Result of FASTA (omim) for
pF1KE0073
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0073, 1320 aa
1>>>pF1KE0073 1320 - 1320 aa - 1320 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 15.5191+/-0.000486; mu= -22.5180+/- 0.030
mean_var=750.1776+/-154.091, 0's: 0 Z-trim(125.3): 192 B-trim: 0 in 0/61
Lambda= 0.046827
statistics sampled from 48510 (48756) to 48510 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.804), E-opt: 0.2 (0.572), width: 16
Scan time: 22.020
The best scores are: opt bits E(85289)
NP_002421 (OMIM: 156100,607174) transcriptional ac (1320) 9395 651.1 1.5e-185
XP_016874318 (OMIM: 108300,120140,132450,150600,15 (1534) 545 53.2 1.6e-05
XP_016855825 (OMIM: 120280,154780,228520,603932,60 (1515) 532 52.4 3e-05
XP_016874320 (OMIM: 108300,120140,132450,150600,15 (1305) 516 51.2 5.6e-05
NP_000081 (OMIM: 120180,130020,130050) collagen al (1466) 517 51.3 5.8e-05
XP_005257115 (OMIM: 114000,120150,130000,130060,16 (1374) 492 49.6 0.00018
XP_011522643 (OMIM: 114000,120150,130000,130060,16 (1398) 491 49.6 0.00019
NP_000079 (OMIM: 114000,120150,130000,130060,16620 (1464) 478 48.7 0.00036
NP_542197 (OMIM: 120280,154780,228520,603932,60484 (1690) 469 48.1 0.00061
XP_016858786 (OMIM: 120131,203780) PREDICTED: coll (1651) 468 48.1 0.00063
NP_001177638 (OMIM: 120280,154780,228520,603932,60 (1767) 469 48.2 0.00063
NP_001845 (OMIM: 120280,154780,228520,603932,60484 (1806) 469 48.2 0.00064
NP_542196 (OMIM: 120280,154780,228520,603932,60484 (1818) 469 48.2 0.00065
XP_016855824 (OMIM: 120280,154780,228520,603932,60 (1855) 469 48.2 0.00066
XP_016855823 (OMIM: 120280,154780,228520,603932,60 (1857) 469 48.2 0.00066
XP_016884752 (OMIM: 301050,303630) PREDICTED: coll (1136) 455 47.0 0.00088
XP_011517444 (OMIM: 608461,615155) PREDICTED: coll (1401) 454 47.1 0.0011
XP_011517446 (OMIM: 608461,615155) PREDICTED: coll (1352) 453 47.0 0.0011
XP_011517445 (OMIM: 608461,615155) PREDICTED: coll (1353) 453 47.0 0.0011
XP_011517442 (OMIM: 608461,615155) PREDICTED: coll (1842) 449 46.8 0.0017
XP_011517440 (OMIM: 608461,615155) PREDICTED: coll (1858) 435 45.9 0.0032
NP_116277 (OMIM: 608461,615155) collagen alpha-1(X (1860) 435 45.9 0.0032
XP_006717371 (OMIM: 608461,615155) PREDICTED: coll (1842) 429 45.5 0.0042
NP_001007027 (OMIM: 125370,607462) atrophin-1 [Hom (1190) 417 44.5 0.0054
NP_001931 (OMIM: 125370,607462) atrophin-1 [Homo s (1190) 417 44.5 0.0054
XP_016855826 (OMIM: 120280,154780,228520,603932,60 (1323) 418 44.6 0.0056
>>NP_002421 (OMIM: 156100,607174) transcriptional activa (1320 aa)
initn: 9395 init1: 9395 opt: 9395 Z-score: 3452.0 bits: 651.1 E(85289): 1.5e-185
Smith-Waterman score: 9395; 100.0% identity (100.0% similar) in 1320 aa overlap (1-1320:1-1320)
10 20 30 40 50 60
pF1KE0 MFGLDQFEPQVNSRNAGQGERNFNETGLSMNTHFKAPAFHTGGPPGPVDPAMSALGEPPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MFGLDQFEPQVNSRNAGQGERNFNETGLSMNTHFKAPAFHTGGPPGPVDPAMSALGEPPI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LGMNMEPYGFHARGHSELHAGGLQAQPVHGFFGGQQPHHGHPGSHHPHQHHPHFGGNFGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LGMNMEPYGFHARGHSELHAGGLQAQPVHGFFGGQQPHHGHPGSHHPHQHHPHFGGNFGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 PDPGASCLHGGRLLGYGGAAGGLGSQPPFAEGYEHMAESQGPESFGPQRPGNLPDFHSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PDPGASCLHGGRLLGYGGAAGGLGSQPPFAEGYEHMAESQGPESFGPQRPGNLPDFHSSG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 ASSHAVPAPCLPLDQSPNRAASFHGLPSSSGSDSHSLEPRRVTNQGAVDSLEYNYPGEAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ASSHAVPAPCLPLDQSPNRAASFHGLPSSSGSDSHSLEPRRVTNQGAVDSLEYNYPGEAP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 SGHFDMFSPSDSEGQLPHYAAGRQVPGGAFPGASAMPRAAGMVGLSKMHAQPPQQQPQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SGHFDMFSPSDSEGQLPHYAAGRQVPGGAFPGASAMPRAAGMVGLSKMHAQPPQQQPQQQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 QQPQQQQQQHGVFFERFSGARKMPVGLEPSVGSRHPLMQPPQQAPPPPQQQPPQQPPQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QQPQQQQQQHGVFFERFSGARKMPVGLEPSVGSRHPLMQPPQQAPPPPQQQPPQQPPQQQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 PPPPPGLLVRQNSCPPALPRPQQGEAGTPSGGLQDGGPMLPSQHAQFEYPIHRLENRSMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PPPPPGLLVRQNSCPPALPRPQQGEAGTPSGGLQDGGPMLPSQHAQFEYPIHRLENRSMH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 PYSEPVFSMQHPPPQQAPNQRLQHFDAPPYMNVAKRPRFDFPGSAGVDRCASWNGSMHNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PYSEPVFSMQHPPPQQAPNQRLQHFDAPPYMNVAKRPRFDFPGSAGVDRCASWNGSMHNG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 ALDNHLSPSAYPGLPGEFTPPVPDSFPSGPPLQHPAPDHQSLQQQQQQQQQQQQQQQQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ALDNHLSPSAYPGLPGEFTPPVPDSFPSGPPLQHPAPDHQSLQQQQQQQQQQQQQQQQQQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 QQQQQQQQQQRQNAALMIKQMASRNQQQRLRQPNLAQLGHPGDVGQGGLVHGGPVGGLAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QQQQQQQQQQRQNAALMIKQMASRNQQQRLRQPNLAQLGHPGDVGQGGLVHGGPVGGLAQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 PNFEREGGSTGAGRLGTFEQQAPHLAQESAWFSGPHPPPGDLLPRRMGGSGLPADCGPHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PNFEREGGSTGAGRLGTFEQQAPHLAQESAWFSGPHPPPGDLLPRRMGGSGLPADCGPHD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 PSLAPPPPPGGSGVLFRGPLQEPMRMPGEGHVPALPSPGLQFGGSLGGLGQLQSPGAGVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PSLAPPPPPGGSGVLFRGPLQEPMRMPGEGHVPALPSPGLQFGGSLGGLGQLQSPGAGVG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 LPSAASERRPPPPDFATSALGGQPGFPFGAAGRQSTPHSGPGVNSPPSAGGGGGSSGGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LPSAASERRPPPPDFATSALGGQPGFPFGAAGRQSTPHSGPGVNSPPSAGGGGGSSGGGG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 GGGAYPPQPDFQPSQRTSASKLGALSLGSFNKPSSKDNLFGQSCLAALSTACQNMIASLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GGGAYPPQPDFQPSQRTSASKLGALSLGSFNKPSSKDNLFGQSCLAALSTACQNMIASLG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE0 APNLNVTFNKKNPPEGKRKLSQNETDGAAVAGNPGSDYFPGGTAPGAPGPGGPSGTSSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 APNLNVTFNKKNPPEGKRKLSQNETDGAAVAGNPGSDYFPGGTAPGAPGPGGPSGTSSSG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE0 SKASGPPNPPAQGDGTSLSPNYTLESTSGNDGKPVSGGGGRGRGRRKRDSGHVSPGTFFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SKASGPPNPPAQGDGTSLSPNYTLESTSGNDGKPVSGGGGRGRGRRKRDSGHVSPGTFFD
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE0 KYSAAPDSGGAPGVSPGQQQASGAAVGGSSAGETRGAPTPHEKALTSPSWGKGAELLLGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KYSAAPDSGGAPGVSPGQQQASGAAVGGSSAGETRGAPTPHEKALTSPSWGKGAELLLGD
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE0 QPDLIGSLDGGAKSDSSSPNVGEFASDEVSTSYANEDEVSSSSDNPQALVKASRSPLVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QPDLIGSLDGGAKSDSSSPNVGEFASDEVSTSYANEDEVSSSSDNPQALVKASRSPLVTG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE0 SPKLPPRGVGAGEHGPKAPPPALGLGIMSNSTSTPDSYGGGGGPGHPGTPGLEQVRTPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SPKLPPRGVGAGEHGPKAPPPALGLGIMSNSTSTPDSYGGGGGPGHPGTPGLEQVRTPTS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE0 SSGAPPPDEIHPLEILQAQIQLQRQQFSISEDQPLGLKGGKKGECAVGASGAQNGDSELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SSGAPPPDEIHPLEILQAQIQLQRQQFSISEDQPLGLKGGKKGECAVGASGAQNGDSELG
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE0 SCCSEAVKSAMSTIDLDSLMAEHSAAWYMPADKALVDSADDDKTLAPWEKAKPQNPNSKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SCCSEAVKSAMSTIDLDSLMAEHSAAWYMPADKALVDSADDDKTLAPWEKAKPQNPNSKE
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE0 AHDLPANKASASQPGSHLQCLSVHCTDDVGDAKARASVPTWRSLHSDISNRFGTFVAALT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AHDLPANKASASQPGSHLQCLSVHCTDDVGDAKARASVPTWRSLHSDISNRFGTFVAALT
1270 1280 1290 1300 1310 1320
>>XP_016874318 (OMIM: 108300,120140,132450,150600,151210 (1534 aa)
initn: 172 init1: 112 opt: 545 Z-score: 220.0 bits: 53.2 E(85289): 1.6e-05
Smith-Waterman score: 684; 26.0% identity (46.5% similar) in 1184 aa overlap (43-1165:209-1298)
20 30 40 50 60 70
pF1KE0 SRNAGQGERNFNETGLSMNTHFKAPAFHTGGPPGPVDPAMSALGEPPILGMNMEPYGFHA
::::: : : :: :: :. :
XP_016 GPRGDRGDKGEKGAPGPRGRDGEPGTPGNPGPPGPPGPP----G-PPGLGGNFAAQ--MA
180 190 200 210 220 230
80 90 100 110 120 130
pF1KE0 RGHSELHAGGLQAQPVHGFFGGQQPHHGHPG-SHHPHQHHPHFGGNFGGP-DPGASCLHG
: .: .::: : ..: .: . :. : :: . : . : :: : : .::.: :
XP_016 GGFDE-KAGGAQLGVMQGPMGPMGPR-GPPGPAGAPGPQ--GFQGNPGEPGEPGVSGPMG
240 250 260 270 280
140 150 160 170 180
pF1KE0 GRLLGYGGAAGGLGSQPPFAEGYEHMAESQGPESFGPQRPGNLPDFHS-SGASSH-AVPA
: : : : :.. : : .:: ::: ..: . :...: . :.
