FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0155, 243 aa 1>>>pF1KE0155 243 - 243 aa - 243 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6183+/-0.000341; mu= 18.5264+/- 0.021 mean_var=66.1809+/-13.814, 0's: 0 Z-trim(114.7): 21 B-trim: 1482 in 1/52 Lambda= 0.157655 statistics sampled from 24634 (24655) to 24634 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.664), E-opt: 0.2 (0.289), width: 16 Scan time: 6.100 The best scores are: opt bits E(85289) NP_620417 (OMIM: 613766) secretory carrier-associa ( 235) 1600 372.4 3.9e-103 NP_001171582 (OMIM: 613766) secretory carrier-asso ( 235) 1600 372.4 3.9e-103 XP_006720484 (OMIM: 613766) PREDICTED: secretory c ( 235) 1600 372.4 3.9e-103 NP_001171583 (OMIM: 613766) secretory carrier-asso ( 235) 1600 372.4 3.9e-103 XP_006720483 (OMIM: 613766) PREDICTED: secretory c ( 253) 1600 372.4 4.1e-103 NP_524558 (OMIM: 613764) secretory carrier-associa ( 229) 976 230.5 2e-60 XP_016877478 (OMIM: 613766) PREDICTED: secretory c ( 164) 890 210.8 1.2e-54 XP_006720485 (OMIM: 613766) PREDICTED: secretory c ( 164) 890 210.8 1.2e-54 NP_001277158 (OMIM: 606911) secretory carrier-asso ( 312) 754 180.1 4e-45 NP_004857 (OMIM: 606911) secretory carrier-associa ( 338) 754 180.1 4.2e-45 XP_006711169 (OMIM: 606913) PREDICTED: secretory c ( 280) 751 179.4 5.9e-45 NP_443069 (OMIM: 606913) secretory carrier-associa ( 321) 751 179.4 6.5e-45 NP_005689 (OMIM: 606913) secretory carrier-associa ( 347) 751 179.4 6.9e-45 NP_001316468 (OMIM: 613764) secretory carrier-asso ( 185) 747 178.3 8.2e-45 XP_016877345 (OMIM: 606912) PREDICTED: secretory c ( 273) 747 178.4 1.1e-44 NP_005688 (OMIM: 606912) secretory carrier-associa ( 329) 747 178.5 1.2e-44 NP_001307707 (OMIM: 606912) secretory carrier-asso ( 372) 747 178.6 1.4e-44 XP_006711168 (OMIM: 606913) PREDICTED: secretory c ( 333) 682 163.7 3.6e-40 NP_001316469 (OMIM: 613764) secretory carrier-asso ( 195) 547 132.8 4.2e-31 XP_011542029 (OMIM: 606911) PREDICTED: secretory c ( 304) 418 103.7 4e-22 XP_016855480 (OMIM: 606913) PREDICTED: secretory c ( 204) 185 50.5 2.7e-06 >>NP_620417 (OMIM: 613766) secretory carrier-associated (235 aa) initn: 989 init1: 945 opt: 1600 Z-score: 1972.7 bits: 372.4 E(85289): 3.9e-103 Smith-Waterman score: 1600; 96.7% identity (96.7% similar) in 243 aa overlap (1-243:1-235) 10 20 30 40 50 60 pF1KE0 MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHVSMTKRLYYLWMLNSVTLAVNLVGCLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHVSMTKRLYYLWMLNSVTLAVNLVGCLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 WLIGGGGATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSSFSFMAFFFTFMAQLVISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 WLIGGGGATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSSFSFMAFFFTFMAQLVISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 IQAVGIPGWGVCPTLASSCSGWIATISFFGTNIGSAVVMLIPTVMFTVMAVFSFIALSMV :::::::::::: :::::::::::::::::::::::::::::::::::::::: NP_620 IQAVGIPGWGVC--------GWIATISFFGTNIGSAVVMLIPTVMFTVMAVFSFIALSMV 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 HKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQPQTQYSATPNYTYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 HKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQPQTQYSATPNYTYS 180 190 200 210 220 230 pF1KE0 NEM ::: NP_620 NEM >>NP_001171582 (OMIM: 613766) secretory carrier-associat (235 aa) initn: 989 init1: 945 opt: 1600 Z-score: 1972.7 bits: 372.4 E(85289): 