FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0225, 118 aa 1>>>pF1KE0225 118 - 118 aa - 118 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.3359+/-0.000272; mu= -0.0573+/- 0.017 mean_var=238.3043+/-47.422, 0's: 0 Z-trim(127.2): 31 B-trim: 51 in 1/60 Lambda= 0.083082 statistics sampled from 55110 (55151) to 55110 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.88), E-opt: 0.2 (0.647), width: 16 Scan time: 5.240 The best scores are: opt bits E(85289) NP_848525 (OMIM: 612619) late cornified envelope p ( 118) 986 128.7 2.2e-30 NP_848517 (OMIM: 612612) late cornified envelope p ( 110) 650 88.3 2.8e-18 NP_848130 (OMIM: 612607) late cornified envelope p ( 118) 646 87.9 4.1e-18 NP_848128 (OMIM: 612605) late cornified envelope p ( 118) 641 87.3 6.2e-18 NP_848131 (OMIM: 612608) late cornified envelope p ( 118) 640 87.2 6.8e-18 NP_848516 (OMIM: 612611) late cornified envelope p ( 110) 633 86.3 1.2e-17 NP_055172 (OMIM: 612610) late cornified envelope p ( 110) 632 86.2 1.3e-17 NP_848125 (OMIM: 612603) late cornified envelope p ( 110) 628 85.7 1.7e-17 NP_848126 (OMIM: 612604) late cornified envelope p ( 118) 628 85.7 1.8e-17 NP_848515 (OMIM: 612609) late cornified envelope p ( 106) 621 84.9 3.1e-17 NP_848129 (OMIM: 612606) late cornified envelope p ( 114) 591 81.3 3.9e-16 XP_011507023 (OMIM: 612618) PREDICTED: late cornif ( 175) 563 78.1 5.3e-15 NP_848133 (OMIM: 612618) late cornified envelope p ( 99) 518 72.5 1.5e-13 NP_848522 (OMIM: 612617) late cornified envelope p ( 92) 380 55.9 1.4e-08 XP_011507786 (OMIM: 612617) PREDICTED: late cornif ( 92) 380 55.9 1.4e-08 NP_848520 (OMIM: 612614) late cornified envelope p ( 95) 367 54.4 4.1e-08 NP_115952 (OMIM: 612616) late cornified envelope p ( 92) 362 53.7 6.1e-08 NP_848521 (OMIM: 612615) late cornified envelope p ( 94) 360 53.5 7.3e-08 NP_001263260 (OMIM: 612605) late cornified envelop ( 88) 353 52.6 1.3e-07 NP_848518 (OMIM: 612613) late cornified envelope p ( 89) 352 52.5 1.4e-07 NP_001017418 (OMIM: 182268) small proline-rich pro ( 72) 233 38.2 0.0023 NP_005979 (OMIM: 182267) small proline-rich protei ( 72) 233 38.2 0.0023 XP_016857663 (OMIM: 182268) PREDICTED: small proli ( 72) 233 38.2 0.0023 NP_005544 (OMIM: 148021) keratin-associated protei ( 169) 231 38.3 0.005 >>NP_848525 (OMIM: 612619) late cornified envelope prote (118 aa) initn: 986 init1: 986 opt: 986 Z-score: 666.4 bits: 128.7 E(85289): 2.2e-30 Smith-Waterman score: 986; 100.0% identity (100.0% similar) in 118 aa overlap (1-118:1-118) 10 20 30 40 50 60 pF1KE0 MSCQQSQQQCQPPPKCTPKCPPKCTPKCPPKCPPKCPPQCSAPCPPPVSSCCGSSSGGCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 MSCQQSQQQCQPPPKCTPKCPPKCTPKCPPKCPPKCPPQCSAPCPPPVSSCCGSSSGGCC 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 SSEGGGCCLSHHRPRQSLRRRPQSSSCCGSGSGQQSGGSSCCHSSGGSGCCHSSGGCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 SSEGGGCCLSHHRPRQSLRRRPQSSSCCGSGSGQQSGGSSCCHSSGGSGCCHSSGGCC 70 80 90 100 110 >>NP_848517 (OMIM: 612612) late cornified envelope prote (110 aa) initn: 661 init1: 492 opt: 650 Z-score: 449.1 bits: 88.3 E(85289): 2.8e-18 Smith-Waterman score: 652; 68.3% identity (71.4% similar) in 126 aa