FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0156, 261 aa 1>>>pF1KE0156 261 - 261 aa - 261 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.5944+/-0.000336; mu= 19.6097+/- 0.021 mean_var=73.3448+/-14.415, 0's: 0 Z-trim(115.9): 121 B-trim: 156 in 1/52 Lambda= 0.149758 statistics sampled from 26628 (26757) to 26628 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.686), E-opt: 0.2 (0.314), width: 16 Scan time: 7.340 The best scores are: opt bits E(85289) NP_055049 (OMIM: 601417) estradiol 17-beta-dehydro ( 261) 1685 372.9 3.3e-103 NP_004484 (OMIM: 300220,300256,300438) 3-hydroxyac ( 261) 374 89.6 6.2e-18 NP_066284 (OMIM: 611596) dehydrogenase/reductase S ( 278) 369 88.6 1.4e-17 NP_000405 (OMIM: 233400,261515,601860) peroxisomal ( 736) 342 83.2 1.5e-15 XP_016868636 (OMIM: 222745) PREDICTED: 2,4-dienoyl ( 326) 313 76.5 6.7e-14 XP_016868637 (OMIM: 222745) PREDICTED: 2,4-dienoyl ( 326) 313 76.5 6.7e-14 XP_011515182 (OMIM: 222745) PREDICTED: 2,4-dienoyl ( 326) 313 76.5 6.7e-14 NP_001317504 (OMIM: 222745) 2,4-dienoyl-CoA reduct ( 326) 313 76.5 6.7e-14 NP_001350 (OMIM: 222745) 2,4-dienoyl-CoA reductase ( 335) 313 76.5 6.8e-14 NP_060911 (OMIM: 605843) peroxisomal trans-2-enoyl ( 303) 303 74.3 2.8e-13 NP_001182147 (OMIM: 260800,608347) L-xylulose redu ( 242) 299 73.4 4.4e-13 NP_057370 (OMIM: 260800,608347) L-xylulose reducta ( 244) 299 73.4 4.4e-13 NP_001269917 (OMIM: 611596) dehydrogenase/reductas ( 244) 277 68.6 1.2e-11 NP_065715 (OMIM: 615839) peroxisomal 2,4-dienoyl-C ( 292) 274 68.1 2.1e-11 NP_057330 (OMIM: 612832) 17-beta-hydroxysteroid de ( 270) 272 67.6 2.7e-11 NP_001032900 (OMIM: 300220,300256,300438) 3-hydrox ( 252) 271 67.3 3e-11 NP_077284 (OMIM: 616159) dehydrogenase/reductase S ( 260) 271 67.3 3.1e-11 NP_001278956 (OMIM: 233400,261515,601860) peroxiso ( 712) 272 68.0 5.3e-11 NP_001186221 (OMIM: 233400,261515,601860) peroxiso ( 718) 272 68.0 5.3e-11 NP_001186220 (OMIM: 233400,261515,601860) peroxiso ( 761) 272 68.0 5.5e-11 XP_005250865 (OMIM: 222745) PREDICTED: 2,4-dienoyl ( 243) 258 64.5 2.1e-10 XP_011534640 (OMIM: 615194) PREDICTED: dehydrogena ( 204) 254 63.6 3.3e-10 XP_011534641 (OMIM: 615194) PREDICTED: dehydrogena ( 204) 254 63.6 3.3e-10 XP_005267306 (OMIM: 615194) PREDICTED: dehydrogena ( 280) 254 63.7 4.1e-10 NP_005785 (OMIM: 615194) dehydrogenase/reductase S ( 280) 254 63.7 4.1e-10 XP_006720064 (OMIM: 615194) PREDICTED: dehydrogena ( 280) 254 63.7 4.1e-10 XP_006720309 (OMIM: 615195) PREDICTED: putative de ( 244) 252 63.2 5.1e-10 NP_620419 (OMIM: 608989) epidermal retinol dehydro ( 309) 238 60.3 4.9e-09 NP_001304978 (OMIM: 608989) epidermal retinol dehy ( 318) 238 60.3 5e-09 NP_001129522 (OMIM: 610410) dehydrogenase/reductas ( 313) 228 58.1 2.2e-08 NP_612461 (OMIM: 610410) dehydrogenase/reductase S ( 313) 228 58.1 2.2e-08 NP_001317088 (OMIM: 616160) dehydrogenase/reductas ( 310) 225 57.5 3.4e-08 NP_056325 (OMIM: 616160) dehydrogenase/reductase S ( 325) 225 57.5 3.5e-08 XP_016879915 (OMIM: 616160) PREDICTED: dehydrogena ( 325) 225 57.5 3.5e-08 XP_011522088 (OMIM: 616160) PREDICTED: dehydrogena ( 334) 225 57.5 3.6e-08 XP_016879914 (OMIM: 616160) PREDICTED: dehydrogena ( 372) 225 57.6 3.9e-08 XP_005256652 (OMIM: 616160) PREDICTED: dehydrogena ( 372) 225 57.6 3.9e-08 NP_001264793 (OMIM: 615195) putative dehydrogenase ( 150) 215 55.0 9.2e-08 XP_005257715 (OMIM: 616159) PREDICTED: dehydrogena ( 229) 214 55.0 1.4e-07 NP_000851 (OMIM: 119900,259100,601688) 15-hydroxyp ( 266) 210 54.2 2.9e-07 NP_932349 (OMIM: 615196) dehydrogenase/reductase S ( 232) 205 53.0 5.6e-07 XP_011509780 (OMIM: 605843) PREDICTED: peroxisomal ( 157) 200 51.8 9e-07 XP_016862498 (OMIM: 603063) PREDICTED: D-beta-hydr ( 324) 193 50.6 4.2e-06 XP_016862499 (OMIM: 603063) PREDICTED: D-beta-hydr ( 324) 193 50.6 4.2e-06 XP_016862497 (OMIM: 603063) PREDICTED: D-beta-hydr ( 330) 193 50.6 4.3e-06 XP_016862501 (OMIM: 603063) PREDICTED: D-beta-hydr ( 330) 193 50.6 4.3e-06 XP_016862500 (OMIM: 603063) PREDICTED: D-beta-hydr ( 330) 193 50.6 4.3e-06 NP_004042 (OMIM: 603063) D-beta-hydroxybutyrate de ( 343) 193 50.6 4.4e-06 XP_016862496 (OMIM: 603063) PREDICTED: D-beta-hydr ( 343) 193 50.6 4.4e-06 XP_005269409 (OMIM: 603063) PREDICTED: D-beta-hydr ( 343) 193 50.6 4.4e-06 >>NP_055049 (OMIM: 601417) estradiol 17-beta-dehydrogena (261 aa) initn: 1685 init1: 1685 opt: 1685 Z-score: 1973.8 bits: 372.9 E(85289): 3.3e-103 Smith-Waterman score: 1685; 100.0% identity (100.0% similar) in 261 aa overlap (1-261:1-261) 10 20 30 40 50 60 pF1KE0 MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 DKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 QTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFL 190 200 210 220 230 240 250 260 pF1KE0 ASEDSGYITGTSVEVTGGLFM ::::::::::::::::::::: NP_055 ASEDSGYITGTSVEVTGGLFM 250 260 >>NP_004484 (OMIM: 300220,300256,300438) 3-hydroxyacyl-C (261 aa) initn: 324 init1: 240 opt: 374 Z-score: 443.0 bits: 89.6 E(85289): 6.2e-18 Smith-Waterman score: 413; 30.8% identity (65.4% similar) in 266 aa overlap (9-261:8-259) 10 20 30 40 50 60 pF1KE0 MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGS ... .:..::..::.: :.. ::.:.::... :: .... .. :: NP_004 MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLG---- 10 20 30 40 50 70 80 90 100 110 pF1KE0 KEGPPRGNHAAFQ-ADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSE-- :. .: :::. . .. : ... :.: .:.:.::::. .... NP_004 -------NNCVFAPADVTSEKDVQTALALAKGKFGRV-DVAVNCAGIAVASKTYNLKKGQ 60 70 80 90 100 120 130 140 150 160 pF1KE0 ----DDWDKVIAVNLKGTFLVTQAAAQALVSN-----GCRGSIINISSIVGKVGNVGQTN .:...:. ::: ::: : . .: . .: : :: ::: .:... :.:::. NP_004 THTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAA 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE0 YAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPM-GHL :.:::.:..:.: ::.:. ::: .. ::...::. ..:.:: . .. ..:. ..: NP_004 YSASKGGIVGMTLPIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRL 170 180 190 200 210 220 230 240 250 260 pF1KE0 GDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM ::: . : .: . .. ...: ... :.. : NP_004 GDPAEYAHLVQAII--ENPFLNGEVIRLDGAIRMQP 230 240 250 260 >>NP_066284 (OMIM: 611596) dehydrogenase/reductase SDR f (278 aa) initn: 369 init1: 138 opt: 369 Z-score: 436.8 bits: 88.6 E(85289): 1.4e-17 Smith-Waterman score: 369; 32.6% identity (64.4% similar) in 267 aa overlap (1-258:19-273) 10 20 30 pF1KE0 MASQLQNR---LRSALALVTGAGSGIGRAVSVRLAGEGATVA :::. ..: : . .::::.. .::: :.. ::: .:: :. NP_066 MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVV 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE0 ACDLDRAAAQETVRLLGGPG-SKEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPS . . . ....: : : : : : .. .. .: : : . :. . . NP_066 VSSRKQQNVDQAVATLQGEGLSVTG------TVCHVGKAEDRE-RLVATAVK--LHGGID 70 80 90 100 110 100 110 120 130 140 150 pF1KE0 VVVSCAGITQDEF---LLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINIS ..:: :.. . : .. ..:. :::.. .:.:. :.:.:.. . . : ::.. .: NP_066 ILVSNAAV--NPFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGG-GSVVIVS 