FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0161, 265 aa
  1>>>pF1KE0161 265 - 265 aa - 265 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.7871+/-0.000366; mu= 18.0130+/- 0.023
 mean_var=67.2110+/-13.690, 0's: 0 Z-trim(112.4): 50  B-trim: 0 in 0/50
 Lambda= 0.156442
 statistics sampled from 21270 (21315) to 21270 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.63), E-opt: 0.2 (0.25), width:  16
 Scan time:  6.190

The best scores are:                                      opt bits E(85289)
NP_003170 (OMIM: 300802,313475) synaptophysin [Hom ( 313) 1000 234.6 1.7e-61
NP_874384 (OMIM: 616665) synaptophysin-like protei ( 241)  622 149.2 6.7e-36
NP_006745 (OMIM: 616665) synaptophysin-like protei ( 259)  622 149.2 7.1e-36


>>NP_003170 (OMIM: 300802,313475) synaptophysin [Homo sa  (313 aa)
 initn: 775 init1: 675 opt: 1000  Z-score: 1225.1  bits: 234.6 E(85289): 1.7e-61
Smith-Waterman score: 1038; 58.4% identity (78.6% similar) in 281 aa overlap (9-265:35-313)

                                     10        20        30        
pF1KE0                       MCMVIFAPLFAIFAFATCGGYSGGLRLSVDCVNKTESN
                                     .::::::::::.::: :.:::::.:::::.
NP_003 ADMDVVNQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYSGELQLSVDCANKTESD
           10        20        30        40        50        60    

       40        50        60        70        80        90        
pF1KE0 LSIDIAFAYPFRLHQVTFEVPTCEGKERQKLALIGDSSSSAEFFVTVAVFAFLYSLAATV
       :::.. : :::::::: :..:::.:    :. :.:: ::::::::::::::::::..: .
NP_003 LSIEVEFEYPFRLHQVYFDAPTCRGGTT-KVFLVGDYSSSAEFFVTVAVFAFLYSMGALA
           70        80        90        100       110       120   

      100       110       120       130       140       150        
pF1KE0 VYIFFQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLSDVKVATDPKEVLLLMSAC
       .:::.::::::::.::..::..:.::.:.:::.::::::::::::.::::....  : .:
NP_003 TYIFLQNKYRENNKGPMLDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPVC
           130       140       150       160       170       180   

      160       170       180       190       200       210        
pF1KE0 KQPSNKCMAIHSPVMSSLNTSVVFGFLNFILWAGNIWFVFKETGWHSSGQRYLSDPMEKH
       .: .: :  ...:: :.:::::::::::..::.::.::::::::: .   :      ::.
NP_003 RQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFLRAPPGAPEKQ
           190       200       210       220       230       240   

              220          230                240       250        
pF1KE0 --------SSSYNQG--GYN-QDSYGSSSGY---------SQQASLGPTSDEFGQQ---P
               ...:.::  ::. ::::: ..::         :  .. :: .: .:::   :
NP_003 PAPGDAYGDAGYGQGPGGYGPQDSYGPQGGYQPDYGQPAGSGGSGYGPQGD-YGQQGYGP
           250       260       270       280       290        300  

          260     
pF1KE0 TG-PTSFTNQI
        : ::::.::.
NP_003 QGAPTSFSNQM
            310   

>>NP_874384 (OMIM: 616665) synaptophysin-like protein 1   (241 aa)
 initn: 646 init1: 301 opt: 622  Z-score: 765.5  bits: 149.2 E(85289): 6.7e-36
Smith-Waterman score: 623; 44.5% identity (71.8% similar) in 220 aa overlap (11-226:26-234)

                              10        20        30        40     
pF1KE0                MCMVIFAPLFAIFAFATCGGYSGGLRLSVDCVNKTESNLSIDIAF
                                .:::::::::..:  ...:.:   .  : ..  .:
NP_874 MSGFQINLNPLKEPLGFIKVLEWIASIFAFATCGGFKGQTEIQVNCPPAVTENKTVTATF
               10        20        30        40        50        60

