270 280 290
pF1KE0 -ECKCRVGWQGRYCD----ECIRYPGCLHG-TCQQP-----WQCNCQEGWGGLFCNQDLN
.:.: . . : :. : : : .: :.: ..: : :: : :. :.:
XP_011 YKCNCLLPYTGATCEVVLAPCAPSP-CRNGGECRQSEDYESFSCVCPTGWQGQTCEVDIN
580 590 600 610 620 630
300 310 320 330 340 350
pF1KE0 YCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSY
:. .::..::.: :: .:.: : :. ::.: .:: ::.: :.::.::::::: :.
XP_011 ECVL-SPCRHGASCQNT-HGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTA
640 650 660 670 680
360 370 380 390 400 410
pF1KE0 SCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCS
: : ::: : .:: . ::. :: ::. :.: :. :.: ::.:.::..::.. :.
XP_011 FCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDS-YTCTCPAGFSGIHCENNTPDCT
690 700 710 720 730 740
420 430 440 450 460 470
pF1KE0 SSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCP
: : ::. ::: ... : : ::.: .:. .:..: :.:: .::::.:: ... ::::
XP_011 ESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCP
750 760 770 780 790 800
480 490 500 510 520 530
pF1KE0 PGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVV
:::: ::. : :. .::.::. : . .: ::: :. : :
XP_011 QGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQ
810 820 830 840 850 860
540 550 560 570 580 590
pF1KE0 DLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETM
XP_011 GVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYS
870 880 890 900 910 920
>--
initn: 770 init1: 473 opt: 886 Z-score: 608.6 bits: 124.9 E(85289): 3.7e-27
Smith-Waterman score: 1018; 36.4% identity (63.0% similar) in 376 aa overlap (174-527:37-408)
150 160 170 180 190 200
pF1KE0 ISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSV---FCRPRDDAFG
.: : .. :. :. :. .:
XP_011 CFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQ
10 20 30 40 50 60
210 220 230 240 250
pF1KE0 HF-TC-GERG--EKVCNPGWKGPYCTEPI--CLPGCDEQHGFC-DKPGE--CKCRVGWQG
. :: . .: . :: :: : :.: : : . . . : :. . :.: : :
XP_011 NGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTG
70 80 90 100 110 120
260 270 280 290 300
pF1KE0 RYC---DECIRYPGCLHGT-CQ-QPWQ----CNCQEGWGGLFCNQDLNYCT-HHKPCKNG
: : :: : : .:. :. .: . :.: :. : :.::.. :. .::...
XP_011 LLCHLNDACISNP-CNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHA
130 140 150 160 170 180
310 320 330 340 350 360
pF1KE0 ATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGK
. : :: ::. :.: :::: ::. ..:: .::.: ..: : . ..: : ::. :
XP_011 GKCINT-LGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGV
190 200 210 220 230 240
370 380 390 400 410 420
pF1KE0 ICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV
::... ::..::...::: :. . ..:.::.:..: :. .: :.:.::.:::::.
XP_011 HCEVNTDECASSPCLHNGRCLDKINE-FQCECPTGFTGHLCQYDVDECASTPCKNGAKCL
250 260 270 280 290 300
430 440 450 460 470 480
pF1KE0 DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAP
: ..: : : :..: ::. ..:.: .:: . :.:.::: :.: : :::::..: .
