FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0227, 110 aa 1>>>pF1KE0227 110 - 110 aa - 110 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.0443+/-0.000255; mu= 0.0182+/- 0.016 mean_var=200.8604+/-39.340, 0's: 0 Z-trim(127.4): 40 B-trim: 54 in 1/56 Lambda= 0.090496 statistics sampled from 55681 (55730) to 55681 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.89), E-opt: 0.2 (0.653), width: 16 Scan time: 4.870 The best scores are: opt bits E(85289) NP_055172 (OMIM: 612610) late cornified envelope p ( 110) 941 132.9 1e-31 NP_848517 (OMIM: 612612) late cornified envelope p ( 110) 897 127.2 5.4e-30 NP_848516 (OMIM: 612611) late cornified envelope p ( 110) 888 126.0 1.2e-29 NP_848515 (OMIM: 612609) late cornified envelope p ( 106) 817 116.7 7.3e-27 NP_848130 (OMIM: 612607) late cornified envelope p ( 118) 636 93.1 1e-19 NP_848525 (OMIM: 612619) late cornified envelope p ( 118) 632 92.6 1.5e-19 NP_848131 (OMIM: 612608) late cornified envelope p ( 118) 630 92.3 1.8e-19 NP_848129 (OMIM: 612606) late cornified envelope p ( 114) 622 91.3 3.5e-19 NP_848128 (OMIM: 612605) late cornified envelope p ( 118) 622 91.3 3.6e-19 NP_848125 (OMIM: 612603) late cornified envelope p ( 110) 613 90.1 7.8e-19 NP_848126 (OMIM: 612604) late cornified envelope p ( 118) 612 90.0 8.9e-19 XP_011507023 (OMIM: 612618) PREDICTED: late cornif ( 175) 526 78.9 2.9e-15 NP_001263260 (OMIM: 612605) late cornified envelop ( 88) 368 58.0 2.8e-09 NP_848133 (OMIM: 612618) late cornified envelope p ( 99) 363 57.4 4.8e-09 XP_011507786 (OMIM: 612617) PREDICTED: late cornif ( 92) 343 54.8 2.8e-08 NP_848522 (OMIM: 612617) late cornified envelope p ( 92) 343 54.8 2.8e-08 NP_115952 (OMIM: 612616) late cornified envelope p ( 92) 339 54.3 4e-08 NP_848520 (OMIM: 612614) late cornified envelope p ( 95) 326 52.6 1.3e-07 NP_848521 (OMIM: 612615) late cornified envelope p ( 94) 299 49.0 1.5e-06 NP_848518 (OMIM: 612613) late cornified envelope p ( 89) 227 39.6 0.00099 XP_016857663 (OMIM: 182268) PREDICTED: small proli ( 72) 217 38.2 0.0021 NP_001017418 (OMIM: 182268) small proline-rich pro ( 72) 217 38.2 0.0021 NP_005979 (OMIM: 182267) small proline-rich protei ( 72) 217 38.2 0.0021 NP_005544 (OMIM: 148021) keratin-associated protei ( 169) 212 37.9 0.0061 >>NP_055172 (OMIM: 612610) late cornified envelope prote (110 aa) initn: 941 init1: 941 opt: 941 Z-score: 690.6 bits: 132.9 E(85289): 1e-31 Smith-Waterman score: 941; 100.0% identity (100.0% similar) in 110 aa overlap (1-110:1-110) 10 20 30 40 50 60 pF1KE0 MSCQQNQQQCQPPPKCPPKCTPKCPPKCPPKCLPQCPAPCSPAVSSCCGPISGGCCGPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MSCQQNQQQCQPPPKCPPKCTPKCPPKCPPKCLPQCPAPCSPAVSSCCGPISGGCCGPSS 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 GGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCESEPSGGSGCCHSSGGCC :::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCESEPSGGSGCCHSSGGCC 70 80 90 100 110 >>NP_848517 (OMIM: 612612) late cornified envelope prote (110 aa) initn: 897 init1: 897 opt: 897 Z-score: 659.5 bits: 127.2 E(85289): 5.4e-30 Smith-Waterman score: 897; 94.5% identity (98.2% similar) in 110 aa overlap (1-110:1-110) 10 20 30 40 50 60 pF1KE0 MSCQQNQQQCQPPPKCPPKCTPKCPPKCPPKCLPQCPAPCSPAVSSCCGPISGGCCGPSS :::::::::::::::::::::::::::::::: ::::::::::::::::: ::.:::::: NP_848 MSCQQNQQQCQPPPKCPPKCTPKCPPKCPPKCPPQCPAPCSPAVSSCCGPSSGSCCGPSS 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 GGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCESEPSGGSGCCHSSGGCC ::::.::.::::::::::::::::::::::::::::::.::::::::::: NP_848 GGCCSSGGGGCCLSHHRPRLFHRRRHQSPDCCESEPSGASGCCHSSGGCC 70 80 90 100 110 >>NP_848516 (OMIM: 612611) late cornified envelope prote (110 aa) initn: 888 init1: 888 opt: 888 Z-score: 653.2 bits: 126.0 E(85289): 1.2e-29 Smith-Waterman score: 888; 94.5% identity (96.4% similar) in 110 aa overlap (1-110:1-110) 10 20 30 40 50 60 pF1KE0 MSCQQNQQQCQPPPKCPPKCTPKCPPKCPPKCLPQCPAPCSPAVSSCCGPISGGCCGPSS :::::::::::::::::::::::::::::::: ::::::: ::::::::: ::.:::::: NP_848 MSCQQNQQQCQPPPKCPPKCTPKCPPKCPPKCPPQCPAPCFPAVSSCCGPSSGSCCGPSS 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 GGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCESEPSGGSGCCHSSGGCC ::::.:::::: :::::::::::::::::::::::::::::::::::::: NP_848 GGCCSSGAGGCSLSHHRPRLFHRRRHQSPDCCESEPSGGSGCCHSSGGCC 70 80 90 100 110 >>NP_848515 (OMIM: 612609) late cornified envelope prote (106 aa) initn: 738 init1: 738 opt: 817 Z-score: 603.3 bits: 116.7 E(85289): 7.3e-27 Smith-Waterman score: 817; 87.3% identity (90.0% similar) in 110 aa overlap (1-110:1-106) 10 20 30 40 50 60 pF1KE0 MSCQQNQQQCQPPPKCPPKCTPKCPPKCPPKCLPQCPAPCSPAVSSCCGPISGGCCGPSS :::::::::::::::::::: :::::::: ::::::: : ::::::: :::::: :: NP_848 MSCQQNQQQCQPPPKCPPKC----PPKCPPKCRPQCPAPCPPPVSSCCGPSSGGCCGSSS 10 20 30 40 50 70 80 90 100 110 pF1KE0 GGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCESEPSGGSGCCHSSGGCC ::::.::.:::::::::::::::.::::::::: ::::::::::::: :: NP_848 GGCCSSGGGGCCLSHHRPRLFHRHRHQSPDCCECEPSGGSGCCHSSGDCC 60 70 80 90 100 >>NP_848130 (OMIM: 612607) late cornified envelope prote (118 aa) initn: 396 init1: 396 opt: 636 Z-score: 475.0 bits: 93.1 E(85289): 1e-19 Smith-Waterman score: 636; 67.2% identity (78.2% similar) in 119 aa overlap (1-110:1-118) 10 20 30 40 50 pF1KE0 MSCQQNQQQCQPPPKCPPKCTPKCP-PKCPPKCLPQCP---APCSPAVSSCCGPISGGCC :::::.:::::::::: ::: :::: ::::::: :.:: . :: . ..::: ::: : NP_848 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 GPSSGGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCESEPSGGSGCC-----HSSGGCC : ::::::.::.::::::::: . ::.: :: ::: :.:::::.:: . ::::: NP_848 GSSSGGCCSSGGGGCCLSHHRHHRSHRHRPQSSDCC-SQPSGGSSCCGGGSGQHSGGCC 70 80 90 100 110 >>NP_848525 (OMIM: 612619) late cornified envelope prote (118 aa) initn: 698 init1: 458 opt: 632 Z-score: 472.2 bits: 92.6 E(85289): 1.5e-19 Smith-Waterman score: 634; 66.7% identity (70.6% similar) in 126 aa overlap (1-110:1-118) 10 20 30 40 50 pF1KE0 MSCQQNQQQCQPPPKC----PPKCTPKCPPKCPPKCLPQCPAPCSPAVSSCCGPISGGCC :::::.:::::::::: :::::::::::::::: ::: ::: : :::: : NP_848 MSCQQSQQQCQPPPKCTPKCPPKCTPKCPPKCPPKCPPQCSAPCPPPVSSC--------C 10 20 30 40 50 60 70 80 90 100 pF1KE0 GPSSGGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCES------------EPSGGSGCCH : ::::::.: .::::::::::: ::: :: .:: : . :::::::: NP_848 