XP_016 PR--GPPGPPGKPGDDG--EAGKPGKAGERGPP--GPQGARGFPGTPGLPGVKGHRGYPG
290 300 310 320 330 340
190 200 210 220 230 240
pF1KE0 PCLPLDQSPNRAASFHGLPSSSGSDSHSLEPRRVTNQGAVDSLEYNYPGEAPSGHFDMFS
:: . ..:.. :. . ::: ... : . .: . :. : ... . .
XP_016 ----LDGAKGEAGA-PGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQ
350 360 370 380 390
250 260 270 280 290 300
pF1KE0 PSDSEGQLPHYAAGRQVPGGAFPGASAMPRAAGMVGL-SKMHAQPPQQQPQQQQQPQQQQ
:. . : :: : .:::: . :: .: . :: :. .: .:
XP_016 PGPAGPPGPVGPAG----GPGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAG
400 410 420 430 440 450
310 320 330 340 350
pF1KE0 QQHGVFFERFSGARK---MPVGLEPSVGSRHPLMQP-PQQAPPP--PQQQPPQQ-----P
. . . . ::. : :. . : : : :: : : :. : .
XP_016 ASGNPGTDGIPGAKGSAGAP-GIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFK
460 470 480 490 500 510
360 370 380 390 400 410
pF1KE0 PQQQPPPPPGLLVRQNSCPPALPRPQQGEAGTPSGGLQDGGPMLPSQHAQFEYPIHRLEN
.: : :: :.. :: . ..: : : ::. :: :.... : :
XP_016 GEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEP-GGVGPIGP--PGERGA---P----GN
520 530 540 550 560
420 430 440 450 460 470
pF1KE0 RSMHPYSEPVFSMQHPPPQQAPNQRLQHFDAPPYMNVAKRPRFDFPGSAGVDRCASWNGS
:.. : .. . . :. ::..: : : . : :: :. . .:
XP_016 RGF-PGQDGLAG-----PKGAPGERGPSGLAGPKGANGDPGR---PGEPGLPGARGLTGR
570 580 590 600 610
480 490 500 510 520 530
pF1KE0 MHNGALDNHLSPSAYPGLPGEFTPPVPDSFPSGPPLQHPAPDHQSLQQQQQQQQQQQQQQ
... .....::. :: :. :: :.. : : : .. . . . ..
XP_016 PGDAGPQGKVGPSGAPGEDGRPGPPGPQG-ARGQPGVMGFPGPKGANGEPGKAGEKGLPG
620 630 640 650 660 670
540 550 560 570 580 590
pF1KE0 QQQQQQQQQQQQQQRQNAALMIKQMASRNQQQRLRQPNLAQL--GHPGDVGQGGLV--HG
. .. . . :.. .: :. : : :: :.:: .:
XP_016 APGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQG
680 690 700 710 720 730
600 610 620 630 640
pF1KE0 --GPVG--GLAQPNFER----EGGSTGA-GRLGTFEQQAPHLAQESAWFSGPHPPPGDLL
: .: ::. : :: : :: :: : : . .. ::: :::
XP_016 VPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQG
740 750 760 770 780 790
650 660 670 680 690 700
pF1KE0 PRRMGGSGLPADCGPHDPSLAPPPPPGGSGVLFRGPLQEPMRMPGEGHVPALPSPGLQFG
: : .:.:.. : ..: : :. : .:: : . :.: . . :: .
XP_016 P--PGLQGMPGERGA--AGIAGPKGDRGD-VGEKGPEGAPGKDGGRGLTGPIGPPG--PA
800 810 820 830 840
710 720 730 740 750
pF1KE0 GSLGGLGQLQSPG----AGV-GLPSAASERRPP-PPDFA-TSALGGQPGFPF--GAAGRQ
:. : :.. :: ::. : :. .: :: : :: . :::: : :: :
XP_016 GANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAG-Q
850 860 870 880 890 900
760 770 780 790 800 810
pF1KE0 STPHSGPGVNSPPSAGGGGGSSGGGGGGGAYPPQ-PDFQPSQRTSASKLGALSLGSFNKP
. ..:: ..: .: : : .: : :: : : . .:...: . .. :
XP_016 KGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGPPGSNGNPGP
910 920 930 940 950 960
820 830 840 850 860
pF1KE0 SSKDNLFGQSCLAALSTACQNMIASLGAPNLNVTFNKKNPPEGKRKLSQNETDGA-----
. . :.. . . . .. . : :.:. . .:: : . ... .::
XP_016 PGPPGPSGKDGPKG-ARGDSGPPGRAGEPGLQ---GPAGPPGEKGEPGDDGPSGAEGPPG
970 980 990 1000 1010
870 880 890 900 910
pF1KE0 --AVAGNPGSDYFPGGTA----PGAPGPGG-PSGTSSSGSKAS-GPPNP--PAQGDGTSL
..::. : .:: . :: :::.: :. .. :.... :::.: : : .
XP_016 PQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPPGLTGPAG
1020 1030 1040 1050 1060 1070
920 930 940 950 960 970
pF1KE0 SPNYTLESTSGNDGKPVSGGGGRGRGRRKRDSGHVSPGTFFDKYSAAPDSGGAPGVSPGQ
:. :.. : :: : :.. .: : ..: :. :: . : :: :::
XP_016 EPGR--EGSPGADGPPGRDGAAGVKGDRG-ETGAVG----------APGAPGPPG-SPGP
1080 1090 1100 1110 1120
980 990 1000 1010 1020 1030
pF1KE0 QQASGAAVGGSSAGETRGAPTPHEKALTSPSWGKGAELLLGDQPDLIGSLDGGAKSDSSS
.: .. ::. :: : .:: ::. . : : : :....
XP_016 AGPTGKQ---GDRGEA-GAQGPM-----GPSGPAGARGIQGPQGPR------GDKGEAGE
1130 1140 1150 1160 1170
1040 1050 1060 1070 1080 1090
pF1KE0 PNVGEFASDEVSTSYANEDEVSSSSDNPQALVKASRSPLVTGSPKLPPRGVGA-------
:. . . . :. . . : . ... .: ..:. :: ::
XP_016 PGERGLKGHRGFTGLQGLPGPPGPSGD-----QGASGPAGPSGPRGPPGPVGPSGKDGAN
1180 1190 1200 1210 1220
1100 1110 1120 1130 1140 1150
pF1KE0 GEHGPKAPPPALGLGIMSNSTSTPDSYGGGGGPGHPGTPGLEQVRTPTSSSGAPPPDEIH
: :: .:: : . .. .. : . : : :: :: ::... . :: ..
XP_016 GIPGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPG-PGIDMSAFAGLGPREKGPDPLQ
1230 1240 1250 1260 1270 1280
1160 1170 1180 1190 1200 1210
pF1KE0 PLEILQAQIQLQRQQFSISEDQPLGLKGGKKGECAVGASGAQNGDSELGSCCSEAVKSAM
.. :: :...
XP_016 YMRADQAAGGLRQHDAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHPEWKSGD
1290 1300 1310 1320 1330 1340
>>XP_016855825 (OMIM: 120280,154780,228520,603932,604841 (1515 aa)
initn: 187 init1: 79 opt: 532 Z-score: 215.3 bits: 52.4 E(85289): 3e-05
Smith-Waterman score: 610; 26.6% identity (45.1% similar) in 1163 aa overlap (44-1152:447-1415)
20 30 40 50 60
pF1KE0 RNAGQGERNFNETGLSMNTHFKAPAFHTGGPP----GPVDPAMSALGEPPILGMNMEPYG
:: :: :: . . : : : . ::
XP_016 DGRDSDLLVDGDLGEYDFYEYKEYEDKPTSPPNEEFGPGVPAETDITETSINGHG--AYG
420 430 440 450 460 470
70 80 90 100 110 120
pF1KE0 FHA-RGHSELHAGGLQAQPVHGFFGGQQPHHGHPGSHHPHQHHPHFGGNFGGPD----PG
.. .:. . :. .. : .: : :: . : : :. : : ::
XP_016 EKGQKGEPAVVEPGMLVEGPPGP-AGPAGIMGPPGLQGP-TGPPGDPGDRGPPGRPGLPG
480 490 500 510 520 530
130 140 150 160
pF1KE0 ASCLHG--GRLLGYGGAAGGLGSQPPFAEGYEHMAES---------QGPESFGPQ----R
:. : : : .: :: ::. : . : .:.. .:: ::. :
XP_016 ADGLPGPPGTMLMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPP--GPMGLTGR
540 550 560 570 580 590
170 180 190 200 210 220
pF1KE0 PGNLPDFHSSGASSHAV-PAPCLPLD----QSPNRAASFHGLPSSSGSDSHSLEPRRVTN
:: . ::::.... :.: : .:. . .: :...:. . :: .
XP_016 PGPVGGPGSSGAKGESGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGD
600 610 620 630 640 650
230 240 250 260 270 280
pF1KE0 QGAVDSLEYNYPGEAPSGHFDMFSPSDSEGQLPHYAAGRQVPGGAFPGASAMPRAAGMVG
.: :.: . ::. .:: .:. : : : . : . : ..: :: :
XP_016 RG-FDGLP-GLPGD--KGHRGERGPQGPPG--PPGDDGMRGEDGEI-GPRGLPGEAGPRG
660 670 680 690 700
290 300 310 320 330 340
pF1KE0 LSKMHAQPPQQQPQQQQQPQQQQQQHGVFFERFSGARKMPVGLEPSVGSRHPLMQPPQQA
: :. : :: . :: .: : : . ..: ::
XP_016 L-----LGPRGTPGAPGQPGMA----GV-----DG----PPGPKGNMG--------PQGE
710 720 730
350 360 370 380 390 400
pF1KE0 PPPPQQQ--P-PQQ-PPQQQPPPPPGLLVRQNSCPPALPRPQQGEAGTPSGGLQDGGPML
: :: :: : :: : : : ::: :. . : :: :.. :: :
XP_016 PGPPGQQGNPGPQGLPGPQGPIGPPG---------EKGPQGKPGLAGLPGA---DGPPGH
740 750 760 770 780
410 420 430 440 450 460
pF1KE0 PSQHAQFEYPIHRLENRSMHPYSEPVFSMQHPPPQQAPNQRLQHFDAPPYMNVAKRPRFD
:....: :. .. : . : . .: :. . . :. .. .:
XP_016 PGKEGQ------SGEKGALGPPG-PQGPIGYPGPRGVKGA-----DGVRGLKGSK-----
790 800 810 820
470 480 490 500 510 520
pF1KE0 FPGSAGVDRCASWNGSMHNGALDNHLSPSAYPGLPGEFTPPVPDSFPSGPPLQHPAPDHQ
: : : ...:.: .: . . . : :: : : . . : :.:. :
XP_016 --GEKGEDGFPGFKGDM---GLKGDRGEVGQIGPRGEDGPEGPKG--RAGPTGDPGPSGQ
830 840 850 860 870 880
530 540 550 560 570 580
pF1KE0 SLQQQQQQQQQQQQQQQQQQQQQQQQQQQQRQNAALMIKQMASRNQQQRLRQPNLAQLGH
. .. . .: . .. . . . : .. : ..: :.