XP_011 DGPNTYTCVCTEGYTGTHCEVDIDECDPDPC-HYGSCKDGVATFTCLCRPGYTGHHCETN
310 320 330 340 350 360
490 500 510 520 530 540
pF1KE0 VSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGG
...: ::..:.::..: . :.: : .: ::::.. : . .:
XP_011 INECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYE
370 380 390 400 410 420
550 560 570 580 590 600
pF1KE0 PFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREKD
XP_011 CACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSN
430 440 450 460 470 480
>--
initn: 698 init1: 407 opt: 432 Z-score: 303.5 bits: 68.4 E(85289): 3.6e-10
Smith-Waterman score: 817; 39.0% identity (59.7% similar) in 305 aa overlap (238-525:854-1149)
210 220 230 240 250 260
pF1KE0 GEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHG-
: :. .:.:. : . : : : ::
XP_011 SSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPS-VSCEVAAQRQGVD-VARL--CQHGG
830 840 850 860 870
270 280 290 300 310 320
pF1KE0 TC---QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGA
: . .: :: :. : .:.. .. :. .::.::::::. :.:.:.: :: :.
XP_011 LCVDAGNTHHCRCQAGYTGSYCEDLVDECSP-SPCQNGATCTDY-LGGYSCKCVAGYHGV
880 890 900 910 920 930
330 340 350 360 370
pF1KE0 TCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTC-------ADGP-C
.: :::: ::.:::.: :: :.:.:.:: : : ::... : . .: :
XP_011 NCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKC
940 950 960 970 980 990
380 390 400 410 420 430
pF1KE0 FNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPC-SNGAK-CVDLGDAYLCRCQA
::.: : :. ::::: :: :. : :: .. : :.:: . :.. ::. . . :.:.:
XP_011 FNNGTCVDQV-GGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRA
1000 1010 1020 1030 1040 1050
440 450 460 470 480 490
pF1KE0 GFSGRHCDDNVDDCASSPCANGGTCRDGVND---FSCTCPPGYTGRNCSAPVSRCEHAPC
: .::.:.. .. : ..:: ::::: . : : : :: :. : .: . : :
XP_011 GHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRC
1060 1070 1080 1090 1100 1110
500 510 520 530 540 550
pF1KE0 HNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCA
::.:: . .: : . ::.::: : :
XP_011 LNGGTCISGPRSPTCLCLGPFTGPECQF--PASSPCLGGNPCYNQGTCEPTSESPFYRCL
1120 1130 1140 1150 1160 1170
560 570 580 590 600 610
pF1KE0 GVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREKDISVSIIGAT
XP_011 CPAKFNGLLCHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWD
1180 1190 1200 1210 1220 1230
>--
initn: 301 init1: 301 opt: 326 Z-score: 232.2 bits: 55.2 E(85289): 3.4e-06
Smith-Waterman score: 326; 46.8% identity (74.0% similar) in 77 aa overlap (414-490:409-484)
390 400 410 420 430 440
pF1KE0 SPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDN
:..:. :.: :.: : :. :..: :. :
XP_011 DRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGT-CLDKIDGYECACEPGYTGSMCNIN
380 390 400 410 420 430
450 460 470 480 490 500
pF1KE0 VDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRY
.:.::..:: :::::.::.: :.: :: :: .: . :..:. ::
XP_011 IDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYK
440 450 460 470 480 490
510 520 530 540 550 560
pF1KE0 VCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCA
XP_011 CDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASN
500 510 520 530 540 550
>>NP_060087 (OMIM: 109730,190198,616028) neurogenic locu (2555 aa)
initn: 1396 init1: 540 opt: 1001 Z-score: 685.4 bits: 139.2 E(85289): 1.9e-31
Smith-Waterman score: 1065; 39.6% identity (61.4% similar) in 376 aa overlap (163-516:726-1094)
140 150 160 170 180 190
pF1KE0 DDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSV--
.:.. : .:. .:. :: . : .:..
