Result of FASTA (omim) for
pF1KE0199
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0199, 1106 aa
1>>>pF1KE0199 1106 - 1106 aa - 1106 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 14.0034+/-0.000481; mu= -17.1709+/- 0.030
mean_var=732.5482+/-160.595, 0's: 0 Z-trim(123.8): 849 B-trim: 0 in 0/58
Lambda= 0.047387
statistics sampled from 42933 (44222) to 42933 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.795), E-opt: 0.2 (0.518), width: 16
Scan time: 16.660
The best scores are: opt bits E(85289)
XP_011536491 (OMIM: 165220) PREDICTED: zinc finger (1106) 7851 553.2 3.1e-156
NP_005260 (OMIM: 165220) zinc finger protein GLI1 (1106) 7851 553.2 3.1e-156
NP_001161081 (OMIM: 165220) zinc finger protein GL (1065) 7320 516.9 2.6e-145
NP_001153517 (OMIM: 165220) zinc finger protein GL ( 978) 6974 493.2 3.2e-138
XP_011536492 (OMIM: 165220) PREDICTED: zinc finger (1029) 4755 341.5 1.5e-92
XP_011513576 (OMIM: 146510,165240,174200,174700,17 (1521) 1285 104.5 5.1e-21
XP_016867486 (OMIM: 146510,165240,174200,174700,17 (1579) 1285 104.5 5.2e-21
NP_000159 (OMIM: 146510,165240,174200,174700,17570 (1580) 1285 104.5 5.2e-21
XP_011509275 (OMIM: 165230,610829,615849) PREDICTE (1461) 1207 99.1 2e-19
XP_011509273 (OMIM: 165230,610829,615849) PREDICTE (1521) 1207 99.1 2.1e-19
XP_011509272 (OMIM: 165230,610829,615849) PREDICTE (1539) 1207 99.1 2.1e-19
XP_011509274 (OMIM: 165230,610829,615849) PREDICTE (1553) 1207 99.1 2.1e-19
NP_005261 (OMIM: 165230,610829,615849) zinc finger (1586) 1207 99.2 2.1e-19
XP_011509271 (OMIM: 165230,610829,615849) PREDICTE (1670) 1207 99.2 2.2e-19
XP_011509276 (OMIM: 165230,610829,615849) PREDICTE (1444) 1197 98.4 3.2e-19
XP_006712485 (OMIM: 165230,610829,615849) PREDICTE (1569) 1197 98.5 3.4e-19
XP_016859307 (OMIM: 165230,610829,615849) PREDICTE (1653) 1197 98.5 3.5e-19
XP_011516067 (OMIM: 610192,610199) PREDICTED: zinc ( 868) 793 70.6 4.7e-11
XP_011516069 (OMIM: 610192,610199) PREDICTED: zinc ( 708) 783 69.8 6.6e-11
XP_005251444 (OMIM: 610192,610199) PREDICTED: zinc ( 708) 783 69.8 6.6e-11
XP_005251445 (OMIM: 610192,610199) PREDICTED: zinc ( 708) 783 69.8 6.6e-11
NP_689842 (OMIM: 610192,610199) zinc finger protei ( 775) 783 69.8 7e-11
XP_016869850 (OMIM: 610192,610199) PREDICTED: zinc ( 775) 783 69.8 7e-11
XP_005251443 (OMIM: 610192,610199) PREDICTED: zinc ( 775) 783 69.8 7e-11
XP_011516068 (OMIM: 610192,610199) PREDICTED: zinc ( 775) 783 69.8 7e-11
XP_011516066 (OMIM: 610192,610199) PREDICTED: zinc ( 930) 783 69.9 7.9e-11
XP_011516065 (OMIM: 610192,610199) PREDICTED: zinc ( 930) 783 69.9 7.9e-11
NP_001035878 (OMIM: 610192,610199) zinc finger pro ( 930) 783 69.9 7.9e-11
NP_671726 (OMIM: 610378) zinc finger protein GLIS1 ( 620) 767 68.6 1.3e-10
XP_016855900 (OMIM: 610378) PREDICTED: zinc finger ( 629) 767 68.6 1.3e-10
XP_016855899 (OMIM: 610378) PREDICTED: zinc finger ( 795) 767 68.7 1.5e-10
XP_016855897 (OMIM: 610378) PREDICTED: zinc finger ( 795) 767 68.7 1.5e-10
XP_016855898 (OMIM: 610378) PREDICTED: zinc finger ( 791) 756 68.0 2.5e-10
NP_001305847 (OMIM: 608539,611498) zinc finger pro ( 524) 696 63.7 3.3e-09
NP_115964 (OMIM: 608539,611498) zinc finger protei ( 524) 696 63.7 3.3e-09
XP_005255698 (OMIM: 608539,611498) PREDICTED: zinc ( 524) 696 63.7 3.3e-09
NP_001161851 (OMIM: 608948) zinc finger protein ZI ( 372) 606 57.4 1.9e-07
NP_115529 (OMIM: 608948) zinc finger protein ZIC 4 ( 334) 603 57.1 2e-07
NP_001161850 (OMIM: 608948) zinc finger protein ZI ( 384) 603 57.2 2.2e-07
NP_009060 (OMIM: 603073,609637) zinc finger protei ( 532) 605 57.5 2.5e-07
NP_003403 (OMIM: 600470,616602) zinc finger protei ( 447) 588 56.2 5e-07
XP_011519412 (OMIM: 603073,609637) PREDICTED: zinc ( 427) 580 55.7 7.1e-07
NP_003404 (OMIM: 300265,306955,314390) zinc finger ( 467) 577 55.5 8.7e-07
NP_001317590 (OMIM: 300265,306955,314390) zinc fin ( 457) 567 54.8 1.4e-06
XP_005253184 (OMIM: 603433) PREDICTED: zinc finger ( 435) 462 47.6 0.00019
XP_016873745 (OMIM: 603433) PREDICTED: zinc finger ( 606) 462 47.8 0.00024
NP_001269586 (OMIM: 603433) zinc finger protein 14 ( 607) 462 47.8 0.00024
XP_016873742 (OMIM: 603433) PREDICTED: zinc finger ( 621) 462 47.8 0.00024
XP_016873741 (OMIM: 603433) PREDICTED: zinc finger ( 622) 462 47.8 0.00024
XP_016873743 (OMIM: 603433) PREDICTED: zinc finger ( 637) 462 47.8 0.00025
>>XP_011536491 (OMIM: 165220) PREDICTED: zinc finger pro (1106 aa)
initn: 7851 init1: 7851 opt: 7851 Z-score: 2925.9 bits: 553.2 E(85289): 3.1e-156
Smith-Waterman score: 7851; 100.0% identity (100.0% similar) in 1106 aa overlap (1-1106:1-1106)
10 20 30 40 50 60
pF1KE0 MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SCTEGPLFSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCTEGPLFSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 YGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 SELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 GCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 HKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 PYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 GPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 LDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 RRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 TSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 GCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 YMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETW
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 GEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE0 PPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCN
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE0 YVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE0 SGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLG
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE0 GGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGP
1030 1040 1050 1060 1070 1080
1090 1100
pF1KE0 PNMAVGNMSVLLRSLPGETEFLNSSA
::::::::::::::::::::::::::
XP_011 PNMAVGNMSVLLRSLPGETEFLNSSA
1090 1100
>>NP_005260 (OMIM: 165220) zinc finger protein GLI1 isof (1106 aa)
initn: 7851 init1: 7851 opt: 7851 Z-score: 2925.9 bits: 553.2 E(85289): 3.1e-156
Smith-Waterman score: 7851; 100.0% identity (100.0% similar) in 1106 aa overlap (1-1106:1-1106)
10 20 30 40 50 60