3.9e-103 Smith-Waterman score: 1600; 96.7% identity (96.7% similar) in 243 aa overlap (1-243:1-235) 10 20 30 40 50 60 pF1KE0 MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHVSMTKRLYYLWMLNSVTLAVNLVGCLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHVSMTKRLYYLWMLNSVTLAVNLVGCLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 WLIGGGGATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSSFSFMAFFFTFMAQLVISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLIGGGGATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSSFSFMAFFFTFMAQLVISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 IQAVGIPGWGVCPTLASSCSGWIATISFFGTNIGSAVVMLIPTVMFTVMAVFSFIALSMV :::::::::::: :::::::::::::::::::::::::::::::::::::::: NP_001 IQAVGIPGWGVC--------GWIATISFFGTNIGSAVVMLIPTVMFTVMAVFSFIALSMV 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 HKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQPQTQYSATPNYTYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQPQTQYSATPNYTYS 180 190 200 210 220 230 pF1KE0 NEM ::: NP_001 NEM >>XP_006720484 (OMIM: 613766) PREDICTED: secretory carri (235 aa) initn: 989 init1: 945 opt: 1600 Z-score: 1972.7 bits: 372.4 E(85289): 3.9e-103 Smith-Waterman score: 1600; 96.7% identity (96.7% similar) in 243 aa overlap (1-243:1-235) 10 20 30 40 50 60 pF1KE0 MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHVSMTKRLYYLWMLNSVTLAVNLVGCLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHVSMTKRLYYLWMLNSVTLAVNLVGCLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 WLIGGGGATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSSFSFMAFFFTFMAQLVISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WLIGGGGATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSSFSFMAFFFTFMAQLVISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 IQAVGIPGWGVCPTLASSCSGWIATISFFGTNIGSAVVMLIPTVMFTVMAVFSFIALSMV :::::::::::: :::::::::::::::::::::::::::::::::::::::: XP_006 IQAVGIPGWGVC--------GWIATISFFGTNIGSAVVMLIPTVMFTVMAVFSFIALSMV 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 HKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQPQTQYSATPNYTYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQPQTQYSATPNYTYS 180 190 200 210 220 230 pF1KE0 NEM ::: XP_006 NEM >>NP_001171583 (OMIM: 613766) secretory carrier-associat (235 aa) initn: 989 init1: 945 opt: 1600 Z-score: 1972.7 bits: 372.4 E(85289): 3.9e-103 Smith-Waterman score: 1600; 96.7% identity (96.7% similar) in 243 aa overlap (1-243:1-235) 10 20 30 40 50 60 pF1KE0 MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHVSMTKRLYYLWMLNSVTLAVNLVGCLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHVSMTKRLYYLWMLNSVTLAVNLVGCLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 WLIGGGGATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSSFSFMAFFFTFMAQLVISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLIGGGGATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSSFSFMAFFFTFMAQLVISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 IQAVGIPGWGVCPTLASSCSGWIATISFFGTNIGSAVVMLIPTVMFTVMAVFSFIALSMV :::::::::::: :::::::::::::::::::::::::::::::::::::::: NP_001 IQAVGIPGWGVC--------GWIATISFFGTNIGSAVVMLIPTVMFTVMAVFSFIALSMV 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 HKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQPQTQYSATPNYTYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQPQTQYSATPNYTYS 180 190 200 210 220 230 pF1KE0 NEM ::: NP_001 NEM >>XP_006720483 (OMIM: 613766) PREDICTED: secretory carri (253 aa) initn: 