NP_060 GINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLN-GYKCDCDPGWSGTNCDINN
700 710 720 730 740 750
200 210 220 230 240
pF1KE0 -FCRPRDDAFGHFTCGERGEK---VCNPGWKGPYCTEPI--CLPG-CDEQHGFC--DKPG
:. . : :: . .: :..:: : : : . : .: : : : :
NP_060 NECESNPCVNGG-TCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQ-GTCIDDVAG
760 770 780 790 800 810
250 260 270 280 290
pF1KE0 -ECKCRVGWQGRYCD----ECIRYPGCLHG-TCQQP-----WQCNCQEGWGGLFCNQDLN
.:.: . . : :. : : : .: :.: ..: : :: : :. :.:
NP_060 YKCNCLLPYTGATCEVVLAPCAPSP-CRNGGECRQSEDYESFSCVCPTGWQGQTCEVDIN
820 830 840 850 860 870
300 310 320 330 340 350
pF1KE0 YCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSY
:. .::..::.: :: .:.: : :. ::.: .:: ::.: :.::.::::::: :.
NP_060 ECVL-SPCRHGASCQNT-HGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTA
880 890 900 910 920
360 370 380 390 400 410
pF1KE0 SCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCS
: : ::: : .:: . ::. :: ::. :.: :. :.: ::.:.::..::.. :.
NP_060 FCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDS-YTCTCPAGFSGIHCENNTPDCT
930 940 950 960 970 980
420 430 440 450 460 470
pF1KE0 SSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCP
: : ::. ::: ... : : ::.: .:. .:..: :.:: .::::.:: ... ::::
NP_060 ESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCP
990 1000 1010 1020 1030 1040
480 490 500 510 520 530
pF1KE0 PGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVV
:::: ::. : :. .::.::. : . .: ::: :. : :
NP_060 QGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQ
1050 1060 1070 1080 1090 1100
540 550 560 570 580 590
pF1KE0 DLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETM
NP_060 GVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYS
1110 1120 1130 1140 1150 1160
>--
initn: 1051 init1: 473 opt: 924 Z-score: 633.7 bits: 129.7 E(85289): 1.5e-28
Smith-Waterman score: 1018; 36.4% identity (63.0% similar) in 376 aa overlap (174-527:278-649)
150 160 170 180 190 200
pF1KE0 ISRLATQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSV---FCRPRDDAFG
.: : .. :. :. :. .:
NP_060 GFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQ
250 260 270 280 290 300
210 220 230 240 250
pF1KE0 HF-TC-GERG--EKVCNPGWKGPYCTEPI--CLPGCDEQHGFC-DKPGE--CKCRVGWQG
. :: . .: . :: :: : :.: : : . . . : :. . :.: : :
NP_060 NGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTG
310 320 330 340 350 360
260 270 280 290 300
pF1KE0 RYC---DECIRYPGCLHGT-CQ-QPWQ----CNCQEGWGGLFCNQDLNYCT-HHKPCKNG
: : :: : : .:. :. .: . :.: :. : :.::.. :. .::...
NP_060 LLCHLNDACISNP-CNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHA
370 380 390 400 410 420
310 320 330 340 350 360
pF1KE0 ATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGK
. : :: ::. :.: :::: ::. ..:: .::.: ..: : . ..: : ::. :
NP_060 GKCINT-LGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGV
430 440 450 460 470 480
370 380 390 400 410 420
pF1KE0 ICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCV
::... ::..::...::: :. . ..:.::.:..: :. .: :.:.::.:::::.
NP_060 HCEVNTDECASSPCLHNGRCLDKINE-FQCECPTGFTGHLCQYDVDECASTPCKNGAKCL
490 500 510 520 530 540
430 440 450 460 470 480
pF1KE0 DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAP
: ..: : : :..: ::. ..:.: .:: . :.:.::: :.: : :::::..: .