pF1KE0 MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SCTEGPLFSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SCTEGPLFSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 YGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 SELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 GCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 HKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 PYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 GPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 LDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 RRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 TSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 GCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 YMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETW
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 GEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE0 PPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCN
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE0 YVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE0 SGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLG
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE0 GGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGP
1030 1040 1050 1060 1070 1080
1090 1100
pF1KE0 PNMAVGNMSVLLRSLPGETEFLNSSA
::::::::::::::::::::::::::
NP_005 PNMAVGNMSVLLRSLPGETEFLNSSA
1090 1100
>>NP_001161081 (OMIM: 165220) zinc finger protein GLI1 i (1065 aa)
initn: 7310 init1: 7310 opt: 7320 Z-score: 2729.9 bits: 516.9 E(85289): 2.6e-145
Smith-Waterman score: 7460; 96.3% identity (96.3% similar) in 1106 aa overlap (1-1106:1-1065)
10 20 30 40 50 60
pF1KE0 MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETN
:::::::::::::::::::::::::::::::::
NP_001 MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTE---------------------------
10 20 30
70 80 90 100 110 120
pF1KE0 SCTEGPLFSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGS
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 --------------VKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGS
40 50 60 70
130 140 150 160 170 180
pF1KE0 YGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLK
80 90 100 110 120 130
190 200 210 220 230 240
pF1KE0 SELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWD
140 150 160 170 180 190
250 260 270 280 290 300
pF1KE0 GCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKP
200 210 220 230 240 250
310 320 330 340 350 360
pF1KE0 HKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEK
260 270 280 290 300 310
370 380 390 400 410 420
pF1KE0 PYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREG
320 330 340 350 360 370
430 440 450 460 470 480
pF1KE0 GPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSS
380 390 400 410 420 430
490 500 510 520 530 540
pF1KE0 LDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLE
440 450 460 470 480 490
550 560 570 580 590 600
pF1KE0 RRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGG
500 510 520 530 540 550
610 620 630 640 650 660
pF1KE0 TSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSL
560 570 580 590 600 610
670 680 690 700 710 720
pF1KE0 GCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNP
620 630 640 650 660 670
730 740 750 760 770 780
pF1KE0 YMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETW
680 690 700 710 720 730
790 800 810 820 830 840
pF1KE0 GEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEG
740 750 760 770 780 790
850 860 870 880 890 900
pF1KE0 PPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCN
800 810 820 830 840 850
910 920 930 940 950 960
pF1KE0 YVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHK
860 870 880 890 900 910
970 980 990 1000 1010 1020
pF1KE0 SGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLG
920 930 940 950 960 970
1030 1040 1050 1060 1070 1080
pF1KE0 GGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGP
980 990 1000 1010 1020 1030
1090 1100
pF1KE0 PNMAVGNMSVLLRSLPGETEFLNSSA
::::::::::::::::::::::::::
NP_001 PNMAVGNMSVLLRSLPGETEFLNSSA
1040 1050 1060
>>NP_001153517 (OMIM: 165220) zinc finger protein GLI1 i (978 aa)
initn: 6974 init1: 6974 opt: 6974 Z-score: 2602.5 bits: 493.2 E(85289): 3.2e-138
Smith-Waterman score: 6974; 100.0% identity (100.0% similar) in 978 aa overlap (129-1106:1-978)
100 110 120 130 140 150
pF1KE0 IRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHD
::::::::::::::::::::::::::::::
NP_001 MSPSLGFPAQMNHQKGPSPSFGVQPCGPHD
10 20 30
160 170 180 190 200 210
pF1KE0 SARGGMIPHPQSRGPFPTCQLKSELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SARGGMIPHPQSRGPFPTCQLKSELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGR
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE0 EDLEREEKREPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDLEREEKREPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRE
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE0 LRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGC
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE0 SKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHR
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE0 GDGPLPRAPSISTVEPKREREGGPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDGPLPRAPSISTVEPKREREGGPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSA
280 290 300 310 320 330
460 470 480 490 500 510
pF1KE0 ANTDSGVEMTGNAGGSTEDLSSLDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANTDSGVEMTGNAGGSTEDLSSLDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLK
340 350 360 370 380 390
520 530 540 550 560 570
pF1KE0 LPSLSHTGTTVSRRVGPPVSLERRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPSLSHTGTTVSRRVGPPVSLERRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSL
400 410 420 430 440 450
580 590 600 610 620 630
pF1KE0 PGLMPAQHYLLRARYASARGGGTSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGLMPAQHYLLRARYASARGGGTSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRR
460 470 480 490 500 510
640 650 660 670 680 690
pF1KE0 ASDPAQAADRPAPARVQRFKSLGCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASDPAQAADRPAPARVQRFKSLGCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAM
520 530 540 550 560 570
700 710 720 730 740 750
pF1KE0 DARGLQEEPEVGTSMVGSGLNPYMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DARGLQEEPEVGTSMVGSGLNPYMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPP
580 590 600 610 620 630
760 770 780 790 800 810
pF1KE0 TNYGPNPCPQQASYPDPTQETWGEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TNYGPNPCPQQASYPDPTQETWGEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQ
640 650 660 670 680 690
820 830 840 850 860 870
pF1KE0 GCPVGSDSTGLAPCLNAHPSEGPPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GCPVGSDSTGLAPCLNAHPSEGPPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPR
700 710 720 730 740 750
880 890 900 910 920 930
pF1KE0 PCLDFDSPTHSTGQLKAQLVCNYVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PCLDFDSPTHSTGQLKAQLVCNYVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSP
760 770 780 790 800 810
940 950 960 970 980 990
pF1KE0 SRAKAPVNTYGPGFGPNLPNHKSGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRAKAPVNTYGPGFGPNLPNHKSGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTC
820 830 840 850 860 870
1000 1010 1020 1030 1040 1050
pF1KE0 YGPLKVGGTNPSCGHPEVGRLGGGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGPLKVGGTNPSCGHPEVGRLGGGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQG
880 890 900 910 920 930
1060 1070 1080 1090 1100
pF1KE0 LSPPPSHDQRGSSGHTPPPSGPPNMAVGNMSVLLRSLPGETEFLNSSA
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSPPPSHDQRGSSGHTPPPSGPPNMAVGNMSVLLRSLPGETEFLNSSA
940 950 960 970
>>XP_011536492 (OMIM: 165220) PREDICTED: zinc finger pro (1029 aa)
initn: 4755 init1: 4755 opt: 4755 Z-score: 1782.4 bits: 341.5 E(85289): 1.5e-92
Smith-Waterman score: 7147; 93.0% identity (93.0% similar) in 1106 aa overlap (1-1106:1-1029)
10 20 30 40 50 60
pF1KE0 MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SCTEGPLFSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCTEGPLFSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 YGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 SELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 GCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 HKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 PYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREG
:
XP_011 P-----------------------------------------------------------
430 440 450 460 470 480
pF1KE0 GPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSS
::::::::::::::::::::::::::::::::::::::::::
XP_011 ------------------QPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSS
370 380 390 400
490 500 510 520 530 540
pF1KE0 LDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLE
410 420 430 440 450 460
550 560 570 580 590 600
pF1KE0 RRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGG
470 480 490 500 510 520
610 620 630 640 650 660
pF1KE0 TSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSL
530 540 550 560 570 580
670 680 690 700 710 720
pF1KE0 GCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNP
590 600 610 620 630 640
730 740 750 760 770 780
pF1KE0 YMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETW
650 660 670 680 690 700
790 800 810 820 830 840
pF1KE0 GEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEG
710 720 730 740 750 760
850 860 870 880 890 900
pF1KE0 PPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCN
770 780 790 800 810 820
910 920 930 940 950 960
pF1KE0 YVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHK
830 840 850 860 870 880
970 980 990 1000 1010 1020
pF1KE0 SGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLG
890 900 910 920 930 940
1030 1040 1050 1060 1070 1080
pF1KE0 GGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGP
950 960 970 980 990 1000
1090 1100
pF1KE0 PNMAVGNMSVLLRSLPGETEFLNSSA
::::::::::::::::::::::::::
XP_011 PNMAVGNMSVLLRSLPGETEFLNSSA
1010 1020
>>XP_011513576 (OMIM: 146510,165240,174200,174700,175700 (1521 aa)
initn: 1493 init1: 1138 opt: 1285 Z-score: 498.3 bits: 104.5 E(85289): 5.1e-21
Smith-Waterman score: 1805; 37.5% identity (55.5% similar) in 1145 aa overlap (20-952:161-1263)
10 20 30 40
pF1KE0 MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSG
: : :: . :.: . :: :..:
XP_011 FSPPHPYINPYMDYIRSLHSSPSLSMISATRGLSPTDAPHA---GVSPAEYYHQMALLTG
140 150 160 170 180
50 60 70 80 90
pF1KE0 PHS-YG---PARETNSC----------TEGPLFSSPRSAVKLTKKRALSISPLSDASLDL
.: :. :. : . .. ::::: ... ..::.:::::::: :.::
XP_011 QRSPYADIIPSAATAGTGAIHMEYLHAMDSTRFSSPRLSARPSRKRTLSISPLSDHSFDL
190 200 210 220 230 240
100 110 120 130 140
pF1KE0 QTVIRTSPSSLVAFIN-SRCTSPG-GSYGHLSIGTMSPSLGF-----PAQMN-HQK----
::.:::::.:::...: :: .: . ::::::: ...::.:.: :.... ::.
XP_011 QTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYSSAPVSLHMHQQILSR
250 260 270 280 290 300
150 160 170 180
pF1KE0 --------GPSPSFGVQPCGPHDSARG--G----MIPHPQSRGPFPTCQLKSELDMLVG-
: :: . ..: . : : . : : :: . : : . :.
XP_011 QQSLGSAFGHSPPL-IHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQNKPTSESAVSS
310 320 330 340 350 360
190 200 210 220 230
pF1KE0 --------KCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREE-KREPESVYETDCRW
. . .: : :. ::.. : :. : .:. ...: :.::: .:::.:.:
XP_011 TGDPMHNKRSKIKPDE-DLPSPGARGQQEQPEGTTLVKEEGDKDESKQEPEVIYETNCHW
370 380 390 400 410 420
240 250 260 270 280 290
pF1KE0 DGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEK
.::..:::.:::::::::..:::::.:::::.: :::: .:::::::::::::::::::
XP_011 EGCAREFDTQEQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEK
430 440 450 460 470 480
300 310 320 330 340 350
pF1KE0 PHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNE
::::::::: :.::::::::::::::::::::.::::::.::::::::::::::::::::
XP_011 PHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNE
490 500 510 520 530 540
360 370 380 390 400 410
pF1KE0 KPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGD-GPLPRAPSISTVEPKRER
::::::.:::::::::::::::::::::::.:::::..::: : : : : . . .
XP_011 KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDIHPRPPPPRDSGSHSQSRS
550 560 570 580 590 600
420 430 440 450
pF1KE0 EGGPI----------------REES---RLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAA
: : ::: . . : : :::::.::::::..:: .. .
XP_011 PGRPTQGALGEQQDLSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPISNYS
610 620 630 640 650 660
460 470 480 490 500
pF1KE0 NTDSGVEMTGNAGGSTEDLSSLDEGPCI------AGTGLSTLRR--------LENLRLDQ
: ::.:. . ::: :::..:: : . : :.:. : .:...:..
XP_011 N--SGLELPLTDGGSIGDLSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHVKLER
670 680 690 700 710 720
510 520 530
pF1KE0 LHQ-------LRPI--------------GTRGLKLPSLSHTGTTVSRRV---GPPVS---
:.: : :: ::.. . ::. : . : : :.
XP_011 LKQVNGMFPRLNPILPPKAPAVSPLIGNGTQSNNTCSLGGPMTLLPGRSDLSGVDVTMLN
730 740 750 760 770 780
540 550 560 570
pF1KE0 -LERRSSSSSSISSAYTVSRRSSLASP-------------------------FPPGSPPE
:.::.::.:.::::: ::::: :: . : :
XP_011 MLNRRDSSASTISSAYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPISTDA
790 800 810 820 830 840
580 590 600 610
pF1KE0 NGASS-------LPGLM---PAQHYLLRARYASARGGGTSPTAASSLDRIG---------
. :: ::.:. :::.: :.:.::.: :: :: ...:..
XP_011 SRRSSEASQSDGLPSLLSLTPAQQYRLKAKYAAATGG-PPPTPLPNMERMSLKTRLALLG
850 860 870 880 890 900
620 630 640 650
pF1KE0 -----GLPMPPWRS--------------RAEYPGYNPNAGVTRRASDPAQAADRP-APAR
:. .:: .. : : :. :: ::::::...... : :
XP_011 DALEPGVALPPVHAPRRCSDGGAHGYGRRHLQPHDAPGHGV-RRASDPVRTGSEGLALPR
910 920 930 940 950 960
660 670 680 690 700
pF1KE0 VQRFKSLG-CVHTPPTVAGGG-------QNFD-PYLPTSVY---SPQPPSITENAAMDAR
: ::.::. : .::..: .. ::. : : :: :::::::.....
