FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0193, 359 aa 1>>>pF1KE0193 359 - 359 aa - 359 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0170+/-0.000338; mu= 17.5452+/- 0.021 mean_var=58.1644+/-11.940, 0's: 0 Z-trim(115.8): 27 B-trim: 718 in 1/49 Lambda= 0.168169 statistics sampled from 26475 (26501) to 26475 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.311), width: 16 Scan time: 8.480 The best scores are: opt bits E(85289) NP_001135764 (OMIM: 609552,616887) VIP36-like prot ( 359) 2468 606.9 2.3e-173 NP_001309276 (OMIM: 609552,616887) VIP36-like prot ( 221) 1498 371.4 1.1e-102 NP_001309281 (OMIM: 609552,616887) VIP36-like prot ( 221) 1498 371.4 1.1e-102 NP_001309283 (OMIM: 609552,616887) VIP36-like prot ( 214) 1281 318.8 7.3e-87 NP_001309275 (OMIM: 609552,616887) VIP36-like prot ( 214) 1281 318.8 7.3e-87 NP_001309285 (OMIM: 609552,616887) VIP36-like prot ( 203) 1211 301.8 9e-82 NP_001309280 (OMIM: 609552,616887) VIP36-like prot ( 203) 1211 301.8 9e-82 NP_001309284 (OMIM: 609552,616887) VIP36-like prot ( 203) 1211 301.8 9e-82 NP_001309279 (OMIM: 609552,616887) VIP36-like prot ( 210) 1206 300.6 2.2e-81 NP_110432 (OMIM: 609552,616887) VIP36-like protein ( 348) 1206 300.7 3.3e-81 NP_006807 (OMIM: 609551) vesicular integral-membra ( 356) 706 179.4 1.1e-44 NP_005561 (OMIM: 227300,601567) protein ERGIC-53 p ( 510) 319 85.6 2.8e-16 NP_068591 (OMIM: 609548) protein ERGIC-53-like pre ( 526) 286 77.6 7.3e-14 >>NP_001135764 (OMIM: 609552,616887) VIP36-like protein (359 aa) initn: 2468 init1: 2468 opt: 2468 Z-score: 3233.5 bits: 606.9 E(85289): 2.3e-173 Smith-Waterman score: 2468; 100.0% identity (100.0% similar) in 359 aa overlap (1-359:1-359) 10 20 30 40 50 60 pF1KE0 MAATLGPLGSWQQWRRCLSARDGSRMLLLLLLLGSGQGPQQVGAGQTFEYLKREHSLSKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAATLGPLGSWQQWRRCLSARDGSRMLLLLLLLGSGQGPQQVGAGQTFEYLKREHSLSKP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 YQGVGTGSSSLWNLMGNAMVMTQYIRLTPDMQSKQGALWNRVPCFLRDWELQVHFKIHGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YQGVGTGSSSLWNLMGNAMVMTQYIRLTPDMQSKQGALWNRVPCFLRDWELQVHFKIHGQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 GKKNLHGDGLAIWYTKDRMQPGPVFGNMDKFVGLGVFVDTYPNEEKQQEAQKRRYSPGVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKKNLHGDGLAIWYTKDRMQPGPVFGNMDKFVGLGVFVDTYPNEEKQQEAQKRRYSPGVQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 RVFPYISAMVNNGSLSYDHERDGRPTELGGCTAIVRNLHYDTFLVIRYVKRHLTIMMDID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVFPYISAMVNNGSLSYDHERDGRPTELGGCTAIVRNLHYDTFLVIRYVKRHLTIMMDID 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 