NP_060 DGPNTYTCVCTEGYTGTHCEVDIDECDPDPC-HYGSCKDGVATFTCLCRPGYTGHHCETN
550 560 570 580 590 600
490 500 510 520 530 540
pF1KE0 VSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGG
...: ::..:.::..: . :.: : .: ::::.. : . .:
NP_060 INECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYE
610 620 630 640 650 660
550 560 570 580 590 600
pF1KE0 PFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREKD
NP_060 CACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSN
670 680 690 700 710 720
>--
initn: 389 init1: 298 opt: 564 Z-score: 391.7 bits: 84.9 E(85289): 4.4e-15
Smith-Waterman score: 716; 37.1% identity (58.0% similar) in 264 aa overlap (217-463:20-277)
190 200 210 220 230 240
pF1KE0 GCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEP--ICLPG--CDEQHGFCDKPGE
.:: :..: :: : :. .:
NP_060 MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANG----TEA
10 20 30 40
250 260 270 280 290
pF1KE0 CKCRVGWQGRYCDE---CIRYPGCLHGTCQ-------QPWQCNCQEGWGGLFCNQDLNYC
: : .. : :.. :. : :::. . :.: :..: .: :.
NP_060 CVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNA
50 60 70 80 90 100
300 310 320 330 340 350
pF1KE0 THHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSC
.::.::.:: : : : ::..: .:. . : : .:: :::.: .: :: :
NP_060 CLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQA-DPCASNPCANGGQCLPFEASYIC
110 120 130 140 150 160
360 370 380 390 400 410
pF1KE0 TCPPGFYGKICELSAMTCADGP--CFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCS
:::.:.: :. .. :.. : : .:: : . :.: : : . ..: :::. ::
NP_060 HCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEV-GSYRCVCRATHTGPNCERPYVPCS
170 180 190 200 210 220
420 430 440 450 460
pF1KE0 SSPCSNGAKCVDLGDA-YLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTC
:::.::. : ::. . : : ::.:..:..:.::: .. : :::.: ::::
NP_060 PSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRC
230 240 250 260 270 280
470 480 490 500 510 520
pF1KE0 PPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAV
NP_060 PPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAA
290 300 310 320 330 340
>--
initn: 698 init1: 407 opt: 432 Z-score: 303.0 bits: 68.5 E(85289): 3.9e-10
Smith-Waterman score: 817; 39.0% identity (59.7% similar) in 305 aa overlap (238-525:1095-1390)
210 220 230 240 250 260
pF1KE0 GEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHG-
: :. .:.:. : . : : : ::
NP_060 SSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPS-VSCEVAAQRQGVD-VARL--CQHGG
1070 1080 1090 1100 1110 1120
270 280 290 300 310 320
pF1KE0 TC---QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGA
: . .: :: :. : .:.. .. :. .::.::::::. :.:.:.: :: :.
NP_060 LCVDAGNTHHCRCQAGYTGSYCEDLVDECSP-SPCQNGATCTDY-LGGYSCKCVAGYHGV
1130 1140 1150 1160 1170
330 340 350 360 370
pF1KE0 TCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTC-------ADGP-C
.: :::: ::.:::.: :: :.:.:.:: : : ::... : . .: :
NP_060 NCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKC
1180 1190 1200 1210 1220 1230
380 390 400 410 420 430
pF1KE0 FNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPC-SNGAK-CVDLGDAYLCRCQA
::.: : :. ::::: :: :. : :: .. : :.:: . :.. ::. . . :.:.:
NP_060 FNNGTCVDQV-GGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRA
1240 1250 1260 1270 1280 1290
440 450 460 470 480 490
pF1KE0 GFSGRHCDDNVDDCASSPCANGGTCRDGVND---FSCTCPPGYTGRNCSAPVSRCEHAPC
: .::.:.. .. : ..:: ::::: . : : : :: :. : .: . : :
NP_060 GHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRC
1300 1310 1320 1330 1340 1350
500 510 520 530 540 550
pF1KE0 HNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCA
::.:: . .: : . ::.::: : :
NP_060 LNGGTCISGPRSPTCLCLGPFTGPECQF--PASSPCLGGNPCYNQGTCEPTSESPFYRCL
1360 1370 1380 1390 1400 1410
560 570 580 590 600 610
pF1KE0 GVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQREKDISVSIIGAT
NP_060 CPAKFNGLLCHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWD
1420 1430 1440 1450 1460 1470
>--