          50        60            70        80        90       100 
pF1KE0 AYPFRLHQVTFEVPT----CEGKERQKLALIGDSSSSAEFFVTVAVFAFLYSLAATVVYI
       .:::::....:. :     :. . ..  .:::: ::::.:.:: :::.::: .:: ..:.
NP_874 GYPFRLNEASFQPPPGVNICDVNWKD-YVLIGDYSSSAQFYVTFAVFVFLYCIAALLLYV
               70        80         90       100       110         

             110       120       130       140       150       160 
pF1KE0 FFQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLSDVKVATDPKEVLLLMSACKQP
        . . : .. . :.:::.::.: .:::::..:::::.:.:.:.::  ....  .  ::. 
NP_874 GYTSLYLDSRKLPMIDFVVTLVATFLWLVSTSAWAKALTDIKIATG-HNIIDELPPCKKK
     120       130       140       150       160        170        

             170       180       190       200       210       220 
pF1KE0 SNKCMAIHSPVMSSLNTSVVFGFLNFILWAGNIWFVFKETGWHSSGQRYLSDPMEKHSSS
       .  :.      :.:::.::.:::::.:::.:: :::.:::. ::      :.    ::  
NP_874 AVLCYFGSVTSMGSLNVSVIFGFLNMILWGGNAWFVYKETSLHSP-----SNTSAPHS--
      180       190       200       210       220            230   

             230       240       250       260     
pF1KE0 YNQGGYNQDSYGSSSGYSQQASLGPTSDEFGQQPTGPTSFTNQI
         :::                                       
NP_874 --QGGIPPPTGI                                
               240                                 

>>NP_006745 (OMIM: 616665) synaptophysin-like protein 1   (259 aa)
 initn: 629 init1: 301 opt: 622  Z-score: 765.1  bits: 149.2 E(85289): 7.1e-36
Smith-Waterman score: 623; 44.5% identity (71.8% similar) in 220 aa overlap (11-226:44-252)

                                   10        20        30        40
pF1KE0                     MCMVIFAPLFAIFAFATCGGYSGGLRLSVDCVNKTESNLS
                                     .:::::::::..:  ...:.:   .  : .
NP_006 RLGQRMSGFQINLNPLKEPLGFIKVLEWIASIFAFATCGGFKGQTEIQVNCPPAVTENKT
            20        30        40        50        60        70   

               50        60            70        80        90      
pF1KE0 IDIAFAYPFRLHQVTFEVPT----CEGKERQKLALIGDSSSSAEFFVTVAVFAFLYSLAA
       .  .:.:::::....:. :     :. . ..  .:::: ::::.:.:: :::.::: .::
NP_006 VTATFGYPFRLNEASFQPPPGVNICDVNWKD-YVLIGDYSSSAQFYVTFAVFVFLYCIAA
            80        90       100        110       120       130  

        100       110       120       130       140       150      
pF1KE0 TVVYIFFQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLSDVKVATDPKEVLLLMS
        ..:. . . : .. . :.:::.::.: .:::::..:::::.:.:.:.::  ....  . 
NP_006 LLLYVGYTSLYLDSRKLPMIDFVVTLVATFLWLVSTSAWAKALTDIKIATG-HNIIDELP
            140       150       160       170       180        190 

        160       170       180       190       200       210      
pF1KE0 ACKQPSNKCMAIHSPVMSSLNTSVVFGFLNFILWAGNIWFVFKETGWHSSGQRYLSDPME
        ::. .  :.      :.:::.::.:::::.:::.:: :::.:::. ::      :.   
NP_006 PCKKKAVLCYFGSVTSMGSLNVSVIFGFLNMILWGGNAWFVYKETSLHSP-----SNTSA
             200       210       220       230       240           

        220       230       240       250       260     
pF1KE0 KHSSSYNQGGYNQDSYGSSSGYSQQASLGPTSDEFGQQPTGPTSFTNQI
        ::    :::                                       
NP_006 PHS----QGGIPPPTGI                                
            250                                         




265 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 23:23:06 2016 done: Thu Nov  3 23:23:07 2016
 Total Scan time:  6.190 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]