GKHEWRDCIEVPGVRLPRGYYFGTSSITGDLSDNHDVISLKLFELTVERTPEEEKLHRDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKHEWRDCIEVPGVRLPRGYYFGTSSITGDLSDNHDVISLKLFELTVERTPEEEKLHRDV 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 FLPSVDNMKLPEMTAPLPPLSGLALFLIVFFSLVFSVFAIVIGIILYNKWQEQSRKRFY ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLPSVDNMKLPEMTAPLPPLSGLALFLIVFFSLVFSVFAIVIGIILYNKWQEQSRKRFY 310 320 330 340 350 >>NP_001309276 (OMIM: 609552,616887) VIP36-like protein (221 aa) initn: 1498 init1: 1498 opt: 1498 Z-score: 1964.8 bits: 371.4 E(85289): 1.1e-102 Smith-Waterman score: 1498; 100.0% identity (100.0% similar) in 221 aa overlap (139-359:1-221) 110 120 130 140 150 160 pF1KE0 WELQVHFKIHGQGKKNLHGDGLAIWYTKDRMQPGPVFGNMDKFVGLGVFVDTYPNEEKQQ :::::::::::::::::::::::::::::: NP_001 MQPGPVFGNMDKFVGLGVFVDTYPNEEKQQ 10 20 30 170 180 190 200 210 220 pF1KE0 EAQKRRYSPGVQRVFPYISAMVNNGSLSYDHERDGRPTELGGCTAIVRNLHYDTFLVIRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAQKRRYSPGVQRVFPYISAMVNNGSLSYDHERDGRPTELGGCTAIVRNLHYDTFLVIRY 40 50 60 70 80 90 230 240 250 260 270 280 pF1KE0 VKRHLTIMMDIDGKHEWRDCIEVPGVRLPRGYYFGTSSITGDLSDNHDVISLKLFELTVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKRHLTIMMDIDGKHEWRDCIEVPGVRLPRGYYFGTSSITGDLSDNHDVISLKLFELTVE 100 110 120 130 140 150 290 300 310 320 330 340 pF1KE0 RTPEEEKLHRDVFLPSVDNMKLPEMTAPLPPLSGLALFLIVFFSLVFSVFAIVIGIILYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTPEEEKLHRDVFLPSVDNMKLPEMTAPLPPLSGLALFLIVFFSLVFSVFAIVIGIILYN 160 170 180 190 200 210 350 pF1KE0 KWQEQSRKRFY ::::::::::: NP_001 KWQEQSRKRFY 220 >>NP_001309281 (OMIM: 609552,616887) VIP36-like protein (221 aa) initn: 1498 init1: 1498 opt: 1498 Z-score: 1964.8 bits: 371.4 E(85289): 1.1e-102 Smith-Waterman score: 1498; 100.0% identity (100.0% similar) in 221 aa overlap (139-359:1-221) 110 120 130 140 150 160 pF1KE0 WELQVHFKIHGQGKKNLHGDGLAIWYTKDRMQPGPVFGNMDKFVGLGVFVDTYPNEEKQQ :::::::::::::::::::::::::::::: NP_001 MQPGPVFGNMDKFVGLGVFVDTYPNEEKQQ 10 20 30 170 180 190 200 210 220 pF1KE0 EAQKRRYSPGVQRVFPYISAMVNNGSLSYDHERDGRPTELGGCTAIVRNLHYDTFLVIRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAQKRRYSPGVQRVFPYISAMVNNGSLSYDHERDGRPTELGGCTAIVRNLHYDTFLVIRY 40 50 60 70 80 90 230 240 250 260 270 280 pF1KE0 VKRHLTIMMDIDGKHEWRDCIEVPGVRLPRGYYFGTSSITGDLSDNHDVISLKLFELTVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKRHLTIMMDIDGKHEWRDCIEVPGVRLPRGYYFGTSSITGDLSDNHDVISLKLFELTVE 100 110 120 130 140 150 290 300 310 320 330 340 pF1KE0 RTPEEEKLHRDVFLPSVDNMKLPEMTAPLPPLSGLALFLIVFFSLVFSVFAIVIGIILYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTPEEEKLHRDVFLPSVDNMKLPEMTAPLPPLSGLALFLIVFFSLVFSVFAIVIGIILYN 160 170 180 190 200 210 350 pF1KE0 KWQEQSRKRFY ::::::::::: NP_001 KWQEQSRKRFY 220 >>NP_001309283 (OMIM: 609552,616887) VIP36-like