989 init1: 945 opt: 1600 Z-score: 1972.3 bits: 372.4 E(85289): 4.1e-103 Smith-Waterman score: 1600; 96.7% identity (96.7% similar) in 243 aa overlap (1-243:19-253) 10 20 30 40 pF1KE0 MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHVSMTKRLYY :::::::::::::::::::::::::::::::::::::::::: XP_006 MEFRTKRCGQATGPAGNIMAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHVSMTKRLYY 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 LWMLNSVTLAVNLVGCLAWLIGGGGATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LWMLNSVTLAVNLVGCLAWLIGGGGATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSS 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 FSFMAFFFTFMAQLVISIIQAVGIPGWGVCPTLASSCSGWIATISFFGTNIGSAVVMLIP :::::::::::::::::::::::::::::: :::::::::::::::::::::: XP_006 FSFMAFFFTFMAQLVISIIQAVGIPGWGVC--------GWIATISFFGTNIGSAVVMLIP 130 140 150 160 170 170 180 190 200 210 220 pF1KE0 TVMFTVMAVFSFIALSMVHKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TVMFTVMAVFSFIALSMVHKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQG 180 190 200 210 220 230 230 240 pF1KE0 AMNQPQTQYSATPNYTYSNEM ::::::::::::::::::::: XP_006 AMNQPQTQYSATPNYTYSNEM 240 250 >>NP_524558 (OMIM: 613764) secretory carrier-associated (229 aa) initn: 978 init1: 705 opt: 976 Z-score: 1205.8 bits: 230.5 E(85289): 2e-60 Smith-Waterman score: 981; 55.8% identity (79.8% similar) in 242 aa overlap (1-242:1-227) 10 20 30 40 50 60 pF1KE0 MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHVSMTKRLYYLWMLNSVTLAVNLVGCLA :.:: :::::::::::.::::::.: .:: .: ..::.: :::. .::.:::..::: NP_524 MSEKENNFPPLPKFIPVKPCFYQNFSDEIPVEHQVLVKRIYRLWMFYCATLGVNLIACLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 WLIGGGGATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSSFSFMAFFFTFMAQLVISI : ::::..:::::::.::.:::::.:::::::.::::..::::.:::::: : ::.:... NP_524 WWIGGGSGTNFGLAFVWLLLFTPCGYVCWFRPVYKAFRADSSFNFMAFFFIFGAQFVLTV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 IQAVGIPGWGVCPTLASSCSGWIATISFFGTNIGSAVVMLIPTVMFTVMAVFSFIALSMV :::.:. :::.: ::...:.:: . :.:::::.:..::.: :.. ::. : NP_524 IQAIGFSGWGAC--------GWLSAIGFFQYSPGAAVVMLLPAIMFSVSAAMMAIAIMKV 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 HKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQPQTQYSATPNYTYS :..:::.::::.::: ::.::.:.:: ..: : : . :. : ..:.: : NP_524 HRIYRGAGGSFQKAQTEWNTGTWRNPPSREAQYNNFSGNSL-----PE--YPTVPSYPGS 180 190 200 210 220 pF1KE0 NEM .. NP_524 GQWP >>XP_016877478 (OMIM: 613766) PREDICTED: secretory carri (164 aa) initn: 685 init1: 685 opt: 890 Z-score: 1102.0 bits: 210.8 E(85289): 1.2e-54 Smith-Waterman score: 890; 94.5% identity (94.5% similar) in 145 aa overlap (99-243:28-164) 70 80 90 100 110 120 pF1KE0 TNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSSFSFMAFFFTFMAQLVISIIQAVGIPG :::::::::::::::::::::::::::::: XP_016 MFLPRLRGRYSSPACQHDQAPLLPLDVTDSSFSFMAFFFTFMAQLVISIIQAVGIPG 10 20 30 40 50 130 140 150 160 170 180 pF1KE0 WGVCPTLASSCSGWIATISFFGTNIGSAVVMLIPTVMFTVMAVFSFIALSMVHKFYRGSG :::: :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WGVC--------GWIATISFFGTNIGSAVVMLIPTVMFTVMAVFSFIALSMVHKFYRGSG 60 70 80 90 100 190 200 210 220 230 240 pF1KE0 GSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQPQTQYSATPNYTYSNEM ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQPQTQYSATPNYTYSNEM 110 120 130 140 150 160 >>XP_006720485 (OMIM: 613766) PREDICTED: secretory carri (164 aa) initn: 685 init1: 685 opt: 890 Z-score: 1102.0 bits: 210.8 E(85289): 1.2e-54 