XP_016 AGEKGKLGVPGLPGYPGRQGPK-----------GSTGFPGFPGANGEKGAR--GVA--GK
890 900 910 920
590 600 610 620 630
pF1KE0 PGDVGQGGLVHGGPVG--GLAQPNFER--EGGSTGAGRLGTFEQQAPHLAQESAWFSGPH
:: :: : . :: : : :. . .: : : : : ...:. : . : ::.
XP_016 PGPRGQRGPT--GPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPK
930 940 950 960 970 980
640 650 660 670 680 690
pF1KE0 PPPGDLLPRRMGGSGLPADCGPHD-PSLAPPPPPGGSGVLFRGPLQEPMRMPGEGHVPAL
::: : . : : :.. : . . :: ::: : .:: : . .:: :.
XP_016 GPPGP--PGKDGLPGHPGQRGETGFQGKTGPPGPGGV-VGPQGPTGETGPIGERGH-PGP
990 1000 1010 1020 1030 1040
700 710 720 730 740 750
pF1KE0 PSPGLQFGGSLGGLGQLQSPGAGVGLPSAASERRPPPPDFATSALGGQPGFPFGAAGRQS
:.: :: :::.::. .. : . ....:. : : : :
XP_016 PGP----------------PGEQ-GLPGAAG-KEGAKGDPGPQGISGKDG-PAGLRGF--
1050 1060 1070
760 770 780 790 800 810
pF1KE0 TPHSGPGVNSPPSAGGGGGSSGGGGGGGAYPPQPDFQPSQRTSASKLGALSLGSFNKPSS
:: . :.: :. : .:: : : :: : .:..: ::. : ..: . :..
XP_016 -----PGERGLPGAQGAPGLKGGEGPQG--PPGPVGSPGERGSAGTAGPIGLPGRPGPQG
1080 1090 1100 1110 1120 1130
820 830 840 850 860 870
pF1KE0 KDNLFGQSCLAALSTACQNMIASLGAPNLNVTFNKKNP--PEGKRKLSQNETDGAAVAGN
. :.. :::. .:.: : :. :: : :
XP_016 PPGPAGEK----------------GAPG------EKGPQGPAGR--------DG--VQGP
1140 1150 1160
880 890 900 910 920
pF1KE0 PGSDYFPGGTAP-GAPGPGG-------PSGTSSSGSKA-SGPPNPPAQGDGTSLSPNYTL
: .:: ..: :.:: : :. .:.:.:. .:::.::. .: .:
XP_016 VG---LPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGL-QGPVGAP----
1170 1180 1190 1200 1210
930 940 950 960 970 980
pF1KE0 ESTSGNDGKPVSGGGGRGRGRRKRDSGHVSPGTFFDKYSAAPDSGGAPGVSPGQQQASGA
. .:.::.: . : .: .: : : . : : . : :: ::.. .:
XP_016 -GIAGGDGEP-GPRGQQGMFGQKGDEG--ARG--FPGPPGPIGLQGLPG-PPGEKGENGD
1220 1230 1240 1250 1260
990 1000 1010 1020 1030 1040
pF1KE0 AVGGSSAGETRGAPTPHEKALTSPSWGKGAELLLGDQPDLIGSLDG-GAKSDSS-SPNVG
:: : : : :. .:. .::. : : .::. : : :.. . . : :
XP_016 -VG--PMGPP-GPPGPR-----GPQGPNGADGPQGP-PGSVGSVGGVGEKGEPGEAGNPG
1270 1280 1290 1300 1310
1050 1060 1070 1080 1090 1100
pF1KE0 EFASDEVSTSYANEDEVSSSSDNPQALVKASRSPLVTGSPKLPPRGVG-AGEHGPKAPP-
. :. ... : . .. : ....: .:: : :: :. :: . :
XP_016 PPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPG
1320 1330 1340 1350 1360 1370
1110 1120 1130 1140 1150
pF1KE0 PALGLGIMSNSTSTPDSYGGGGGPGHPGTPGLEQVRTPTSSSGAP-PPDEIHPLEILQAQ
:: :. ... : : ::.:: :: :.. .: : :: . :
XP_016 PAGQDGVGGDK-------GEDGDPGQPGPPG------PSGEAGPPGPPGKRGPPGAAGAE
1380 1390 1400 1410 1420
1160 1170 1180 1190 1200 1210
pF1KE0 IQLQRQQFSISEDQPLGLKGGKKGECAVGASGAQNGDSELGSCCSEAVKSAMSTIDLDSL
XP_016 GRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPP
1430 1440 1450 1460 1470 1480
>>XP_016874320 (OMIM: 108300,120140,132450,150600,151210 (1305 aa)
initn: 223 init1: 112 opt: 516 Z-score: 210.3 bits: 51.2 E(85289): 5.6e-05
Smith-Waterman score: 664; 26.1% identity (44.5% similar) in 1201 aa overlap (9-1165:38-1069)
10 20 30
pF1KE0 MFGLDQFEPQVNSRNAGQGERNFNETGLSMNTHFKAPA
:: . : :. .: :.: ..:
XP_016 KAGGAQLGVMQGPMGPMGPRGPPGPAGAPGPQGFQGNPGEP----GEPGVSGPMGPRGPP
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE0 FHTGGPPG-PVDPAMSALGEPPILGMNMEPYGFHARGHSELHAGGLQAQPVH-GFFG--G
:::: : : . . :.: : : ::: . :: . : :. : :
XP_016 ----GPPGKPGDDGEA--GKPGKAGERGPPGPQGARGFP--GTPGLPGVKGHRGYPGLDG
70 80 90 100 110
100 110 120 130 140 150
pF1KE0 QQPHHGHPGSHHPHQHHPHFGGNFGGPDP-GASCLHGGRLLGYGGAAGGLGSQPPFAEGY
. . : :: . .. : :. :.: : : : : : : : ::. : :.:
XP_016 AKGEAGAPGVKG-ESGSP---GENGSPGPMGPRGLPGER--GRTGPAGAAG-----ARGN
120 130 140 150 160
160 170 180 190 200 210
pF1KE0 EHMAESQGPESFGPQRPGNLPDFHSS-GASSHAVPAPCL-PLDQSPNRAASFHGLPSSSG
. . :: :: :.. : : .. ::...: :. : . :. : :.: :
XP_016 DGQPGPAGPP--GPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEP--GTPGSPG
170 180 190 200 210 220
220 230 240 250 260 270
pF1KE0 SDSHSLEPRRVTNQGAVDSLEYNYPGEAPSGHFDMFSPSDSEGQLPHYAAGRQVPGGAFP
. : .: :: : . :: : . : .: : :. :.: : :
XP_016 PAGASGNPGTDGIPGAKGSA--GAPGIAGAPGFP--GPRGPPG--PQGATG---PLGP-K
230 240 250 260 270
280 290 300 310 320 330
pF1KE0 GASAMPRAAGMVGLSKMHAQPPQQQPQQQQQPQQQQQQHGVFFERFSGARKMPVGLEPSV
: .. : ::. : . ...: :: : .. ..: :: : :. : .
XP_016 GQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRG--------ARGEPGGVGP-I
280 290 300 310 320
340 350 360 370 380 390
pF1KE0 GSRHPLMQPPQQAPPPPQQQPPQQPPQQQPPPPPGLLVRQNSCPPALPRPQQGEAGTPSG
: :: . : .. : : : :: . : .: :. : : :.
XP_016 G-------PPGERGAPGNRGFPGQDGLAGPKGAPG-----ERGPSGLAGPK-GANGDPG-
330 340 350 360
400 410 420 430 440
pF1KE0 GLQDGGPMLPSQHAQFEYPIHRLENRSMHPYSEPVFSMQH-PP-PQQAPNQR-LQHFDAP
. : : ::. .. : . .. : . : . . :: :: : .: .. : .:
XP_016 --RPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGP
370 380 390 400 410 420
450 460 470 480 490 500
pF1KE0 PYMN--VAKRPRFDFPGSAGVDRCASWNGSMHNGALDNHLSPSAYPGLPGEFTPPVPDSF
: .: . .::. :. . .: ..:: .:.. : :: : :..:
XP_016 KGANGEPGKAGEKGLPGAPGLRGLPGKDG--ETGAAGPP-GPAGPAGERGEQGAPGPSGF
430 440 450 460 470 480
510 520 530 540 550 560
pF1KE0 PSGPPLQHPAPDHQSLQQQQQQQQQQQQQQQQQQQQQQQQQQQQRQNAALMIKQMASRNQ
. : :.: .. . .: . . .. .: . .
XP_016 QGLPG--PPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPG-----------
490 500 510 520
570 580 590 600 610 620
pF1KE0 QQRLRQPNLAQLGHPGDVG-QGGLVHGGPVGGLAQPNFEREGGSTGAGRLGTFEQQAPHL
: :. : . : :: : .:. .:: :. . :... : ::. .. .:.
XP_016 AQGLQGPR-GLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIA-----GPKG
530 540 550 560 570 580
630 640 650 660 670
pF1KE0 AQESAWFSGPHPPPGDLLPRRMGGSGLPADCGPHDPSLA--------PPPPPGGSGVLFR
. .. .::. :: . :: :: . :: :. : :: : :..:. :
XP_016 DRGDVGEKGPEGAPG-----KDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGA--R
590 600 610 620 630
680 690 700 710 720 730
pF1KE0 GPLQEPMRM--PGEGHVPALPSPGLQFG--GSLGGLGQLQSPGA-GVGLPSAASERRPPP
: : . :: . . :. : : : : :: . :: : ::.: . :
XP_016 GAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPT
640 650 660 670 680 690
740 750 760 770 780
pF1KE0 ----PDFATSALG--GQPGFPFGAAGRQSTPHSG--PGVNSPPSAGGGGGSSGGGGGGGA
: : .: : : ::: ::::: . : :. :: .::. .: : .:. : .:
XP_016 GVTGPKGARGAQGPPGATGFP-GAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSG-
700 710 720 730 740 750
790 800 810 820 830 840
pF1KE0 YPPQPDFQPSQRTSASKLGALSLGSFNKPSSKDNLFGQSCLAALSTACQNMIASLGAPNL
:: .:. . : . :. : : :.
