FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0239, 275 aa 1>>>pF1KE0239 275 - 275 aa - 275 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2738+/-0.000792; mu= 15.3206+/- 0.048 mean_var=64.0497+/-13.022, 0's: 0 Z-trim(108.0): 11 B-trim: 388 in 1/50 Lambda= 0.160257 statistics sampled from 9925 (9934) to 9925 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.694), E-opt: 0.2 (0.305), width: 16 Scan time: 2.070 The best scores are: opt bits E(32554) CCDS43173.1 KCNMB3 gene_id:27094|Hs108|chr3 ( 275) 1906 449.0 1.7e-126 CCDS3226.1 KCNMB3 gene_id:27094|Hs108|chr3 ( 279) 1783 420.6 6.1e-118 CCDS3225.1 KCNMB3 gene_id:27094|Hs108|chr3 ( 277) 1782 420.4 7.1e-118 CCDS43172.1 KCNMB3 gene_id:27094|Hs108|chr3 ( 257) 1775 418.7 2.1e-117 CCDS54683.1 KCNMB3 gene_id:27094|Hs108|chr3 ( 173) 911 218.9 2e-57 CCDS3223.1 KCNMB2 gene_id:10242|Hs108|chr3 ( 235) 633 154.7 5.8e-38 CCDS8997.1 KCNMB4 gene_id:27345|Hs108|chr12 ( 210) 479 119.0 2.7e-27 >>CCDS43173.1 KCNMB3 gene_id:27094|Hs108|chr3 (275 aa) initn: 1906 init1: 1906 opt: 1906 Z-score: 2384.7 bits: 449.0 E(32554): 1.7e-126 Smith-Waterman score: 1906; 100.0% identity (100.0% similar) in 275 aa overlap (1-275:1-275) 10 20 30 40 50 60 pF1KE0 MFPLLYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLGFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 MFPLLYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLGFA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 MMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 MMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 CLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 CLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 PFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 PFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKY 190 200 210 220 230 240 250 260 270 pF1KE0 STVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS ::::::::::::::::::::::::::::::::::: CCDS43 STVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS 250 260 270 >>CCDS3226.1 KCNMB3 gene_id:27094|Hs108|chr3 (279 aa) initn: 1783 init1: 1783 opt: 1783 Z-score: 2230.9 bits: 420.6 E(32554): 6.1e-118 Smith-Waterman score: 1783; 99.6% identity (100.0% similar) in 258 aa overlap (18-275:22-279) 10 20 30 40 50 pF1KE0 MFPLLYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVM .:::::::::::::::::::::::::::::::::::::: CCDS32 MDFSPSSELGFHFVAFILLTRHRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVM 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 LGFAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 LGFAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 GKYPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 GKYPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDH 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 KNGTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 KNGTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLL 190 200 210 220 230 240 240 250 260 270 pF1KE0 CEKYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS ::::::::::::::::::::::::::::::::::::::: CCDS32 CEKYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS 250 260 270 >>CCDS3225.1 KCNMB3 gene_id:27094|Hs108|chr3 (277 aa) initn: 1782 init1: 1782 opt: 1782 Z-score: 2229.7 bits: 420.4 E(32554): 7.1e-118 Smith-Waterman score: 1782; 100.0% identity (100.0% similar) in 257 aa overlap (19-275:21-277) 10 20 30 40 50 pF1KE0 MFPLLYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLG :::::::::::::::::::::::::::::::::::::::: CCDS32 MQPFSIPVQITLQGSRRRQGRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 FAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 FAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 YPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 YPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKN 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 GTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 GTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCE 190 200 210 220 230 240 240 250 260 270 pF1KE0 KYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS ::::::::::::::::::::::::::::::::::::: CCDS32 KYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS 250 260 270 >>CCDS43172.1 KCNMB3 gene_id:27094|Hs108|chr3 (257 aa) initn: 1775 init1: 1775 opt: 1775 Z-score: 2221.4 bits: 418.7 E(32554): 2.1e-117 Smith-Waterman score: 1775; 100.0% identity (100.0% similar) in 256 