XP_011 VPRFSSLSSC--NPPAMATSAEKRSLVLQNYTRPEGGQSRNFHSSPCPPSITENVTLESL
970 980 990 1000 1010
710 720 730 740 750
pF1KE0 GLQEEPEVGTSMVGSGLNPYMDFPPTDTLGYGGPEGAAAE----PYGARGPGSLPLGPG-
.. . ..:: :: : :.. : . .. :. : . ...: :::
XP_011 TMDAD---------ANLNDE-DFLPDDVVQYLNSQNQAGYEQHFPSALPDDSKVPHGPGD
1020 1030 1040 1050 1060
760 770 780 790 800
pF1KE0 ------PPTNYGPN------PCPQQASYPDPTQETWGEFPSHSGLYPGPKALGGTYSQCP
: .. : . :::. .. : : :.: : :. . : : :
XP_011 FDAPGLPDSHAGQQFHALEQPCPEGSKTDLPIQ--WNEVSSGSADLSSSKLKCGPRPAVP
1070 1080 1090 1100 1110 1120
810 820 830 840 850
pF1KE0 RLEHYG---QVQVKPEQGCPVGSDSTGLAPCL--NAHPSEGPPHPQPLFSHYPQPSPPQY
. . .: . :.:.. :. : .: : :..: :: : :. : . :
XP_011 QTRAFGFCNGMVVHPQN--PLRSGPAGGYQTLGENSNPYGGPEH---LMLH----NSPGS
1130 1140 1150 1160 1170
860 870 880 890 900 910
pF1KE0 LQSGPYTQPPPDYLPSEPRPCLDFD--SPTHSTGQLKAQLVCNYVQSQQELLWEGGGRED
:: . : :. ::. . .: : : . . ..: . .::. .
XP_011 GTSGNAFHEQPCKAPQYGN-CLNRQPVAPGALDGACGAGIQASKLKSTP--MQGSGGQLN
1180 1190 1200 1210 1220 1230
920 930 940 950 960 970
pF1KE0 APAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHKSGSYPTPSPCHENFVVG
: .:. .::.:. . . :: : :.
XP_011 FGL--PV--APNESAGSMVNGMQNQDPV---GQGYLAHQLLGDSMQHPGAGRPGQQMLGQ
1240 1250 1260 1270 1280
980 990 1000 1010 1020 1030
pF1KE0 ANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLGGGPALYPPPEGQVCNPL
XP_011 ISATSHINIYQGPESCLPGAHGMGSQPSSLAVVRGYQPCASFGGSRRQAMPRDSLALQSG
1290 1300 1310 1320 1330 1340
>>XP_016867486 (OMIM: 146510,165240,174200,174700,175700 (1579 aa)
initn: 1493 init1: 1138 opt: 1285 Z-score: 498.1 bits: 104.5 E(85289): 5.2e-21
Smith-Waterman score: 1805; 37.5% identity (55.5% similar) in 1145 aa overlap (20-952:219-1321)
10 20 30 40
pF1KE0 MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSG
: : :: . :.: . :: :..:
XP_016 FSPPHPYINPYMDYIRSLHSSPSLSMISATRGLSPTDAPHA---GVSPAEYYHQMALLTG
190 200 210 220 230 240
50 60 70 80 90
pF1KE0 PHS-YG---PARETNSC----------TEGPLFSSPRSAVKLTKKRALSISPLSDASLDL
.: :. :. : . .. ::::: ... ..::.:::::::: :.::
XP_016 QRSPYADIIPSAATAGTGAIHMEYLHAMDSTRFSSPRLSARPSRKRTLSISPLSDHSFDL
250 260 270 280 290 300
100 110 120 130 140
pF1KE0 QTVIRTSPSSLVAFIN-SRCTSPG-GSYGHLSIGTMSPSLGF-----PAQMN-HQK----
::.:::::.:::...: :: .: . ::::::: ...::.:.: :.... ::.
XP_016 QTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYSSAPVSLHMHQQILSR
310 320 330 340 350 360
150 160 170 180
pF1KE0 --------GPSPSFGVQPCGPHDSARG--G----MIPHPQSRGPFPTCQLKSELDMLVG-
: :: . ..: . : : . : : :: . : : . :.
XP_016 QQSLGSAFGHSPPL-IHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQNKPTSESAVSS
370 380 390 400 410 420
190 200 210 220 230
pF1KE0 --------KCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREE-KREPESVYETDCRW
. . .: : :. ::.. : :. : .:. ...: :.::: .:::.:.:
XP_016 TGDPMHNKRSKIKPDE-DLPSPGARGQQEQPEGTTLVKEEGDKDESKQEPEVIYETNCHW
430 440 450 460 470 480
240 250 260 270 280 290
pF1KE0 DGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEK
.::..:::.:::::::::..:::::.:::::.: :::: .:::::::::::::::::::
XP_016 EGCAREFDTQEQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEK
490 500 510 520 530 540
300 310 320 330 340 350
pF1KE0 PHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNE
::::::::: :.::::::::::::::::::::.::::::.::::::::::::::::::::
XP_016 PHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNE
550 560 570 580 590 600
360 370 380 390 400 410
pF1KE0 KPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGD-GPLPRAPSISTVEPKRER
::::::.:::::::::::::::::::::::.:::::..::: : : : : . . .
XP_016 KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDIHPRPPPPRDSGSHSQSRS
610 620 630 640 650 660
420 430 440 450
pF1KE0 EGGPI----------------REES---RLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAA
: : ::: . . : : :::::.::::::..:: .. .
XP_016 PGRPTQGALGEQQDLSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPISNYS
670 680 690 700 710 720
460 470 480 490 500
pF1KE0 NTDSGVEMTGNAGGSTEDLSSLDEGPCI------AGTGLSTLRR--------LENLRLDQ
: ::.:. . ::: :::..:: : . : :.:. : .:...:..
XP_016 N--SGLELPLTDGGSIGDLSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHVKLER
730 740 750 760 770 780
510 520 530
pF1KE0 LHQ-------LRPI--------------GTRGLKLPSLSHTGTTVSRRV---GPPVS---
:.: : :: ::.. . ::. : . : : :.
XP_016 LKQVNGMFPRLNPILPPKAPAVSPLIGNGTQSNNTCSLGGPMTLLPGRSDLSGVDVTMLN
790 800 810 820 830 840
540 550 560 570
pF1KE0 -LERRSSSSSSISSAYTVSRRSSLASP-------------------------FPPGSPPE
:.::.::.:.::::: ::::: :: . : :
XP_016 MLNRRDSSASTISSAYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPISTDA
850 860 870 880 890 900
580 590 600 610
pF1KE0 NGASS-------LPGLM---PAQHYLLRARYASARGGGTSPTAASSLDRIG---------
. :: ::.:. :::.: :.:.::.: :: :: ...:..