XP_016 -PPGRAGEPGLQ-----------GPAGPPGEK-----------------------GEPGD
760 770
850 860 870 880 890 900
pF1KE0 NVTFNKKNPPEGKRKLSQNETDGAAVAGNPGSDYFPGGTAP-GAPGPGGPSGTSSSGSKA
. . ..:: : . :. .. ... :. : ::: .: : :: : : .::..
XP_016 DGPSGAEGPP-GPQGLA-GQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPG--ASGDR-
780 790 800 810 820 830
910 920 930 940 950 960
pF1KE0 SGPPNP--PAQGDGTSLSPNYTLESTSGNDGKPVSGGGGRGRGRRKRDSGHVSPGTFFDK
:::.: : : . :. :.. : :: : :.. .: : ..: :.
XP_016 -GPPGPVGPPGLTGPAGEPGR--EGSPGADGPPGRDGAAGVKGDRG-ETGAVG-------
840 850 860 870 880
970 980 990 1000 1010 1020
pF1KE0 YSAAPDSGGAPGVSPGQQQASGAAVGGSSAGETRGAPTPHEKALTSPSWGKGAELLLGDQ
:: . : :: ::: .: .. ::. :: : .:: ::. . : :
XP_016 ---APGAPGPPG-SPGPAGPTGKQ---GDRGEA-GAQGPM-----GPSGPAGARGIQGPQ
890 900 910 920 930
1030 1040 1050 1060 1070 1080
pF1KE0 PDLIGSLDGGAKSDSSSPNVGEFASDEVSTSYANEDEVSSSSDNPQALVKASRSPLVTGS
: :.... :. . . . :. . . : . ... .: ..
XP_016 GP------RGDKGEAGEPGERGLKGHRGFTGLQGLPGPPGPSGD-----QGASGPAGPSG
940 950 960 970
1090 1100 1110 1120 1130
pF1KE0 PKLPPRGVGA-------GEHGPKAPPPALGLGIMSNSTSTPDSYGGGGGPGHPGTPGLEQ
:. :: :: : :: .:: : . .. .. : . : : :: :: ::...
XP_016 PRGPPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPG-PGIDM
980 990 1000 1010 1020 1030
1140 1150 1160 1170 1180 1190
pF1KE0 VRTPTSSSGAPPPDEIHPLEILQAQIQLQRQQFSISEDQPLGLKGGKKGECAVGASGAQN
. :: .. .. :: :...
XP_016 SAFAGLGPREKGPDPLQYMRADQAAGGLRQHDAEVDATLKSLNNQIESIRSPEGSRKNPA
1040 1050 1060 1070 1080 1090
1200 1210 1220 1230 1240 1250
pF1KE0 GDSELGSCCSEAVKSAMSTIDLDSLMAEHSAAWYMPADKALVDSADDDKTLAPWEKAKPQ
XP_016 RTCRDLKLCHPEWKSGDYWIDPNQGCTLDAMKVFCNMETGETCVYPNPANVPKKNWWSSK
1100 1110 1120 1130 1140 1150
>>NP_000081 (OMIM: 120180,130020,130050) collagen alpha- (1466 aa)
initn: 182 init1: 113 opt: 517 Z-score: 210.0 bits: 51.3 E(85289): 5.8e-05
Smith-Waterman score: 695; 27.1% identity (46.2% similar) in 1175 aa overlap (42-1131:127-1194)
20 30 40 50 60 70
pF1KE0 NSRNAGQGERNFNETGLSMNTHFKAPAFHTGGPPGPVDPAMSALGEP-PILGMNMEPYGF
: : .: .:. .. : : .:. :
NP_000 RPPNGQGPQGPKGDPGPPGIPGRNGDPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYD
100 110 120 130 140 150
80 90 100 110 120
pF1KE0 HARGHSELHAGGLQAQPVHGFFGGQQPHHGHPG-SHHPHQHHPHFGGNFGGPDPGASCLH
.: . .::: . : : : : : :: : :: . : : . :: ::
NP_000 SYDVKSGVAVGGLAGYP--GPAGPPGPP-GPPGTSGHPGS--PGSPG-YQGP-PGEP---
160 170 180 190 200
130 140 150 160 170 180
pF1KE0 GGRLLGYGGAAGGLGSQPPFAEGYEHMAESQGPESFGPQRPGNLPDFHSSGASSHAVPAP
: .: .: : :: : : : ..: :: : :::. ...:.:
NP_000 -----GQAGPSGPPG--PPGAIGPSGPAGKDG-ESGRPGRPGE-----------RGLPGP
210 220 230 240
190 200 210 220 230 240
pF1KE0 CLPLDQSPNRAASFHGLPSSSGSDSHSLEPRRVTNQGAVDSLEYNYPGE--APSGHFDMF
: ..: .: :. . : :... : .. : : . ::: ::.
NP_000 --PGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKG--ENGLPGENGAPGPMGPRG
250 260 270 280 290 300
250 260 270 280 290 300
pF1KE0 SPSD-SEGQLPHYAAGRQVPGG----AFPGASAMPRAAGMVGLSKMHAQ-PPQQQPQQQQ
.:.. .. :: :..: :. . :: . : .::. : ... : .: ..
NP_000 APGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNG
310 320 330 340 350 360
310 320 330 340 350
pF1KE0 QPQQQQQQHGVFFERFSGAR--KMPVGLEPSVGSRHPLMQPPQQAPPPPQQQPPQQPPQQ
: :. . . .::. : :.. : :.. . : : : . . ::
NP_000 APGQRGEPGP---QGHAGAQGPPGPPGINGSPGGKGEM--GPAGIPGAPGLMGARGPPGP
370 380 390 400 410
360 370 380 390 400
pF1KE0 QPPP-PPGLLVRQNSCPPAL--------PRPQQGEAGTPS--GGL-QDGGPMLPSQHAQF
::: : .. :. :: ..:::: :. :. .:: :.. .
NP_000 AGANGAPGL--RGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEPGAN
420 430 440 450 460 470
410 420 430 440 450 460
pF1KE0 EYPIHRLENRSMHPYSEPVFSMQHPPPQQAPNQRLQHFDAPPYMNVAKRPRFDFPGSAGV
: : :. . :. : . ..: : : ... : ::. :.
NP_000 GLPGAAGE-RGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPGGPGM
480 490 500 510 520 530
470 480 490 500 510 520
pF1KE0 DRCASWNGSMHNGALDNHLSPSAYPGLPGEFTPPVPDSFPSGPP--LQHPAPDHQSLQQQ
. :: . . :.. .: . : :. :: : : : : : . :.: ..
NP_000 R---GMPGSPGGPGSDGKPGPPGSQGESGRPGPPGP-SGPRGQPGVMGFPGPKGNDGAPG
540 550 560 570 580 590
530 540 550 560 570 580
pF1KE0 QQQQQQQQ----QQQQQQQQQQQQQQQQQRQNAALMIKQMASRNQQQRLRQ-PNLAQLGH
.. .. : .. . : .. : .. : :. :. . :
NP_000 KNGERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGLQGLPGTG--GP
600 610 620 630 640
590 600 610 620 630 640
pF1KE0 PGDVGQGGLVHGGPVGGLAQPNFEREGGSTGAGRLGTFEQQAPHLAQESAWFSGPHPPPG
::. :. : . :: : . :. ::. :: : :. : :: . . : :::
NP_000 PGENGKPG--EPGPKGDAGAPG--APGGKGDAGAPG--ERGPPGLAGAPG-LRGGAGPPG
650 660 670 680 690 700
650 660 670 680 690
pF1KE0 DLLPRRMGGSGLPADCGPHDPSLAPPPP----PGGSGVLF----RGPLQEPMRMPGEGHV
:. ::.: . :: :. : : :: : : .: :: :: :
NP_000 ---PE--GGKGAAGPPGP--PGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGG-PGADGV
710 720 730 740 750
700 710 720 730 740
pF1KE0 PALPSPGLQFG--GSLGGLGQLQSPGAG--VGLPSAASERRPPPPDFATSALGGQPGFPF
:. .: : : : :: . : : :::. :. : : . . .. : :::
NP_000 PGKDGPRGPTGPIGPPGPAGQPGDKGEGGAPGLPGIAGPR-GSPGERGETGPPGPAGFP-
760 770 780 790 800 810
750 760 770 780 790 800
pF1KE0 GAAGRQSTPHSGPGVNSPPSAGGGGGSSG--G--GGGGGAYPPQPDFQPSQRTSASKLGA
:: :... : .: : . :. : :: : : ::.: : :: :. ..: : . ::
NP_000 GAPGQNGEP-GGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPGGPGA
820 830 840 850 860 870
810 820 830 840
pF1KE0 LSL----------GSFNKPS--------SKDNLFGQS--CLAALSTACQNMIASLGAPNL
.. :: ..:. .::. : . : : . .. .. : :.
NP_000 AGFPGARGLPGPPGSNGNPGPPGPSGSPGKDGPPGPAGNTGAPGSPGVSGPKGDAGQPGE
880 890 900 910 920 930
850 860 870 880 890
pF1KE0 NVTFNKKNPPEGKRKLSQNETDGA-AVAGNPGSDYFPGGTAPGAPGPGGPSGTS----SS
. . . ..:: . :. :: ..:: :: .:: :.::: : .: : ..
NP_000 KGSPGAQGPPGAPGPLGIAGITGARGLAGPPG---MPGPR--GSPGPQGVKGESGKPGAN
940 950 960 970 980
900 910 920 930 940 950
pF1KE0 G-SKASGPPNPPAQG----DGTSLSPNYTLESTSGNDGKPVSGGGGRGRGRRKRDSGHVS
: : :::.: :: ::. :. ... :.:: : :. :.: : .... .
NP_000 GLSGERGPPGP--QGLPGLAGTAGEPGR--DGNPGSDGLPGRDGSPGGKGDRGENGSPGA
990 1000 1010 1020 1030 1040
960 970 980 990 1000
pF1KE0 PGTFFDKYSAAPDSGGAPG-VSP----GQQQASGAA--VGGSSAGETRGAPTPHEKALTS
:: :: : :: :.: :.. :: : .:. . . .:::: :. .