initn: 301 init1: 301 opt: 326 Z-score: 231.8 bits: 55.3 E(85289): 3.6e-06
Smith-Waterman score: 326; 46.8% identity (74.0% similar) in 77 aa overlap (414-490:650-725)
390 400 410 420 430 440
pF1KE0 SPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDN
:..:. :.: :.: : :. :..: :. :
NP_060 DRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGT-CLDKIDGYECACEPGYTGSMCNIN
620 630 640 650 660 670
450 460 470 480 490 500
pF1KE0 VDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRY
.:.::..:: :::::.::.: :.: :: :: .: . :..:. ::
NP_060 IDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYK
680 690 700 710 720 730
510 520 530 540 550 560
pF1KE0 VCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCA
NP_060 CDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASN
740 750 760 770 780 790
>>NP_001186930 (OMIM: 102500,600275,610205) neurogenic l (1235 aa)
initn: 1224 init1: 521 opt: 950 Z-score: 654.5 bits: 132.4 E(85289): 1e-29
Smith-Waterman score: 1021; 32.9% identity (51.3% similar) in 593 aa overlap (16-549:519-1098)
10 20 30 40
pF1KE0 MGSRCALALAVLSALLCQVWSSG-VFELKLQEFVNKKGLLGNRNC
:: .: : .. ... . : : .
NP_001 VHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAK--
490 500 510 520 530 540
50 60 70 80 90 100
pF1KE0 CRGGAGPPPCACRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSL---PDGGGA-
: . : : : : : . . . :: .:. :.::.. : ::
NP_001 CIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQD---GIDSYTCICNPGYMGAI
550 560 570 580 590 600
110 120 130 140
pF1KE0 -----DSAFSNP-------IRFPFGFT---WPGTFSLIIEALHTDSPDDLATENPE-RLI
: .:.: : . :. ::: .. : . :: :. :: . :
NP_001 CSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEI----NFDDCAS-NPCIHGI
610 620 630 640 650
150 160 170 180
pF1KE0 SRLATQRHLTV------GEEWSQDLHS-------SGRTDLK--YSYRFVCDEHYYGEGCS
. .:. : :.. . :. .: : .. ..: .: : . .:
NP_001 CMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCY
660 670 680 690 700 710
190 200 210 220 230 240
pF1KE0 V---FCRPRDDAFGHFTCGERGEK-VCNPGWKGPYCT--EPICLPGCDEQHGFCDK--PG
: :. : : : : .:. :: : : . :: . .. : ::. :
NP_001 SQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNG
720 730 740 750 760 770
250 260 270 280 290
pF1KE0 -ECKCRVGWQGRYC----DECIRYPGCLH-GTCQQP---WQCNCQEGWGGLFCNQDLNYC
.: :. :..: : ::: : ::. ::: . . :.: . : :. : :
NP_001 YRCTCKKGFKGYNCQVNIDECASNP-CLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPC
780 790 800 810 820 830
300 310 320 330 340 350
pF1KE0 THHKPCKNGATCTNTGQ-GSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYS
. . ::.:.:.: .. . :::: : ::. : : . :::: .:: : : : . ..::
NP_001 SPN-PCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYM
840 850 860 870 880 890
360 370 380 390 400 410
pF1KE0 CTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSS
: ::::: : :: . : .:: ::: : :. . .:: : :..: .:. .. : :
NP_001 CECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNT-FSCLCLPGFTGDKCQTDMNECLS
900 910 920 930 940 950
420 430 440 450 460 470
pF1KE0 SPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPP
::.::. : : ..: :.:::::.: ::..:...:. : : ::::: ::.:.::: ::
NP_001 EPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPV
960 970 980 990 1000 1010
480 490 500 510 520 530
pF1KE0 GYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVD
:.:: : ...: :: : .:: . : : : :: : ::: :. .:
NP_001 GFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNK
1020 1030 1040 1050 1060 1070
540 550 560 570 580
pF1KE0 LT---EKLEGQG-GPFPWV-AVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGE
: .: :.: : :. : :
NP_001 GTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYC
1080 1090 1100 1110 1120 1130
>--
initn: 847 init1: 439 opt: 882 Z-score: 608.8 bits: 124.0 E(85289): 3.6e-27
Smith-Waterman score: 889; 35.5% identity (57.4% similar) in 392 aa overlap (179-541:92-477)
150 160 170 180 190 200
pF1KE0 TQRHLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGC----SVFC---RP-RDDAFG
: . :: : : : :: . .
