FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0104, 462 aa 1>>>pF1KE0104 462 - 462 aa - 462 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9509+/-0.00104; mu= 14.1934+/- 0.062 mean_var=105.6736+/-20.461, 0's: 0 Z-trim(106.9): 116 B-trim: 0 in 0/51 Lambda= 0.124765 statistics sampled from 9131 (9262) to 9131 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.663), E-opt: 0.2 (0.285), width: 16 Scan time: 3.160 The best scores are: opt bits E(32554) CCDS4096.1 NUDT12 gene_id:83594|Hs108|chr5 ( 462) 3134 575.3 4.5e-164 CCDS75284.1 NUDT12 gene_id:83594|Hs108|chr5 ( 444) 2689 495.2 5.6e-140 CCDS60553.1 NUDT13 gene_id:25961|Hs108|chr10 ( 226) 388 80.8 1.6e-15 CCDS31220.1 NUDT13 gene_id:25961|Hs108|chr10 ( 352) 388 81.0 2.3e-15 CCDS73148.1 NUDT13 gene_id:25961|Hs108|chr10 ( 155) 351 74.0 1.2e-13 >>CCDS4096.1 NUDT12 gene_id:83594|Hs108|chr5 (462 aa) initn: 3134 init1: 3134 opt: 3134 Z-score: 3059.2 bits: 575.3 E(32554): 4.5e-164 Smith-Waterman score: 3134; 100.0% identity (100.0% similar) in 462 aa overlap (1-462:1-462) 10 20 30 40 50 60 pF1KE0 MSSVKRSLKQEIVTQFHCSAAEGDIAKLTGILSHSPSLLNETSENGWTALMYAARNGHPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 MSSVKRSLKQEIVTQFHCSAAEGDIAKLTGILSHSPSLLNETSENGWTALMYAARNGHPE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 IVQFLLEKGCDRSIVNKSRQTALDIAVFWGYKHIANLLATAKGGKKPWFLTNEVEECENY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 IVQFLLEKGCDRSIVNKSRQTALDIAVFWGYKHIANLLATAKGGKKPWFLTNEVEECENY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 FSKTLLDRKSEKRNNSDWLLAKESHPATVFILFSDLNPLVTLGGNKESFQQPEVRLCQLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 FSKTLLDRKSEKRNNSDWLLAKESHPATVFILFSDLNPLVTLGGNKESFQQPEVRLCQLN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 YTDIKDYLAQPEKITLIFLGVELEIKDKLLNYAGEVPREEEDGLVAWFALGIDPIAAEEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 YTDIKDYLAQPEKITLIFLGVELEIKDKLLNYAGEVPREEEDGLVAWFALGIDPIAAEEF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 KQRHENCYFLHPPMPALLQLKEKEAGVVAQARSVLAWHSRYKFCPTCGNATKIEEGGYKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 KQRHENCYFLHPPMPALLQLKEKEAGVVAQARSVLAWHSRYKFCPTCGNATKIEEGGYKR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 LCLKEDCPSLNGVHNTSYPRVDPVVIMQVIHPDGTKCLLGRQKRFPPGMFTCLAGFIEPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 LCLKEDCPSLNGVHNTSYPRVDPVVIMQVIHPDGTKCLLGRQKRFPPGMFTCLAGFIEPG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 ETIEDAVRREVEEESGVKVGHVQYVACQPWPMPSSLMIGCLALAVSTEIKVDKNEIEDAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS40 ETIEDAVRREVEEESGVKVGHVQYVACQPWPMPSSLMIGCLALAVSTEIKVDKNEIEDAR 370 380 390 400 410 420 430 440 450 460 pF1KE0 WFTREQVLDVLTKGKQQAFFVPPSRAIAHQLIKHWIRINPNL :::::::::::::::::::::::::::::::::::::::::: CCDS40 WFTREQVLDVLTKGKQQAFFVPPSRAIAHQLIKHWIRINPNL 430 440 450 460 >>CCDS75284.1 NUDT12 gene_id:83594|Hs108|chr5 (444 aa) initn: 2999 init1: 