overlap (1-118:1-110) 10 20 30 40 50 pF1KE0 MSCQQSQQQCQPPPKCTPKCPPKCTPKCPPKCPPKCPPQCSAPCPPPVSSCCGSSSG--- :::::.:::::::::: :::::::::::::::::::: ::: : :::::: ::: NP_848 MSCQQNQQQCQPPPKC----PPKCTPKCPPKCPPKCPPQCPAPCSPAVSSCCGPSSGSCC 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 -----GCCSSEGGGCCLSHHRPRQSLRRRPQSSSCCGSGSGQQSGGSSCCHSSGGSGCCH ::::: :::::::::::: ::: :: .:: : . ::.::::: NP_848 GPSSGGCCSSGGGGCCLSHHRPRLFHRRRHQSPDCCES------------EPSGASGCCH 60 70 80 90 100 pF1KE0 SSGGCC :::::: NP_848 SSGGCC 110 >>NP_848130 (OMIM: 612607) late cornified envelope prote (118 aa) initn: 372 init1: 372 opt: 646 Z-score: 446.1 bits: 87.9 E(85289): 4.1e-18 Smith-Waterman score: 646; 69.8% identity (77.8% similar) in 126 aa overlap (1-118:1-118) 10 20 30 40 50 pF1KE0 MSCQQSQQQCQPPPKCTPKCPPKC-TPKCPPKCPPKCPPQ---CSAP----CPPPVSSCC :::::::::::::::::::::::: :::::::::::::: ::. : .. : NP_848 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 GSSSGGCCSSEGGGCCLSHHRPRQSLRRRPQSSSCCGSGSGQQSGGSSCCHSSGGSGCCH :::::::::: :::::::::: ..: :.:::::.::. : ::::::: .:::: . NP_848 GSSSGGCCSSGGGGCCLSHHRHHRSHRHRPQSSDCCS----QPSGGSSCC--GGGSG--Q 70 80 90 100 110 pF1KE0 SSGGCC ::::: NP_848 HSGGCC >>NP_848128 (OMIM: 612605) late cornified envelope prote (118 aa) initn: 386 init1: 386 opt: 641 Z-score: 442.9 bits: 87.3 E(85289): 6.2e-18 Smith-Waterman score: 641; 69.8% identity (77.0% similar) in 126 aa overlap (1-118:1-118) 10 20 30 40 50 pF1KE0 MSCQQSQQQCQPPPKCTPKCPPKC-TPKCPPKCPPKCPPQ---CSAP----CPPPVSSCC :::::::::::::::::::::::: :::::::::::::: ::. : .. : NP_848 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 GSSSGGCCSSEGGGCCLSHHRPRQSLRRRPQSSSCCGSGSGQQSGGSSCCHSSGGSGCCH :::::::::: :::::::::: :.: .:::::.::. : ::::::: .:::: . NP_848 GSSSGGCCSSGGGGCCLSHHRRRRSHCHRPQSSGCCS----QPSGGSSCC--GGGSG--Q 70 80 90 100 110 pF1KE0 SSGGCC ::::: NP_848 HSGGCC >>NP_848131 (OMIM: 612608) late cornified envelope prote (118 aa) initn: 398 init1: 398 opt: 640 Z-score: 442.3 bits: 87.2 E(85289): 6.8e-18 Smith-Waterman score: 640; 69.3% identity (77.2% similar) in 127 aa overlap (1-118:1-118) 10 20 30 40 50 pF1KE0 MSCQQSQQQCQPPPKCTPKCPPKC-TPKCPPKCPPKCPPQCSAPCPPPVSSCCGSSSGGC :::::::::::::::::::::::: :::::::::::::: :. : ..::::::::: NP_848 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPP-VSSCCSVSSGGCCGSSSGGC 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 CSSEGGGCC--------LSHHRPRQSLRRRPQSSSCCGSGSGQQSGGSSCCHSSGGSGCC ::: ::::: ::::: :.: :.:::::.::. : :.::::: .:::: NP_848 CSSGGGGCCSSGGGGCCLSHHRRRRSHRHRPQSSDCCS----QPSAGSSCC--GGGSG-- 60 70 80 90 100 110 pF1KE0 HSSGGCC . ::::: NP_848 QHSGGCC >>NP_848516 (OMIM: 612611) late cornified envelope prote (110 aa) initn: 503 init1: 466 opt: 633 Z-score: 438.1 bits: 86.3 E(85289): 1.2e-17 Smith-Waterman score: 635; 67.5% identity (70.6% similar) in 126 aa overlap (1-118:1-110) 10 20 30 40 50 pF1KE0 MSCQQSQQQCQPPPKCTPKCPPKCTPKCPPKCPPKCPPQCSAPCPPPVSSCCGSSSG--- :::::.:::::::::: :::::::::::::::::::: ::: : :::::: ::: NP_848 MSCQQNQQQCQPPPKC----PPKCTPKCPPKCPPKCPPQCPAPCFPAVSSCCGPSSGSCC 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 -----GCCSSEGGGCCLSHHRPRQSLRRRPQSSSCCGSGSGQQSGGSSCCHSSGGSGCCH ::::: .::: ::::::: ::: :: .:: : . :::::::: NP_848 GPSSGGCCSSGAGGCSLSHHRPRLFHRRRHQSPDCCES------------EPSGGSGCCH 60 70 80 90 100 pF1KE0 SSGGCC :::::: NP_848 SSGGCC 110 >>NP_055172 (OMIM: 612610) late cornified envelope prote (110 aa) initn: 591 init1: 458 opt: 632 Z-score: 437.5 bits: 86.2 E(85289): 1.3e-17 Smith-Waterman score: 634; 66.7% identity (70.6% similar) in 126 aa overlap (1-118:1-110) 10 20 30 40 50 pF1KE0 MSCQQSQQQCQPPPKCTPKCPPKCTPKCPPKCPPKCPPQCSAPCPPPVSSCCGS------ :::::.:::::::::: :::::::::::::::: ::: ::: : :::::: NP_055 MSCQQNQQQCQPPPKC----PPKCTPKCPPKCPPKCLPQCPAPCSPAVSSCCGPISGGCC 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 --SSGGCCSSEGGGCCLSHHRPRQSLRRRPQSSSCCGSGSGQQSGGSSCCHSSGGSGCCH ::::::.: .::::::::::: ::: :: .:: : . :::::::: NP_055 GPSSGGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCES------------EPSGGSGCCH 60 70 80 90 100 pF1KE0 SSGGCC :::::: NP_055 SSGGCC 110 >>NP_848125 (OMIM: 612603) late cornified envelope prote (110 aa) initn: 788 init1: 453 opt: 628 Z-score: 434.9 bits: 85.7 E(85289): 1.7e-17 Smith-Waterman score: 628; 71.4% identity (79.8% similar) in 119 aa overlap (1-118:1-110) 10 20 30 40 50 pF1KE0 MSCQQSQQQCQPPPKCTPKCPPKC-TPKCPPKCPPKCPPQCSAPCPPPVSSCCGSSSGGC :::::::::::::::::::::::: :::::::::::::: :. : ..:::::::: NP_848 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPP-VSSCCSVSSGGCCGSSSGGG 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 CSSEGGGCCLSHHRPRQSLRRRPQSSSCCGSGSGQQSGGSSCCHSSGGSGCCHSSGGCC ::: :::::::::: ..: :.: :::.::. : ::::::: .: :: . ::::: NP_848 CSSGGGGCCLSHHRRHRSHRHRLQSSGCCS----QPSGGSSCC--GGDSG--QHSGGCC 60 70 80 90 100 110 >>NP_848126 (OMIM: 612604) late cornified envelope prote (118 aa) initn: 375 init1: 375 opt: 628 Z-score: 434.5 bits: 85.7 E(85289): 1.8e-17 Smith-Waterman score: 628; 67.5% identity (76.2% similar) in 126 aa overlap (1-118:1-118) 10 20 30 40 50 pF1KE0 MSCQQSQQQCQPPPKCTPKCPPKC-TPKCPPKCPPKCPPQ---CSAP----CPPPVSSCC :::::.:::::::::: ::::::: ::.::::::::::: ::. : .. : NP_848 MSCQQNQQQCQPPPKCIPKCPPKCLTPRCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 GSSSGGCCSSEGGGCCLSHHRPRQSLRRRPQSSSCCGSGSGQQSGGSSCCHSSGGSGCCH :::::::::: :::::::::: :.: .:::::.::. : ::::::: .:::: . NP_848 GSSSGGCCSSGGGGCCLSHHRRRRSHCHRPQSSGCCS----QPSGGSSCC--GGGSG--Q 70 80 90 100 110 pF1KE0 SSGGCC ::::: NP_848 HSGGCC >>NP_848515 (OMIM: 612609) late cornified envelope prote (106 aa) initn: 550 init1: 550 opt: 621 Z-score: 430.5 bits: 84.9 E(85289): 3.1e-17 Smith-Waterman score: 637; 66.1% identity (72.9% similar) in 118 aa overlap (1-118:1-106) 10 20 30 40 50 60 pF1KE0 MSCQQSQQQCQPPPKCTPKCPPKCTPKCPPKCPPKCPPQCSAPCPPPVSSCCGSSSGGCC :::::.:::::::::: ::::::: ::: :.:: ::: :. : : ..:::::::::: NP_848 MSCQQNQQQCQPPPKCPPKCPPKCPPKCRPQCPAPCPPPVSSCCGPSSGGCCGSSSGGCC 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 SSEGGGCCLSHHRPRQSLRRRPQSSSCCGSGSGQQSGGSSCCHSSGGSGCCHSSGGCC :: :::::::::::: :.: :: .:: :. ::::::::::: :: NP_848 SSGGGGCCLSHHRPRLFHRHRHQSPDCCE------------CEPSGGSGCCHSSGDCC 70 80 90 100 118 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 20:34:28 2016 done: Thu Nov 3 20:34:29 2016 Total Scan time: 5.240 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]