NP_000 PG--------APGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPGPQ-----G
1050 1060 1070 1080
1010 1020 1030 1040 1050 1060
pF1KE0 PSWGKGAELLLGDQPDLIGSLDGGAKSDSSSPNVGEFASDEVSTSYANEDEVSSSSDNPQ
: :: :.. :. .: :. . : :. .. ... ..: .:
NP_000 PRGDKGET---GER----GA--AGIKGHRGFP--GNPGAPGSPGPAGQQGAIGSP--GP-
1090 1100 1110 1120 1130
1070 1080 1090 1100 1110 1120
pF1KE0 ALVKASRSPLVTGSPKLPPRGVGAGEH-GPKAPPPALGLGIMSNSTSTPDSYGGGGGPGH
. :.:. .:. :: :.. : :: .:: : .: ..: : : ::
NP_000 ---AGPRGPV---GPSGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGP
1140 1150 1160 1170 1180
1130 1140 1150 1160 1170 1180
pF1KE0 PGTPGLEQVRTPTSSSGAPPPDEIHPLEILQAQIQLQRQQFSISEDQPLGLKGGKKGECA
::.::
NP_000 PGAPGPCCGGVGAAAIAGIGGEKAGGFAPYYGDEPMDFKINTDEIMTSLKSVNGQIESLI
1190 1200 1210 1220 1230 1240
>>XP_005257115 (OMIM: 114000,120150,130000,130060,166200 (1374 aa)
initn: 272 init1: 105 opt: 492 Z-score: 201.3 bits: 49.6 E(85289): 0.00018
Smith-Waterman score: 642; 26.6% identity (45.8% similar) in 1151 aa overlap (43-1151:142-1120)
20 30 40 50 60 70
pF1KE0 SRNAGQGERNFNETGLSMNTHFKAPAFHTGGPPGPVDPAMSALGEPPILGMNMEPYGFHA
::::: : : :: :: :. : .
XP_005 GPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPP----G-PPGLGGNFAPQ--LS
120 130 140 150 160
80 90 100 110 120 130
pF1KE0 RGHSELHAGGLQAQPVHGFFGGQQPHHGHPGSHHPHQHHPHFGGNFGGPDPGASCLHGGR
:..: .::.. : : .: . :. : :: : :. .: :: ::
XP_005 YGYDEKSTGGIS---VPGPMGPSGPR-GLPGP--PGAPGPQ---GFQGP-PGEP------
170 180 190 200
140 150 160 170 180 190
pF1KE0 LLGYGGAAGGLGSQ-PPFAEGYEHMAESQGPESFGPQRPGNLPDFHSSGASSHAVPAPC-
: ::.: .: . :: : ... :. : :::. .:: ...:.
XP_005 --GEPGASGPMGPRGPPGPPG----KNGDDGEAGKPGRPGERGPPGPQGA--RGLPGTAG
210 220 230 240 250 260
200 210 220 230 240
pF1KE0 LPLDQSPNRAASFHGLPSSSGSDSHSLEPRRVTNQGAVDSL-EYNYPGEAPSGHFDMFSP
:: .. ... : ...: . . :: ..:: .. . ::: :. .:
XP_005 LPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGE--RGRPGAPGP
270 280 290 300 310
250 260 270 280 290 300
pF1KE0 SDSEGQLPHYAAGRQVPGGAFPGASAMPRAAGMVGLSKMHAQPPQQQPQQQQQPQQQQQQ
. ..:. :.: : : : .. : : :: .: .: : : :. .. :: . .
XP_005 AGARGN--DGATGAAGPPGP-TGPAGPPGFPGAVG-AKGEAGP--QGPRGSEGPQGVRGE
320 330 340 350 360 370
310 320 330 340 350 360
pF1KE0 HGVFFERFSGARKMPVGLEPSVGSRHPLMQPP-QQAPPPPQQQPPQQPPQQQPPPPPGLL
: ... : . . :.. : :: : . :. : : : :::
XP_005 PGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGP--QGPGGPPG--
380 390 400 410 420
370 380 390 400 410 420
pF1KE0 VRQNSCPPALP--RPQQGEAGTPSG-GLQDGGPMLPSQHAQFEYPIHRLENRSMHPYSEP
. :: :. : . . : : :. :.: :: :. : . .:. . :
XP_005 PKGNSGEPGAPGSKGDTGAKGEPGPVGVQ--GP--PG-------PAGEEGKRGARGEPGP
430 440 450 460 470
430 440 450 460 470 480
pF1KE0 VFSMQHPPPQQA-PNQRLQHFDAPPYMNVAKRPRFDF--PGSAGVDRCASWNGSMHNGAL
. .. :: ... :..: : . . : : . :: :: . : ...:
XP_005 T-GLPGPPGERGGPGSR--GFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGL
480 490 500 510 520 530
490 500 510 520 530 540
pF1KE0 DNHLSPSAYPGLPGEFTPPVPDSFPSGPPLQHPAPDHQSLQQQQQQQQQQQQQQQQQQQQ
. . .. :: :: ::. .::: :: :. .
XP_005 PGAKGLTGSPGSPG------PDG-KTGPP--GPAG--------------------QDGRP
540 550 560
550 560 570 580 590 600
pF1KE0 QQQQQQQQRQNAALMIKQMASRNQQQRLRQPNLAQLGHPGDVGQGGLVHGGPVGGLAQPN
: .:..: . :. : :.:: .:. :. :: :... .
XP_005 GPPGPPGARGQAGVM-----------GFPGPKGAA-GEPGKAGERGV--PGPPGAVGPAG
570 580 590 600 610
610 620 630 640 650
pF1KE0 FEREGGSTG----AGRLGTFEQQAPHLAQESAWFSGPHPPPGDLLPRRMGGSGLPADCGP
. :.:. : :: : .:.: . . :: :::. . : .:.:.: :
XP_005 KDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGE--AGKPGEQGVPGDLGA
620 630 640 650 660
660 670 680 690 700
pF1KE0 HDPSLA------PPP-----PPGGSGVLFRGPLQEPMRMPGEGHVPALPSPGLQFGGSLG
:: : : ::: .: :: : ..: . : .:: : . .:
XP_005 PGPSGARGERGFPGERGVQGPPGPAGP--RGANGAPGNDGAKGDAGAPGAPGSQGAPGLQ
670 680 690 700 710 720
710 720 730 740 750
pF1KE0 GLGQLQSPG--AGVGLPSAASERRPPPPDFATSALG--GQPGF--PFGAAGRQSTP----
:. :: ...:::. ..: : : .. : : :. :.: : ..:
XP_005 GM-----PGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKG
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE0 HSGP-GVNSPPSAGGGGGSSG--G--GGGGGAYPPQPDFQPSQRTSASKLGALSLGSFNK
.::: : .: .: :. :. : : : .: : :: : ::. . . :: . ..
XP_005 ESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPG
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE0 PSSKDNLFGQSCLAALSTACQNMIASLGAPNLNVTFNKKNPPEGKRKLSQNETDGAAVAG
:.. . : :...:::. . . .. .:: ::. :
XP_005 PAGPAGPPGP-------------IGNVGAPGAKGARGSAGPP------------GAT--G
850 860 870
880 890 900 910 920 930
pF1KE0 NPGSDYFPGGTAP-GAPGPGGPSGTSSSGSKASGPPNPPAQGDGTSLSPNYTLESTSGND
::. : .: : :: :::: .:: . :::.: . : . :. :: .
XP_005 FPGAAGRVGPPGPSGEPGKQGPSG--ASGER--GPPGPMGP-PGLAGPPG-----ESGRE
880 890 900 910 920
940 950 960 970 980 990
pF1KE0 GKPVSGGGGRGRGRRKRDSGHVSPGTFFDKYSAAPDSGGAPGVSPGQQQASGAAVGGSSA
: : :..: ::. :::. :. ..: .: :: .:: : : :: ..
XP_005 GAP----GAEGSP--GRDG---SPGAKGDRGETGP--AGPPG-APGAPGAPGP-VGPAGK
930 940 950 960 970
1000 1010 1020 1030 1040 1050
pF1KE0 GETRGAPTPHEKALTSPSWGKGAELLLGDQPDLIGSLDGGAKSDSSSPNVGEFASDEVST
. :: : : .: ::. : : . . : ..: . . :.. .
XP_005 SGDRGETGPAGPA--GPVGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPP
980 990 1000 1010 1020 1030
1060 1070 1080 1090 1100 1110
pF1KE0 SYANEDEVSSSSDNPQALVKASRSPLVTGSPKLPPRGVGA-GEHGPKAPPPALGLGIMSN
. .: . :. :: .: ..:. :: ..:: :. : .. : .: .
XP_005 G-------PPGSPGEQGPSGAS-GP---AGPRGPPGSAGAPGKDGLNGLPGPIGPPGPRG
1040 1050 1060 1070
1120 1130 1140 1150 1160 1170
pF1KE0 STSTPDSYGGGGGPGHPGTPGLEQVRTPTSSSGAPPPDEIHPLEILQAQIQLQRQQFSIS
:. : : :: :: :: .. : :: .. :
XP_005 RTGDAGPVGPPGPPGPPGPPGPPSAGFDFSFLPQPPQEKAHDGGRYYRADDANVVRDRDL
1080 1090 1100 1110 1120 1130
1180 1190 1200 1210 1220 1230
pF1KE0 EDQPLGLKGGKKGECAVGASGAQNGDSELGSCCSEAVKSAMSTIDLDSLMAEHSAAWYMP
XP_005 EVDTTLKSLSQQIENIRSPEGSRKNPARTCRDLKMCHSDWKSGEYWIDPNQGCNLDAIKV
1140 1150 1160 1170 1180 1190
>>XP_011522643 (OMIM: 114000,120150,130000,130060,166200 (1398 aa)
initn: 378 init1: 105 opt: 491 Z-score: 200.8 bits: 49.6 E(85289): 0.00019
Smith-Waterman score: 628; 26.9% identity (45.9% similar) in 1132 aa overlap (43-1131:142-1124)
20 30 40 50 60 70
pF1KE0 SRNAGQGERNFNETGLSMNTHFKAPAFHTGGPPGPVDPAMSALGEPPILGMNMEPYGFHA
::::: : : :: :: :. : .
XP_011 GPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPP----G-PPGLGGNFAPQ--LS
120 130 140 150 160
80 90 100 110 120 130
pF1KE0 RGHSELHAGGLQAQPVHGFFGGQQPHHGHPGSHHPHQHHPHFGGNFGGPDPGASCLHGGR
:..: .::.. : : .: . :. : :: : :. .: :: ::
XP_011 YGYDEKSTGGIS---VPGPMGPSGPR-GLPGP--PGAPGPQ---GFQGP-PGEP------
170 180 190 200
140 150 160 170 180 190
pF1KE0 LLGYGGAAGGLGSQ-PPFAEGYEHMAESQGPESFGPQRPGNLPDFHSSGASSHAVPAPC-
: ::.: .: . :: : ... :. : :::. .:: ...:.
XP_011 --GEPGASGPMGPRGPPGPPG----KNGDDGEAGKPGRPGERGPPGPQGA--RGLPGTAG
210 220 230 240 250 260
200 210 220 230 240
pF1KE0 LPLDQSPNRAASFHGLPSSSGSDSHSLEPRRVTNQGAVDSL-EYNYPGEAPSGHFDMFSP
:: .. ... : ...: . . :: ..:: .. . ::: :. .:
XP_011 LPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGE--RGRPGAPGP
270 280 290 300 310
250 260 270 280 290 300
pF1KE0 SDSEGQLPHYAAGRQVPGGAFPGASAMPRAAGMVGLSKMHAQPPQQQPQQQQQPQQQQQQ
. . : : :. ::. ::.. : :: :. .. : : :. .. .
