FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0224, 89 aa 1>>>pF1KE0224 89 - 89 aa - 89 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7667+/-0.000338; mu= 10.4795+/- 0.021 mean_var=45.9910+/- 9.408, 0's: 0 Z-trim(112.3): 17 B-trim: 0 in 0/53 Lambda= 0.189120 statistics sampled from 21135 (21146) to 21135 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.248), width: 16 Scan time: 3.970 The best scores are: opt bits E(85289) NP_000406 (OMIM: 147940) islet amyloid polypeptide ( 89) 562 160.4 3.4e-40 NP_001316130 (OMIM: 147940) islet amyloid polypept ( 89) 562 160.4 3.4e-40 NP_000719 (OMIM: 114160) calcitonin gene-related p ( 127) 145 46.7 8.4e-06 NP_001029125 (OMIM: 114130) calcitonin gene-relate ( 128) 135 44.0 5.6e-05 >>NP_000406 (OMIM: 147940) islet amyloid polypeptide pre (89 aa) initn: 562 init1: 562 opt: 562 Z-score: 842.6 bits: 160.4 E(85289): 3.4e-40 Smith-Waterman score: 562; 100.0% identity (100.0% similar) in 89 aa overlap (1-89:1-89) 10 20 30 40 50 60 pF1KE0 MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAIL 10 20 30 40 50 60 70 80 pF1KE0 SSTNVGSNTYGKRNAVEVLKREPLNYLPL ::::::::::::::::::::::::::::: NP_000 SSTNVGSNTYGKRNAVEVLKREPLNYLPL 70 80 >>NP_001316130 (OMIM: 147940) islet amyloid polypeptide (89 aa) initn: 562 init1: 562 opt: 562 Z-score: 842.6 bits: 160.4 E(85289): 3.4e-40 Smith-Waterman score: 562; 100.0% identity (100.0% similar) in 89 aa overlap (1-89:1-89) 10 20 30 40 50 60 pF1KE0 MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAIL 10 20 30 40 50 60 70 80 pF1KE0 SSTNVGSNTYGKRNAVEVLKREPLNYLPL ::::::::::::::::::::::::::::: NP_001 SSTNVGSNTYGKRNAVEVLKREPLNYLPL 70 80 >>NP_000719 (OMIM: 114160) calcitonin gene-related pepti (127 aa) initn: 159 init1: 135 opt: 145 Z-score: 225.2 bits: 46.7 E(85289): 8.4e-06 Smith-Waterman score: 145; 36.8% identity (70.6% similar) in 68 aa overlap (6-73:54-121) 10 20 30 pF1KE0 MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKC .: .. . . :.. . : : ..:: : NP_000 QAAPFRSALESSPDPATLSKEDARLLLAALVQDYVQMKASELKQEQETQGSSSAAQKRAC 30 40 50 60 70 80 40 50 60 70 80 pF1KE0 NTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKRNAVEVLKREPLNYLPL :::::.:.:::..: .:.. . . :::::...:.: NP_000 NTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAFGRRRRDLQA 90 100 110 120 >>NP_001029125 (OMIM: 114130) calcitonin gene-related pe (128 aa) initn: 143 init1: 127 opt: 135 Z-score: 210.4 bits: 44.0 E(85289): 5.6e-05 Smith-Waterman score: 135; 34.7% identity (68.0% similar) in 75 aa overlap (7-73:48-122) 10 20 pF1KE0 MGILKLQVFLIVLSVALNHLKATPIESHQ------- ...: .: ..::. .:..: NP_001 LQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQMKASELEQEQEREGSRI 20 30 40 50 60 70 30 40 50 60 70 80 pF1KE0 -VEKRKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKRNAVEVLKREPLNYLP ..:: :.::::.:.:::..: .:.. . :::::...:.: NP_001 IAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFGRRRRDLQA 80 90 100 110 120 pF1KE0 L 89 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 01:21:30 2016 done: Sat Nov 5 01:21:30 2016 Total Scan time: 3.970 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]