aa overlap (20-275:2-257) 10 20 30 40 50 60 pF1KE0 MFPLLYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLGFA ::::::::::::::::::::::::::::::::::::::::: CCDS43 MTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLGFA 10 20 30 40 70 80 90 100 110 120 pF1KE0 MMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 MMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYP 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE0 CLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 CLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGT 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE0 PFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 PFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKY 170 180 190 200 210 220 250 260 270 pF1KE0 STVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS ::::::::::::::::::::::::::::::::::: CCDS43 STVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS 230 240 250 >>CCDS54683.1 KCNMB3 gene_id:27094|Hs108|chr3 (173 aa) initn: 927 init1: 911 opt: 911 Z-score: 1144.5 bits: 218.9 E(32554): 2e-57 Smith-Waterman score: 911; 100.0% identity (100.0% similar) in 131 aa overlap (19-149:21-151) 10 20 30 40 50 pF1KE0 MFPLLYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLG :::::::::::::::::::::::::::::::::::::::: CCDS54 MQPFSIPVQITLQGSRRRQGRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 FAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 FAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 YPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKN ::::::::::::::::::::::::::::::: CCDS54 YPCLQVFVNLSHPGQKALLHYNEEAVQINPKRDVTDCRVKEKQTLTVSDEHKQ 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 GTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCE >>CCDS3223.1 KCNMB2 gene_id:10242|Hs108|chr3 (235 aa) initn: 593 init1: 224 opt: 633 Z-score: 795.1 bits: 154.7 E(32554): 5.8e-38 Smith-Waterman score: 633; 43.9% identity (74.1% similar) in 212 aa overlap (35-245:27-235) 10 20 30 40 50 60 pF1KE0 LYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKRLPS-SAGEDRAVMLGFAMMG : : :: .: . . .::::::..::.::: CCDS32 MFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMV 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 FSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYPCLQ :..:.:::: :.:. .: :. ::: :: ....: . . .:.:.:: : ..::::: CCDS32 CSIMMYFLLGITLLRSYMQSVWTEESQCTLLNASITETF-NCSFSCGPDCWKLSQYPCLQ 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 VFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGTPFS :.:::. :.: ::...::...:: :: : ::: .. .. .. . . : : .. :: CCDS32 VYVNLTSSGEKLLLYHTEETIKINQKCSYIPKCGKNFEESMSLVNVVMENF--RKYQHFS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 CFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKYSTV :. .: .....::: : :.. ..:: ::::. . ::. ::.::.:::.::::::. . . CCDS32 CYSDPEGNQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRI 180 190 200 210 220 230 250 260 270 pF1KE0 VRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS : CCDS32 NR >>CCDS8997.1 KCNMB4 gene_id:27345|Hs108|chr12 (210 aa) initn: 456 init1: 316 opt: 479 Z-score: 603.4 bits: 119.0 E(32554): 2.7e-27 Smith-Waterman score: 479; 31.8% identity (74.5% similar) in 192 aa overlap (48-238:11-202) 20 30 40 50 60 70 pF1KE0 QRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLGFAMMGFSVLMFFLLGTTIL . .::... ::. .. .:. .:..: : CCDS89 MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWL 10 20 30 40 80 90 100 110 120 130 pF1KE0 KPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYPCLQVFVNLSHPGQKALL .: . ..: :..::.. .. . . ..:.::::. :.: ..:::.::.:: :. ...::: CCDS89 SPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALL 50 60 70 80 90 100 140 150 160 170 180 190 pF1KE0 HYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGT-PFSCFYSPASQSEDVI : .:. . :::: : : :... . :.:... .... . :. ::.:... .. .::. CCDS89 HSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVL 110 120 130 140 150 160 200 210 220 230 240 250 pF1KE0 LIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKYSTVVRDEVGGKVPYIE : . .:.....::..:: .:.. :.::: .. .. :.. : CCDS89 LHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS 170 180 190 200 210 260 270 pF1KE0 QHQFKLCIMRRSKGRAEKS 275 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 19:47:27 2016 done: Thu Nov 3 19:47:27 2016 Total Scan time: 2.070 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]