FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0091, 632 aa 1>>>pF1KE0091 632 - 632 aa - 632 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1015+/-0.000399; mu= 20.6167+/- 0.025 mean_var=69.7799+/-14.430, 0's: 0 Z-trim(111.4): 97 B-trim: 1102 in 1/49 Lambda= 0.153536 statistics sampled from 19865 (19965) to 19865 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.571), E-opt: 0.2 (0.234), width: 16 Scan time: 7.500 The best scores are: opt bits E(85289) NP_055044 (OMIM: 607952) sodium- and chloride-depe ( 632) 4383 980.5 0 NP_057699 (OMIM: 615097) sodium- and chloride-depe ( 602) 2961 665.5 1.5e-190 XP_016862562 (OMIM: 607952) PREDICTED: sodium- and ( 458) 2933 659.3 8.6e-189 NP_001193860 (OMIM: 603080) sodium- and chloride-d ( 614) 2831 636.8 6.9e-182 NP_001116320 (OMIM: 603080) sodium- and chloride-d ( 614) 2831 636.8 6.9e-182 XP_011519312 (OMIM: 603080) PREDICTED: sodium- and ( 614) 2831 636.8 6.9e-182 NP_001116319 (OMIM: 603080) sodium- and chloride-d ( 614) 2831 636.8 6.9e-182 NP_003035 (OMIM: 603080) sodium- and chloride-depe ( 614) 2831 636.8 6.9e-182 XP_005253804 (OMIM: 603080) PREDICTED: sodium- and ( 610) 2808 631.7 2.3e-180 XP_005253805 (OMIM: 603080) PREDICTED: sodium- and ( 571) 2799 629.6 8.9e-180 XP_006719068 (OMIM: 603080) PREDICTED: sodium- and ( 570) 2793 628.3 2.2e-179 XP_011532332 (OMIM: 186854) PREDICTED: sodium- and ( 620) 2619 589.8 9.5e-168 NP_003034 (OMIM: 186854) sodium- and chloride-depe ( 620) 2619 589.8 9.5e-168 XP_006713370 (OMIM: 186854) PREDICTED: sodium- and ( 649) 2619 589.8 9.8e-168 NP_001127839 (OMIM: 186854) sodium- and chloride-d ( 721) 2619 589.8 1.1e-167 XP_011532335 (OMIM: 607952) PREDICTED: sodium- and ( 381) 2599 585.2 1.4e-166 XP_011519314 (OMIM: 615097) PREDICTED: sodium- and ( 483) 2376 535.9 1.2e-151 NP_005620 (OMIM: 300036,300352) sodium- and chlori ( 635) 2329 525.6 2.1e-148 NP_001177926 (OMIM: 615097) sodium- and chloride-d ( 510) 2195 495.8 1.5e-139 XP_011519315 (OMIM: 615097) PREDICTED: sodium- and ( 440) 2164 488.9 1.6e-137 XP_011519316 (OMIM: 615097) PREDICTED: sodium- and ( 440) 2164 488.9 1.6e-137 NP_003033 (OMIM: 137165,616421) sodium- and chlori ( 599) 2158 487.7 5.1e-137 XP_016862561 (OMIM: 137165,616421) PREDICTED: sodi ( 599) 2158 487.7 5.1e-137 XP_011532327 (OMIM: 137165,616421) PREDICTED: sodi ( 599) 2158 487.7 5.1e-137 XP_016862560 (OMIM: 137165,616421) PREDICTED: sodi ( 599) 2158 487.7 5.1e-137 XP_005265467 (OMIM: 137165,616421) PREDICTED: sodi ( 599) 2158 487.7 5.1e-137 XP_006713369 (OMIM: 137165,616421) PREDICTED: sodi ( 599) 2158 487.7 5.1e-137 XP_011532329 (OMIM: 137165,616421) PREDICTED: sodi ( 599) 2158 487.7 5.1e-137 XP_005265468 (OMIM: 137165,616421) PREDICTED: sodi ( 599) 2158 487.7 5.1e-137 XP_016875333 (OMIM: 615097) PREDICTED: sodium- and ( 394) 2075 469.2 1.3e-131 XP_016875330 (OMIM: 603080) PREDICTED: sodium- and ( 426) 2035 460.3 6.2e-129 NP_001136278 (OMIM: 300036,300352) sodium- and chl ( 520) 2004 453.5 8.4e-127 XP_011532333 (OMIM: 186854) PREDICTED: sodium- and ( 449) 1917 434.2 4.8e-121 NP_055043 (OMIM: 606205) sodium-dependent proline ( 636) 1772 402.2 2.9e-111 NP_001165972 (OMIM: 163970,604715) sodium-dependen ( 617) 1765 400.6 8.3e-111 NP_001034 (OMIM: 163970,604715) sodium-dependent n ( 617) 1765 400.6 8.3e-111 XP_006721326 (OMIM: 163970,604715) PREDICTED: sodi ( 628) 1765 400.6 8.4e-111 XP_011521597 (OMIM: 163970,604715) PREDICTED: sodi ( 628) 1765 400.6 8.4e-111 NP_001165975 (OMIM: 163970,604715) sodium-dependen ( 628) 1765 400.6 8.4e-111 XP_016875334 (OMIM: 615097) PREDICTED: sodium- and ( 359) 1746 396.3 1e-109 XP_006719071 (OMIM: 615097) PREDICTED: sodium- and ( 359) 1746 396.3 1e-109 NP_001036 (OMIM: 164230,182138,607834) sodium-depe ( 630) 1733 393.5 1.2e-108 NP_001035 (OMIM: 126455,188890,613135) sodium-depe ( 620) 1686 383.1 1.5e-105 XP_016875335 (OMIM: 615097) PREDICTED: sodium- and ( 325) 1634 371.4 2.7e-102 XP_016875336 (OMIM: 615097) PREDICTED: sodium- and ( 325) 1634 371.4 2.7e-102 NP_001136277 (OMIM: 300036,300352) sodium- and chl ( 625) 1607 365.6 2.9e-100 XP_016865259 (OMIM: 606205) PREDICTED: sodium-depe ( 555) 1547 352.3 2.6e-96 NP_001304335 (OMIM: 607952) sodium- and chloride-d ( 208) 1467 334.3 2.6e-91 XP_016875332 (OMIM: 615097) PREDICTED: sodium- and ( 442) 1408 321.4 4.1e-87 NP_001165973 (OMIM: 163970,604715) sodium-dependen ( 512) 1388 317.1 9.9e-86 >>NP_055044 (OMIM: 607952) sodium- and chloride-dependen (632 aa) initn: 4383 init1: 4383 opt: 4383 Z-score: 5244.2 bits: 980.5 E(85289): 0 Smith-Waterman score: 4383; 100.0% identity (100.0% similar) in 632 aa overlap (1-632:1-632) 10 20 30 40 50 60 pF1KE0 MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGIT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 CWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 CWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 VEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 FCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 FCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 DAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 YEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 YEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 AVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 AVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 IFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 IFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKY 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 NNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 NNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKL 550 560 570 580 590 600 610 620 630 pF1KE0 GVSPRMVTVNDCDAKLKSDGTIAAITEKETHF :::::::::::::::::::::::::::::::: NP_055 GVSPRMVTVNDCDAKLKSDGTIAAITEKETHF 610 620 630 >>NP_057699 (OMIM: 615097) sodium- and chloride-dependen (602 aa) initn: 2976 init1: 2148 opt: 2961 Z-score: 3542.2 bits: 665.5 E(85289): 1.5e-190 Smith-Waterman score: 2961; 70.8% identity (88.8% similar) in 579 aa overlap (27-603:7-583) 10 20 30 40 50 pF1KE0 MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRV--KRDKAVHERGHWNNKVE : .:.: . .: . :.. .. ::::::::.: NP_057 MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKME 10 20 30 40 60 70 80 90 100 110 pF1KE0 FVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGG ::::::::::::::::::::::::::::::.:::.::.. ::::::.:::::::.::.:: NP_057 FVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGG 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE0 ITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTE .: :::.::.:::::::.:.: :::::::.::::.::: . :: .:::. : :::::: NP_057 VTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE0 NCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTI .:.:::: : .. . .: .::::::.::::.::: :::::.:.: :::::::::: ::.: NP_057 HCMEFQKTN-GSLNGTS-ENATSPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVI 170 180 190 200 210 240 250 260 270 280 290 pF1KE0 CYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQV ::::::::.:::::::: ::::::.::..:::::::::::..::.:::::.:.:: :::: NP_057 CYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQV 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE0 WVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGF :.:::::::::.::::::::::::::.:.:::::::: :: :::::::::::::::.::: NP_057 WMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGF 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE0 MAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESL :. ::::::.:::::::::::::::.::.:.:.::::: ::.:...::::::::::::: NP_057 MSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESL 340 350 360 370 380 390 420 430 440 450 460 470 pF1KE0 VTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLF :::.:::::.:::. :::.:::..::.:...::.::::::::.::::: :::::::::: NP_057 VTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLF 400 410 420 430 440 450 480 490 500 510 520 530 pF1KE0 VAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPL ::::: .:..::::..:::::::::::::: :::.::...::..:.. :.: :::: :: NP_057 VAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPL 460 470 480 490 500 510 540 550 560 570 580 590 pF1KE0 KYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRG ::. :::: :: ..:::.:::::.::: : . .: . :....: :. :: .:. NP_057 TYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRN 520 530 540 550 560 570 600 610 620 630 pF1KE0 KLGVSPRMVTVNDCDAKLKSDGTIAAITEKETHF : : NP_057 PAGPSAPATPRTSLLRLTELESHC 580 590 600 >>XP_016862562 (OMIM: 607952) PREDICTED: sodium- and chl (458 aa) initn: 2916 init1: 2916 opt: 2933 Z-score: 3510.4 bits: 659.3 E(85289): 8.6e-189 Smith-Waterman score: 2933; 98.4% identity (98.9% similar) in 435 aa overlap (198-632:25-458) 170 180 190 200 210 220 pF1KE0 WATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWE .:.:: : ::::::::::::::::::: XP_016 MCLCRMPPPLSWSFGNEEAETQRGDAASPRWSSW-HRVLAISDGIEHIGNLRWE 10 20 30 40 50 230 240 250 260 270 280 pF1KE0 LALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLY 60 70 80 90 100 110 290 300 310 320 330 340 pF1KE0 PDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFV 120 130 140 150 160 170 350 360 370 380 390 400 pF1KE0 AGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLG 180 190 200 210 220 230 410 420 430 440 450 460 pF1KE0 LDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFD 240 250 260 270 280 290 470 480 490 500 510 520 pF1KE0 SYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGI 300 310 320 330 340 350 530 540 550 560 570 580 pF1KE0 FIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKL 360 370 380 390 400 410 590 600 610 620 630 pF1KE0 TTPSTDLKMRGKLGVSPRMVTVNDCDAKLKSDGTIAAITEKETHF ::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTPSTDLKMRGKLGVSPRMVTVNDCDAKLKSDGTIAAITEKETHF 420 430 440 450 >>NP_001193860 (OMIM: 603080) sodium- and chloride-depen (614 aa) initn: 2843 init1: 2057 opt: 2831 Z-score: 3386.5 bits: 636.8 E(85289): 6.9e-182 Smith-Waterman score: 2831; 67.8% identity (87.7% similar) in 587 aa overlap (47-632:33-614) 20 30 40 50 60 70 pF1KE0 EARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRF :..::.:.::.::::::::::::::::::: NP_001 GKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRF 10 20 30 40 50 60 80 90 100 110 120 130 pF1KE0 PYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYAT ::::::::::::.::: .::. :::::::::.::::.::.:..: :::.::::.::: :. NP_001 PYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLAS 70 80 90 100 110 120 140 150 160 170 180 190 pF1KE0 QVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVS- :::..::::::::::::.::: . ::.::::.::.. ::::.:..: :: :. . :. NP_001 VVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDF--LNHSGAGTVTP 130 140 150 160 170 180 200 210 220 230 240 250 pF1KE0 LQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVY ..: :::::::::.:::.:..::. .:.:::::::::: ::.:::::::::.:::::::: NP_001 FENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVY 190 200 210 220 230 240 260 270 280 290 300 310 pF1KE0 VTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLG ::::::.::.:::::::::::: .:: .:: ::: ::.:::::.:::::::::.::: : NP_001 FTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQG 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE0 CLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGP :::::::::.:.::::.::: :: :::.:::::::..::.::::. ::::::.::::::: NP_001 CLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGP 310 320 330 340 350 360 380 390 400 410 420 430 pF1KE0 GLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYR ::::::.:::::::::: ::. :::.::::::::::::::: :::: .::.:. .:.. : NP_001 GLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGR 370 380 390 400 410 420 440 450 460 470 480 490 pF1KE0 RELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNR ::::::...:. :..:: ..:::::::::::: ::.::.::::...:: .::.::::..: NP_001 RELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADR 430 440 450 460 470 480 500 510 520 530 540 550 pF1KE0 FYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGW ::::::::::::: :.: :...:::.: . :.: : :: ::::::.:.:: :::.::: NP_001 FYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGW 490 500 510 520 530 540 560 570 580 590 600 610 pF1KE0 LMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAK ..:::::.:.::.. ::. ::.: . ..:..: ::...: . . . : . NP_001 FLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSP 550 560 570 580 590 600 620 630 pF1KE0 LKSDGTIAAITEKETHF . .: ::. :::::. NP_001 TR-EGLIAG--EKETHL 610 >>NP_001116320 (OMIM: 603080) sodium- and chloride-depen (614 aa) initn: 2843 init1: 2057 opt: 2831 Z-score: 3386.5 bits: 636.8 E(85289): 6.9e-182 Smith-Waterman score: 2831; 67.8% identity (87.7% similar) in 587 aa overlap (47-632:33-614) 20 30 40 50 60 70 pF1KE0 EARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRF :..::.:.::.::::::::::::::::::: NP_001 GKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRF 10 20 30 40 50 60 80 90 100 110 120 130 pF1KE0 PYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYAT ::::::::::::.::: .::. :::::::::.::::.::.:..: :::.::::.::: :. NP_001 PYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLAS 70 80 90 100 110 120 140 150 160 170 180 190 pF1KE0 QVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVS- :::..::::::::::::.::: . ::.::::.::.. ::::.:..: :: :. . :. NP_001 VVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDF--LNHSGAGTVTP 130 140 150 160 170 180 200 210 220 230 240 250 pF1KE0 LQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVY ..: :::::::::.:::.:..::. .:.:::::::::: ::.:::::::::.:::::::: NP_001 FENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVY 190 200 210 220 230 240 260 270 280 290 300 310 pF1KE0 VTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLG ::::::.::.:::::::::::: .:: .:: ::: ::.:::::.:::::::::.::: : NP_001 FTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQG 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE0 CLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGP :::::::::.:.::::.::: :: :::.:::::::..::.::::. ::::::.::::::: NP_001 CLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGP 310 320 330 340 350 360 380 390 400 410 420 430 pF1KE0 GLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYR ::::::.:::::::::: ::. :::.::::::::::::::: :::: .::.:. .:.. : NP_001 GLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGR 370 380 390 400 410 420 440 450 460 470 480 490 pF1KE0 RELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNR ::::::...:. :..:: ..:::::::::::: ::.::.::::...:: .::.::::..: NP_001 RELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADR 430 440 450 460 470 480 500 510 520 530 540 550 pF1KE0 FYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGW ::::::::::::: :.: :...:::.: . :.: : :: ::::::.:.:: :::.::: NP_001 FYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGW 490 500 510 520 530 540 560 570 580 590 600 610 pF1KE0 LMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAK ..:::::.:.::.. ::. ::.: . ..:..: ::...: . . . : . NP_001 FLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSP 550 560 570 580 590 600 620 630 pF1KE0 LKSDGTIAAITEKETHF . .: ::. :::::. NP_001 TR-EGLIAG--EKETHL 610 >>XP_011519312 (OMIM: 603080) PREDICTED: sodium- and chl (614 aa) initn: 2843 init1: 2057 opt: 2831 Z-score: 3386.5 bits: 636.8 E(85289): 6.9e-182 Smith-Waterman score: 2831; 67.8% identity (87.7% similar) in 587 aa overlap (47-632:33-614) 20 30 40 50 60 70 pF1KE0 EARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRF :..::.:.::.::::::::::::::::::: XP_011 GKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRF 10 20 30 40 50 60 80 90 100 110 120 130 pF1KE0 PYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYAT ::::::::::::.::: .::. :::::::::.::::.::.:..: :::.::::.::: :. XP_011 PYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLAS 70 80 90 100 110 120 140 150 160 170 180 190 pF1KE0 QVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVS- :::..::::::::::::.::: . ::.::::.::.. ::::.:..: :: :. . :. XP_011 VVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDF--LNHSGAGTVTP 130 140 150 160 170 180 200 210 220 230 240 250 pF1KE0 LQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVY ..: :::::::::.:::.:..::. .:.:::::::::: ::.:::::::::.:::::::: XP_011 FENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVY 190 200 210 220 230 240 260 270 280 290 300 310 pF1KE0 VTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLG ::::::.::.:::::::::::: .:: .:: ::: ::.:::::.:::::::::.::: : XP_011 FTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQG 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE0 CLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGP :::::::::.:.::::.::: :: :::.:::::::..::.::::. ::::::.::::::: XP_011 CLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGP 310 320 330 340 350 360 380 390 400 410 420 430 pF1KE0 GLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYR ::::::.:::::::::: ::. :::.::::::::::::::: :::: .::.:. .:.. : XP_011 GLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGR 370 380 390 400 410 420 440 450 460 470 480 490 pF1KE0 RELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNR ::::::...:. :..:: ..:::::::::::: ::.::.::::...:: .::.::::..: XP_011 RELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADR 430 440 450 460 470 480 500 510 520 530 540 550 pF1KE0 FYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGW ::::::::::::: :.: :...:::.: . :.: : :: ::::::.:.:: :::.::: XP_011 FYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGW 490 500 510 520 530 540 560 570 580 590 600 610 pF1KE0 LMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAK ..:::::.:.::.. ::. ::.: . ..:..: ::...: . . . : . XP_011 FLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSP 550 560 570 580 590 600 620 630 pF1KE0 LKSDGTIAAITEKETHF . .: ::. :::::. XP_011 TR-EGLIAG--EKETHL 610 >>NP_001116319 (OMIM: 603080) sodium- and chloride-depen (614 aa) initn: 2843 init1: 2057 opt: 2831 Z-score: 3386.5 bits: 636.8 E(85289): 6.9e-182 Smith-Waterman score: 2831; 67.8% identity (87.7% similar) in 587 aa overlap (47-632:33-614) 20 30 40 50 60 70 pF1KE0 EARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRF :..::.:.::.::::::::::::::::::: NP_001 GKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRF 10 20 30 40 50 60 80 90 100 110 120 130 pF1KE0 PYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYAT ::::::::::::.::: .::. :::::::::.::::.::.:..: :::.::::.::: :. NP_001 PYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLAS 70 80 90 100 110 120 140 150 160 170 180 190 pF1KE0 QVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVS- :::..::::::::::::.::: . ::.::::.::.. ::::.:..: :: :. . :. NP_001 VVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDF--LNHSGAGTVTP 130 140 150 160 170 180 200 210 220 230 240 250 pF1KE0 LQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVY ..: :::::::::.:::.:..::. .:.:::::::::: ::.:::::::::.:::::::: NP_001 FENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVY 190 200 210 220 230 240 260 270 280 290 300 310 pF1KE0 VTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLG ::::::.::.:::::::::::: .:: .:: ::: ::.:::::.:::::::::.::: : NP_001 FTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQG 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE0 CLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGP :::::::::.:.::::.::: :: :::.:::::::..::.::::. ::::::.::::::: NP_001 CLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGP 310 320 330 340 350 360 380 390 400 410 420 430 pF1KE0 GLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYR ::::::.:::::::::: ::. :::.::::::::::::::: :::: .::.:. .:.. : NP_001 GLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGR 370 380 390 400 410 420 440 450 460 470 480 490 pF1KE0 RELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNR ::::::...:. :..:: ..:::::::::::: ::.::.::::...:: .::.::::..: NP_001 RELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADR 430 440 450 460 470 480 500 510 520 530 540 550 pF1KE0 FYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGW ::::::::::::: :.: :...:::.: . :.: : :: ::::::.:.:: :::.::: NP_001 FYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGW 490 500 510 520 530 540 560 570 580 590 600 610 pF1KE0 LMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAK ..:::::.:.::.. ::. ::.: . ..:..: ::...: . . . : . NP_001 FLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSP 550 560 570 580 590 600 620 630 pF1KE0 