XP_016 SRRSSEASQSDGLPSLLSLTPAQQYRLKAKYAAATGG-PPPTPLPNMERMSLKTRLALLG
910 920 930 940 950 960
620 630 640 650
pF1KE0 -----GLPMPPWRS--------------RAEYPGYNPNAGVTRRASDPAQAADRP-APAR
:. .:: .. : : :. :: ::::::...... : :
XP_016 DALEPGVALPPVHAPRRCSDGGAHGYGRRHLQPHDAPGHGV-RRASDPVRTGSEGLALPR
970 980 990 1000 1010
660 670 680 690 700
pF1KE0 VQRFKSLG-CVHTPPTVAGGG-------QNFD-PYLPTSVY---SPQPPSITENAAMDAR
: ::.::. : .::..: .. ::. : : :: :::::::.....
XP_016 VPRFSSLSSC--NPPAMATSAEKRSLVLQNYTRPEGGQSRNFHSSPCPPSITENVTLESL
1020 1030 1040 1050 1060 1070
710 720 730 740 750
pF1KE0 GLQEEPEVGTSMVGSGLNPYMDFPPTDTLGYGGPEGAAAE----PYGARGPGSLPLGPG-
.. . ..:: :: : :.. : . .. :. : . ...: :::
XP_016 TMDAD---------ANLNDE-DFLPDDVVQYLNSQNQAGYEQHFPSALPDDSKVPHGPGD
1080 1090 1100 1110 1120
760 770 780 790 800
pF1KE0 ------PPTNYGPN------PCPQQASYPDPTQETWGEFPSHSGLYPGPKALGGTYSQCP
: .. : . :::. .. : : :.: : :. . : : :
XP_016 FDAPGLPDSHAGQQFHALEQPCPEGSKTDLPIQ--WNEVSSGSADLSSSKLKCGPRPAVP
1130 1140 1150 1160 1170 1180
810 820 830 840 850
pF1KE0 RLEHYG---QVQVKPEQGCPVGSDSTGLAPCL--NAHPSEGPPHPQPLFSHYPQPSPPQY
. . .: . :.:.. :. : .: : :..: :: : :. : . :
XP_016 QTRAFGFCNGMVVHPQN--PLRSGPAGGYQTLGENSNPYGGPEH---LMLH----NSPGS
1190 1200 1210 1220 1230
860 870 880 890 900 910
pF1KE0 LQSGPYTQPPPDYLPSEPRPCLDFD--SPTHSTGQLKAQLVCNYVQSQQELLWEGGGRED
:: . : :. ::. . .: : : . . ..: . .::. .
XP_016 GTSGNAFHEQPCKAPQYGN-CLNRQPVAPGALDGACGAGIQASKLKSTP--MQGSGGQLN
1240 1250 1260 1270 1280 1290
920 930 940 950 960 970
pF1KE0 APAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHKSGSYPTPSPCHENFVVG
: .:. .::.:. . . :: : :.
XP_016 FGL--PV--APNESAGSMVNGMQNQDPV---GQGYLAHQLLGDSMQHPGAGRPGQQMLGQ
1300 1310 1320 1330 1340
980 990 1000 1010 1020 1030
pF1KE0 ANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLGGGPALYPPPEGQVCNPL
XP_016 ISATSHINIYQGPESCLPGAHGMGSQPSSLAVVRGYQPCASFGGSRRQAMPRDSLALQSG
1350 1360 1370 1380 1390 1400
>>NP_000159 (OMIM: 146510,165240,174200,174700,175700,18 (1580 aa)
initn: 1493 init1: 1138 opt: 1285 Z-score: 498.1 bits: 104.5 E(85289): 5.2e-21
Smith-Waterman score: 1805; 37.5% identity (55.5% similar) in 1145 aa overlap (20-952:220-1322)
10 20 30 40
pF1KE0 MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSG
: : :: . :.: . :: :..:
NP_000 FSPPHPYINPYMDYIRSLHSSPSLSMISATRGLSPTDAPHA---GVSPAEYYHQMALLTG
190 200 210 220 230 240
50 60 70 80 90
pF1KE0 PHS-YG---PARETNSC----------TEGPLFSSPRSAVKLTKKRALSISPLSDASLDL
.: :. :. : . .. ::::: ... ..::.:::::::: :.::
NP_000 QRSPYADIIPSAATAGTGAIHMEYLHAMDSTRFSSPRLSARPSRKRTLSISPLSDHSFDL
250 260 270 280 290 300
100 110 120 130 140
pF1KE0 QTVIRTSPSSLVAFIN-SRCTSPG-GSYGHLSIGTMSPSLGF-----PAQMN-HQK----
::.:::::.:::...: :: .: . ::::::: ...::.:.: :.... ::.
NP_000 QTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYSSAPVSLHMHQQILSR
310 320 330 340 350 360
150 160 170 180
pF1KE0 --------GPSPSFGVQPCGPHDSARG--G----MIPHPQSRGPFPTCQLKSELDMLVG-
: :: . ..: . : : . : : :: . : : . :.
NP_000 QQSLGSAFGHSPPL-IHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQNKPTSESAVSS
370 380 390 400 410 420
190 200 210 220 230
pF1KE0 --------KCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREE-KREPESVYETDCRW
. . .: : :. ::.. : :. : .:. ...: :.::: .:::.:.:
NP_000 TGDPMHNKRSKIKPDE-DLPSPGARGQQEQPEGTTLVKEEGDKDESKQEPEVIYETNCHW
430 440 450 460 470 480
240 250 260 270 280 290
pF1KE0 DGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEK
.::..:::.:::::::::..:::::.:::::.: :::: .:::::::::::::::::::
NP_000 EGCAREFDTQEQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEK
490 500 510 520 530 540
300 310 320 330 340 350
pF1KE0 PHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNE
::::::::: :.::::::::::::::::::::.::::::.::::::::::::::::::::
NP_000 PHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNE
550 560 570 580 590 600
360 370 380 390 400 410
pF1KE0 KPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGD-GPLPRAPSISTVEPKRER
::::::.:::::::::::::::::::::::.:::::..::: : : : : . . .
NP_000 KPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDIHPRPPPPRDSGSHSQSRS
610 620 630 640 650 660
420 430 440 450
pF1KE0 EGGPI----------------REES---RLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAA
: : ::: . . : : :::::.::::::..:: .. .
NP_000 PGRPTQGALGEQQDLSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPISNYS
670 680 690 700 710 720
460 470 480 490 500
pF1KE0 NTDSGVEMTGNAGGSTEDLSSLDEGPCI------AGTGLSTLRR--------LENLRLDQ
: ::.:. . ::: :::..:: : . : :.:. : .:...:..
