FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0125, 121 aa 1>>>pF1KE0125 121 - 121 aa - 121 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2112+/-0.000311; mu= 10.8843+/- 0.019 mean_var=58.0640+/-11.676, 0's: 0 Z-trim(115.8): 25 B-trim: 86 in 1/51 Lambda= 0.168314 statistics sampled from 26427 (26452) to 26427 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.715), E-opt: 0.2 (0.31), width: 16 Scan time: 4.170 The best scores are: opt bits E(85289) NP_115903 (OMIM: 601242) microtubule-associated pr ( 121) 806 203.4 7.5e-53 XP_011527387 (OMIM: 601242) PREDICTED: microtubule ( 182) 806 203.4 1.1e-52 XP_011527386 (OMIM: 601242) PREDICTED: microtubule ( 223) 806 203.5 1.3e-52 XP_011527385 (OMIM: 601242) PREDICTED: microtubule ( 223) 806 203.5 1.3e-52 NP_852610 (OMIM: 601242) microtubule-associated pr ( 125) 711 180.3 6.8e-46 NP_073729 (OMIM: 609604) microtubule-associated pr ( 125) 669 170.1 8e-43 XP_005273196 (OMIM: 609605) PREDICTED: microtubule ( 147) 466 120.8 6.4e-28 NP_001004343 (OMIM: 609605) microtubule-associated ( 147) 466 120.8 6.4e-28 NP_009216 (OMIM: 607452) gamma-aminobutyric acid r ( 117) 332 88.3 3.3e-18 NP_113600 (OMIM: 607420) gamma-aminobutyric acid r ( 117) 270 73.2 1.1e-13 NP_009209 (OMIM: 605125) gamma-aminobutyric acid r ( 117) 240 65.9 1.7e-11 XP_005253401 (OMIM: 607420) PREDICTED: gamma-amino ( 146) 213 59.4 2e-09 >>NP_115903 (OMIM: 601242) microtubule-associated protei (121 aa) initn: 806 init1: 806 opt: 806 Z-score: 1069.8 bits: 203.4 E(85289): 7.5e-53 Smith-Waterman score: 806; 100.0% identity (100.0% similar) in 121 aa overlap (1-121:1-121) 10 20 30 40 50 60 pF1KE0 MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYASQETFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 SELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYASQETFG 70 80 90 100 110 120 pF1KE0 F : NP_115 F >>XP_011527387 (OMIM: 601242) PREDICTED: microtubule-ass (182 aa) initn: 806 init1: 806 opt: 806 Z-score: 1067.0 bits: 203.4 E(85289): 1.1e-52 Smith-Waterman score: 806; 100.0% identity (100.0% similar) in 121 aa overlap (1-121:62-182) 10 20 30 pF1KE0 MPSDRPFKQRRSFADRCKEVQQIRDQHPSK :::::::::::::::::::::::::::::: XP_011 REARSPRSPQTADTSPRPRAPACAPSRARAMPSDRPFKQRRSFADRCKEVQQIRDQHPSK 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE0 IPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVS 100 110 120 130 140 150 100 110 120 pF1KE0 VSTPIADIYEQEKDEDGFLYMVYASQETFGF ::::::::::::::::::::::::::::::: XP_011 VSTPIADIYEQEKDEDGFLYMVYASQETFGF 160 170 180 >>XP_011527386 (OMIM: 601242) PREDICTED: microtubule-ass (223 aa) initn: 806 init1: 806 opt: 806 Z-score: 1065.6 bits: 203.5 E(85289): 1.3e-52 Smith-Waterman score: 806; 100.0% identity (100.0% similar) in 121 aa overlap (1-121:103-223) 10 20 30 pF1KE0 MPSDRPFKQRRSFADRCKEVQQIRDQHPSK :::::::::::::::::::::::::::::: XP_011 REARSPRSPQTADTSPRPRAPACAPSRARAMPSDRPFKQRRSFADRCKEVQQIRDQHPSK 80 90 100 110 120 130 40 50 60 70 80 90 pF1KE0 IPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVS 140 150 160 170 180 190 100 110 120 pF1KE0 VSTPIADIYEQEKDEDGFLYMVYASQETFGF ::::::::::::::::::::::::::::::: XP_011 VSTPIADIYEQEKDEDGFLYMVYASQETFGF 200 210 220 >>XP_011527385 (OMIM: 601242) PREDICTED: microtubule-ass (223 aa) initn: 806 init1: 806 opt: 806 Z-score: 1065.6 bits: 203.5 E(85289): 1.3e-52 Smith-Waterman score: 806; 100.0% identity (100.0% similar) in 121 aa overlap (1-121:103-223) 10 20 30 pF1KE0 MPSDRPFKQRRSFADRCKEVQQIRDQHPSK :::::::::::::::::::::::::::::: XP_011 REARSPRSPQTADTSPRPRAPACAPSRARAMPSDRPFKQRRSFADRCKEVQQIRDQHPSK 80 90 100 110 120 130 40 50 60 70 80 90 pF1KE0 IPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVS 140 150 160 170 180 190 100 110 120 pF1KE0 VSTPIADIYEQEKDEDGFLYMVYASQETFGF ::::::::::::::::::::::::::::::: XP_011 VSTPIADIYEQEKDEDGFLYMVYASQETFGF 200 210 220 >>NP_852610 (OMIM: 601242) microtubule-associated protei (125 aa) initn: 711 init1: 711 opt: 711 Z-score: 944.9 bits: 180.3 E(85289): 6.8e-46 Smith-Waterman score: 711; 100.0% identity (100.0% similar) in 108 aa overlap (14-121:18-125) 10 20 30 40 50 pF1KE0 MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLVPD ::::::::::::::::::::::::::::::::::::::::::: NP_852 MKMRFFSSPCGKAAVDPADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLVPD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 HVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYASQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_852 HVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYASQ 70 80 90 100 110 120 120 pF1KE0 ETFGF ::::: NP_852 ETFGF >>NP_073729 (OMIM: 609604) microtubule-associated protei (125 aa) initn: 669 init1: 669 opt: 669 Z-score: 889.8 bits: 170.1 E(85289): 8e-43 Smith-Waterman score: 669; 82.5% identity (95.0% similar) in 120 aa overlap (1-120:1-120) 10 20 30 40 50 60 pF1KE0 MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM :::.. :::::.: .: ..:. ::.:::.::::::::::::::::::::::::::::::: NP_073 MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYASQETFG :::.:::::::::: .:::::::: ::::::::::...::.::::::::::::::::::: NP_073 SELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFG 70 80 90 100 110 120 pF1KE0 F NP_073 MKLSV >>XP_005273196 (OMIM: 609605) PREDICTED: microtubule-ass (147 aa) initn: 466 init1: 466 opt: 466 Z-score: 622.3 bits: 120.8 E(85289): 6.4e-28 Smith-Waterman score: 466; 59.2% identity (85.0% similar) in 120 aa overlap (1-120:7-126) 10 20 30 40 50 pF1KE0 MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLV .:: ::::::.:.: : .:: :: . :.::::..::: : :: :::::::: XP_005 MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERYPRETFLPPLDKTKFLV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 PDHVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYA :....:.....::: :. : :.::.::::..:.::.:. .:.::.. ::::::.::.:: XP_005 PQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMAEIYRDYKDEDGFVYMTYA 70 80 90 100 110 120 120 pF1KE0 SQETFGF :::::: XP_005 SQETFGCLESAAPRDGSSLEDRPCNPL 130 140 >>NP_001004343 (OMIM: 609605) microtubule-associated pro (147 aa) initn: 466 init1: 466 opt: 466 Z-score: 622.3 bits: 120.8 E(85289): 6.4e-28 Smith-Waterman score: 466; 59.2% identity (85.0% similar) in 120 aa overlap (1-120:7-126) 10 20 30 40 50 pF1KE0 MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLV .:: ::::::.:.: : .:: :: . :.::::..::: : :: :::::::: NP_001 MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERYPRETFLPPLDKTKFLV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 PDHVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYA :....:.....::: :. : :.::.::::..:.::.:. .:.::.. ::::::.::.:: NP_001 PQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMAEIYRDYKDEDGFVYMTYA 70 80 90 100 110 120 120 pF1KE0 SQETFGF :::::: NP_001 SQETFGCLESAAPRDGSSLEDRPCNPL 130 140 >>NP_009216 (OMIM: 607452) gamma-aminobutyric acid recep (117 aa) initn: 328 init1: 127 opt: 332 Z-score: 448.0 bits: 88.3 E(85289): 3.3e-18 Smith-Waterman score: 332; 41.7% identity (80.9% similar) in 115 aa overlap (7-121:5-117) 10 20 30 40 50 60 pF1KE0 MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM ::. .:. :: : .:: ..:...:::.:. .: .:. .:: :.:::. ... NP_009 MKWMFKEDHSLEHRCVESAKIRAKYPDRVPVIVEKVSG-SQIVDIDKRKYLVPSDITV 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 SELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYASQETFG .... :::.:.:: .:.::.:.. .. . : ....::.:::::::::..:....::: NP_009 AQFMWIIRKRIQLPSEKAIFLFVDK-TVPQSSLTMGQLYEKEKDEDGFLYVAYSGENTFG 60 70 80 90 100 110 pF1KE0 F : NP_009 F >>NP_113600 (OMIM: 607420) gamma-aminobutyric acid recep (117 aa) initn: 260 init1: 123 opt: 270 Z-score: 366.6 bits: 73.2 E(85289): 1.1e-13 Smith-Waterman score: 270; 34.2% identity (78.9% similar) in 114 aa overlap (7-120:5-116) 10 20 30 40 50 60 pF1KE0 MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM .:. . : : :: ..:: ..:...:::.:. . ..: ::: :.:::. ... NP_113 MKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAP-KARVPDLDKRKYLVPSDLTV 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 SELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYASQETFG ... .::.:..: : .:.:..:: ... .:. ....::....:: :::..:... ..: NP_113 GQFYFLIRKRIHLRPEDALFFFVN-NTIPPTSATMGQLYEDNHEEDYFLYVAYSDESVYG 60 70 80 90 100 110 pF1KE0 F NP_113 K 121 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 01:58:27 2016 done: Fri Nov 4 01:58:27 2016 Total Scan time: 4.170 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]