GSSSGGCCSSEGGGCCLSHHRPRQSLRRRPQSSSCCGSGSGQQSGGSSCCHSSGGSGCCH 60 70 80 90 100 110 110 pF1KE0 SSGGCC :::::: NP_848 SSGGCC >>NP_848131 (OMIM: 612608) late cornified envelope prote (118 aa) initn: 532 init1: 399 opt: 630 Z-score: 470.7 bits: 92.3 E(85289): 1.8e-19 Smith-Waterman score: 630; 65.5% identity (79.0% similar) in 119 aa overlap (1-110:1-118) 10 20 30 40 50 pF1KE0 MSCQQNQQQCQPPPKCPPKCTPKCP-PKCPPKCLPQCP---APCSPAVSSCCGPISGGCC :::::.:::::::::: ::: :::: ::::::: :.:: . :: . ..::: ::::: NP_848 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGCC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 GPSSGGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCESEPSGGSGCC-----HSSGGCC . ..::::.::.::::::::: : ::.: :: ::: :.::.::.:: . ::::: NP_848 SSGGGGCCSSGGGGCCLSHHRRRRSHRHRPQSSDCC-SQPSAGSSCCGGGSGQHSGGCC 70 80 90 100 110 >>NP_848129 (OMIM: 612606) late cornified envelope prote (114 aa) initn: 801 init1: 509 opt: 622 Z-score: 465.3 bits: 91.3 E(85289): 3.5e-19 Smith-Waterman score: 622; 68.1% identity (78.4% similar) in 116 aa overlap (1-110:1-114) 10 20 30 40 50 pF1KE0 MSCQQNQQQCQPPPKCPPKCTPKCP-PKCPPKCLPQCPAPCSPAVSSCCGPISGGCCGPS :::::.:::::::::: :::::::: ::::::: : . :: . ..::: ::: :: . NP_848 MSCQQSQQQCQPPPKCTPKCTPKCPAPKCPPKC-PPVSSCCSVSSGGCCGSSSGGGCGSN 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 SGGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCESEPSGGSGCC-----HSSGGCC :::::.::.::::::::: . :::: :: ::: :.:::::.:: . ::::: NP_848 SGGCCSSGGGGCCLSHHRRHRSHRRRPQSSDCC-SQPSGGSSCCGGGSSQHSGGCC 60 70 80 90 100 110 >>NP_848128 (OMIM: 612605) late cornified envelope prote (118 aa) initn: 525 init1: 382 opt: 622 Z-score: 465.1 bits: 91.3 E(85289): 3.6e-19 Smith-Waterman score: 622; 66.4% identity (76.5% similar) in 119 aa overlap (1-110:1-118) 10 20 30 40 50 pF1KE0 MSCQQNQQQCQPPPKCPPKCTPKCP-PKCPPKCLPQCP---APCSPAVSSCCGPISGGCC :::::.:::::::::: ::: :::: ::::::: :.:: . :: . ..::: ::: : NP_848 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 GPSSGGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCESEPSGGSGCC-----HSSGGCC : ::::::.::.::::::::: : : .: :: :: :.:::::.:: . ::::: NP_848 GSSSGGCCSSGGGGCCLSHHRRRRSHCHRPQSSGCC-SQPSGGSSCCGGGSGQHSGGCC 70 80 90 100 110 >>NP_848125 (OMIM: 612603) late cornified envelope prote (110 aa) initn: 437 init1: 437 opt: 613 Z-score: 459.2 bits: 90.1 E(85289): 7.8e-19 Smith-Waterman score: 613; 69.0% identity (77.6% similar) in 116 aa overlap (1-110:1-110) 10 20 30 40 50 pF1KE0 MSCQQNQQQCQPPPKCPPKCTPKCP-PKCPPKCLPQCPAPCSPAVSSCCGPISGGCCGPS :::::.:::::::::: ::: :::: ::::::: :.:: : :::::. :::::: : NP_848 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCP----P-VSSCCSVSSGGCCGSS 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 SGGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCESEPSGGSGCC-----HSSGGCC ::: :.::.::::::::: . ::.: :: :: :.:::::.:: . ::::: NP_848 SGGGCSSGGGGCCLSHHRRHRSHRHRLQSSGCC-SQPSGGSSCCGGDSGQHSGGCC 60 70 80 90 100 110 110 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 20:32:59 2016 done: Thu Nov 3 20:33:00 2016 Total Scan time: 4.870 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]