Smith-Waterman score: 890; 94.5% identity (94.5% similar) in 145 aa overlap (99-243:28-164) 70 80 90 100 110 120 pF1KE0 TNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSSFSFMAFFFTFMAQLVISIIQAVGIPG :::::::::::::::::::::::::::::: XP_006 MFLPRLRGRYSSPACQHDQAPLLPLDVTDSSFSFMAFFFTFMAQLVISIIQAVGIPG 10 20 30 40 50 130 140 150 160 170 180 pF1KE0 WGVCPTLASSCSGWIATISFFGTNIGSAVVMLIPTVMFTVMAVFSFIALSMVHKFYRGSG :::: :::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WGVC--------GWIATISFFGTNIGSAVVMLIPTVMFTVMAVFSFIALSMVHKFYRGSG 60 70 80 90 100 190 200 210 220 230 240 pF1KE0 GSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQPQTQYSATPNYTYSNEM ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQPQTQYSATPNYTYSNEM 110 120 130 140 150 160 >>NP_001277158 (OMIM: 606911) secretory carrier-associat (312 aa) initn: 796 init1: 315 opt: 754 Z-score: 931.1 bits: 180.1 E(85289): 4e-45 Smith-Waterman score: 754; 47.0% identity (79.5% similar) in 219 aa overlap (6-223:92-302) 10 20 30 pF1KE0 MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHVS ::.::::. .:. ::::::: .::: . . NP_001 LKRQEELERKAAELDRREREMQNLSQHGRKNNWPPLPSNFPVGPCFYQDFSVDIPVEFQK 70 80 90 100 110 120 40 50 60 70 80 90 pF1KE0 MTKRLYYLWMLNSVTLAVNLVGCLAWL-IGGGGATNFGLAFLWLILFTPCSYVCWFRPIY .: .:::::...::: .:. :::::. . .. :..:::..::..::::::.:::.::.: NP_001 TVKLMYYLWMFHAVTLFLNIFGCLAWFCVDSARAVDFGLSILWFLLFTPCSFVCWYRPLY 130 140 150 160 170 180 100 110 120 130 140 150 pF1KE0 KAFKTDSSFSFMAFFFTFMAQLVISIIQAVGIPGWGVCPTLASSCSGWIATISFFGTNIG ::..:::: :..:::... :... ..::.:. .:: : :::.... .. :: NP_001 GAFRSDSSFRFFVFFFVYICQFAVHVLQAAGFHNWGNC--------GWISSLTGLNQNIP 190 200 210 220 230 160 170 180 190 200 210 pF1KE0 SAVVMLIPTVMFTVMAVFSFIALSMVHKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQN ...:.: ...::. ::.:.. .. :: .:: .:.:: :::.:..::. .: :: :: : NP_001 VGIMMIIIAALFTASAVISLVMFKKVHGLYRTTGASFEKAQQEFATGVMSNKTVQTAAAN 240 250 260 270 280 290 220 230 240 pF1KE0 AAMGAAQGAMNQPQTQYSATPNYTYSNEM :: ::..: NP_001 AASTAASSAAQNAFKGNQI 300 310 >>NP_004857 (OMIM: 606911) secretory carrier-associated (338 aa) initn: 796 init1: 315 opt: 754 Z-score: 930.7 bits: 180.1 E(85289): 4.2e-45 Smith-Waterman score: 754; 47.0% identity (79.5% similar) in 219 aa overlap (6-223:118-328) 10 20 30 pF1KE0 MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHVS ::.::::. .:. ::::::: .::: . . NP_004 LKRQEELERKAAELDRREREMQNLSQHGRKNNWPPLPSNFPVGPCFYQDFSVDIPVEFQK 90 100 110 120 130 140 40 50 60 70 80 90 pF1KE0 MTKRLYYLWMLNSVTLAVNLVGCLAWL-IGGGGATNFGLAFLWLILFTPCSYVCWFRPIY .: .:::::...::: .:. :::::. . .. :..:::..::..::::::.:::.::.: NP_004 TVKLMYYLWMFHAVTLFLNIFGCLAWFCVDSARAVDFGLSILWFLLFTPCSFVCWYRPLY 150 160 170 180 190 200 100 110 120 130 140 150 pF1KE0 KAFKTDSSFSFMAFFFTFMAQLVISIIQAVGIPGWGVCPTLASSCSGWIATISFFGTNIG ::..:::: :..:::... :... ..::.:. .:: : :::.... .. :: NP_004 GAFRSDSSFRFFVFFFVYICQFAVHVLQAAGFHNWGNC--------GWISSLTGLNQNIP 210 220 230 240 250 160 170 180 190 200 210 pF1KE0 SAVVMLIPTVMFTVMAVFSFIALSMVHKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQN ...:.: ...::. ::.:.. .. :: .:: .:.:: :::.:..::. .: :: :: : NP_004 VGIMMIIIAALFTASAVISLVMFKKVHGLYRTTGASFEKAQQEFATGVMSNKTVQTAAAN 260 270 280 290 300 310 220 230 240 pF1KE0 AAMGAAQGAMNQPQTQYSATPNYTYSNEM :: ::..: NP_004 AASTAASSAAQNAFKGNQI 320 330 243 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 23:45:00 2016 done: Thu Nov 3 23:45:01 2016 Total Scan time: 6.100 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]