protein (214 aa) initn: 1281 init1: 1281 opt: 1281 Z-score: 1680.5 bits: 318.8 E(85289): 7.3e-87 Smith-Waterman score: 1281; 99.5% identity (100.0% similar) in 191 aa overlap (169-359:24-214) 140 150 160 170 180 190 pF1KE0 MQPGPVFGNMDKFVGLGVFVDTYPNEEKQQEAQKRRYSPGVQRVFPYISAMVNNGSLSYD .::::::::::::::::::::::::::::: NP_001 MDKERRICMGMAWQSGTQRIGCSQAQKRRYSPGVQRVFPYISAMVNNGSLSYD 10 20 30 40 50 200 210 220 230 240 250 pF1KE0 HERDGRPTELGGCTAIVRNLHYDTFLVIRYVKRHLTIMMDIDGKHEWRDCIEVPGVRLPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HERDGRPTELGGCTAIVRNLHYDTFLVIRYVKRHLTIMMDIDGKHEWRDCIEVPGVRLPR 60 70 80 90 100 110 260 270 280 290 300 310 pF1KE0 GYYFGTSSITGDLSDNHDVISLKLFELTVERTPEEEKLHRDVFLPSVDNMKLPEMTAPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYYFGTSSITGDLSDNHDVISLKLFELTVERTPEEEKLHRDVFLPSVDNMKLPEMTAPLP 120 130 140 150 160 170 320 330 340 350 pF1KE0 PLSGLALFLIVFFSLVFSVFAIVIGIILYNKWQEQSRKRFY ::::::::::::::::::::::::::::::::::::::::: NP_001 PLSGLALFLIVFFSLVFSVFAIVIGIILYNKWQEQSRKRFY 180 190 200 210 >>NP_001309275 (OMIM: 609552,616887) VIP36-like protein (214 aa) initn: 1281 init1: 1281 opt: 1281 Z-score: 1680.5 bits: 318.8 E(85289): 7.3e-87 Smith-Waterman score: 1281; 99.5% identity (100.0% similar) in 191 aa overlap (169-359:24-214) 140 150 160 170 180 190 pF1KE0 MQPGPVFGNMDKFVGLGVFVDTYPNEEKQQEAQKRRYSPGVQRVFPYISAMVNNGSLSYD .::::::::::::::::::::::::::::: NP_001 MDKERRICMGMAWQSGTQRIGCSQAQKRRYSPGVQRVFPYISAMVNNGSLSYD 10 20 30 40 50 200 210 220 230 240 250 pF1KE0 HERDGRPTELGGCTAIVRNLHYDTFLVIRYVKRHLTIMMDIDGKHEWRDCIEVPGVRLPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HERDGRPTELGGCTAIVRNLHYDTFLVIRYVKRHLTIMMDIDGKHEWRDCIEVPGVRLPR 60 70 80 90 100 110 260 270 280 290 300 310 pF1KE0 GYYFGTSSITGDLSDNHDVISLKLFELTVERTPEEEKLHRDVFLPSVDNMKLPEMTAPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYYFGTSSITGDLSDNHDVISLKLFELTVERTPEEEKLHRDVFLPSVDNMKLPEMTAPLP 120 130 140 150 160 170 320 330 340 350 pF1KE0 PLSGLALFLIVFFSLVFSVFAIVIGIILYNKWQEQSRKRFY ::::::::::::::::::::::::::::::::::::::::: NP_001 PLSGLALFLIVFFSLVFSVFAIVIGIILYNKWQEQSRKRFY 180 190 200 210 >>NP_001309285 (OMIM: 609552,616887) VIP36-like protein (203 aa) initn: 1211 init1: 1211 opt: 1211 Z-score: 1589.0 bits: 301.8 E(85289): 9e-82 Smith-Waterman score: 1211; 100.0% identity (100.0% similar) in 180 aa overlap (180-359:24-203) 150 160 170 180 190 200 pF1KE0 KFVGLGVFVDTYPNEEKQQEAQKRRYSPGVQRVFPYISAMVNNGSLSYDHERDGRPTELG :::::::::::::::::::::::::::::: NP_001 MDKERRICMGMAWQSGTQRIGCSQRVFPYISAMVNNGSLSYDHERDGRPTELG 10 20 30 40 50 210 220 230 240 250 260 pF1KE0 GCTAIVRNLHYDTFLVIRYVKRHLTIMMDIDGKHEWRDCIEVPGVRLPRGYYFGTSSITG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GCTAIVRNLHYDTFLVIRYVKRHLTIMMDIDGKHEWRDCIEVPGVRLPRGYYFGTSSITG 