NP_000 N--SGLELPLTDGGSIGDLSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHVKLER
730 740 750 760 770 780
510 520 530
pF1KE0 LHQ-------LRPI--------------GTRGLKLPSLSHTGTTVSRRV---GPPVS---
:.: : :: ::.. . ::. : . : : :.
NP_000 LKQVNGMFPRLNPILPPKAPAVSPLIGNGTQSNNTCSLGGPMTLLPGRSDLSGVDVTMLN
790 800 810 820 830 840
540 550 560 570
pF1KE0 -LERRSSSSSSISSAYTVSRRSSLASP-------------------------FPPGSPPE
:.::.::.:.::::: ::::: :: . : :
NP_000 MLNRRDSSASTISSAYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPISTDA
850 860 870 880 890 900
580 590 600 610
pF1KE0 NGASS-------LPGLM---PAQHYLLRARYASARGGGTSPTAASSLDRIG---------
. :: ::.:. :::.: :.:.::.: :: :: ...:..
NP_000 SRRSSEASQSDGLPSLLSLTPAQQYRLKAKYAAATGG-PPPTPLPNMERMSLKTRLALLG
910 920 930 940 950 960
620 630 640 650
pF1KE0 -----GLPMPPWRS--------------RAEYPGYNPNAGVTRRASDPAQAADRP-APAR
:. .:: .. : : :. :: ::::::...... : :
NP_000 DALEPGVALPPVHAPRRCSDGGAHGYGRRHLQPHDAPGHGV-RRASDPVRTGSEGLALPR
970 980 990 1000 1010 1020
660 670 680 690 700
pF1KE0 VQRFKSLG-CVHTPPTVAGGG-------QNFD-PYLPTSVY---SPQPPSITENAAMDAR
: ::.::. : .::..: .. ::. : : :: :::::::.....
NP_000 VPRFSSLSSC--NPPAMATSAEKRSLVLQNYTRPEGGQSRNFHSSPCPPSITENVTLESL
1030 1040 1050 1060 1070
710 720 730 740 750
pF1KE0 GLQEEPEVGTSMVGSGLNPYMDFPPTDTLGYGGPEGAAAE----PYGARGPGSLPLGPG-
.. . ..:: :: : :.. : . .. :. : . ...: :::
NP_000 TMDAD---------ANLNDE-DFLPDDVVQYLNSQNQAGYEQHFPSALPDDSKVPHGPGD
1080 1090 1100 1110 1120
760 770 780 790 800
pF1KE0 ------PPTNYGPN------PCPQQASYPDPTQETWGEFPSHSGLYPGPKALGGTYSQCP
: .. : . :::. .. : : :.: : :. . : : :
NP_000 FDAPGLPDSHAGQQFHALEQPCPEGSKTDLPIQ--WNEVSSGSADLSSSKLKCGPRPAVP
1130 1140 1150 1160 1170 1180
810 820 830 840 850
pF1KE0 RLEHYG---QVQVKPEQGCPVGSDSTGLAPCL--NAHPSEGPPHPQPLFSHYPQPSPPQY
. . .: . :.:.. :. : .: : :..: :: : :. : . :
NP_000 QTRAFGFCNGMVVHPQN--PLRSGPAGGYQTLGENSNPYGGPEH---LMLH----NSPGS
1190 1200 1210 1220 1230
860 870 880 890 900 910
pF1KE0 LQSGPYTQPPPDYLPSEPRPCLDFD--SPTHSTGQLKAQLVCNYVQSQQELLWEGGGRED
:: . : :. ::. . .: : : . . ..: . .::. .
NP_000 GTSGNAFHEQPCKAPQYGN-CLNRQPVAPGALDGACGAGIQASKLKSTP--MQGSGGQLN
1240 1250 1260 1270 1280 1290
920 930 940 950 960 970
pF1KE0 APAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHKSGSYPTPSPCHENFVVG
: .:. .::.:. . . :: : :.
NP_000 FGL--PV--APNESAGSMVNGMQNQDPV---GQGYLAHQLLGDSMQHPGAGRPGQQMLGQ
1300 1310 1320 1330 1340
980 990 1000 1010 1020 1030
pF1KE0 ANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLGGGPALYPPPEGQVCNPL
NP_000 ISATSHINIYQGPESCLPGAHGMGSQPSSLAVVRGYQPCASFGGSRRQAMPRDSLALQSG
1350 1360 1370 1380 1390 1400
>>XP_011509275 (OMIM: 165230,610829,615849) PREDICTED: z (1461 aa)
initn: 1817 init1: 1096 opt: 1207 Z-score: 469.7 bits: 99.1 E(85289): 2e-19
Smith-Waterman score: 1894; 38.0% identity (55.6% similar) in 1195 aa overlap (40-1001:51-1197)
10 20 30 40 50 60
pF1KE0 ISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSG-PHSYGPA-RETNSCTEGPL
. :: .:..: : :: .... . .:
XP_011 RGLSPADVAQEHLKERGLFGLPAPGTTPSDYYHQMTLVAGHPAPYGDLLMQSGGAASAPH
30 40 50 60 70 80
70 80 90 100 110
pF1KE0 ------------FSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFIN-SRC
::::: . .:..::::::::::::::::: .:::::.::::.:: ::
XP_011 LHDYLNPVDVSRFSSPRVTPRLSRKRALSISPLSDASLDLQRMIRTSPNSLVAYINNSRS
90 100 110 120 130 140
120 130 140 150
pF1KE0 TSPG-GSYGHLSIGTMSPSLGFPAQMN---------HQKGPSPSFG-----VQPC----G
.: . ::::::: :..::.. :: .: .:.: . .:: .:: .
XP_011 SSAASGSYGHLSAGALSPAFTFPHPINPVAYQQILSQQRGLGSAFGHTPPLIQPSPTFLA
150 160 170 180 190 200
160 170 180 190
pF1KE0 PHDSARGGMIPHPQSRGPFPTC-----QLKSELDMLVG------------KCREEP----
. : .. : . . .: : :. . :. : . ::
XP_011 QQPMALTSINATPTQLSSSSNCLSDTNQNKQSSESAVSSTVNPVAIHKRSKVKTEPEGLR
210 220 230 240 250 260
200 210 220 230 240
pF1KE0 -------LEGDMSSPNSTGIQDPLLG--MLDGREDLEREE-KREPESV-YETDCRWDGCS
.:..:. .: : :: . : .:::.:.. :.: : : :::.:.:. :.
XP_011 PASPLALTQGQVSGHGSCGCALPLSQEQLADLKEDLDRDDCKQEAEVVIYETNCHWEDCT
270 280 290 300 310 320
250 260 270 280 290 300
pF1KE0 QEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKC
.:.:.:::::::::.::::::.:::::.: .:.:: .:::::::::::::::::::::::
XP_011 KEYDTQEQLVHHINNEHIHGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKC
330 340 350 360 370 380
310 320 330 340 350 360
pF1KE0 TFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEKPYV
::::: :.::::::::::::::::::::.::::::.:::::::::::::::::::::::.
