FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0210, 270 aa 1>>>pF1KE0210 270 - 270 aa - 270 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2781+/-0.00036; mu= 14.9149+/- 0.022 mean_var=64.5556+/-13.041, 0's: 0 Z-trim(112.8): 8 B-trim: 46 in 1/53 Lambda= 0.159627 statistics sampled from 21920 (21928) to 21920 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.642), E-opt: 0.2 (0.257), width: 16 Scan time: 7.330 The best scores are: opt bits E(85289) NP_065108 (OMIM: 610775) fructose-2,6-bisphosphata ( 270) 1770 416.3 2.9e-116 NP_001715 (OMIM: 222800,613896) bisphosphoglycerat ( 259) 145 42.1 0.0013 NP_001280014 (OMIM: 222800,613896) bisphosphoglyce ( 259) 145 42.1 0.0013 XP_011514829 (OMIM: 222800,613896) PREDICTED: bisp ( 259) 145 42.1 0.0013 NP_954655 (OMIM: 222800,613896) bisphosphoglycerat ( 259) 145 42.1 0.0013 NP_000281 (OMIM: 261670,612931) phosphoglycerate m ( 253) 140 40.9 0.0028 >>NP_065108 (OMIM: 610775) fructose-2,6-bisphosphatase T (270 aa) initn: 1770 init1: 1770 opt: 1770 Z-score: 2208.2 bits: 416.3 E(85289): 2.9e-116 Smith-Waterman score: 1770; 100.0% identity (100.0% similar) in 270 aa overlap (1-270:1-270) 10 20 30 40 50 60 pF1KE0 MARFALTVVRHGETRFNKEKIIQGQGVDEPLSETGFKQAAAAGIFLNNVKFTHAFSSDLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MARFALTVVRHGETRFNKEKIIQGQGVDEPLSETGFKQAAAAGIFLNNVKFTHAFSSDLM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 RTKQTMHGILERSKFCKDMTVKYDSRLRERKYGVVEGKALSELRAMAKAAREECPVFTPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 RTKQTMHGILERSKFCKDMTVKYDSRLRERKYGVVEGKALSELRAMAKAAREECPVFTPP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 GGETLDQVKMRGIDFFEFLCQLILKEADQKEQFSQGSPSNCLETSLAEIFPLGKNHSSKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GGETLDQVKMRGIDFFEFLCQLILKEADQKEQFSQGSPSNCLETSLAEIFPLGKNHSSKV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 NSDSGIPGLAASVLVVSHGAYMRSLFDYFLTDLKCSLPATLSRSELMSVTPNTGMSLFII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 NSDSGIPGLAASVLVVSHGAYMRSLFDYFLTDLKCSLPATLSRSELMSVTPNTGMSLFII 190 200 210 220 230 240 250 260 270 pF1KE0 NFEEGREVKPTVQCICMNLQDHLNGLTETR :::::::::::::::::::::::::::::: NP_065 NFEEGREVKPTVQCICMNLQDHLNGLTETR 250 260 270 >>NP_001715 (OMIM: 222800,613896) bisphosphoglycerate mu (259 aa) initn: 98 init1: 67 opt: 145 Z-score: 186.0 bits: 42.1 E(85289): 0.0013 Smith-Waterman score: 154; 24.8% identity (53.1% similar) in 258 aa overlap (1-250:1-231) 10 20 30 40 50 pF1KE0 MARFALTVVRHGETRFNKEKIIQGQGVDEPLSETGFKQAAAAGIFLN--NVKFTHAFSSD :... : ..:::: .:::. . . ::. :. :...: : :. : .: .:.: NP_001 MSKYKLIMLRHGEGAWNKENRFCSW-VDQKLNSEGMEEARNCGKQLKALNFEFDLVFTSV 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 LMRTKQTMHGILERSKFCKD-MTVKYDSRLRERKYGVVEG-----KALSELRAMAKAARE : :. .: ::: .. .. . :. . :: ::.::.. : ::.. . ... :. NP_001 LNRSIHTAWLILE--ELGQEWVPVESSWRLNERHYGALIGLNREQMALNHGEEQVRLWRR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 