60 70 80 90 100 110 270 280 290 300 310 320 pF1KE0 DLSDNHDVISLKLFELTVERTPEEEKLHRDVFLPSVDNMKLPEMTAPLPPLSGLALFLIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLSDNHDVISLKLFELTVERTPEEEKLHRDVFLPSVDNMKLPEMTAPLPPLSGLALFLIV 120 130 140 150 160 170 330 340 350 pF1KE0 FFSLVFSVFAIVIGIILYNKWQEQSRKRFY :::::::::::::::::::::::::::::: NP_001 FFSLVFSVFAIVIGIILYNKWQEQSRKRFY 180 190 200 >>NP_001309280 (OMIM: 609552,616887) VIP36-like protein (203 aa) initn: 1211 init1: 1211 opt: 1211 Z-score: 1589.0 bits: 301.8 E(85289): 9e-82 Smith-Waterman score: 1211; 100.0% identity (100.0% similar) in 180 aa overlap (180-359:24-203) 150 160 170 180 190 200 pF1KE0 KFVGLGVFVDTYPNEEKQQEAQKRRYSPGVQRVFPYISAMVNNGSLSYDHERDGRPTELG :::::::::::::::::::::::::::::: NP_001 MDKERRICMGMAWQSGTQRIGCSQRVFPYISAMVNNGSLSYDHERDGRPTELG 10 20 30 40 50 210 220 230 240 250 260 pF1KE0 GCTAIVRNLHYDTFLVIRYVKRHLTIMMDIDGKHEWRDCIEVPGVRLPRGYYFGTSSITG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GCTAIVRNLHYDTFLVIRYVKRHLTIMMDIDGKHEWRDCIEVPGVRLPRGYYFGTSSITG 60 70 80 90 100 110 270 280 290 300 310 320 pF1KE0 DLSDNHDVISLKLFELTVERTPEEEKLHRDVFLPSVDNMKLPEMTAPLPPLSGLALFLIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLSDNHDVISLKLFELTVERTPEEEKLHRDVFLPSVDNMKLPEMTAPLPPLSGLALFLIV 120 130 140 150 160 170 330 340 350 pF1KE0 FFSLVFSVFAIVIGIILYNKWQEQSRKRFY :::::::::::::::::::::::::::::: NP_001 FFSLVFSVFAIVIGIILYNKWQEQSRKRFY 180 190 200 >>NP_001309284 (OMIM: 609552,616887) VIP36-like protein (203 aa) initn: 1211 init1: 1211 opt: 1211 Z-score: 1589.0 bits: 301.8 E(85289): 9e-82 Smith-Waterman score: 1211; 100.0% identity (100.0% similar) in 180 aa overlap (180-359:24-203) 150 160 170 180 190 200 pF1KE0 KFVGLGVFVDTYPNEEKQQEAQKRRYSPGVQRVFPYISAMVNNGSLSYDHERDGRPTELG :::::::::::::::::::::::::::::: NP_001 MDKERRICMGMAWQSGTQRIGCSQRVFPYISAMVNNGSLSYDHERDGRPTELG 10 20 30 40 50 210 220 230 240 250 260 pF1KE0 GCTAIVRNLHYDTFLVIRYVKRHLTIMMDIDGKHEWRDCIEVPGVRLPRGYYFGTSSITG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GCTAIVRNLHYDTFLVIRYVKRHLTIMMDIDGKHEWRDCIEVPGVRLPRGYYFGTSSITG 60 70 80 90 100 110 270 280 290 300 310 320 pF1KE0 DLSDNHDVISLKLFELTVERTPEEEKLHRDVFLPSVDNMKLPEMTAPLPPLSGLALFLIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLSDNHDVISLKLFELTVERTPEEEKLHRDVFLPSVDNMKLPEMTAPLPPLSGLALFLIV 120 130 140 150 160 170 330 340 350 pF1KE0 FFSLVFSVFAIVIGIILYNKWQEQSRKRFY :::::::::::::::::::::::::::::: NP_001 FFSLVFSVFAIVIGIILYNKWQEQSRKRFY 180 190 200 >>NP_001309279 (OMIM: 609552,616887) VIP36-like protein (210 aa) initn: 1206 init1: 1206 opt: 1206 Z-score: 1582.2 bits: 300.6 E(85289): 2.2e-81 Smith-Waterman score: 1391; 95.0% identity (95.0% similar) in 221 aa overlap (139-359:1-210) 