XP_011 TFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYI
390 400 410 420 430 440
370 380 390 400 410 420
pF1KE0 CKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKRE--REGG
::.:::::::::::::::::::::::::::::..:.: : :.: .. .. . ::
XP_011 CKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRNDVHL-RTPLLKENGDSEAGTEPGG
450 460 470 480 490
430 440 450 460
pF1KE0 PIREES-------------RLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMT
: :. : :.. : ::::::::::. :: ::: :.::::::
XP_011 PESTEASSTSQAVEDCLHVRAIKTESSGLCQSSPGAQSSCSSEPSPLGSAPNNDSGVEMP
500 510 520 530 540 550
470 480 490 500 510
pF1KE0 GNAGGSTEDLSSLDEGPCIAGT---------GL------STLRRLENLRLDQLHQLR---
:.. :: ::..::. : : : :: .:..:.:.:. ..:..:.
XP_011 GTGPGSLGDLTALDDTPPGADTSALAAPSAGGLQLRKHMTTMHRFEQLKKEKLKSLKDSC
560 570 580 590 600 610
520 530 540
pF1KE0 ----PIG-TRGLKLPSLSHTGTTVSRRVGP----PVSL---------------------E
: ::. ::: : .:. . : :..: :
XP_011 SWAGPTPHTRNTKLPPLPGSGSILENFSGSGGGGPAGLLPNPRLSELSASEVTMLSQLQE
620 630 640 650 660 670
550 560 570
pF1KE0 RRSSSSSSISSAYTVSRRSSLASPF------PPGSP-----PEN----------------
::.::.:..::::::::::: ::. .:: :.:
XP_011 RRDSSTSTVSSAYTVSRRSSGISPYFSSRRSSEASPLGAGRPHNASSADSYDPISTDASR
680 690 700 710 720 730
580 590 600 610
pF1KE0 ---------GASSLPGLMPAQHYLLRARYASARGGGTSPTAASSLDRIG-----------
:.:.: .: :::.: :::.::.: :: :: .:.:..
XP_011 RSSEASQCSGGSGLLNLTPAQQYSLRAKYAAATGG-PPPTPLPGLERMSLRTRLALLDAP
740 750 760 770 780 790
620 630 640 650
pF1KE0 ------GLPMP--PWRSR-------------AEYPGYNPNAGVTRRASDPAQAADRPAPA
: : : : :. .: :..:. ::::::.. : .
XP_011 ERTLPAGCPRPLGPRRGSDGPTYGHGHAGAAPAFPHEAPGGGA-RRASDPVRRPDALSLP
800 810 820 830 840 850
660 670 680 690 700
pF1KE0 RVQRFKSLGCVHT---PPTVAGGGQNF------DPYLPTSVYSPQPPSITENAAMDARGL
:::::.: :. :: . : . : : ..:::.::::.::.::.:
XP_011 RVQRFHSTHNVNPGPLPPCADRRGLRLQSHPSTDGGLARGAYSPRPPSISENVAMEA---
860 870 880 890 900 910
710 720 730 740 750 760
pF1KE0 QEEPEVGTSMVGSGLNPYMDFPPTD-TLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYG
:.... :.: . . .: : .: . :. :: :. . : :...
XP_011 -----VAAGVDGAGPEADLGLPEDDLVLPDDVVQYIKAHASGALDEGTGQVYPTESTGFS
920 930 940 950 960
770 780 790 800 810 820
pF1KE0 PNPCPQQASYPDPTQETWGEF-PSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCP
:: :.: . .. . :.. :. ::: : .: . ... :
XP_011 DNP-----RLPSPGLHGQRRMVAADSNVGPSAPMLGG----CQL--GFGAPSSLNKNNMP
970 980 990 1000 1010
830 840 850 860
pF1KE0 VGSD--STGLAPCLNAHPSEGPPHPQ---------PLFSHYPQPSPPQYLQSGP----YT
: . :.: . : : . :: :: : :..:: :: : ::..: :
XP_011 VQWNEVSSGTVDAL-ASQVKPPPFPQGNLAVVQQKPAFGQYPGYSP-QGLQASPGGLDST
1020 1030 1040 1050 1060 1070
870 880 890 900 910 920
pF1KE0 QPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCNYVQSQQELLWEGGGREDAPAQEPSYQ
:: .: .:: .:... .. ::.: .: .: . :.. ..
XP_011 QP---HL--QPRS----GAPSQGIPRV------NYMQ---QLRQPVAGSQ-CPGMTTTM-
1080 1090 1100 1110
930 940 950 960 970 980
pF1KE0 SPKFLGGS---QVSPSRAKAPVNTYGPGFGPNLPNHKSG--SYPTPSPCHENFVVGANRA
::. :. :.::: .. .: . : :.: : : ..: . . .. .::
XP_011 SPHACYGQVHPQLSPSTISGALNQF-PQSCSNMPA-KPGHLGHPQQTEVAPDPTTMGNR-
1120 1130 1140 1150 1160 1170
990 1000 1010 1020 1030
pF1KE0 SHRA-AAPPRLL----PPLPTCYGPLKVGGTNPSCGHPEVGRLGGGPALYPPPEGQVCNP
:: ..: : :: :. :
XP_011 -HRELGVPDSALAGVPPPHPVQSYPQQSHHLAASMSQEGYHQVPSLLPARQPGFMEPQTG
1180 1190 1200 1210 1220 1230
>>XP_011509273 (OMIM: 165230,610829,615849) PREDICTED: z (1521 aa)
initn: 1817 init1: 1096 opt: 1207 Z-score: 469.5 bits: 99.1 E(85289): 2.1e-19
Smith-Waterman score: 1894; 38.0% identity (55.6% similar) in 1195 aa overlap (40-1001:111-1257)
10 20 30 40 50 60
pF1KE0 ISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSG-PHSYGPA-RETNSCTEGPL
. :: .:..: : :: .... . .:
XP_011 RGLSPADVAQEHLKERGLFGLPAPGTTPSDYYHQMTLVAGHPAPYGDLLMQSGGAASAPH
90 100 110 120 130 140
70 80 90 100 110
pF1KE0 ------------FSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFIN-SRC
::::: . .:..::::::::::::::::: .:::::.::::.:: ::
XP_011 LHDYLNPVDVSRFSSPRVTPRLSRKRALSISPLSDASLDLQRMIRTSPNSLVAYINNSRS
150 160 170 180 190 200
120 130 140 150
pF1KE0 TSPG-GSYGHLSIGTMSPSLGFPAQMN---------HQKGPSPSFG-----VQPC----G
.: . ::::::: :..::.. :: .: .:.: . .:: .:: .