2689 opt: 2689 Z-score: 2626.5 bits: 495.2 E(32554): 5.6e-140 Smith-Waterman score: 2967; 96.1% identity (96.1% similar) in 462 aa overlap (1-462:1-444) 10 20 30 40 50 60 pF1KE0 MSSVKRSLKQEIVTQFHCSAAEGDIAKLTGILSHSPSLLNETSENGWTALMYAARNGHPE ::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 MSSVKRSLKQEIVTQFHCSAAEGDIAKLTGILSHSPSLLNETSENGWTALM--------- 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 IVQFLLEKGCDRSIVNKSRQTALDIAVFWGYKHIANLLATAKGGKKPWFLTNEVEECENY ::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 ---------CDRSIVNKSRQTALDIAVFWGYKHIANLLATAKGGKKPWFLTNEVEECENY 60 70 80 90 100 130 140 150 160 170 180 pF1KE0 FSKTLLDRKSEKRNNSDWLLAKESHPATVFILFSDLNPLVTLGGNKESFQQPEVRLCQLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 FSKTLLDRKSEKRNNSDWLLAKESHPATVFILFSDLNPLVTLGGNKESFQQPEVRLCQLN 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE0 YTDIKDYLAQPEKITLIFLGVELEIKDKLLNYAGEVPREEEDGLVAWFALGIDPIAAEEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 YTDIKDYLAQPEKITLIFLGVELEIKDKLLNYAGEVPREEEDGLVAWFALGIDPIAAEEF 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE0 KQRHENCYFLHPPMPALLQLKEKEAGVVAQARSVLAWHSRYKFCPTCGNATKIEEGGYKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 KQRHENCYFLHPPMPALLQLKEKEAGVVAQARSVLAWHSRYKFCPTCGNATKIEEGGYKR 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE0 LCLKEDCPSLNGVHNTSYPRVDPVVIMQVIHPDGTKCLLGRQKRFPPGMFTCLAGFIEPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 LCLKEDCPSLNGVHNTSYPRVDPVVIMQVIHPDGTKCLLGRQKRFPPGMFTCLAGFIEPG 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE0 ETIEDAVRREVEEESGVKVGHVQYVACQPWPMPSSLMIGCLALAVSTEIKVDKNEIEDAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 ETIEDAVRREVEEESGVKVGHVQYVACQPWPMPSSLMIGCLALAVSTEIKVDKNEIEDAR 350 360 370 380 390 400 430 440 450 460 pF1KE0 WFTREQVLDVLTKGKQQAFFVPPSRAIAHQLIKHWIRINPNL :::::::::::::::::::::::::::::::::::::::::: CCDS75 WFTREQVLDVLTKGKQQAFFVPPSRAIAHQLIKHWIRINPNL 410 420 430 440 >>CCDS60553.1 NUDT13 gene_id:25961|Hs108|chr10 (226 aa) initn: 556 init1: 263 opt: 388 Z-score: 392.1 bits: 80.8 E(32554): 1.6e-15 Smith-Waterman score: 557; 44.3% identity (70.8% similar) in 212 aa overlap (256-456:15-216) 230 240 250 260 270 280 pF1KE0 AWFALGIDPIAAEEFKQRHENCYFLHPPMPALLQLKEKEAGVVAQARSVLAWHSRYKFCP ::.::. ..:.... :...: ::. ..:: CCDS60 METELKGSFIELRKALFQLNARDASLLSTAQALLRWHDAHQFCS 10 20 30 40 290 300 310 320 330 340 pF1KE0 TCGNATKIEEGGYKRLCLKEDCPSLNGVHNTSYPRVDPVVIMQVIHPDGTKCLLGRQKRF :. :: . .: ::.: :: : .. ::.. ::.: : :::.:::.::. : CCDS60 RSGQPTKKNVAGSKRVC-----PSNNIIY---YPQMAPVAITLV--SDGTRCLLARQSSF 50 60 70 80 90 350 360 370 380 390 400 pF1KE0 PPGMFTCLAGFIEPGETIEDAVRREVEEESGVKVGHVQYVACQPWPMPS-SLMIGCLALA : ::.. :::: . ::..:...:::: :: :..: .:: : : ::.:: ::::.: : . CCDS60 PKGMYSALAGFCDIGESVEETIRREVAEEVGLEVESLQYYASQHWPFPSGSLMIACHATV 100 110 120 130 140 150 410 420 430 440 450 pF1KE0 V--STEIKVDKNEIEDARWFTREQVLDVLT-KG---KQQA----FFVPPSRAIAHQLIKH .:::.:. :.: : ::....: .: :: .:: :..::. ::.:::::. CCDS60 KPGQTEIQVNLRELETAAWFSHDEVATALKRKGPYTQQQNGTFPFWLPPKLAISHQLIKE 160 170 180 190 200 210 460 pF1KE0 WIRINPNL :. CCDS60 WVEKQTCSSLPA 220 >>CCDS31220.1 NUDT13 gene_id:25961|Hs108|chr10 (352 aa) initn: 562 init1: 263 opt: 388 Z-score: 389.5 bits: 81.0 E(32554): 2.3e-15 Smith-Waterman score: 577; 36.8% identity (62.0% similar) in 334 aa overlap (142-456:41-342) 120 130 140 150 160 170 pF1KE0 NEVEECENYFSKTLLDRKSEKRNNSDWLLAKESHPATVFILFSDLNPLVTLGGNKESFQQ :... . .: :: .: ::. .... . CCDS31 RKFFWCYRLLSTYVTKTRYLFELKEDDDACKKAQQTGAFYLFHSLAPLLQTSAHQ--YLA 20 30 40 50 60 180 190 200 210 220 230 pF1KE0 PEVRLCQLNYTDIKDYLAQPEKITLIFLGVELEIKDKLLNYAGEVPREEEDGLVAWFAL- :. : .: :.. : .:.:..: : ..: ::::: CCDS31 PRHSLLEL------------ERLLGKFGQDAQRIEDSVL--IGCSEQQE-----AWFALD 70 80 90 100 240 250 260 270 280 pF1KE0 -GIDP---IAAEEFKQRHENCY---FLHPPMPALLQLKEKEAGVVAQARSVLAWHSRYKF :.: :.: : . :. :.. ::.::. ..:.... :...: ::. ..: CCDS31 LGLDSSFSISASLHKPEMETELKGSFIEL-RKALFQLNARDASLLSTAQALLRWHDAHQF 110 120 130 140 150 160 290 300 310 320 330 340 pF1KE0 CPTCGNATKIEEGGYKRLCLKEDCPSLNGVHNTSYPRVDPVVIMQVIHPDGTKCLLGRQK : :. :: . .: ::.: :: : .. ::.. ::.: : :::.:::.::. CCDS31 CSRSGQPTKKNVAGSKRVC-----PSNNIIY---YPQMAPVAITLV--SDGTRCLLARQS 170 180 190 200 210 350 360 370 380 390 400 pF1KE0 RFPPGMFTCLAGFIEPGETIEDAVRREVEEESGVKVGHVQYVACQPWPMPS-SLMIGCLA :: ::.. :::: . ::..:...:::: :: :..: .:: : : ::.:: ::::.: : CCDS31 SFPKGMYSALAGFCDIGESVEETIRREVAEEVGLEVESLQYYASQHWPFPSGSLMIACHA 220 230 240 250 260 270 410 420 430 440 450 pF1KE0 LAV--STEIKVDKNEIEDARWFTREQVLDVLT-KG---KQQA----FFVPPSRAIAHQLI . .:::.:. :.: : ::....: .: :: .:: :..::. ::.:::: CCDS31 TVKPGQTEIQVNLRELETAAWFSHDEVATALKRKGPYTQQQNGTFPFWLPPKLAISHQLI 280 290 300 310 320 330 460 pF1KE0 KHWIRINPNL :.:. CCDS31 KEWVEKQTCSSLPA 340 350 >>CCDS73148.1 NUDT13 gene_id:25961|Hs108|chr10 (155 aa) initn: 390 init1: 263 opt: 351 Z-score: 358.2 bits: 74.0 E(32554): 1.2e-13 Smith-Waterman score: 420; 49.0% identity (72.4% similar) in 145 aa overlap (323-456:3-145) 300 310 320 330 340 350 pF1KE0 IEEGGYKRLCLKEDCPSLNGVHNTSYPRVDPVVIMQVIHPDGTKCLLGRQKRFPPGMFTC ::.: : :::.:::.::. :: ::.. CCDS73 MAPVAITLV--SDGTRCLLARQSSFPKGMYSA 10 20 30 360 370 380 390 400 pF1KE0 LAGFIEPGETIEDAVRREVEEESGVKVGHVQYVACQPWPMPS-SLMIGCLALAV--STEI :::: . ::..:...:::: :: :..: .:: : : ::.:: ::::.: : . .::: CCDS73 LAGFCDIGESVEETIRREVAEEVGLEVESLQYYASQHWPFPSGSLMIACHATVKPGQTEI 40 50 60 70 80 90 410 420 430 440 450 460 pF1KE0 KVDKNEIEDARWFTREQVLDVLT-KG---KQQA----FFVPPSRAIAHQLIKHWIRINPN .:. :.: : ::....: .: :: .:: :..::. ::.:::::.:. CCDS73 QVNLRELETAAWFSHDEVATALKRKGPYTQQQNGTFPFWLPPKLAISHQLIKEWVEKQTC 100 110 120 130 140 150 pF1KE0 L CCDS73 SSLPA 462 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 03:04:45 2016 done: Fri Nov 4 03:04:46 2016 Total Scan time: 3.160 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]