XP_011 AGNPG-----ADGQ--PGAK--GANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGE
320 330 340 350 360
310 320 330 340 350
pF1KE0 HGVFFERF-SGARKMP--VGLE----PS--VGSRHPLMQP-PQQAPPPPQQQ--PPQQ--
:. . .::. : ::.. :. :.: .: : : :: .. : ..
XP_011 PGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGF
370 380 390 400 410 420
360 370 380 390 400 410
pF1KE0 PPQQQPPPPPGLLVRQNSCPPALPRPQQGEAGTPSGGLQDGGPMLPSQHAQFEYPIHRLE
: . : : ...: :: :. . :::: : : ::. .. :
XP_011 PGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRP------GEAGLPGAKGLTGSPGSPGP
430 440 450 460 470 480
420 430 440 450 460 470
pF1KE0 NRSMHPYSEPVFSMQHPPPQQAPNQRLQHFDAPPYMNVAKRPRFDFPGSAGVDRCASWNG
. . : . :. . .: : :. : : .: . ::: :. . :
XP_011 DGKTGPPG-PAGQDGRPGPPGPPGARGQ-------AGV-----MGFPGPKGAAGEPGKAG
490 500 510 520 530
480 490 500 510 520 530
pF1KE0 SMHNGALDNHLSPSAYPGLPGEFTPPVPDSFPSGP-PLQHPA--PDHQSLQQQQQQQQQQ
. . ..:.. : : :: : . :.: : :: : :.: .
XP_011 ERGVPGPPGAVGPAGKDGEAGAQGPPGPAG-PAGERGEQGPAGSPGFQGLPGPAGPPGEA
540 550 560 570 580
540 550 560 570 580 590
pF1KE0 QQQQQQQQQQQQQQQQQQRQNAALMIKQMASRNQQQRLRQPNLAQLGHPGDVG-QGGLVH
. .: . . ..:... : ::. : ::
XP_011 GKPGEQGVPGDLGAPGPS-----------GARGER-----------GFPGERGVQGPPGP
590 600 610 620
600 610 620 630 640
pF1KE0 GGPVGGLAQPNFEREGGSTGA-GRLGTFEQQAPHLA-----QESAWFSGPHPPPGDLLPR
.:: :. . :. . :..:: : :. : :: : . .: . ::. :: :.
XP_011 AGPRGANGAPGNDGAKGDAGAPGAPGS--QGAPGLQGMPGERGAAGLPGPKGDRGDAGPK
630 640 650 660 670 680
650 660 670 680 690
pF1KE0 RMGGS-------GLPADCGPHDPSLAPPPPPGGSGVLFRGPLQEP-MR-MPGEGHVPALP
:: :: . :: :. :: : :: :: : ::. :. :
XP_011 GADGSPGKDGVRGLTGPIGPPGPAGAPGDK-GESGP--SGPAGPTGARGAPGDRGEPGPP
690 700 710 720 730 740
700 710 720 730 740 750
pF1KE0 SPGLQFGGSLGGLGQLQSPGAGVGLPSAASERRPP-PPDFATSALGGQPGFPFGAAGRQS
.:. :.: :. :: ::: : :. :. . :: : : : :: :.: .: .
XP_011 GPA-GFAGPPGADGQ---PGAK-GEPGDAGAKGDAGPPGPAGPA--GPPG-PIGNVGAPG
750 760 770 780 790
760 770 780 790 800 810
pF1KE0 TPHSGPGVNSPPSAGGGGGSSG--G--GGGGGAYPPQPDFQPSQRTSASKLGALSLGSFN
. ... : .::.: : :..: : : .:.: :: : :. :.: :. . . .
XP_011 A-KGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGP---PGP---AGKEGGKGPRGET
800 810 820 830 840
820 830 840 850 860 870
pF1KE0 KPSSKDNLFGQSCLAALSTACQNMIASLGAPNLNVTFNKKNPPEGKRKLSQNETDGAAVA
:... . : . . : .. :.:. . . . : . .: . : .
XP_011 GPAGRPGEVGPP--GPPGPAGEK-----GSPGADGPAGAPGTPGPQGIAGQRGVVG--LP
850 860 870 880 890
880 890 900 910 920 930
pF1KE0 GNPGSDYFPGGTAP-GAPGPGGPSGTSSSGSKASGPPNPPAQGDGTSLSPNYTLESTSGN
:. : ::: .: : :: :::: .:: . :::.: . : . :. ::
XP_011 GQRGERGFPGLPGPSGEPGKQGPSG--ASGER--GPPGPMGP-PGLAGPPG-----ESGR
900 910 920 930 940
940 950 960 970 980 990
pF1KE0 DGKPVSGGGGRGRGRRKRDSGHVSPGTFFDKYSAAPDSGGAPGVSPGQQQASGAAVGGSS
.: : :..: ::. :::. :. ..: .: :: .:: : : :: ..
XP_011 EGAP----GAEGSP--GRDG---SPGAKGDRGETGP--AGPPG-APGAPGAPGP-VGPAG
950 960 970 980 990
1000 1010 1020 1030 1040 1050
pF1KE0 AGETRGAPTPHEKALTSPSWGKGAELLLGDQPDLIGSLDGGAKSDSSSPNVGEFASDEVS
. :: : : .: ::. : : . . : ..: . . :.. .
XP_011 KSGDRGETGPAGPA--GPVGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGP
1000 1010 1020 1030 1040 1050
1060 1070 1080 1090 1100
pF1KE0 TSYANEDEVSSSSDNPQALVKASRSPLVTGSPKLPPRGVGA-GEHGPKAPPPALGLGIMS
. .: . :. :: .: ..:. :: ..:: :. : .. : .:
XP_011 PG-------PPGSPGEQGPSGAS-GP---AGPRGPPGSAGAPGKDGLNGLPGPIGPPGPR
1060 1070 1080 1090 1100
1110 1120 1130 1140 1150 1160
pF1KE0 NSTSTPDSYGGGGGPGHPGTPGLEQVRTPTSSSGAPPPDEIHPLEILQAQIQLQRQQFSI
. :. : : :: :: ::
XP_011 GRTGDAGPVGPPGPPGPPGPPGPPSAGFDFSFLPQPPQEKAHDGGRYYRADDANVVRDRD
1110 1120 1130 1140 1150 1160
>>NP_000079 (OMIM: 114000,120150,130000,130060,166200,16 (1464 aa)
initn: 291 init1: 105 opt: 478 Z-score: 195.8 bits: 48.7 E(85289): 0.00036
Smith-Waterman score: 636; 27.7% identity (46.2% similar) in 1155 aa overlap (43-1134:142-1129)
20 30 40 50 60 70
pF1KE0 SRNAGQGERNFNETGLSMNTHFKAPAFHTGGPPGPVDPAMSALGEPPILGMNMEPYGFHA
::::: : : :: :: :. : .
NP_000 GPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPP----G-PPGLGGNFAPQ--LS
120 130 140 150 160
80 90 100 110 120 130
pF1KE0 RGHSELHAGGLQAQPVHGFFGGQQPHHGHPGSHHPHQHHPHFGGNFGGPDPGASCLHGGR
:..: .::.. : : .: . :. : :: : :. .: :: ::
NP_000 YGYDEKSTGGIS---VPGPMGPSGPR-GLPGP--PGAPGPQ---GFQGP-PGEP------
170 180 190 200
140 150 160 170 180 190
pF1KE0 LLGYGGAAGGLGSQ-PPFAEGYEHMAESQGPESFGPQRPGNLPDFHSSGASSHAVPAPC-
: ::.: .: . :: : ... :. : :::. .:: ...:.
NP_000 --GEPGASGPMGPRGPPGPPG----KNGDDGEAGKPGRPGERGPPGPQGA--RGLPGTAG
210 220 230 240 250 260
200 210 220 230 240
pF1KE0 LPLDQSPNRAASFHGLPSSSGSDSHSLEPRRVTNQGAVDSL-EYNYPGEAPSGHFDMFSP
:: .. ... : ...: . . :: ..:: .. . ::: :. .:
NP_000 LPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGE--RGRPGAPGP
270 280 290 300 310
250 260 270 280 290 300
pF1KE0 SDSEGQLPHYAAGRQVPGGAFPGASAMPRAAGMVGLSKMHAQPPQQQPQQQQQPQQQQQQ
. ..:. :.: : : : .. : : :: .: .: : : :. .. :: . .
NP_000 AGARGN--DGATGAAGPPGP-TGPAGPPGFPGAVG-AKGEAGP--QGPRGSEGPQGVRGE
320 330 340 350 360 370
310 320 330 340 350 360
pF1KE0 HGVFFERFSGARKMPVGLEPSVGSRHPLMQPP-QQAPPPPQQQPPQQPPQQQPPPPPGLL
: ... : . . :.. : :: : . :. : : : :::
NP_000 PGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGP--QGPGGPPG--
380 390 400 410 420
370 380 390 400 410 420
pF1KE0 VRQNSCPPALP--RPQQGEAGTPSG-GLQDGGPMLPSQHAQFEYPIHRLENRSMHPYSEP
. :: :. : . . : : :. :.: :: :. : . .:. . :
NP_000 PKGNSGEPGAPGSKGDTGAKGEPGPVGVQ--GP--PG-------PAGEEGKRGARGEPGP
430 440 450 460 470
430 440 450 460 470 480
pF1KE0 VFSMQHPPPQQA-PNQRLQHFDAPPYMNVAKRPRFDF--PGSAGVDRCASWNGSMHNGAL
. .. :: ... :..: : . . : : . :: :: . : ...:
NP_000 T-GLPGPPGERGGPGSR--GFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGL
480 490 500 510 520 530
490 500 510 520 530 540
pF1KE0 DNHLSPSAYPGLPGEFTPPVPDSFPSGPPLQHPAPDHQSLQQQQQQQQQQQQQQQQQQQQ
. . .. :: :: ::. .::: :: :. .
NP_000 PGAKGLTGSPGSPG------PDG-KTGPP--GPAG--------------------QDGRP
540 550 560
550 560 570 580 590 600
pF1KE0 QQQQQQQQRQNAALMIKQMASRNQQQRLRQPNLAQLGHPGDVGQGGLVHGGPVGGLAQPN
: .:..: . :. : :.:: .:. :. :: :... .
NP_000 GPPGPPGARGQAGVM-----------GFPGPKGAA-GEPGKAGERGV--PGPPGAVGPAG
570 580 590 600 610
610 620 630 640 650
pF1KE0 FEREGGSTG----AGRLGTFEQQAPHLAQESAWFSGPHPPPGDLLPRRMGGSGLPADCGP
. :.:. : :: : .:.: . . :: :::. . : .:.:.: :
NP_000 KDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGE--AGKPGEQGVPGDLGA
620 630 640 650 660
660 670 680 690 700
pF1KE0 HDPSLA------PPP-----PPGGSGVLFRGPLQEPMRMPGEGHVPALPSPGLQFGGSLG
:: : : ::: .: :: : ..: . : .:: : :. :
NP_000 PGPSGARGERGFPGERGVQGPPGPAGP--RGANGAPGNDGAKGDAGAPGAPGSQ--GAPG
670 680 690 700 710 720
710 720 730 740 750
pF1KE0 GLGQLQSPGAGVGLPSAASERRPPPPDFATSALG--GQPGF--PFGAAGRQSTP----HS
:. ::. :::. ..: : : .. : : :. :.: : ..: .:
NP_000 LQGMPGERGAA-GLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGES
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE0 GP-GVNSPPSAGGGGGSSG--G--GGGGGAYPPQPDFQPSQRTSASKLGALSLGSFNKPS
:: : .: .: :. :. : : : .: : :: : ::. . . :: :. . :.
