FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0181, 269 aa 1>>>pF1KE0181 269 - 269 aa - 269 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.3647+/-0.000431; mu= 19.8259+/- 0.026 mean_var=59.2721+/-12.378, 0's: 0 Z-trim(108.8): 25 B-trim: 942 in 1/50 Lambda= 0.166590 statistics sampled from 16938 (16953) to 16938 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.553), E-opt: 0.2 (0.199), width: 16 Scan time: 6.320 The best scores are: opt bits E(85289) NP_149351 (OMIM: 185660) surfeit locus protein 4 i ( 269) 1787 438.2 7.8e-123 XP_011517246 (OMIM: 185660) PREDICTED: surfeit loc ( 260) 1685 413.6 1.8e-115 XP_011517245 (OMIM: 185660) PREDICTED: surfeit loc ( 260) 1685 413.6 1.8e-115 NP_001267717 (OMIM: 185660) surfeit locus protein ( 254) 1678 411.9 5.7e-115 NP_001267720 (OMIM: 185660) surfeit locus protein ( 226) 1500 369.1 4e-102 NP_001267719 (OMIM: 185660) surfeit locus protein ( 226) 1500 369.1 4e-102 NP_001267718 (OMIM: 185660) surfeit locus protein ( 159) 1052 261.3 8e-70 NP_001267722 (OMIM: 185660) surfeit locus protein ( 152) 985 245.2 5.4e-65 NP_001267721 (OMIM: 185660) surfeit locus protein ( 128) 816 204.5 8.1e-53 XP_016870551 (OMIM: 185660) PREDICTED: surfeit loc ( 160) 715 180.3 1.9e-45 XP_011517247 (OMIM: 185660) PREDICTED: surfeit loc ( 206) 585 149.2 5.9e-36 >>NP_149351 (OMIM: 185660) surfeit locus protein 4 isofo (269 aa) initn: 1787 init1: 1787 opt: 1787 Z-score: 2326.3 bits: 438.2 E(85289): 7.8e-123 Smith-Waterman score: 1787; 100.0% identity (100.0% similar) in 269 aa overlap (1-269:1-269) 10 20 30 40 50 60 pF1KE0 MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 CGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 CGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 LALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 SIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 SIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFF 190 200 210 220 230 240 250 260 pF1KE0 QTMSVIGGLLLVVALGPGGVSMDEKKKEW ::::::::::::::::::::::::::::: NP_149 QTMSVIGGLLLVVALGPGGVSMDEKKKEW 250 260 >>XP_011517246 (OMIM: 185660) PREDICTED: surfeit locus p (260 aa) initn: 1685 init1: 1685 opt: 1685 Z-score: 2194.0 bits: 413.6 E(85289): 1.8e-115 Smith-Waterman score: 1685; 98.8% identity (99.6% similar) in 257 aa overlap (13-269:4-260) 10 20 30 40 50 60 pF1KE0 MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWN .: .:::::::::::::::::::::::::::::::::::::::::::: XP_011 MRSLATEFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWN 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 CGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 LALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFF 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 SIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFF 180 190 200 210 220 230 250 260 pF1KE0 QTMSVIGGLLLVVALGPGGVSMDEKKKEW ::::::::::::::::::::::::::::: XP_011 QTMSVIGGLLLVVALGPGGVSMDEKKKEW 240 250 260 >>XP_011517245 (OMIM: 185660) PREDICTED: surfeit locus p (260 aa) initn: 1685 init1: 1685 opt: 1685 Z-score: 2194.0 bits: 413.6 E(85289): 1.8e-115 Smith-Waterman score: 1685; 98.8% identity (99.6% similar) in 257 aa overlap (13-269:4-260) 10 20 30 40 50 60 pF1KE0 MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWN .: .:::::::::::::::::::::::::::::::::::::::::::: XP_011 MRSLATEFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWN 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 CGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 LALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFF 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 SIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFF 180 190 200 210 220 230 250 260 pF1KE0 QTMSVIGGLLLVVALGPGGVSMDEKKKEW ::::::::::::::::::::::::::::: XP_011 QTMSVIGGLLLVVALGPGGVSMDEKKKEW 240 250 260 >>NP_001267717 (OMIM: 185660) surfeit locus protein 4 is (254 aa) initn: 1678 init1: 1678 opt: 1678 Z-score: 2185.0 bits: 411.9 E(85289): 5.7e-115 Smith-Waterman score: 1678; 100.0% identity (100.0% similar) in 253 aa overlap (17-269:2-254) 10 20 30 40 50 60 pF1KE0 MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWN :::::::::::::::::::::::::::::::::::::::::::: NP_001 MFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWN 10 20 30 40 70 80 90 100 110 120 pF1KE0 CGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRN 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE0 LALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFF 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE0 SIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFF 170 180 190 200 210 220 250 260 pF1KE0 QTMSVIGGLLLVVALGPGGVSMDEKKKEW ::::::::::::::::::::::::::::: NP_001 QTMSVIGGLLLVVALGPGGVSMDEKKKEW 230 240 250 >>NP_001267720 (OMIM: 185660) surfeit locus protein 4 is (226 aa) initn: 1500 init1: 1500 opt: 1500 Z-score: 1954.5 bits: 369.1 E(85289): 4e-102 Smith-Waterman score: 1500; 100.0% identity (100.0% similar) in 226 aa overlap (44-269:1-226) 20 30 40 50 60 70 pF1KE0 ADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWNCGYLLASSFVFLN :::::::::::::::::::::::::::::: NP_001 MWFQWSEQRDYIDTTWNCGYLLASSFVFLN 10 20 30 80 90 100 110 120 130 pF1KE0 LLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAE 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE0 SRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMI 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE0 LVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVV 160 170 180 190 200 210 260 pF1KE0 ALGPGGVSMDEKKKEW :::::::::::::::: NP_001 ALGPGGVSMDEKKKEW 220 >>NP_001267719 (OMIM: 185660) surfeit locus protein 4 is (226 aa) initn: 1500 init1: 1500 opt: 1500 Z-score: 1954.5 bits: 369.1 E(85289): 4e-102 Smith-Waterman score: 1500; 100.0% identity (100.0% similar) in 226 aa overlap (44-269:1-226) 20 30 40 50 60 70 pF1KE0 ADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWNCGYLLASSFVFLN :::::::::::::::::::::::::::::: NP_001 MWFQWSEQRDYIDTTWNCGYLLASSFVFLN 10 20 30 80 90 100 110 120 130 pF1KE0 LLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAE 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE0 SRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMI 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE0 LVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVV 160 170 180 190 200 210 260 pF1KE0 ALGPGGVSMDEKKKEW :::::::::::::::: NP_001 ALGPGGVSMDEKKKEW 220 >>NP_001267718 (OMIM: 185660) surfeit locus protein 4 is (159 aa) initn: 1070 init1: 1052 opt: 1052 Z-score: 1374.5 bits: 261.3 E(85289): 8e-70 Smith-Waterman score: 1052; 99.4% identity (100.0% similar) in 157 aa overlap (1-157:1-157) 10 20 30 40 50 60 pF1KE0 MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 CGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFF ::::::::::::::::::::::::::::::::::::. NP_001 LALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYLPG 130 140 150 190 200 210 220 230 240 pF1KE0 SIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFF >>NP_001267722 (OMIM: 185660) surfeit locus protein 4 is (152 aa) initn: 985 init1: 985 opt: 985 Z-score: 1287.8 bits: 245.2 E(85289): 5.4e-65 Smith-Waterman score: 985; 100.0% identity (100.0% similar) in 152 aa overlap (118-269:1-152) 90 100 110 120 130 140 pF1KE0 NFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPT :::::::::::::::::::::::::::::: NP_001 MRNLALGGGLLLLLAESRSEGKSMFAGVPT 10 20 30 150 160 170 180 190 200 pF1KE0 MRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTKLAALT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTKLAALT 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE0 LVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKK 100 110 120 130 140 150 pF1KE0 EW :: NP_001 EW >>NP_001267721 (OMIM: 185660) surfeit locus protein 4 is (128 aa) initn: 816 init1: 816 opt: 816 Z-score: 1069.2 bits: 204.5 E(85289): 8.1e-53 Smith-Waterman score: 816; 100.0% identity (100.0% similar) in 119 aa overlap (1-119:1-119) 10 20 30 40 50 60 pF1KE0 MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 CGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRN ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFF NP_001 SRTSWAQL >>XP_016870551 (OMIM: 185660) PREDICTED: surfeit locus p (160 aa) initn: 715 init1: 715 opt: 715 Z-score: 936.8 bits: 180.3 E(85289): 1.9e-45 Smith-Waterman score: 715; 99.1% identity (99.1% similar) in 106 aa overlap (14-119:46-151) 10 20 30 40 pF1KE0 MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIR : :::::::::::::::::::::::::::: XP_016 ASVPHTPRPRTCLAAAWCSPPQPPHPWVSVALQFLRVTKQYLPHVARLCLISTFLEDGIR 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE0 MWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIAL 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE0 QTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRV :::::::::::::::: XP_016 QTIAYSILWDLKFLMRLSRTSWAQL 140 150 160 269 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 22:24:11 2016 done: Thu Nov 3 22:24:12 2016 Total Scan time: 6.320 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]