ECPVFTPPGGETLDQVKMRGIDFFEFLCQLILKEADQKEQFSQGSPSNCLETSLAEIFPL : :: :. . : .:.. : :: . :. :. : ...: NP_001 SYNVTPPPIEESHPYYQEIYNDRRYKVCDVPL---DQLPR------SESLKDVLERLLPY 120 130 140 150 160 180 190 200 210 220 230 pF1KE0 GKNHSSKVNSDSGIPGLAASVLVVSHGAYMRSLFDYFLTDLKCSLPATLSRSELMSVTPN .. .. . . : ..:. .:: :.:. .. .: .....: NP_001 WNE---RIAPEV-LRG--KTILISAHGNSSRALLKHL---------EGISDEDIINITLP 170 180 190 200 210 240 250 260 270 pF1KE0 TGMSLFIINFEEGREVKPTVQCICMNLQDHLNGLTETR ::. ... :. : : : NP_001 TGVPILLELDENLRAVGPHQFLGDQEAIQAAIKKVEDQGKVKQAKK 220 230 240 250 >>NP_001280014 (OMIM: 222800,613896) bisphosphoglycerate (259 aa) initn: 98 init1: 67 opt: 145 Z-score: 186.0 bits: 42.1 E(85289): 0.0013 Smith-Waterman score: 154; 24.8% identity (53.1% similar) in 258 aa overlap (1-250:1-231) 10 20 30 40 50 pF1KE0 MARFALTVVRHGETRFNKEKIIQGQGVDEPLSETGFKQAAAAGIFLN--NVKFTHAFSSD :... : ..:::: .:::. . . ::. :. :...: : :. : .: .:.: NP_001 MSKYKLIMLRHGEGAWNKENRFCSW-VDQKLNSEGMEEARNCGKQLKALNFEFDLVFTSV 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 LMRTKQTMHGILERSKFCKD-MTVKYDSRLRERKYGVVEG-----KALSELRAMAKAARE : :. .: ::: .. .. . :. . :: ::.::.. : ::.. . ... :. NP_001 LNRSIHTAWLILE--ELGQEWVPVESSWRLNERHYGALIGLNREQMALNHGEEQVRLWRR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 ECPVFTPPGGETLDQVKMRGIDFFEFLCQLILKEADQKEQFSQGSPSNCLETSLAEIFPL : :: :. . : .:.. : :: . :. :. : ...: NP_001 SYNVTPPPIEESHPYYQEIYNDRRYKVCDVPL---DQLPR------SESLKDVLERLLPY 120 130 140 150 160 180 190 200 210 220 230 pF1KE0 GKNHSSKVNSDSGIPGLAASVLVVSHGAYMRSLFDYFLTDLKCSLPATLSRSELMSVTPN .. .. . . : ..:. .:: :.:. .. .: .....: NP_001 WNE---RIAPEV-LRG--KTILISAHGNSSRALLKHL---------EGISDEDIINITLP 170 180 190 200 210 240 250 260 270 pF1KE0 TGMSLFIINFEEGREVKPTVQCICMNLQDHLNGLTETR ::. ... :. : : : NP_001 TGVPILLELDENLRAVGPHQFLGDQEAIQAAIKKVEDQGKVKQAKK 220 230 240 250 >>XP_011514829 (OMIM: 222800,613896) PREDICTED: bisphosp (259 aa) initn: 98 init1: 67 opt: 145 Z-score: 186.0 bits: 42.1 E(85289): 0.0013 Smith-Waterman score: 154; 24.8% identity (53.1% similar) in 258 aa overlap (1-250:1-231) 10 20 30 40 50 pF1KE0 MARFALTVVRHGETRFNKEKIIQGQGVDEPLSETGFKQAAAAGIFLN--NVKFTHAFSSD :... : ..:::: .:::. . . ::. :. :...: : :. : .: .:.: XP_011 MSKYKLIMLRHGEGAWNKENRFCSW-VDQKLNSEGMEEARNCGKQLKALNFEFDLVFTSV 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 LMRTKQTMHGILERSKFCKD-MTVKYDSRLRERKYGVVEG-----KALSELRAMAKAARE : :. .: ::: .. .. . :. . :: ::.::.. : ::.. . ... :. XP_011 LNRSIHTAWLILE--ELGQEWVPVESSWRLNERHYGALIGLNREQMALNHGEEQVRLWRR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 ECPVFTPPGGETLDQVKMRGIDFFEFLCQLILKEADQKEQFSQGSPSNCLETSLAEIFPL : :: :. . : .:.. : :: . :. :. : ...: XP_011 SYNVTPPPIEESHPYYQEIYNDRRYKVCDVPL---DQLPR------SESLKDVLERLLPY 120 130 140 150 160 180 190 200 210 220 230 pF1KE0 GKNHSSKVNSDSGIPGLAASVLVVSHGAYMRSLFDYFLTDLKCSLPATLSRSELMSVTPN .. .. . . : ..:. .:: :.:. .. .: .....: XP_011 WNE---RIAPEV-LRG--KTILISAHGNSSRALLKHL---------EGISDEDIINITLP 