LKSDGTIAAITEKETHF . .: ::. :::::. NP_001 TR-EGLIAG--EKETHL 610 >>NP_003035 (OMIM: 603080) sodium- and chloride-dependen (614 aa) initn: 2843 init1: 2057 opt: 2831 Z-score: 3386.5 bits: 636.8 E(85289): 6.9e-182 Smith-Waterman score: 2831; 67.8% identity (87.7% similar) in 587 aa overlap (47-632:33-614) 20 30 40 50 60 70 pF1KE0 EARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRF :..::.:.::.::::::::::::::::::: NP_003 GKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRF 10 20 30 40 50 60 80 90 100 110 120 130 pF1KE0 PYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYAT ::::::::::::.::: .::. :::::::::.::::.::.:..: :::.::::.::: :. NP_003 PYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLAS 70 80 90 100 110 120 140 150 160 170 180 190 pF1KE0 QVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVS- :::..::::::::::::.::: . ::.::::.::.. ::::.:..: :: :. . :. NP_003 VVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDF--LNHSGAGTVTP 130 140 150 160 170 180 200 210 220 230 240 250 pF1KE0 LQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVY ..: :::::::::.:::.:..::. .:.:::::::::: ::.:::::::::.:::::::: NP_003 FENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVY 190 200 210 220 230 240 260 270 280 290 300 310 pF1KE0 VTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLG ::::::.::.:::::::::::: .:: .:: ::: ::.:::::.:::::::::.::: : NP_003 FTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQG 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE0 CLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGP :::::::::.:.::::.::: :: :::.:::::::..::.::::. ::::::.::::::: NP_003 CLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGP 310 320 330 340 350 360 380 390 400 410 420 430 pF1KE0 GLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYR ::::::.:::::::::: ::. :::.::::::::::::::: :::: .::.:. .:.. : NP_003 GLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGR 370 380 390 400 410 420 440 450 460 470 480 490 pF1KE0 RELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNR ::::::...:. :..:: ..:::::::::::: ::.::.::::...:: .::.::::..: NP_003 RELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADR 430 440 450 460 470 480 500 510 520 530 540 550 pF1KE0 FYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGW ::::::::::::: :.: :...:::.: . :.: : :: ::::::.:.:: :::.::: NP_003 FYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGW 490 500 510 520 530 540 560 570 580 590 600 610 pF1KE0 LMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAK ..:::::.:.::.. ::. ::.: . ..:..: ::...: . . . : . NP_003 FLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSP 550 560 570 580 590 600 620 630 pF1KE0 LKSDGTIAAITEKETHF . .: ::. :::::. NP_003 TR-EGLIAG--EKETHL 610 >>XP_005253804 (OMIM: 603080) PREDICTED: sodium- and chl (610 aa) initn: 2808 init1: 2022 opt: 2808 Z-score: 3359.0 bits: 631.7 E(85289): 2.3e-180 Smith-Waterman score: 2808; 69.5% identity (89.1% similar) in 561 aa overlap (47-604:33-589) 20 30 40 50 60 70 pF1KE0 EARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRF :..::.:.::.::::::::::::::::::: XP_005 GKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRF 10 20 30 40 50 60 80 90 100 110 120 130 pF1KE0 PYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYAT ::::::::::::.::: .::. :::::::::.::::.::.:..: :::.::::.::: :. XP_005 PYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLAS 70 80 90 100 110 120 140 150 160 170 180 190 pF1KE0 QVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVS- :::..::::::::::::.::: . ::.::::.::.. ::::.:..: :: :. . :. XP_005 VVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDF--LNHSGAGTVTP 130 140 150 160 170 180 200 210 220 230 240 250 pF1KE0 LQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVY ..: :::::::::.:::.:..::. .:.:::::::::: ::.:::::::::.:::::::: XP_005 FENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVY 190 200 210 220 230 240 260 270 280 290 300 310 pF1KE0 VTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLG ::::::.::.:::::::::::: .:: .:: ::: ::.:::::.:::::::::.::: : XP_005 FTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQG 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE0 CLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGP :::::::::.:.::::.::: :: :::.:::::::..::.::::. ::::::.::::::: XP_005 CLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGP 310 320 330 340 350 360 380 390 400 410 420 430 pF1KE0 GLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYR ::::::.:::::::::: ::. :::.::::::::::::::: :::: .::.:. .:.. : XP_005 GLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGR 370 380 390 400 410 420 440 450 460 470 480 490 pF1KE0 RELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNR ::::::...:. :..:: ..:::::::::::: ::.::.::::...:: .::.::::..: XP_005 RELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADR 430 440 450 460 470 480 500 510 520 530 540 550 pF1KE0 FYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGW ::::::::::::: :.: :...:::.: . :.: : :: ::::::.:.:: :::.::: XP_005 FYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGW 490 500 510 520 530 540 560 570 580 590 600 610 pF1KE0 LMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTP--STDLKMRGKLGVSPRMVTVNDCD ..:::::.:.::.. ::. ::.: : . . .: : .. .: : . ..: XP_005 FLALSSMVCVPLFVVITLLKTRG--PFRKMAVTIPVITSAFKARRREQMAPPPPPPTVVA 550 560 570 580 590 620 630 pF1KE0 AKLKSDGTIAAITEKETHF XP_005 VPLIRRKIIDTY 600 610 >>XP_005253805 (OMIM: 603080) PREDICTED: sodium- and chl (571 aa) initn: 2814 init1: 2028 opt: 2799 Z-score: 3348.6 bits: 629.6 E(85289): 8.9e-180 Smith-Waterman score: 2799; 71.3% identity (90.7% similar) in 540 aa overlap (47-585:33-570) 20 30 40 50 60 70 pF1KE0 EARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRF :..::.:.::.::::::::::::::::::: XP_005 GKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRF 10 20 30 40 50 60 80 90 100 110 120 130 pF1KE0 PYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYAT ::::::::::::.::: .::. :::::::::.::::.::.:..: :::.::::.::: :. XP_005 PYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLAS 70 80 90 100 110 120 140 150 160 170 180 190 pF1KE0 QVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVS- :::..::::::::::::.::: . ::.::::.::.. ::::.:..: :: :. . :. XP_005 VVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDF--LNHSGAGTVTP 130 140 150 160 170 180 200 210 220 230 240 250 pF1KE0 LQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVY ..: :::::::::.:::.:..::. .:.:::::::::: ::.:::::::::.:::::::: XP_005 FENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVY 190 200 210 220 230 240 260 270 280 290 300 310 pF1KE0 VTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLG ::::::.::.:::::::::::: .:: .:: ::: ::.:::::.:::::::::.::: : XP_005 FTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQG 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE0 CLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGP :::::::::.:.::::.::: :: :::.:::::::..::.::::. ::::::.::::::: XP_005 CLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGP 310 320 330 340 350 360 380 390 400 410 420 430 pF1KE0 GLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYR ::::::.:::::::::: ::. :::.::::::::::::::: :::: .::.:. .:.. : XP_005 GLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGR 370 380 390 400 410 420 440 450 460 470 480 490 pF1KE0 RELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNR ::::::...:. :..:: ..:::::::::::: ::.::.::::...:: .::.::::..: XP_005 RELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADR 430 440 450 460 470 480 500 510 520 530 540 550 pF1KE0 FYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGW ::::::::::::: :.: :...:::.: . :.: : :: ::::::.:.:: :::.::: XP_005 FYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGW 490 500 510 520 530 540 560 570 580 590 600 610 pF1KE0 LMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAK ..:::::.:.::.. ::. ::.: . .:.. XP_005 FLALSSMVCVPLFVVITLLKTRGPFRKKVRD 550 560 570 632 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 03:37:25 2016 done: Fri Nov 4 03:37:26 2016 Total Scan time: 7.500 Total Display time: 0.150 Function used was FASTA [36.3.4 Apr, 2011]