FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0114, 308 aa 1>>>pF1KE0114 308 - 308 aa - 308 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1888+/-0.000314; mu= 16.1225+/- 0.020 mean_var=66.6234+/-13.630, 0's: 0 Z-trim(116.6): 11 B-trim: 616 in 1/53 Lambda= 0.157131 statistics sampled from 27901 (27910) to 27901 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.706), E-opt: 0.2 (0.327), width: 16 Scan time: 7.830 The best scores are: opt bits E(85289) NP_009194 (OMIM: 606942) coatomer subunit epsilon ( 308) 2016 465.6 5.6e-131 NP_955476 (OMIM: 606942) coatomer subunit epsilon ( 256) 1242 290.1 3.2e-78 NP_955474 (OMIM: 606942) coatomer subunit epsilon ( 257) 1050 246.6 4e-65 NP_001317398 (OMIM: 606942) coatomer subunit epsil ( 331) 1047 245.9 8e-65 XP_011525958 (OMIM: 606942) PREDICTED: coatomer su ( 279) 958 225.7 8.2e-59 >>NP_009194 (OMIM: 606942) coatomer subunit epsilon isof (308 aa) initn: 2016 init1: 2016 opt: 2016 Z-score: 2472.4 bits: 465.6 E(85289): 5.6e-131 Smith-Waterman score: 2016; 100.0% identity (100.0% similar) in 308 aa overlap (1-308:1-308) 10 20 30 40 50 60 pF1KE0 MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESRRDSIVAELDREMSRSVDVTNTTFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 LAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESRRDSIVAELDREMSRSVDVTNTTFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LMAASIYLHDQNPDAALRALHQGDSLECTAMTVQILLKLDRLDLARKELKRMQDLDEDAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 LMAASIYLHDQNPDAALRALHQGDSLECTAMTVQILLKLDRLDLARKELKRMQDLDEDAT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LTQLATAWVSLATGGEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWEAAEGLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 LTQLATAWVSLATGGEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWEAAEGLLQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 EALDKDSGYPETLVNLIVLSQHLGKPPEVTNRYLSQLKDAHRSHPFIKEYQAKENDFDRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 EALDKDSGYPETLVNLIVLSQHLGKPPEVTNRYLSQLKDAHRSHPFIKEYQAKENDFDRL 250 260 270 280 290 300 pF1KE0 VLQYAPSA :::::::: NP_009 VLQYAPSA >>NP_955476 (OMIM: 606942) coatomer subunit epsilon isof (256 aa) initn: 1242 init1: 1242 opt: 1242 Z-score: 1525.3 bits: 290.1 E(85289): 3.2e-78 Smith-Waterman score: 1547; 83.1% identity (83.1% similar) in 308 aa overlap (1-308:1-256) 10 20 30 40 50 60 pF1KE0 MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESRRDSIVAELDREMSRSVDVTNTTFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 LAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESRRDSIVAELDREMSRSVDVTNTTFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LMAASIYLHDQNPDAALRALHQGDSLECTAMTVQILLKLDRLDLARKELKRMQDLDEDAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 LMAASIYLHDQNPDAALRALHQGDSLECTAMTVQILLKLDRLDLARKELKRMQDLDEDAT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LTQLATAWVSLATGGEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWEAAEGLLQ ::::::::::::: NP_955 LTQLATAWVSLAT----------------------------------------------- 190 250 260 270 280 290 300 pF1KE0 EALDKDSGYPETLVNLIVLSQHLGKPPEVTNRYLSQLKDAHRSHPFIKEYQAKENDFDRL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 -----DSGYPETLVNLIVLSQHLGKPPEVTNRYLSQLKDAHRSHPFIKEYQAKENDFDRL 200 210 220 230 240 pF1KE0 VLQYAPSA :::::::: NP_955 VLQYAPSA 250 >>NP_955474 (OMIM: 606942) coatomer subunit epsilon isof (257 aa) initn: 1045 init1: 1045 opt: 1050 Z-score: 1290.1 bits: 246.6 E(85289): 4e-65 Smith-Waterman score: 1570; 83.1% identity (83.1% similar) in 308 aa overlap (1-308:1-257) 10 20 30 40 50 60 pF1KE0 MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESRRDSIVAELDREMSRSVDVTNTTFL :::::::::::::::::::::::::::::::::::: NP_955 LAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESRS----------------------- 70 80 90 130 140 150 160 170 180 pF1KE0 LMAASIYLHDQNPDAALRALHQGDSLECTAMTVQILLKLDRLDLARKELKRMQDLDEDAT :::::::::::::::::::::::::::::::: NP_955 ----------------------------TAMTVQILLKLDRLDLARKELKRMQDLDEDAT 100 110 120 190 200 210 220 230 240 pF1KE0 LTQLATAWVSLATGGEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWEAAEGLLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 LTQLATAWVSLATGGEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWEAAEGLLQ 130 140 150 160 170 180 250 260 270 280 290 300 pF1KE0 EALDKDSGYPETLVNLIVLSQHLGKPPEVTNRYLSQLKDAHRSHPFIKEYQAKENDFDRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 EALDKDSGYPETLVNLIVLSQHLGKPPEVTNRYLSQLKDAHRSHPFIKEYQAKENDFDRL 190 200 210 220 230 240 pF1KE0 VLQYAPSA :::::::: NP_955 VLQYAPSA 250 >>NP_001317398 (OMIM: 606942) coatomer subunit epsilon i (331 aa) initn: 1989 init1: 1045 opt: 1047 Z-score: 1284.8 bits: 245.9 E(85289): 8e-65 Smith-Waterman score: 1943; 92.7% identity (92.7% similar) in 331 aa overlap (1-308:1-331) 10 20 30 40 50 60 pF1KE0 MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESRRDSIVAELDREMSRSVDVTNTTFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESRRDSIVAELDREMSRSVDVTNTTFL 70 80 90 100 110 120 130 140 150 pF1KE0 LMAASIYLHDQNPDAALRALHQGDSLE-----------------------CTAMTVQILL ::::::::::::::::::::::::::: ::::::::: NP_001 LMAASIYLHDQNPDAALRALHQGDSLEWVSSPGRALHLEAQPMEAASPDGRTAMTVQILL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 KLDRLDLARKELKRMQDLDEDATLTQLATAWVSLATGGEKLQDAYYIFQEMADKCSPTLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLDRLDLARKELKRMQDLDEDATLTQLATAWVSLATGGEKLQDAYYIFQEMADKCSPTLL 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE0 LLNGQAACHMAQGRWEAAEGLLQEALDKDSGYPETLVNLIVLSQHLGKPPEVTNRYLSQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLNGQAACHMAQGRWEAAEGLLQEALDKDSGYPETLVNLIVLSQHLGKPPEVTNRYLSQL 250 260 270 280 290 300 280 290 300 pF1KE0 KDAHRSHPFIKEYQAKENDFDRLVLQYAPSA ::::::::::::::::::::::::::::::: NP_001 KDAHRSHPFIKEYQAKENDFDRLVLQYAPSA 310 320 330 >>XP_011525958 (OMIM: 606942) PREDICTED: coatomer subuni (279 aa) initn: 1366 init1: 958 opt: 958 Z-score: 1176.8 bits: 225.7 E(85289): 8.2e-59 Smith-Waterman score: 1474; 77.0% identity (77.0% similar) in 331 aa overlap (1-308:1-279) 10 20 30 40 50 60 pF1KE0 MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESRRDSIVAELDREMSRSVDVTNTTFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESRRDSIVAELDREMSRSVDVTNTTFL 70 80 90 100 110 120 130 140 150 pF1KE0 LMAASIYLHDQNPDAALRALHQGDSLE-----------------------CTAMTVQILL ::::::::::::::::::::::::::: ::::::::: XP_011 LMAASIYLHDQNPDAALRALHQGDSLEWVSSPGRALHLEAQPMEAASPDGRTAMTVQILL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 KLDRLDLARKELKRMQDLDEDATLTQLATAWVSLATGGEKLQDAYYIFQEMADKCSPTLL :::::::::::::::::::::::::::::::::::: XP_011 KLDRLDLARKELKRMQDLDEDATLTQLATAWVSLAT------------------------ 190 200 210 220 230 240 250 260 270 pF1KE0 LLNGQAACHMAQGRWEAAEGLLQEALDKDSGYPETLVNLIVLSQHLGKPPEVTNRYLSQL :::::::::::::::::::::::::::::::: XP_011 ----------------------------DSGYPETLVNLIVLSQHLGKPPEVTNRYLSQL 220 230 240 280 290 300 pF1KE0 KDAHRSHPFIKEYQAKENDFDRLVLQYAPSA ::::::::::::::::::::::::::::::: XP_011 KDAHRSHPFIKEYQAKENDFDRLVLQYAPSA 250 260 270 308 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 02:31:23 2016 done: Fri Nov 4 02:31:24 2016 Total Scan time: 7.830 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]