120 130 140 150 160 160 170 180 190 200 210 pF1KE0 SIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKV--PQK ::.. . : . : .::....:::.: : ::. ..:: : . ::.: : ... . .. NP_066 SIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKE 170 180 190 200 210 220 220 230 240 250 260 pF1KE0 VVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM ... : . . .::.::: : .:.:: :::..:::: .: : :: NP_066 KEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL 230 240 250 260 270 >>NP_000405 (OMIM: 233400,261515,601860) peroxisomal mul (736 aa) initn: 365 init1: 145 opt: 342 Z-score: 400.1 bits: 83.2 E(85289): 1.5e-15 Smith-Waterman score: 357; 34.2% identity (62.0% similar) in 263 aa overlap (1-260:1-237) 10 20 30 40 50 pF1KE0 MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDL--DRAAAQETVRLLGGP :.: : :. . ..::::::.:.::: .. .: .:: :.. :: : .. . : . NP_000 MGSPL--RFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKG-SLAADK 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 GSKEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSED .: ::..:. :. . .. .. ... . :.: .:::. ::: .:. . ..:.. NP_000 VVEEIRRRGGKAV--ANYDSVEEGEKVVKTALDAFGRI-DVVVNNAGILRDRSFARISDE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 DWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIG ::: . :.:.:.: ::.:: . . .. : :: :: : :: ::.::.:.: :..: NP_000 DWDIIHRVHLRGSFQVTRAAWEHMKKQK-YGRIIMTSSASGIYGNFGQANYSAAKLGLLG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 LTQTAARELGRHGIRCNSVLPGFIATPMTQKV-PQKVVDKITEMIPMGHLGDPEDVADVV :... : : . .:.::.. :. .. ::: : :. .:. . :: :: .: NP_000 LANSLAIEGRKSNIHCNTIAPN-AGSRMTQTVMPEDLVEALK----------PEYVAPLV 180 190 200 210 220 240 250 260 pF1KE0 AFLASEDSGYITGTSVEVTGGLFM .: : : : .:::: NP_000 LWLCHE--------SCEENGGLFEVGAGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWK 230 240 250 260 270 >>XP_016868636 (OMIM: 222745) PREDICTED: 2,4-dienoyl-CoA (326 aa) initn: 243 init1: 156 opt: 313 Z-score: 370.6 bits: 76.5 E(85289): 6.7e-14 Smith-Waterman score: 313; 26.4% identity (62.4% similar) in 258 aa overlap (7-258:46-293) 10 20 30 pF1KE0 MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGA : ... .:..::.:.:.:..... :.. :: XP_016 FSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGA 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE0 TVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHA-AFQADVSEARAARCLLEQVQACFSR : . :.. . .: . . . . ::.. :.: :: . .. . .. .. XP_016 Q---C----VIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGH 80 90 100 110 120 100 110 120 130 140 150 pF1KE0 PPSVVVSCAG--ITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIIN : :. . :: :. : ..: . : . . :.:: .:: .. :.. ..... XP_016 PNIVINNAAGNFISPTE---RLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 ISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATP--MTQKVP :..: ...:. . :..:::: ..... : : :..:.: : . :: : : ... : XP_016 ITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDP 190 200 210 220 230 240 220 230 240 250 260 pF1KE0 QKVVDK-ITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM . .: . :: :.:: :..:...::: :. ...:.:. .. :: XP_016 TGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDL 250 260 270 280 290 300 XP_016 RKVTKEQWDTIEELIRKTKGS 310 320 >>XP_016868637 (OMIM: 222745) PREDICTED: 2,4-dienoyl-CoA (326 aa) initn: 243 init1: 156 opt: 313 Z-score: 370.6 bits: 76.5 E(85289): 6.7e-14 Smith-Waterman score: 313; 26.4% identity (62.4% similar) in 258 aa overlap (7-258:46-293) 10 20 30 