NP_000 GPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGA--KGDAGPPG
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE0 SKDNLFGQSCLAALSTACQNMIASLGAPNLNVTFNKKNPPEGKRKLSQNETDGAA-VAGN
: .. . :...:::. . . .. .:: : . ::: .:
NP_000 P-----------AGPAGPPGPIGNVGAPGAKGARGSAGPP-GATGFP-----GAAGRVGP
850 860 870 880
880 890 900 910 920
pF1KE0 PGSDYFPGGTA--PGAPGPGG------PSGTSSSGSKAS--GPPNPPAQGDGTSLSPNYT
:: :.:.: :: :::.: : : .. ... . :::.::. . : . ::.
NP_000 PG----PSGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPA-GEKGSPG--
890 900 910 920 930
930 940 950 960 970 980
pF1KE0 LESTSGNDGKPVSGGGGRGRGRRKRDSGHVS-PGTFFDKYSAAPDSGGAPGVS--PGQQQ
..: : : . : :.: : :. :: .. . : : :: : ::.:
NP_000 ---ADGPAGAPGTPGPQGIAGQR----GVVGLPGQRGER--GFP---GLPGPSGEPGKQG
940 950 960 970 980
990 1000 1010 1020 1030
pF1KE0 ASGAAVGGSSAGETRGAPTPH-EKALTSPSWGKGAELLLGDQ--PDLIGSLDGGAKSDSS
:::. :: :: : : .:..: .: : : . : :: :::.:
NP_000 PSGAS------GE-RGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGS--PGAKGDR-
990 1000 1010 1020 1030
1040 1050 1060 1070 1080 1090
pF1KE0 SPNVGEFASDEVSTSYANEDEVSSSSDNPQALVKASRSPLV--TG--SPKLPPRGVGA-G
:: :. :. . .. : . :..: :: .: : ::: :
NP_000 ----GE-------TGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARG
1040 1050 1060 1070 1080
1100 1110 1120 1130 1140
pF1KE0 EHGPKAPPPALGLGIMSNSTSTPDSYG-GG--GGPGHPGTPGLEQVRTPTSSSGAPPPDE
::..: : ... . : .: : :: ::.:: ::
NP_000 PAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPG-EQGPSGASGPAGPRGPP
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE0 IHPLEILQAQIQLQRQQFSISEDQPLGLKGGKKGECAVGASGAQNGDSELGSCCSEAVKS
NP_000 GSAGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGPPGPPGPPGPPSAGFDFSFLPQP
1150 1160 1170 1180 1190 1200
>>NP_542197 (OMIM: 120280,154780,228520,603932,604841) c (1690 aa)
initn: 275 init1: 102 opt: 469 Z-score: 191.7 bits: 48.1 E(85289): 0.00061
Smith-Waterman score: 663; 25.1% identity (45.4% similar) in 1246 aa overlap (9-1172:288-1448)
10 20 30
pF1KE0 MFGLDQFEPQVNSRNAGQGERN----FNETGLSMNTHF
: :. .. .: : : ..: : . .
NP_542 IDEYAPEDIIEYDYEYGEAEYKEAESVTEGPTVTEETIAQTEINGHGAYGEKGQKGEPAV
260 270 280 290 300 310
40 50 60 70 80
pF1KE0 KAPAFHTGGPPGPVDPAMSALGEPPILGMNMEPYGFHARGHSELH----AGGLQAQP---
:.. . :::::. :: . .: : . : . : :: : :: . :
NP_542 VEPGMLVEGPPGPAGPA-GIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTM
320 330 340 350 360 370
90 100 110 120 130 140
pF1KE0 -VHGFFGGQQPHHGHPGSHHPHQHHPHFGGN---FGGPDPGASCLHGGRLLGYGGAAGGL
. : : . .: : . : . . . :: :: : : : : .::
NP_542 LMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGP-PGP---MG--LTGRPGPVGGP
380 390 400 410 420 430
150 160 170 180 190 200
pF1KE0 GSQPPFAEGYEHMAESQGPESF-GPQRPGNLPDFHSSGASSHAVPAPCLPLDQSPNRAAS
::. :.: :::.. :: : . : .. ... . : : . .:.
NP_542 GSSG--AKGESGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEP-GAKGDRG--
440 450 460 470 480
210 220 230 240 250
pF1KE0 FHGLPSSSGSDSHSLEPRRVTNQGAVDSLEYNYPGEAPSGHFDMFSPSDSE-GQ--LPHY
: :::. :. .: : : :: :: : : : . :.: : ::
NP_542 FDGLPGLPGDKGHRGE--R-GPQGP--------PG--PPGD-DGMRGEDGEIGPRGLPGE
490 500 510 520 530
260 270 280 290 300 310
pF1KE0 AAGRQV--PGGAFPGASAMPRAAGMVGLSKMHAQPPQQQPQQQQQPQQQQQQHGVFFERF
:. : . : :. ::: ..: ::.:.. . .. :: . : :: . : . .
NP_542 AGPRGLLGPRGT-PGAPGQP---GMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGP--QGL
540 550 560 570 580
320 330 340 350 360 370
pF1KE0 SGARKMPVGLEPSVGSRHPLMQPPQQAPPPPQQQPPQQPPQQQPPPPPGLLVRQNSCPP-
: . :.: : : . : .: : : . :: .: .. : : . :
NP_542 PGP-QGPIG--PP-GEKGPQGKPGL-AGLPGADGPPGHPGKEGQSGEKGALGPPGPQGPI
590 600 610 620 630 640
380 390 400 410 420 430
pF1KE0 ALPRPQ-----QGEAGTPSGGLQDGGPMLPSQHAQFEYPIHRLENRSMHPYSEPVFSMQH
. : :. .: : .. . : .:. .... : : .. : .: . .
NP_542 GYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGED--GPEG
650 660 670 680 690
440 450 460 470 480 490
pF1KE0 PPPQQAPNQRLQHFDAPPYMNVAKRPRFDFPGSAGVDRCASWNGSMHNGALDNHLSPSAY
: . .:. : : ..... .. :: : . .:: .. . . ..
NP_542 PKGRAGPTG-----DPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGA
700 710 720 730 740 750
500 510 520 530 540
pF1KE0 PGLPGEFTPPVPDSFPSGP--------PLQHPAPDHQSLQQQQQQQQQQQQQQQQQQQQQ
:. :. : . :.:: : .:.: : . .. : :
NP_542 RGVAGK-PGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVG
760 770 780 790 800 810
550 560 570 580 590
pF1KE0 QQQQQQQRQNAALMIKQMASRNQQQRLRQPNLAQLGHPGDVG----QGGLVHGGPVGGLA
. . :. . :: . .. : :: : :: . ::.: .
NP_542 FPGPKGPPGPPG---KDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERG
820 830 840 850 860
600 610 620 630 640 650
pF1KE0 QPNFEREGGSTG----AGRLGTFEQQAPHLAQESAWFSGPHPPPGDL-LPRRMGGSGLPA
.:. : : ::. :. . .:. . . .: . ::. :: .:. :: .
NP_542 HPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKG
870 880 890 900 910 920
660 670 680 690 700 710
pF1KE0 DCGPHDPSLAPPPPPGGSGVLFRGPLQEPMRMPGEGHVPALPSPGLQFG--GSLGGLGQL
::. .:: : :. : . :. .::. . :.:. . : : : :
NP_542 GEGPQ----GPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPA
930 940 950 960 970 980
720 730 740 750 760
pF1KE0 QSPGAG--VGLPSAASERRPPPPDFATSALG--GQPGFPFGAAGRQSTPHSGPGVNSP--
:. ::::. :. : : . .: :: : : : .. : . ::...:
NP_542 GRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSK-GDKG-ENGPPGPPGLQGPVG
990 1000 1010 1020 1030 1040
770 780 790 800 810 820
pF1KE0 -PSAGGGGGSSGGGGGGGAYPPQPDFQPSQRTSASKLGALSLGSFNKPSSKDNLFGQSCL
:. .:: : : : : . . : . : . : ..: .. : .. . :.
NP_542 APGIAGGDGEPGPRGQQGMFGQKGD--EGARGFPGPPGPIGLQGLPGPPGEKGENGD---
1050 1060 1070 1080 1090
830 840 850 860 870 880
pF1KE0 AALSTACQNMIASLGAPNLNVTFNKKNP-----PEGKRKLSQNETDGAAVAGNPGSDYFP
.. .: :. . ..: :.: : . . :.. :.:: :
NP_542 ----------VGPMGPPGPPGPRGPQGPNGADGPQGPPG-SVGSVGGVGEKGEPGEAGNP
1100 1110 1120 1130 1140
890 900 910 920 930
pF1KE0 GGTAPGAPGPGGPSGTSSSGSKASGPPN---PP-AQG----DGTSLSPNYT-LESTSGND
: :: : :::.: . ..: :::. :: :.: :: . .:. . . . :
NP_542 G--PPGEAGVGGPKGERGEKGEA-GPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPP
1150 1160 1170 1180 1190 1200
940 950 960 970 980
pF1KE0 GKP-VSGGGGRGRGRRKRDSGHVSPGTFFDKYSAAPDSGGAPGVS--PGQQQASGAAVGG
:.: .: : : : . .:. .:: . :.: : :: :: : :
NP_542 GEPGPAGQDGVG-GDKGEDGDPGQPGPPGPSGEAGPP--GPPGKRGPPGAAGAEGRQGEK
1210 1220 1230 1240 1250 1260
990 1000 1010 1020 1030
pF1KE0 SSAGETRGAPTPHEKALTSPSW--GK-GAELLLGDQPDLIG--SLDGGAKSDS-----SS
.. ::. . : . . ..:. :: : : : : : .: .: :.: .:. .
