FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0143, 310 aa 1>>>pF1KE0143 310 - 310 aa - 310 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6410+/-0.000765; mu= 14.7736+/- 0.046 mean_var=82.7092+/-16.248, 0's: 0 Z-trim(109.9): 28 B-trim: 0 in 0/50 Lambda= 0.141025 statistics sampled from 11173 (11197) to 11173 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.708), E-opt: 0.2 (0.344), width: 16 Scan time: 2.800 The best scores are: opt bits E(32554) CCDS78409.1 AUH gene_id:549|Hs108|chr9 ( 310) 2003 416.9 1e-116 CCDS6689.1 AUH gene_id:549|Hs108|chr9 ( 339) 1084 229.9 2.1e-60 CCDS55600.1 ECHDC2 gene_id:55268|Hs108|chr1 ( 292) 753 162.5 3.5e-40 CCDS571.1 ECHDC2 gene_id:55268|Hs108|chr1 ( 261) 698 151.3 7.5e-37 CCDS72794.1 ECHDC2 gene_id:55268|Hs108|chr1 ( 244) 462 103.3 2e-22 CCDS7681.1 ECHS1 gene_id:1892|Hs108|chr10 ( 290) 365 83.6 2e-16 >>CCDS78409.1 AUH gene_id:549|Hs108|chr9 (310 aa) initn: 2003 init1: 2003 opt: 2003 Z-score: 2208.9 bits: 416.9 E(32554): 1e-116 Smith-Waterman score: 2003; 100.0% identity (100.0% similar) in 310 aa overlap (1-310:1-310) 10 20 30 40 50 60 pF1KE0 MAAAVAAAPGALGSLHAGGARLVAACSAWLCPGLRLPGSLAGRRAGPAIWAQGWVPAAGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 MAAAVAAAPGALGSLHAGGARLVAACSAWLCPGLRLPGSLAGRRAGPAIWAQGWVPAAGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 PAPKRGYSSEMKTEDELRVRHLEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 PAPKRGYSSEMKTEDELRVRHLEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 DKKVRTIIIRSEVPGIFCAANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 DKKVRTIIIRSEVPGIFCAANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 TKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLEQNQEGDAAYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 TKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLEQNQEGDAAYR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 KALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIPTKDRLEGLLAFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 KALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIPTKDRLEGLLAFK 250 260 270 280 290 300 310 pF1KE0 EKRPPRYKGE :::::::::: CCDS78 EKRPPRYKGE 310 >>CCDS6689.1 AUH gene_id:549|Hs108|chr9 (339 aa) initn: 1989 init1: 1084 opt: 1084 Z-score: 1197.9 bits: 229.9 E(32554): 2.1e-60 Smith-Waterman score: 1935; 91.4% identity (91.4% similar) in 339 aa overlap (1-310:1-339) 10 20 30 40 50 60 pF1KE0 MAAAVAAAPGALGSLHAGGARLVAACSAWLCPGLRLPGSLAGRRAGPAIWAQGWVPAAGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 MAAAVAAAPGALGSLHAGGARLVAACSAWLCPGLRLPGSLAGRRAGPAIWAQGWVPAAGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 PAPKRGYSSEMKTEDELRVRHLEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 PAPKRGYSSEMKTEDELRVRHLEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKS 70 80 90 100 110 120 130 140 150 pF1KE0 DKKVRTIIIRSEVPGIFCA-----------------------------ANLPVPTIAAID ::::::::::::::::::: :::::::::::: CCDS66 DKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVINDIANLPVPTIAAID 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 GLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 GLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSA 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE0 RVLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS66 RVLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVD 250 260 270 280 290 300 280 290 300 310 pF1KE0 LVTGLAIEEACYAQTIPTKDRLEGLLAFKEKRPPRYKGE ::::::::::::::::::::::::::::::::::::::: CCDS66 LVTGLAIEEACYAQTIPTKDRLEGLLAFKEKRPPRYKGE 310 320 330 >>CCDS55600.1 ECHDC2 gene_id:55268|Hs108|chr1 (292 aa) initn: 871 init1: 738 opt: 753 Z-score: 834.8 bits: 162.5 E(32554): 3.5e-40 Smith-Waterman score: 837; 47.9% identity (75.4% similar) in 280 aa overlap (61-310:13-292) 40 50 60 70 80 pF1KE0 CPGLRLPGSLAGRRAGPAIWAQGWVPAAGGPAPKRGYSSEMKTE-DELRVRHLEEENRGI : :: .:. . .:..:: : ..:: CCDS55 MLRVLCLLRPWRPLRARGCASDGAAGGSEIQVRALAGPDQGI 10 20 30 40 90 100 110 120 130 pF1KE0 VVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCA---------- . . .:: ..:.:.. ... : ... :. :..::....:: : :.::: CCDS55 TEILMNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKEREQM 50 60 70 80 90 100 140 150 160 170 180 pF1KE0 -------------------ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVE : .:.:::::.::.:::::::::::::.::::::: :::.: CCDS55 SEAEVGVFVQRLRGLMNDIAAFPAPTIAAMDGFALGGGLELALACDLRVAASSAVMGLIE 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE0 TKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLEQNQEGDAAYR : ...::.:::::::: .:..:::::::..: :.: ::...::..:.. ::.::::::. CCDS55 TTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGLVNHAVAQNEEGDAAYQ 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE0 KALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIPTKDRLEGLLAFK .: ::.:.:::.:.:.:..:.::..: :::...:.::: ::::.:::.:::::. ::. CCDS55 RARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFR 230 240 250 260 270 280 310 pF1KE0 EKRPPRYKGE ::: :.. :. CCDS55 EKRTPKFVGK 290 >>CCDS571.1 ECHDC2 gene_id:55268|Hs108|chr1 (261 aa) initn: 753 init1: 584 opt: 698 Z-score: 775.1 bits: 151.3 E(32554): 7.5e-37 Smith-Waterman score: 698; 45.2% identity (76.2% similar) in 252 aa overlap (61-310:13-261) 40 50 60 70 80 pF1KE0 CPGLRLPGSLAGRRAGPAIWAQGWVPAAGGPAPKRGYSSEMKTE-DELRVRHLEEENRGI : :: .:. . .:..:: : ..:: CCDS57 MLRVLCLLRPWRPLRARGCASDGAAGGSEIQVRALAGPDQGI 10 20 30 40 90 100 110 120 130 140 pF1KE0 VVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCA-ANLPVPTIA . . .:: ..:.:.. ... : ... :. :..::....:: : :.::: :.: CCDS57 TEILMNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKEREQM 50 60 70 80 90 100 150 160 170 180 190 200 pF1KE0 AIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELI . ... .: :: :::: :::.:: ...::.:::::::: .:..:::::: CCDS57 SEAEVGVFVQRLRGLMNDI---ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELI 110 120 130 140 150 210 220 230 240 250 260 pF1KE0 FSARVLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGM :..: :.: ::...::..:.. ::.::::::..: ::.:.:::.:.:.:..:.::..: CCDS57 FTGRRLSGTEAHVLGLVNHAVAQNEEGDAAYQRARALAQEILPQAPIAVRLGKVAIDRGT 160 170 180 190 200 210 270 280 290 300 310 pF1KE0 EVDLVTGLAIEEACYAQTIPTKDRLEGLLAFKEKRPPRYKGE :::...:.::: ::::.:::.:::::. ::.::: :.. :. CCDS57 EVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKRTPKFVGK 220 230 240 250 260 >>CCDS72794.1 ECHDC2 gene_id:55268|Hs108|chr1 (244 aa) initn: 644 init1: 335 opt: 462 Z-score: 516.0 bits: 103.3 E(32554): 2e-22 Smith-Waterman score: 593; 42.1% identity (69.8% similar) in 252 aa overlap (61-310:13-244) 40 50 60 70 80 pF1KE0 CPGLRLPGSLAGRRAGPAIWAQGWVPAAGGPAPKRGYSSEMKTE-DELRVRHLEEENRGI : :: .:. . .:..:: : ..:: CCDS72 MLRVLCLLRPWRPLRARGCASDGAAGGSEIQVRALAGPDQGI 10 20 30 40 90 100 110 120 130 140 pF1KE0 VVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCA-ANLPVPTIA . . .:: ..:.:.. ... : ... :. :..::....:: : :.::: :.: CCDS72 TEILMNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKEREQM 50 60 70 80 90 100 150 160 170 180 190 200 pF1KE0 AIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELI . ... .: :: :::: :::.:: ...::.:::::::: .:..:::::: CCDS72 SEAEVGVFVQRLRGLMNDI---ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELI 110 120 130 140 150 210 220 230 240 250 260 pF1KE0 FSARVLDGKEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGM :..: :.: ::...::..:.. ::.::::::..: ::.:.::: CCDS72 FTGRRLSGTEAHVLGLVNHAVAQNEEGDAAYQRARALAQEILPQ---------------- 160 170 180 190 200 270 280 290 300 310 pF1KE0 EVDLVTGLAIEEACYAQTIPTKDRLEGLLAFKEKRPPRYKGE ::...:.::: ::::.:::.:::::. ::.::: :.. :. CCDS72 -VDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKRTPKFVGK 210 220 230 240 >>CCDS7681.1 ECHS1 gene_id:1892|Hs108|chr10 (290 aa) initn: 305 init1: 254 opt: 365 Z-score: 408.3 bits: 83.6 E(32554): 2e-16 Smith-Waterman score: 365; 36.1% identity (70.5% similar) in 166 aa overlap (145-310:129-290) 120 130 140 150 160 170 pF1KE0 VDALKSDKKVRTIIIRSEVPGIFCAANLPVPTIAAIDGLALGGGLELALACDIRVAASSA :.:::..: :.::: :::. ::: :. .: CCDS76 DIKEMQNLSFQDCYSSKFLKHWDHLTQVKKPVIAAVNGYAFGGGCELAMMCDIIYAGEKA 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE0 KMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGKEAKAVGLISHVLEQNQE ... : .. :::.:::::: ::.: ::: :..... .....:: .::.:.. CCDS76 QFAQPEILIGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKICPV--- 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE0 GDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIPTKDRLE .. ..:.. :... .. ... .:: ..: ..:. :. : .:. . .:. : :: : CCDS76 -ETLVEEAIQCAEKIASNSKIVVAMAKESVNAAFEMTLTEGSKLEKKLFYSTFATDDRKE 220 230 240 250 260 270 300 310 pF1KE0 GLLAFKEKRPPRYKGE :. :: ::: .: . CCDS76 GMTAFVEKRKANFKDQ 280 290 310 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 00:29:34 2016 done: Fri Nov 4 00:29:35 2016 Total Scan time: 2.800 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]