pF1KE0 MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGA : ... .:..::.:.:.:..... :.. :: XP_016 FSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGA 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE0 TVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHA-AFQADVSEARAARCLLEQVQACFSR : . :.. . .: . . . . ::.. :.: :: . .. . .. .. XP_016 Q---C----VIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGH 80 90 100 110 120 100 110 120 130 140 150 pF1KE0 PPSVVVSCAG--ITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIIN : :. . :: :. : ..: . : . . :.:: .:: .. :.. ..... XP_016 PNIVINNAAGNFISPTE---RLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 ISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATP--MTQKVP :..: ...:. . :..:::: ..... : : :..:.: : . :: : : ... : XP_016 ITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDP 190 200 210 220 230 240 220 230 240 250 260 pF1KE0 QKVVDK-ITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM . .: . :: :.:: :..:...::: :. ...:.:. .. :: XP_016 TGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDL 250 260 270 280 290 300 XP_016 RKVTKEQWDTIEELIRKTKGS 310 320 >>XP_011515182 (OMIM: 222745) PREDICTED: 2,4-dienoyl-CoA (326 aa) initn: 243 init1: 156 opt: 313 Z-score: 370.6 bits: 76.5 E(85289): 6.7e-14 Smith-Waterman score: 313; 26.4% identity (62.4% similar) in 258 aa overlap (7-258:46-293) 10 20 30 pF1KE0 MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGA : ... .:..::.:.:.:..... :.. :: XP_011 FSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGA 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE0 TVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHA-AFQADVSEARAARCLLEQVQACFSR : . :.. . .: . . . . ::.. :.: :: . .. . .. .. XP_011 Q---C----VIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGH 80 90 100 110 120 100 110 120 130 140 150 pF1KE0 PPSVVVSCAG--ITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIIN : :. . :: :. : ..: . : . . :.:: .:: .. :.. ..... XP_011 PNIVINNAAGNFISPTE---RLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 ISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATP--MTQKVP :..: ...:. . :..:::: ..... : : :..:.: : . :: : : ... : XP_011 ITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDP 190 200 210 220 230 240 220 230 240 250 260 pF1KE0 QKVVDK-ITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM . .: . :: :.:: :..:...::: :. ...:.:. .. :: XP_011 TGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDL 250 260 270 280 290 300 XP_011 RKVTKEQWDTIEELIRKTKGS 310 320 >>NP_001317504 (OMIM: 222745) 2,4-dienoyl-CoA reductase, (326 aa) initn: 243 init1: 156 opt: 313 Z-score: 370.6 bits: 76.5 E(85289): 6.7e-14 Smith-Waterman score: 313; 26.4% identity (62.4% similar) in 258 aa overlap (7-258:46-293) 10 20 30 pF1KE0 MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGA : ... .:..::.:.:.:..... :.. :: NP_001 FSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGA 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE0 TVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHA-AFQADVSEARAARCLLEQVQACFSR : . :.. . .: . . . . ::.. :.: :: . .. . .. .. NP_001 Q---C----VIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGH 80 90 100 110 120 100 110 120 130 140 150 pF1KE0 PPSVVVSCAG--ITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIIN : :. . :: :. : ..: . : . . :.:: .:: .. :.. ..... NP_001 PNIVINNAAGNFISPTE---RLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 ISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATP--MTQKVP :..: ...:. . :..:::: ..... : : :..:.: : . :: : : ... : NP_001 ITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDP 190 200 210 220 230 240 220 230 240 250 260 pF1KE0 QKVVDK-ITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM . .: . :: :.:: :..:...::: :. ...:.:. .. :: NP_001 TGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDL 250 260 270 280 290 300 NP_001 RKVTKEQWDTIEELIRKTKGS 310 320 >>NP_001350 (OMIM: 222745) 2,4-dienoyl-CoA reductase, mi (335 aa) initn: 243 init1: 156 opt: 313 Z-score: 370.4 bits: 76.5 E(85289): 6.8e-14 Smith-Waterman score: 313; 26.4% identity (62.4% similar) in 258 aa overlap (7-258:55-302) 10 20 30 pF1KE0 MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGA : ... .:..::.:.:.:..... :.. :: NP_001 FSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGA 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE0 TVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHA-AFQADVSEARAARCLLEQVQACFSR : . :.. . .: . . . . ::.. :.: :: . .. . .. .. NP_001 Q---C----VIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGH 90 100 110 120 130 100 110 120 130 140 150 pF1KE0 PPSVVVSCAG--ITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIIN : :. . :: :. : ..: . : . . :.:: .:: .. :.. ..... NP_001 PNIVINNAAGNFISPTE---RLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLS 140 150 160 170 180 190 160 170 180 190 200 210 pF1KE0 ISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATP--MTQKVP :..: ...:. . :..:::: ..... : : :..:.: : . :: : : ... : NP_001 ITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDP 200 210 220 230 240 250 220 230 240 250 260 pF1KE0 QKVVDK-ITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM . .: . :: :.:: :..:...::: :. ...:.:. .. :: NP_001 TGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDL 260 270 280 290 300 310 NP_001 RKVTKEQWDTIEELIRKTKGS 320 330 >>NP_060911 (OMIM: 605843) peroxisomal trans-2-enoyl-CoA (303 aa) initn: 266 init1: 118 opt: 303 Z-score: 359.3 bits: 74.3 E(85289): 2.8e-13 Smith-Waterman score: 303; 31.3% identity (59.5% similar) in 262 aa overlap (9-258:16-264) 10 20 30 40 pF1KE0 MASQLQNRLRSALALVTGAGSGIGRAVSVRLA--GEGATVAACDLDR--AAAQ :.. .:.:::...:::.:. .: : ....:. :.: .::. NP_060 MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAAD 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 ETVRLLGGPGSKEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQD : : : .:. . .: .. . . . :.... :.. .: . .: NP_060 ELQANL--PPTKQ----ARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGG---- 70 80 90 100 110 110 120 130 140 150 160 pF1KE0 EFLL---HMSEDDWDKVIAVNLKGTFLVTQAAAQALVS-NGCRGSIINISSIVGKVGNVG .:: :.: : :. .:: ::: . .:. .. .. .: :::.:: . :.: NP_060 QFLSPAEHISSKGWHAVLETNLTGTFYMCKAVYSSWMKEHG--GSIVNII-VPTKAGFPL 120 130 140 150 160 170 180 190 200 210 220 pF1KE0 QTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFI----ATPMTQKVPQKVVDKITEM .. .:..::: .::.. : : . ::: : : :: : :. . :. . . NP_060 AVHSGAARAGVYNLTKSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQK 170 180 190 200 210 220 230 240 250 260 pF1KE0 IPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM :: ..: ::.:..:: :: : ...::: ::.: :: NP_060 IPAKRIGVPEEVSSVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPDHDNWPKGAGDL 230 240 250 260 270 280 NP_060 SVVKKMKETFKEKAKL 290 300 261 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 23:38:53 2016 done: Thu Nov 3 23:38:54 2016 Total Scan time: 7.340 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]