XP_011 SSAASGSYGHLSAGALSPAFTFPHPINPVAYQQILSQQRGLGSAFGHTPPLIQPSPTFLA
210 220 230 240 250 260
160 170 180 190
pF1KE0 PHDSARGGMIPHPQSRGPFPTC-----QLKSELDMLVG------------KCREEP----
. : .. : . . .: : :. . :. : . ::
XP_011 QQPMALTSINATPTQLSSSSNCLSDTNQNKQSSESAVSSTVNPVAIHKRSKVKTEPEGLR
270 280 290 300 310 320
200 210 220 230 240
pF1KE0 -------LEGDMSSPNSTGIQDPLLG--MLDGREDLEREE-KREPESV-YETDCRWDGCS
.:..:. .: : :: . : .:::.:.. :.: : : :::.:.:. :.
XP_011 PASPLALTQGQVSGHGSCGCALPLSQEQLADLKEDLDRDDCKQEAEVVIYETNCHWEDCT
330 340 350 360 370 380
250 260 270 280 290 300
pF1KE0 QEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKC
.:.:.:::::::::.::::::.:::::.: .:.:: .:::::::::::::::::::::::
XP_011 KEYDTQEQLVHHINNEHIHGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKC
390 400 410 420 430 440
310 320 330 340 350 360
pF1KE0 TFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEKPYV
::::: :.::::::::::::::::::::.::::::.:::::::::::::::::::::::.
XP_011 TFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYI
450 460 470 480 490 500
370 380 390 400 410 420
pF1KE0 CKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKRE--REGG
::.:::::::::::::::::::::::::::::..:.: : :.: .. .. . ::
XP_011 CKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRNDVHL-RTPLLKENGDSEAGTEPGG
510 520 530 540 550
430 440 450 460
pF1KE0 PIREES-------------RLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMT
: :. : :.. : ::::::::::. :: ::: :.::::::
XP_011 PESTEASSTSQAVEDCLHVRAIKTESSGLCQSSPGAQSSCSSEPSPLGSAPNNDSGVEMP
560 570 580 590 600 610
470 480 490 500 510
pF1KE0 GNAGGSTEDLSSLDEGPCIAGT---------GL------STLRRLENLRLDQLHQLR---
:.. :: ::..::. : : : :: .:..:.:.:. ..:..:.
XP_011 GTGPGSLGDLTALDDTPPGADTSALAAPSAGGLQLRKHMTTMHRFEQLKKEKLKSLKDSC
620 630 640 650 660 670
520 530 540
pF1KE0 ----PIG-TRGLKLPSLSHTGTTVSRRVGP----PVSL---------------------E
: ::. ::: : .:. . : :..: :
XP_011 SWAGPTPHTRNTKLPPLPGSGSILENFSGSGGGGPAGLLPNPRLSELSASEVTMLSQLQE
680 690 700 710 720 730
550 560 570
pF1KE0 RRSSSSSSISSAYTVSRRSSLASPF------PPGSP-----PEN----------------
::.::.:..::::::::::: ::. .:: :.:
XP_011 RRDSSTSTVSSAYTVSRRSSGISPYFSSRRSSEASPLGAGRPHNASSADSYDPISTDASR
740 750 760 770 780 790
580 590 600 610
pF1KE0 ---------GASSLPGLMPAQHYLLRARYASARGGGTSPTAASSLDRIG-----------
:.:.: .: :::.: :::.::.: :: :: .:.:..
XP_011 RSSEASQCSGGSGLLNLTPAQQYSLRAKYAAATGG-PPPTPLPGLERMSLRTRLALLDAP
800 810 820 830 840 850
620 630 640 650
pF1KE0 ------GLPMP--PWRSR-------------AEYPGYNPNAGVTRRASDPAQAADRPAPA
: : : : :. .: :..:. ::::::.. : .
XP_011 ERTLPAGCPRPLGPRRGSDGPTYGHGHAGAAPAFPHEAPGGGA-RRASDPVRRPDALSLP
860 870 880 890 900 910
660 670 680 690 700
pF1KE0 RVQRFKSLGCVHT---PPTVAGGGQNF------DPYLPTSVYSPQPPSITENAAMDARGL
:::::.: :. :: . : . : : ..:::.::::.::.::.:
XP_011 RVQRFHSTHNVNPGPLPPCADRRGLRLQSHPSTDGGLARGAYSPRPPSISENVAMEA---
920 930 940 950 960 970
710 720 730 740 750 760
pF1KE0 QEEPEVGTSMVGSGLNPYMDFPPTD-TLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYG
:.... :.: . . .: : .: . :. :: :. . : :...
XP_011 -----VAAGVDGAGPEADLGLPEDDLVLPDDVVQYIKAHASGALDEGTGQVYPTESTGFS
980 990 1000 1010 1020
770 780 790 800 810 820
pF1KE0 PNPCPQQASYPDPTQETWGEF-PSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCP
:: :.: . .. . :.. :. ::: : .: . ... :
XP_011 DNP-----RLPSPGLHGQRRMVAADSNVGPSAPMLGG----CQL--GFGAPSSLNKNNMP
1030 1040 1050 1060 1070
830 840 850 860
pF1KE0 VGSD--STGLAPCLNAHPSEGPPHPQ---------PLFSHYPQPSPPQYLQSGP----YT
: . :.: . : : . :: :: : :..:: :: : ::..: :
XP_011 VQWNEVSSGTVDAL-ASQVKPPPFPQGNLAVVQQKPAFGQYPGYSP-QGLQASPGGLDST
1080 1090 1100 1110 1120 1130
870 880 890 900 910 920
pF1KE0 QPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCNYVQSQQELLWEGGGREDAPAQEPSYQ
:: .: .:: .:... .. ::.: .: .: . :.. ..
XP_011 QP---HL--QPRS----GAPSQGIPRV------NYMQ---QLRQPVAGSQ-CPGMTTTM-
1140 1150 1160 1170
930 940 950 960 970 980
pF1KE0 SPKFLGGS---QVSPSRAKAPVNTYGPGFGPNLPNHKSG--SYPTPSPCHENFVVGANRA
::. :. :.::: .. .: . : :.: : : ..: . . .. .::
XP_011 SPHACYGQVHPQLSPSTISGALNQF-PQSCSNMPA-KPGHLGHPQQTEVAPDPTTMGNR-
1180 1190 1200 1210 1220 1230
990 1000 1010 1020 1030
pF1KE0 SHRA-AAPPRLL----PPLPTCYGPLKVGGTNPSCGHPEVGRLGGGPALYPPPEGQVCNP
:: ..: : :: :. :
XP_011 -HRELGVPDSALAGVPPPHPVQSYPQQSHHLAASMSQEGYHQVPSLLPARQPGFMEPQTG
1240 1250 1260 1270 1280 1290
1106 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 01:50:18 2016 done: Sat Nov 5 01:50:20 2016
Total Scan time: 16.660 Total Display time: 0.390
Function used was FASTA [36.3.4 Apr, 2011]