NP_542 GAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRG-IPGPVGEQGLPGAAGQDGPPGPMGP
1270 1280 1290 1300 1310 1320
1040 1050 1060 1070 1080 1090
pF1KE0 PNVGEFASDEVSTSYANEDEVSSSSDNP-QALVKASRS-PLVTGSPKLPPRGVGAGEHGP
:.. . .: : . .. . . : . :..:. : . ::: : : ::
NP_542 PGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGP
1330 1340 1350 1360 1370 1380
1100 1110 1120 1130 1140 1150
pF1KE0 KAPPPALGLGIMSNSTSTPDSYGGGGGPGHPGTPGLEQVRTPTSSSGAPPPDEIHPLEIL
.:: :: .. .. : : .: : : :: : .: : :: . :.:: ::
NP_542 LGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPG------PPGSPG-PPGEVIQPLPIL
1390 1400 1410 1420 1430
1160 1170 1180 1190 1200 1210
pF1KE0 QAQIQLQRQQFSISEDQPLGLKGGKKGECAVGASGAQNGDSELGSCCSEAVKSAMSTIDL
... . .:. ... :
NP_542 SSK-KTRRHTEGMQADADDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCK
1440 1450 1460 1470 1480 1490
>>XP_016858786 (OMIM: 120131,203780) PREDICTED: collagen (1651 aa)
initn: 283 init1: 92 opt: 468 Z-score: 191.5 bits: 48.1 E(85289): 0.00063
Smith-Waterman score: 703; 26.1% identity (45.7% similar) in 1265 aa overlap (43-1152:68-1266)
20 30 40 50 60 70
pF1KE0 SRNAGQGERNFNETGLSMNTHFKAPAFHTGGPPGPVDPAMSALGEPPILGMNMEPYGFHA
::::: : .. :: : .:.. :
XP_016 GSGKKYIGPCGGRDCSVCHCVPEKGSRGPPGPPGPQGP-IGPLGAPGPIGLSGEKGMRGD
40 50 60 70 80 90
80 90 100 110 120
pF1KE0 RGHSELHAGGLQAQP--VHGFFGGQQPHHGHPGSHHPHQHHPHFGGNFGG-PDPGASCLH
:: . . : : :: : . :::: : . .: ..:. :. ::: .
XP_016 RGPPGAAGDKGDKGPTGVPGF-PGLDGIPGHPGPPGP-RGKPGMSGHNGSRGDPG---FP
100 110 120 130 140 150
130 140 150 160 170 180
pF1KE0 GGR-LLGYGGAAGGLGSQPPFAEGYEHMAESQGPESFGPQRPGNLPDFHSS-GASSHAVP
::: :: :: : : . ... .. .: . : . .:: . .: ::.. : :
XP_016 GGRGALGPGGPLGHPGEKGEKGNSVFILGAVKGIQ--GDRGDPGLPGLPGSWGAGGPAGP
160 170 180 190 200
190 200 210 220 230 240
pF1KE0 A--PCLPLDQSPNRAASFHGLPSSSGSDSHSL--EPRRVTNQGAVDSLEYNYPGEAPSGH
. : : .: . :: .. : .. .: .: .::. :: :.
XP_016 TGYPGEPGLVGPPGQPGRPGLKGNPGVGVKGQMGDPGEVGQQGS--------PG--PT--
210 220 230 240 250
250 260 270 280 290 300
pF1KE0 FDMFSPSDSEGQLPHYAAGRQVPGGAFPGASAMPRAAGMVGLSKMHAQPPQQQPQQQQQP
. : : . : . . . : .:: ..: : : : . :. . : :
XP_016 -LLVEPPD----FCLYKGEKGIKG--IPGMVGLPGPPGRKGESGIGAKGEKGIPGFPG-P
260 270 280 290 300
310 320 330 340 350
pF1KE0 QQQQQQHGVF-FERFSGARKM---P-----VGLEPSVGSR-HPLMQPPQQ--APPPPQQQ
. . ..: : ..: . : .: . . :.: :: :: .:: : .
XP_016 RGDPGSYGSPGFPGLKGELGLVGDPGLFGLIGPKGDPGNRGHP--GPPGVLVTPPLPLKG
310 320 330 340 350 360
360 370 380 390
pF1KE0 PPQQP--PQQQ-------PPPPPGLLVRQN-SCPPAL--PRPQ--------QGEAGTPSG
:: .: : . :: ::::: : . .: . : :: :::: :
XP_016 PPGDPGFPGRYGETGDVGPPGPPGLLGRPGEACAGMIGPPGPQGFPGLPGLPGEAGIP--
370 380 390 400 410 420
400 410 420 430 440
pF1KE0 GLQDGGPMLPSQHAQFEYPIHRLENRSMHPYSEPVF-SMQHPPPQQA------PNQRLQH
: :..: :.. .. : . . : : .. :. .: :: :. : .
XP_016 GRPDSAPGKPGKPGSPGLP--GAPGLQGLPGSSVIYCSVGNPGPQGIKGKVGPPGGRGPK
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE0 FDAPPYMNVAKRPR-FDFPGSAGVDRCASWNGSMHNGALDNHLSPSAYPGLPGEFTPP-V
. : .: . :: :. . .:: . .: . :. .. :: :: :: .
XP_016 GEKGNEGLCACEPGPMGPPGPPGL---PGRQGSKGDLGLPGWLGTKGDPGPPGAEGPPGL
490 500 510 520 530 540
510 520 530 540 550
pF1KE0 PDSF-PSGPPLQHPAPDHQSLQQQQQQQQQQQQQQQ-----QQQQQQQQQQQQQRQNAAL
: . :::: .. : . ... . .. .. . : .. .. . .. . .
XP_016 PGKHGASGPPGNKGAKGDMVVSRVKGHKGERGPDGPPGFPGQPGSHGRDGHAGEKGDPGP
550 560 570 580 590 600
560 570 580 590 600 610
pF1KE0 MIKQMASRNQQQRLRQPNLAQLGHPGDVGQGGLVHGGPVGGLAQPNFEREGGSTGAGRLG
. . . . : :. :. : :: :: :: : ..:. . : : :
XP_016 PGDHEDATPGGKGFPGP-LGPPGKAGPVGPPGLGFPGPPGERGHPGVPGHPGVRGPDGL-
610 620 630 640 650
620 630 640 650 660
pF1KE0 TFEQQAPHLAQESAWFSGPHPPPG-------DLLPRRMGGSGLPADCG----PHDPSLAP
. : . .. . : : ::: .: .:. :: .. : : :. :
XP_016 --KGQKGDTISCNVTYPGRHGPPGFDGPPGPKGFPGPQGAPGLSGSDGHKGRPGTPGTAE
660 670 680 690 700 710
670 680 690 700 710
pF1KE0 -PPPPGGSGVLFRGPLQEPMRMPGEGHVPALP-----SPGLQFGGSLGG---LGQLQSPG
: ::: ::: . .: .: :. : :::.. .. : .:.: ::
XP_016 IPGPPG-----FRGDMGDPGFGGEKGSSPVGPPGPPGSPGVNGQKGIPGDPAFGHLGPPG
720 730 740 750 760 770
720 730 740 750
pF1KE0 A-GV-GLPSAASERRPPPPDFATSALGGQPGF-----PFGAAGRQSTP-------HS---
:. :.:. . : : : . .: ::: : : :. . : ::
XP_016 KRGLSGVPGIKGPRGDPGCPGAEGP-AGIPGFLGLKGPKGREGHAGFPGVPGPPGHSCER
780 790 800 810 820 830
760 770 780 790 800 810
pF1KE0 -GPGVNSPPSAGGGGGSSGGGGG----GGAYPPQPDFQ---PSQRTSASKLGALSLGSFN
.::. . :. : :: :. :: : . :: : . :. . : .: ..
XP_016 GAPGIPGQPGLPGYPGSPGAPGGKGQPGDVGPPGPAGMKGLPGLPGRPGAHGPPGLPGIP
840 850 860 870 880 890
820 830 840
pF1KE0 KPSSKDNLFG-------------------------QSCLAALSTACQNMIASL-GAPNLN
: . :.: : ..: .: . .. ...: : .:
XP_016 GPFGDDGLPGPPGPKGPRGLPGFPGFPGERGKPGAEGCPGAKGEPGEKGMSGLPGDRGLR
900 910 920 930 940 950
850 860 870 880 890
pF1KE0 VTFNKKNPP--EGKRKL-SQNETDGAAVAGNPGSDYFPG-----GTAPGAPG----PG--
. . .:: ::. . ::. : : : ::.: ::: :: :: : ::
XP_016 GAKGAIGPPGDEGEMAIISQKGTPGEP--GPPGDDGFPGERGDKGT-PGMQGRRGEPGRY
960 970 980 990 1000
900 910 920 930 940
pF1KE0 GPSG--TSSSGSKAS-GPPNPPAQGDGTSLSPNYTLESTSGNDGKPVSGG--GGRG-RGR
:: : . : :.. :::.::. .:.: . . :..:.: : : : : :
XP_016 GPPGFHRGEPGEKGQPGPPGPPGPPGSTGLRGFIGFPGLPGDQGEPGSPGPPGFSGIDGA
1010 1020 1030 1040 1050 1060
950 960 970 980 990
pF1KE0 RKRDSGHVSPGTFFDKYSAAPDSGGAPGVSPGQQQASG-----AAVGGSSAGETRGAP-T
: ... .:.. : . : :.: :: ::.. : . .: . .: :
XP_016 RGPKGNKGDPASHF----GPPGSSGPPGC-PGDHGMPGLRGQPGEMGDPGPRGLQGDPGI
1070 1080 1090 1100 1110 1120
1000 1010 1020 1030 1040 1050
pF1KE0 PHEKALTSPSWGKGAELLLGDQPDLIGSLDGGAKSDSSSPNVGEFASDEVSTSYANEDEV
: .. .:: . : . : : : : . :.:. :. .:: . . ... .
XP_016 PGPPGIKGPSGSPGLNGLHG----LKG--QKGTKGASGLHDVGPPGPVGIPGLKGERGDP
1130 1140 1150 1160 1170
1060 1070 1080 1090 1100 1110
pF1KE0 SSSSDNPQALVKASRSPLVTGSPKLPPRGVGAGEHGPKAPPPALGLGIMSNSTSTPDSYG
.: . .: . . : :: :: .:: ..:: : : ... :: :
XP_016 GSPGISPPGPRGKKGPPGPPGSSG-PPGPAGATGRAPKDIPDPGPPG--DQGPPGPD--G
1180 1190 1200 1210 1220 1230
1120 1130 1140 1150 1160 1170
pF1KE0 GGGGPGHPGTPG-LEQVRTPTSSSGAP-PPDEIHPLEILQAQIQLQRQQFSISEDQPLGL
:.:: :: :: .. .: .. : : :: :
XP_016 PRGAPGPPGLPGSVDLLRGEPGDCGLPGPPGPPGPPGPPGYKGFPGCDGKDGQKGPVGFP
1240 1250 1260 1270 1280 1290
1180 1190 1200 1210 1220 1230
pF1KE0 KGGKKGECAVGASGAQNGDSELGSCCSEAVKSAMSTIDLDSLMAEHSAAWYMPADKALVD
XP_016 GPQGPHGFPGPPGEKGLPGPPGRKGPTGLPGPRGEPGPPADVDDCPRIPGLPGAPGMRGP
1300 1310 1320 1330 1340 1350
1320 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 04:17:55 2016 done: Fri Nov 4 04:17:58 2016
Total Scan time: 22.020 Total Display time: 0.350
Function used was FASTA [36.3.4 Apr, 2011]