110 120 130 140 150 160 pF1KE0 WELQVHFKIHGQGKKNLHGDGLAIWYTKDRMQPGPVFGNMDKFVGLGVFVDTYPNEEKQQ :::::::::::::::::::::::::::::: NP_001 MQPGPVFGNMDKFVGLGVFVDTYPNEEKQQ 10 20 30 170 180 190 200 210 220 pF1KE0 EAQKRRYSPGVQRVFPYISAMVNNGSLSYDHERDGRPTELGGCTAIVRNLHYDTFLVIRY : :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 E-----------RVFPYISAMVNNGSLSYDHERDGRPTELGGCTAIVRNLHYDTFLVIRY 40 50 60 70 230 240 250 260 270 280 pF1KE0 VKRHLTIMMDIDGKHEWRDCIEVPGVRLPRGYYFGTSSITGDLSDNHDVISLKLFELTVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKRHLTIMMDIDGKHEWRDCIEVPGVRLPRGYYFGTSSITGDLSDNHDVISLKLFELTVE 80 90 100 110 120 130 290 300 310 320 330 340 pF1KE0 RTPEEEKLHRDVFLPSVDNMKLPEMTAPLPPLSGLALFLIVFFSLVFSVFAIVIGIILYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTPEEEKLHRDVFLPSVDNMKLPEMTAPLPPLSGLALFLIVFFSLVFSVFAIVIGIILYN 140 150 160 170 180 190 350 pF1KE0 KWQEQSRKRFY ::::::::::: NP_001 KWQEQSRKRFY 200 210 >>NP_110432 (OMIM: 609552,616887) VIP36-like protein iso (348 aa) initn: 1210 init1: 1206 opt: 1206 Z-score: 1578.9 bits: 300.7 E(85289): 3.3e-81 Smith-Waterman score: 2361; 96.9% identity (96.9% similar) in 359 aa overlap (1-359:1-348) 10 20 30 40 50 60 pF1KE0 MAATLGPLGSWQQWRRCLSARDGSRMLLLLLLLGSGQGPQQVGAGQTFEYLKREHSLSKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 MAATLGPLGSWQQWRRCLSARDGSRMLLLLLLLGSGQGPQQVGAGQTFEYLKREHSLSKP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 YQGVGTGSSSLWNLMGNAMVMTQYIRLTPDMQSKQGALWNRVPCFLRDWELQVHFKIHGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 YQGVGTGSSSLWNLMGNAMVMTQYIRLTPDMQSKQGALWNRVPCFLRDWELQVHFKIHGQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 GKKNLHGDGLAIWYTKDRMQPGPVFGNMDKFVGLGVFVDTYPNEEKQQEAQKRRYSPGVQ ::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 GKKNLHGDGLAIWYTKDRMQPGPVFGNMDKFVGLGVFVDTYPNEEKQQE----------- 130 140 150 160 190 200 210 220 230 240 pF1KE0 RVFPYISAMVNNGSLSYDHERDGRPTELGGCTAIVRNLHYDTFLVIRYVKRHLTIMMDID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 RVFPYISAMVNNGSLSYDHERDGRPTELGGCTAIVRNLHYDTFLVIRYVKRHLTIMMDID 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE0 GKHEWRDCIEVPGVRLPRGYYFGTSSITGDLSDNHDVISLKLFELTVERTPEEEKLHRDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 GKHEWRDCIEVPGVRLPRGYYFGTSSITGDLSDNHDVISLKLFELTVERTPEEEKLHRDV 230 240 250 260 270 280 310 320 330 340 350 pF1KE0 FLPSVDNMKLPEMTAPLPPLSGLALFLIVFFSLVFSVFAIVIGIILYNKWQEQSRKRFY ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 FLPSVDNMKLPEMTAPLPPLSGLALFLIVFFSLVFSVFAIVIGIILYNKWQEQSRKRFY 290 300 310 320 330 340 359 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 21:44:18 2016 done: Thu Nov 3 21:44:19 2016 Total Scan time: 8.480 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]