NP_001 CQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTC
70 80 90 100 110 120
210 220 230 240 250
pF1KE0 HFTCGERGEKVCNPGWKGPYCT-EPICLPGCDEQHGFCDKPGE---CKCRVGWQGRYCD-
:. . : .:. :. : : :: . . : .. ::: .:. :. :.
NP_001 HMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCET
130 140 150 160 170 180
260 270 280 290 300
pF1KE0 ---ECIRYPG-CLHG-TCQQ-P--WQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNT
:: :: : :: :: . : .::.: .:. : .:.. :. .:: ::.:: .:
NP_001 DVNEC-DIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAP-SPCVNGGTCRQT
190 200 210 220 230
310 320 330 340 350 360
pF1KE0 GQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSA
:. .. :.: ::. :.::: .::.: :.::: :.: :.:.: ::: . :..: ..
NP_001 GDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDV
240 250 260 270 280 290
370 380 390 400 410 420
pF1KE0 MTCADGP--CFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD
: : : ::: :.. .:::.: : :.:: .: ..:: :. . :. :. :.:
NP_001 DECLLQPNACQNGGTCANR-NGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVA
300 310 320 330 340 350
430 440 450 460 470 480
pF1KE0 AYLCRCQAGFSGRHCDDNVDD-CASSPCANGGTC-RDGVN-DFSCTCPPGYTGRNCSAPV
.. : : : .: : ..:: : :.:: .:. : . .: .. :::: :: : .:. :
NP_001 SFSCMCPEGKAGLLC--HLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDV
360 370 380 390 400 410
490 500 510 520 530
pF1KE0 SRCEHA---PCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPAVVDLTEKLEGQ
..: : ::.... : . . ::: .::.:: :.. . : : : : :.
NP_001 DECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATC-LDKI
420 430 440 450 460 470
540 550 560 570 580 590
pF1KE0 GGPFPWVAVCAGVILVLMLLLGCAAVVVCVRLRLQKHRPPADPCRGETETMNNLANCQRE
::
NP_001 GGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDD
480 490 500 510 520 530
>--
initn: 377 init1: 377 opt: 411 Z-score: 292.2 bits: 65.4 E(85289): 1.5e-09
Smith-Waterman score: 411; 44.4% identity (72.2% similar) in 108 aa overlap (375-482:1120-1226)
350 360 370 380 390 400
pF1KE0 DLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEK
: ..: : .. . : :.::.::.: ::.
NP_001 PSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHY-CQCPLGYTGSYCEE
1090 1100 1110 1120 1130 1140
410 420 430 440 450 460
pF1KE0 KIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVND
..: :.:.::..:: : :. .: :.: :..: .:. .::.: ..:: ::::: : ::
NP_001 QLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNH
1150 1160 1170 1180 1190 1200
470 480 490 500 510 520
pF1KE0 FSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELP
:.:.:::: : . : .
NP_001 FKCSCPPGTRGMKSSLSIFHPGHCLKL
1210 1220 1230
723 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 04:28:34 2016 done: Fri Nov 4 04:28:36 2016
Total Scan time: 10.710 Total Display time: 0.260
Function used was FASTA [36.3.4 Apr, 2011]