FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0099, 267 aa 1>>>pF1KE0099 267 - 267 aa - 267 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.5948+/-0.000442; mu= 6.1068+/- 0.027 mean_var=226.3279+/-45.207, 0's: 0 Z-trim(118.2): 13 B-trim: 639 in 1/55 Lambda= 0.085252 statistics sampled from 30950 (30963) to 30950 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.725), E-opt: 0.2 (0.363), width: 16 Scan time: 8.010 The best scores are: opt bits E(85289) NP_001304947 (OMIM: 105200,107680,604091) apolipop ( 267) 1733 225.6 7.5e-59 NP_001304946 (OMIM: 105200,107680,604091) apolipop ( 267) 1733 225.6 7.5e-59 NP_000030 (OMIM: 105200,107680,604091) apolipoprot ( 267) 1733 225.6 7.5e-59 NP_001304950 (OMIM: 105200,107680,604091) apolipop ( 158) 1006 135.9 4.4e-32 XP_016872658 (OMIM: 144650,145750,606368) PREDICTE ( 366) 232 41.1 0.0034 NP_001160070 (OMIM: 144650,145750,606368) apolipop ( 366) 232 41.1 0.0034 NP_443200 (OMIM: 144650,145750,606368) apolipoprot ( 366) 232 41.1 0.0034 NP_000473 (OMIM: 107690) apolipoprotein A-IV precu ( 396) 228 40.7 0.0051 >>NP_001304947 (OMIM: 105200,107680,604091) apolipoprote (267 aa) initn: 1733 init1: 1733 opt: 1733 Z-score: 1177.6 bits: 225.6 E(85289): 7.5e-59 Smith-Waterman score: 1733; 100.0% identity (100.0% similar) in 267 aa overlap (1-267:1-267) 10 20 30 40 50 60 pF1KE0 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ 190 200 210 220 230 240 250 260 pF1KE0 GLLPVLESFKVSFLSALEEYTKKLNTQ ::::::::::::::::::::::::::: NP_001 GLLPVLESFKVSFLSALEEYTKKLNTQ 250 260 >>NP_001304946 (OMIM: 105200,107680,604091) apolipoprote (267 aa) initn: 1733 init1: 1733 opt: 1733 Z-score: 1177.6 bits: 225.6 E(85289): 7.5e-59 Smith-Waterman score: 1733; 100.0% identity (100.0% similar) in 267 aa overlap (1-267:1-267) 10 20 30 40 50 60 pF1KE0 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ 190 200 210 220 230 240 250 260 pF1KE0 GLLPVLESFKVSFLSALEEYTKKLNTQ ::::::::::::::::::::::::::: NP_001 GLLPVLESFKVSFLSALEEYTKKLNTQ 250 260 >>NP_000030 (OMIM: 105200,107680,604091) apolipoprotein (267 aa) initn: 1733 init1: 1733 opt: 1733 Z-score: 1177.6 bits: 225.6 E(85289): 7.5e-59 Smith-Waterman score: 1733; 100.0% identity (100.0% similar) in 267 aa overlap (1-267:1-267) 10 20 30 40 50 60 pF1KE0 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ 190 200 210 220 230 240 250 260 pF1KE0 GLLPVLESFKVSFLSALEEYTKKLNTQ ::::::::::::::::::::::::::: NP_000 GLLPVLESFKVSFLSALEEYTKKLNTQ 250 260 >>NP_001304950 (OMIM: 105200,107680,604091) apolipoprote (158 aa) initn: 1006 init1: 1006 opt: 1006 Z-score: 697.0 bits: 135.9 E(85289): 4.4e-32 Smith-Waterman score: 1006; 100.0% identity (100.0% similar) in 158 aa overlap (110-267:1-158) 80 90 100 110 120 130 pF1KE0 TFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELY :::::::::::::::::::::::::::::: NP_001 MSKDLEEVKAKVQPYLDDFQKKWQEEMELY 10 20 30 140 150 160 170 180 190 pF1KE0 RQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLA 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE0 ARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEE 100 110 120 130 140 150 260 pF1KE0 YTKKLNTQ :::::::: NP_001 YTKKLNTQ >>XP_016872658 (OMIM: 144650,145750,606368) PREDICTED: a (366 aa) initn: 228 init1: 176 opt: 232 Z-score: 178.3 bits: 41.1 E(85289): 0.0034 Smith-Waterman score: 238; 25.9% identity (59.9% similar) in 232 aa overlap (3-223:5-216) 10 20 30 40 50 pF1KE0 MKAAVLTLAVLFLTG---SQARH-FWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYV ::::: :. .:.. .:::. :: : :. :. :: : XP_016 MASMAAVLTWALALLSAFSATQARKGFW--DYFSQTSGDK---------------GR--V 10 20 30 40 60 70 80 90 100 110 pF1KE0 SQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDL :.. . .... : :. .. ....:. :.: :.. : .. :.:......: XP_016 EQIHQQKMARE-PATLKDSLEQDLNNMNKFLEKLRPLSGSEAPRLPQDPVGMRRQLQEEL 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE0 EEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMR- :::::..:::. . .. ..: ::...: .:.: . ...::::.: .::. . XP_016 EEVKARLQPYMAEAHELVGWNLEGLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKA 110 120 130 140 150 160 180 190 200 210 220 pF1KE0 ------DRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTL :.: : ...:..... .. .... . :.: . : .. : : ... : XP_016 QLLGGVDEAWALLQGLQSRVVHHTGRFKELFHPYAESLVSGIGRHVQELHRSVAPHAPAS 