FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0135, 339 aa 1>>>pF1KE0135 339 - 339 aa - 339 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.2778+/-0.000512; mu= -10.6962+/- 0.032 mean_var=370.5676+/-75.640, 0's: 0 Z-trim(118.6): 3 B-trim: 527 in 1/56 Lambda= 0.066626 statistics sampled from 31758 (31761) to 31758 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.687), E-opt: 0.2 (0.372), width: 16 Scan time: 7.840 The best scores are: opt bits E(85289) NP_004690 (OMIM: 300453) protein FAM50A [Homo sapi ( 339) 2198 225.1 1.8e-58 NP_036267 (OMIM: 614686) protein FAM50B [Homo sapi ( 325) 1158 125.1 2.1e-28 XP_016866218 (OMIM: 614686) PREDICTED: protein FAM ( 325) 1158 125.1 2.1e-28 >>NP_004690 (OMIM: 300453) protein FAM50A [Homo sapiens] (339 aa) initn: 2198 init1: 2198 opt: 2198 Z-score: 1170.9 bits: 225.1 E(85289): 1.8e-58 Smith-Waterman score: 2198; 100.0% identity (100.0% similar) in 339 aa overlap (1-339:1-339) 10 20 30 40 50 60 pF1KE0 MAQYKGAASEAGRAMHLMKKREKQREQMEQMKQRIAEENIMKSNIDKKFSAHYDAVEAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MAQYKGAASEAGRAMHLMKKREKQREQMEQMKQRIAEENIMKSNIDKKFSAHYDAVEAEL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KSSTVGLVTLNDMKAKQEALVKEREKQLAKKEQSKELQMKLEKLREKERKKEAKRKISSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KSSTVGLVTLNDMKAKQEALVKEREKQLAKKEQSKELQMKLEKLREKERKKEAKRKISSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 SFTLEEEEEGGEEEEEAAMYEEEMEREEITTKKRKLGKNPDVDTSFLPDRDREEEENRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SFTLEEEEEGGEEEEEAAMYEEEMEREEITTKKRKLGKNPDVDTSFLPDRDREEEENRLR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 EELRQEWEAKQEKIKSEEIEITFSYWDGSGHRRTVKMRKGNTMQQFLQKALEILRKDFSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EELRQEWEAKQEKIKSEEIEITFSYWDGSGHRRTVKMRKGNTMQQFLQKALEILRKDFSE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 LRSAGVEQLMYIKEDLIIPHHHSFYDFIVTKARGKSGPLFNFDVHDDVRLLSDATVEKDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LRSAGVEQLMYIKEDLIIPHHHSFYDFIVTKARGKSGPLFNFDVHDDVRLLSDATVEKDE 250 260 270 280 290 300 310 320 330 pF1KE0 SHAGKVVLRSWYEKNKHIFPASRWEPYDPEKKWDKYTIR ::::::::::::::::::::::::::::::::::::::: NP_004 SHAGKVVLRSWYEKNKHIFPASRWEPYDPEKKWDKYTIR 310 320 330 >>NP_036267 (OMIM: 614686) protein FAM50B [Homo sapiens] (325 aa) initn: 1726 init1: 1142 opt: 1158 Z-score: 630.9 bits: 125.1 E(85289): 2.1e-28 Smith-Waterman score: 1700; 74.3% identity (90.3% similar) in 339 aa overlap (1-339:1-325) 10 20 30 40 50 60 pF1KE0 MAQYKGAASEAGRAMHLMKKREKQREQMEQMKQRIAEENIMKSNIDKKFSAHYDAVEAEL ::::::. ::::::::.::::.:::::: .:::::::.:.::..::.:::::::::::: NP_036 MAQYKGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAEL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KSSTVGLVTLNDMKAKQEALVKEREKQLAKKEQSKELQMKLEKLREKERKKEAKRKISSL :::::::::::::::.:::::.:::.::::... .: ... :. ::.:...: ::::: : NP_036 KSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 SFTLEEEEEGGEEEEEAAMYEEEMEREEITTKKRKLGKNPDVDTSFLPDRDREEEENRLR ::.:.. .. .. : . . .::::::::::::::::::::::::: NP_036 SFALDDLDDQADAAE--------------ARRAGNLGKNPDVDTSFLPDRDREEEENRLR 130 140 150 160 190 200 210 220 230 240 pF1KE0 EELRQEWEAKQEKIKSEEIEITFSYWDGSGHRRTVKMRKGNTMQQFLQKALEILRKDFSE :::::::::..::.:.::.:.::::::::::::::..:::::.::::.:::. ::::: : NP_036 EELRQEWEAQREKVKDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLE 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE0 LRSAGVEQLMYIKEDLIIPHHHSFYDFIVTKARGKSGPLFNFDVHDDVRLLSDATVEKDE ::::::::::.::::::.::.:.:::::...:::::::::.::::::::::::::.:::: NP_036 LRSAGVEQLMFIKEDLILPHYHTFYDFIIARARGKSGPLFSFDVHDDVRLLSDATMEKDE 230 240 250 260 270 280 310 320 330 pF1KE0 SHAGKVVLRSWYEKNKHIFPASRWEPYDPEKKWDKYTIR ::::::::::::::::::::::::: ::::::::::::: NP_036 SHAGKVVLRSWYEKNKHIFPASRWEAYDPEKKWDKYTIR 290 300 310 320 >>XP_016866218 (OMIM: 614686) PREDICTED: protein FAM50B (325 aa) initn: 1726 init1: 1142 opt: 1158 Z-score: 630.9 bits: 125.1 E(85289): 2.1e-28 Smith-Waterman score: 1700; 74.3% identity (90.3% similar) in 339 aa overlap (1-339:1-325) 10 20 30 40 50 60 pF1KE0 MAQYKGAASEAGRAMHLMKKREKQREQMEQMKQRIAEENIMKSNIDKKFSAHYDAVEAEL ::::::. ::::::::.::::.:::::: .:::::::.:.::..::.:::::::::::: XP_016 MAQYKGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAEL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KSSTVGLVTLNDMKAKQEALVKEREKQLAKKEQSKELQMKLEKLREKERKKEAKRKISSL :::::::::::::::.:::::.:::.::::... .: ... :. ::.:...: ::::: : XP_016 KSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 SFTLEEEEEGGEEEEEAAMYEEEMEREEITTKKRKLGKNPDVDTSFLPDRDREEEENRLR ::.:.. .. .. : . . .::::::::::::::::::::::::: XP_016 SFALDDLDDQADAAE--------------ARRAGNLGKNPDVDTSFLPDRDREEEENRLR 130 140 150 160 190 200 210 220 230 240 pF1KE0 EELRQEWEAKQEKIKSEEIEITFSYWDGSGHRRTVKMRKGNTMQQFLQKALEILRKDFSE :::::::::..::.:.::.:.::::::::::::::..:::::.::::.:::. ::::: : XP_016 EELRQEWEAQREKVKDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLE 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE0 LRSAGVEQLMYIKEDLIIPHHHSFYDFIVTKARGKSGPLFNFDVHDDVRLLSDATVEKDE ::::::::::.::::::.::.:.:::::...:::::::::.::::::::::::::.:::: XP_016 LRSAGVEQLMFIKEDLILPHYHTFYDFIIARARGKSGPLFSFDVHDDVRLLSDATMEKDE 230 240 250 260 270 280 310 320 330 pF1KE0 SHAGKVVLRSWYEKNKHIFPASRWEPYDPEKKWDKYTIR ::::::::::::::::::::::::: ::::::::::::: XP_016 SHAGKVVLRSWYEKNKHIFPASRWEAYDPEKKWDKYTIR 290 300 310 320 339 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 01:09:57 2016 done: Fri Nov 4 01:09:58 2016 Total Scan time: 7.840 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]