170 180 190 200 210 240 250 260 270 pF1KE0 TGMSLFIINFEEGREVKPTVQCICMNLQDHLNGLTETR ::. ... :. : : : XP_011 TGVPILLELDENLRAVGPHQFLGDQEAIQAAIKKVEDQGKVKQAKK 220 230 240 250 >>NP_954655 (OMIM: 222800,613896) bisphosphoglycerate mu (259 aa) initn: 98 init1: 67 opt: 145 Z-score: 186.0 bits: 42.1 E(85289): 0.0013 Smith-Waterman score: 154; 24.8% identity (53.1% similar) in 258 aa overlap (1-250:1-231) 10 20 30 40 50 pF1KE0 MARFALTVVRHGETRFNKEKIIQGQGVDEPLSETGFKQAAAAGIFLN--NVKFTHAFSSD :... : ..:::: .:::. . . ::. :. :...: : :. : .: .:.: NP_954 MSKYKLIMLRHGEGAWNKENRFCSW-VDQKLNSEGMEEARNCGKQLKALNFEFDLVFTSV 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 LMRTKQTMHGILERSKFCKD-MTVKYDSRLRERKYGVVEG-----KALSELRAMAKAARE : :. .: ::: .. .. . :. . :: ::.::.. : ::.. . ... :. NP_954 LNRSIHTAWLILE--ELGQEWVPVESSWRLNERHYGALIGLNREQMALNHGEEQVRLWRR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 ECPVFTPPGGETLDQVKMRGIDFFEFLCQLILKEADQKEQFSQGSPSNCLETSLAEIFPL : :: :. . : .:.. : :: . :. :. : ...: NP_954 SYNVTPPPIEESHPYYQEIYNDRRYKVCDVPL---DQLPR------SESLKDVLERLLPY 120 130 140 150 160 180 190 200 210 220 230 pF1KE0 GKNHSSKVNSDSGIPGLAASVLVVSHGAYMRSLFDYFLTDLKCSLPATLSRSELMSVTPN .. .. . . : ..:. .:: :.:. .. .: .....: NP_954 WNE---RIAPEV-LRG--KTILISAHGNSSRALLKHL---------EGISDEDIINITLP 170 180 190 200 210 240 250 260 270 pF1KE0 TGMSLFIINFEEGREVKPTVQCICMNLQDHLNGLTETR ::. ... :. : : : NP_954 TGVPILLELDENLRAVGPHQFLGDQEAIQAAIKKVEDQGKVKQAKK 220 230 240 250 >>NP_000281 (OMIM: 261670,612931) phosphoglycerate mutas (253 aa) initn: 118 init1: 68 opt: 140 Z-score: 179.9 bits: 40.9 E(85289): 0.0028 Smith-Waterman score: 160; 25.3% identity (54.1% similar) in 257 aa overlap (1-251:1-227) 10 20 30 40 50 pF1KE0 MARFALTVVRHGETRFNKEKIIQGQGVDEPLSETGFKQA--AAAGIFLNNVKFTHAFSSD :: :..:::::. .:.:. . : : ::: : ..: .: .: ...: ..: NP_000 MATHRLVMVRHGESTWNQENRFCGW-FDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSV 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 LMRTKQTMHGILERSKFCKDMTVKYDSRLRERKYGVVEGKALSELRAMAKAAREECPVFT : :. .:. .::. . . : :: ::.:: . : :.. .. :: ..:. .. NP_000 LKRAIRTLWAILDGTDQMW-LPVVRTWRLNERHYGGLTG--LNKAETAAKHGEEQVKIWR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 PPGGETLDQVKMRGIDFFEFLCQLILKEADQKEQFSQGSPSNC--LETSLAEIFPLGKNH ...: . .: . . : :: . .. : .: :. ..:. .:. NP_000 ----RSFD-IPPPPMDEKHPYYNSISKER-RYAGLKPGELPTCESLKDTIARALPFW--- 120 130 140 150 160 180 190 200 210 220 230 pF1KE0 SSKVNSDSGIPGLAAS--VLVVSHGAYMRSLFDYFLTDLKCSLPATLSRSELMSVTPNTG .. .: . :. ::...:: .:.. .. .: . .: .. :: NP_000 -----NEEIVPQIKAGKRVLIAAHGNSLRGIVKHL---------EGMSDQAIMELNLPTG 170 180 190 200 210 240 250 260 270 pF1KE0 MSLFIINFEEGREVKPTVQCICMNLQDHLNGLTETR . : .: ..:.::: NP_000 IP---IVYELNKELKPTKPMQFLGDEETVRKAMEAVAAQGKAK 220 230 240 250 270 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 21:09:39 2016 done: Thu Nov 3 21:09:40 2016 Total Scan time: 7.330 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]