170 180 190 200 210 220 230 240 250 260 pF1KE0 SEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ XP_016 PARLSRCVQVLSRKLTLKAKALHARIQQNLDQLREELSRAFAGTGTEEGAGPDPQMLSEE 230 240 250 260 270 280 >>NP_001160070 (OMIM: 144650,145750,606368) apolipoprote (366 aa) initn: 228 init1: 176 opt: 232 Z-score: 178.3 bits: 41.1 E(85289): 0.0034 Smith-Waterman score: 238; 25.9% identity (59.9% similar) in 232 aa overlap (3-223:5-216) 10 20 30 40 50 pF1KE0 MKAAVLTLAVLFLTG---SQARH-FWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYV ::::: :. .:.. .:::. :: : :. :. :: : NP_001 MASMAAVLTWALALLSAFSATQARKGFW--DYFSQTSGDK---------------GR--V 10 20 30 40 60 70 80 90 100 110 pF1KE0 SQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDL :.. . .... : :. .. ....:. :.: :.. : .. :.:......: NP_001 EQIHQQKMARE-PATLKDSLEQDLNNMNKFLEKLRPLSGSEAPRLPQDPVGMRRQLQEEL 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE0 EEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMR- :::::..:::. . .. ..: ::...: .:.: . ...::::.: .::. . NP_001 EEVKARLQPYMAEAHELVGWNLEGLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKA 110 120 130 140 150 160 180 190 200 210 220 pF1KE0 ------DRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTL :.: : ...:..... .. .... . :.: . : .. : : ... : NP_001 QLLGGVDEAWALLQGLQSRVVHHTGRFKELFHPYAESLVSGIGRHVQELHRSVAPHAPAS 170 180 190 200 210 220 230 240 250 260 pF1KE0 SEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ NP_001 PARLSRCVQVLSRKLTLKAKALHARIQQNLDQLREELSRAFAGTGTEEGAGPDPQMLSEE 230 240 250 260 270 280 >>NP_443200 (OMIM: 144650,145750,606368) apolipoprotein (366 aa) initn: 228 init1: 176 opt: 232 Z-score: 178.3 bits: 41.1 E(85289): 0.0034 Smith-Waterman score: 238; 25.9% identity (59.9% similar) in 232 aa overlap (3-223:5-216) 10 20 30 40 50 pF1KE0 MKAAVLTLAVLFLTG---SQARH-FWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYV ::::: :. .:.. .:::. :: : :. :. :: : NP_443 MASMAAVLTWALALLSAFSATQARKGFW--DYFSQTSGDK---------------GR--V 10 20 30 40 60 70 80 90 100 110 pF1KE0 SQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDL :.. . .... : :. .. ....:. :.: :.. : .. :.:......: NP_443 EQIHQQKMARE-PATLKDSLEQDLNNMNKFLEKLRPLSGSEAPRLPQDPVGMRRQLQEEL 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE0 EEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMR- :::::..:::. . .. ..: ::...: .:.: . ...::::.: .::. . NP_443 EEVKARLQPYMAEAHELVGWNLEGLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKA 110 120 130 140 150 160 180 190 200 210 220 pF1KE0 ------DRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTL :.: : ...:..... .. .... . :.: . : .. : : ... : NP_443 QLLGGVDEAWALLQGLQSRVVHHTGRFKELFHPYAESLVSGIGRHVQELHRSVAPHAPAS 170 180 190 200 210 220 230 240 250 260 pF1KE0 SEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ NP_443 PARLSRCVQVLSRKLTLKAKALHARIQQNLDQLREELSRAFAGTGTEEGAGPDPQMLSEE 230 240 250 260 270 280 >>NP_000473 (OMIM: 107690) apolipoprotein A-IV precursor (396 aa) initn: 459 init1: 208 opt: 228 Z-score: 175.2 bits: 40.7 E(85289): 0.0051 Smith-Waterman score: 343; 25.5% identity (61.6% similar) in 263 aa overlap (3-265:5-257) 10 20 30 40 50 pF1KE0 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFE :.:::::.. ..: :: . :. :: : . :...... : ... NP_000 MFLKAVVLTLALVAVAG--ARAEVSADQVATVMWD--------YFSQLSNNAKEAVEHLQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 GSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVK : : .::: . :. :.. . :...: : . :. . : :..: :..:..:.:::.. NP_000 KSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 AKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARA :.. :. .. ..: .... .:..:: .:. . . ..:...:.: ...:. : NP_000 ARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 HVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDL ..:.:.. : :..:::. .. .: :: :...: . . : .. : .: NP_000 NADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDT 180 190 200 210 220 230 240 250 260 pF1KE0 RQGLLPVLESFKVSFLSALEEYTKKLNTQ .. : ::.. .. . :: ... NP_000 QEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLA 240 250 260 270 280 290 267 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 02:12:51 2016 done: Sat Nov 5 02:12:53 2016 Total Scan time: 8.010 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]